Mechanisms Underlying the Anti-inflammatory and Immunosuppressive Activity of Ruxolitinib

scientific article published on 07 November 2019

Mechanisms Underlying the Anti-inflammatory and Immunosuppressive Activity of Ruxolitinib is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.3389/FONC.2019.01186
P932PMC publication ID6854013
P698PubMed publication ID31788449

P50authorGiuseppe Alberto PalumboQ61037582
P2093author name stringFrancesca Palandri
Francesco Mendicino
Claudia Baratè
Elena Maria Elli
P2860cites workOvercoming treatment challenges in myelofibrosis and polycythemia vera: the role of ruxolitinibQ26750696
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Ruxolitinib as Salvage Therapy in Steroid-Refractory Acute Graft-versus-Host Disease in Pediatric Hematopoietic Stem Cell Transplant PatientsQ33440405
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Pharmacologic blockade of JAK1/JAK2 reduces GvHD and preserves the graft-versus-leukemia effectQ34301568
An opportunistic infection associated with ruxolitinib, a novel janus kinase 1,2 inhibitorQ34343220
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The effect of long-term ruxolitinib treatment on JAK2p.V617F allele burden in patients with myelofibrosisQ36091279
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Immunological Consequences of JAK Inhibition: Friend or Foe?Q38570383
Aggressive Skin Cancers Occurring in Patients Treated With the Janus Kinase Inhibitor RuxolitinibQ38719157
Transient blocking of NK cell function with small molecule inhibitors for helper dependant adenoviral vector-mediated gene deliveryQ38862771
Ruxolitinib in myelofibrosis: to be or not to be an immune disruptor.Q38938526
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Evidence that the JAK2 G1849T (V617F) mutation occurs in a lymphomyeloid progenitor in polycythemia vera and idiopathic myelofibrosis.Q40235276
Homozygous calreticulin mutations in patients with myelofibrosis lead to acquired myeloperoxidase deficiency.Q40741460
Long-term findings from COMFORT-II, a phase 3 study of ruxolitinib vs best available therapy for myelofibrosis.Q40742224
JAK Inhibition Impairs NK Cell Function in Myeloproliferative NeoplasmsQ41127061
JAK1/2 inhibition impairs T cell function in vitro and in patients with myeloproliferative neoplasmsQ41138516
JAK inhibition induces silencing of T Helper cytokine secretion and a profound reduction in T regulatory cellsQ41160178
JAK inhibitors and myelofibrosis, Einstein and ruxolitinibQ42660823
The JAK-inhibitor ruxolitinib impairs dendritic cell function in vitro and in vivoQ43451422
Progressive multifocal leukoencephalopathy associated with ruxolitinibQ44509111
Bilateral toxoplasmosis retinitis associated with ruxolitinibQ44909357
Reactivation of hepatitis B virus infection following ruxolitinib treatment in a patient with myelofibrosis.Q45350105
Rapid and long-lasting decrease of T-regulatory cells in patients with myelofibrosis treated with ruxolitinib.Q46891342
Compassionate use of ruxolitinib in acute and chronic graft versus host disease refractory both to corticosteroids and extracorporeal photopheresis.Q47114304
Repression of interferon β-regulated cytokines by the JAK1/2 inhibitor ruxolitinib in inflammatory human macrophagesQ47334119
JAK inhibition as a therapeutic strategy for immune and inflammatory diseasesQ47439880
The BCR-ABL1-negative myeloproliferative neoplasms: a review of JAK inhibitors in the therapeutic armamentariumQ47581193
Ruxolitinib-associated infections: A systematic review and meta-analysis.Q48278553
Long-term effects of ruxolitinib versus best available therapy on bone marrow fibrosis in patients with myelofibrosis.Q51733623
Epidemiology, outcome, and risk factors for infectious complications in myelofibrosis patients receiving ruxolitinib: A multicenter study on 446 patients.Q52721155
The JAK inhibitor ruxolitinib impairs dendritic cell migration via off-target inhibition of ROCK.Q53095310
Topical Ruxolitinib for the Treatment of Alopecia Universalis.Q54229292
Ruxolitinib is a potent immunosuppressive compound: is it time for anti-infective prophylaxis?Q54393708
Preliminary clinical activity of a topical JAK1/2 inhibitor in the treatment of psoriasis.Q54533845
Ruxolitinib for the treatment of inadequately controlled polycythemia vera without splenomegaly: 80-week follow-up from the RESPONSE-2 trialQ56335282
Ruxolitinib-associated tuberculosis: a case of successful ruxolitinib rechallengeQ56970836
Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapyQ57075545
The Role of New Technologies in Myeloproliferative NeoplasmsQ64085216
New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and TreatmentQ79802927
The JAK2 V617F mutation involves B- and T-lymphocyte lineages in a subgroup of patients with Philadelphia-chromosome negative chronic myeloproliferative disordersQ79805830
SMAD3 prevents graft-versus-host disease by restraining Th1 differentiation and granulocyte-mediated tissue damageQ82674325
Activity of therapeutic JAK 1/2 blockade in graft-versus-host diseaseQ87635679
Characteristics of patients with myeloproliferative neoplasms with lymphoma, with or without JAK inhibitor therapyQ91842389
Second cancer in Philadelphia negative myeloproliferative neoplasms (MPN-K). A nested case-control studyQ92382938
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectruxolitinibQ7383611
P304page(s)1186
P577publication date2019-11-07
P1433published inFrontiers in OncologyQ26839986
P1476titleMechanisms Underlying the Anti-inflammatory and Immunosuppressive Activity of Ruxolitinib
P478volume9

Reverse relations

cites work (P2860)
Q98726025COVID-19 in Philadelphia-negative myeloproliferative disorders: a GIMEMA survey
Q96618090COVID-19: review on latest available drugs and therapies against SARS-CoV-2. Coagulation and inflammation cross-talking
Q97522230Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing
Q97069845How the coronavirus pandemic has affected the clinical management of Philadelphia-negative chronic myeloproliferative neoplasms in Italy-a GIMEMA MPN WP survey
Q104558729Innate Inhibiting Proteins Enhance Expression and Immunogenicity of Self-Amplifying RNA
Q91522442Treatment and unmet needs in steroid-refractory acute graft-versus-host disease
Q92060483Tuberculosis Peritonitis During Treatment of Polycythemia Vera with Ruxolitinib

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