The JAK inhibitor ruxolitinib impairs dendritic cell migration via off-target inhibition of ROCK.

scientific article

The JAK inhibitor ruxolitinib impairs dendritic cell migration via off-target inhibition of ROCK. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/LEU.2016.155
P698PubMed publication ID27220666

P2093author name stringW Kolanus
D Wolf
P Brossart
A Heine
J Trebicka
J Rudolph
T Quast
P2860cites workCCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathwayQ28209767
Non-muscle myosin II takes centre stage in cell adhesion and migrationQ28262326
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organsQ28594485
Rapid leukocyte migration by integrin-independent flowing and squeezingQ29620345
Dendritic-cell trafficking to lymph nodes through lymphatic vesselsQ33989067
The V617F JAK2 mutation and the myeloproliferative disordersQ36312018
Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter surveyQ36862931
JAK Inhibition Impairs NK Cell Function in Myeloproliferative NeoplasmsQ41127061
JAK1/2 inhibition impairs T cell function in vitro and in patients with myeloproliferative neoplasmsQ41138516
The JAK-inhibitor ruxolitinib impairs dendritic cell function in vitro and in vivoQ43451422
Differential requirement for ROCK in dendritic cell migration within lymphatic capillaries in steady-state and inflammation.Q50505877
Specificity and mechanism-of-action of the JAK2 tyrosine kinase inhibitors ruxolitinib and SAR302503 (TG101348).Q50860871
Myelofibrosis with myeloid metaplasiaQ73712758
Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturationQ77353738
Activity of therapeutic JAK 1/2 blockade in graft-versus-host diseaseQ87635679
P433issue10
P921main subjectdendritic cellQ506253
ruxolitinibQ7383611
P304page(s)2119-2123
P577publication date2016-05-25
P1433published inLeukemiaQ6534498
P1476titleThe JAK inhibitor ruxolitinib impairs dendritic cell migration via off-target inhibition of ROCK.
P478volume30

Reverse relations

cites work (P2860)
Q91587430Mechanisms Underlying the Anti-inflammatory and Immunosuppressive Activity of Ruxolitinib
Q91949140Myeloproliferative and lymphoproliferative disorders: State of the art
Q39015300Primary myelofibrosis: 2017 update on diagnosis, risk-stratification, and management
Q38938526Ruxolitinib in myelofibrosis: to be or not to be an immune disruptor.
Q91598124Targeting senescent cells: approaches, opportunities, challenges
Q41716360Tumor-related interleukins: old validated targets for new anti-cancer drug development

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