Translating the MAM model of psychosis to humans

scientific article

Translating the MAM model of psychosis to humans is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.TINS.2014.12.005
P932PMC publication ID4455929
P698PubMed publication ID25554679
P5875ResearchGate publication ID270278540

P50authorAnthony A. GraceQ28823334
Gemma ModinosQ63987320
Paul AllenQ37834596
Philip McGuireQ37834611
P2860cites workThe dopamine hypothesis of schizophrenia: version III--the final common pathwayQ22242827
Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjectsQ22248075
GABA concentration is reduced in visual cortex in schizophrenia and correlates with orientation-specific surround suppressionQ24610466
The hippocampal-prefrontal pathway: the weak link in psychiatric disorders?Q26822528
Functional outcome in people at high risk for psychosis predicted by thalamic glutamate levels and prefronto-striatal activationQ27320072
Parallel Organization of Functionally Segregated Circuits Linking Basal Ganglia and CortexQ29391304
Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responsesQ29618915
Abnormal stress responsivity in a rodent developmental disruption model of schizophreniaQ30429962
Transition to psychosis associated with prefrontal and subcortical dysfunction in ultra high-risk individualsQ30447851
Abnormal relationship between medial temporal lobe and subcortical dopamine function in people with an ultra high risk for psychosisQ30450082
Antipsychotic drug effects in schizophrenia: a review of longitudinal FMRI investigations and neural interpretationsQ30455338
A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophreniaQ30465716
Altered prefrontal and hippocampal function during verbal encoding and recognition in people with prodromal symptoms of psychosisQ30466268
Dopaminergic dysfunction in schizophrenia: salience attribution revisited.Q30475711
Sustained activation of the hippocampus in response to fearful faces in schizophrenia.Q50971006
Altered medial temporal activation related to local glutamate levels in subjects with prodromal signs of psychosis.Q51032268
Inflammation: its role in schizophrenia and the potential anti-inflammatory effects of antipsychoticsQ60644228
Observation of metabolic changes in chronic schizophrenia after neuroleptic treatment by in vivo hydrogen magnetic resonance spectroscopyQ71410459
Decreased glutamic acid decarboxylase67 messenger RNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophreniaQ73535859
Hippocampal pathology in schizophrenia: magnetic resonance imaging and spectroscopy studiesQ73815830
Glutamate dysfunction in people with prodromal symptoms of psychosis: relationship to gray matter volume.Q45950519
Reduction of brain gamma-aminobutyric acid (GABA) concentrations in early-stage schizophrenia patients: 3T Proton MRS study.Q45999628
Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics.Q46022290
Elevated striatal dopamine function linked to prodromal signs of schizophreniaQ46174418
Interrelated neuropsychological and anatomical evidence of hippocampal pathology in the at-risk mental stateQ46349634
Acute effects of single-dose aripiprazole and haloperidol on resting cerebral blood flow (rCBF) in the human brainQ46599084
HPA axis functioning associated with transition to psychosis: combined DEX/CRH testQ46887505
Aberrant hippocampal activity underlies the dopamine dysregulation in an animal model of schizophrenia.Q46945434
Longitudinal grey-matter and glutamatergic losses in first-episode schizophreniaQ46974035
The rat prefrontostriatal system analyzed in 3D: evidence for multiple interacting functional units.Q48107164
Increased dopamine synthesis rate in medial prefrontal cortex and striatum in schizophrenia indicated by L-(beta-11C) DOPA and PET.Q48121459
Altered brain function directly related to structural abnormalities in people at ultra high risk of psychosis: longitudinal VBM-fMRI studyQ48152135
Measurement of striatal D2 dopamine receptor density and affinity with [11C]-raclopride in vivo: a test-retest analysisQ48278378
Abnormal prefrontal activation directly related to pre-synaptic striatal dopamine dysfunction in people at clinical high risk for psychosisQ48394255
Maternal immune activation during pregnancy increases limbic GABAA receptor immunoreactivity in the adult offspring: implications for schizophreniaQ48395602
Dopamine D2 densities and the schizophrenic brain.Q48404440
Absolute coding of stimulus novelty in the human substantia nigra/VTA.Q48436853
Non-reduction in hippocampal volume is associated with higher risk of psychosisQ48457063
Hippocampal novelty activations in schizophrenia: disease and medication effectsQ48581541
Magnetic resonance spectroscopy and tissue protein concentrations together suggest lower glutamate signaling in dentate gyrus in schizophreniaQ48723751
An fMRI study of "theory of mind" in at-risk states of psychosis: comparison with manifest schizophrenia and healthy controlsQ48731158
Hippocampal and anterior cingulate morphology in subjects at ultra-high-risk for psychosis: the role of family history of psychotic illnessQ48891953
Increased brain dopamine and dopamine receptors in schizophrenia.Q48903689
Increased hippocampal glutamate and volumetric deficits in unmedicated patients with schizophrenia.Q48948657
Blunted cortisol awakening response in people at ultra high risk of developing psychosis.Q50631753
Maternal separation results in early emergence of adult-like fear and extinction learning in infant rats.Q50643617
Overactivation of fear systems to neutral faces in schizophrenia.Q50802890
Thalamic glutamate levels as a predictor of cortical response during executive functioning in subjects at high risk for psychosis.Q50803831
Increased neural response related to neutral faces in individuals at risk for psychosis.Q50876145
Increased medial temporal lobe activation during the passive viewing of emotional and neutral facial expressions in schizophrenia.Q50950002
Review of pathological hallmarks of schizophrenia: comparison of genetic models with patients and nongenetic modelsQ30476810
Gestational methylazoxymethanol acetate administration: a developmental disruption model of schizophreniaQ30478274
The neural basis of the blood-oxygen-level-dependent functional magnetic resonance imaging signalQ30499888
Amygdala-hippocampal shape differences in schizophrenia: the application of 3D shape models to volumetric MR dataQ30711472
Do we still believe in the dopamine hypothesis? New data bring new evidenceQ30906669
Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studiesQ31023592
Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studiesQ31043017
Brain abnormality in schizophrenia. A systematic and quantitative review of volumetric magnetic resonance imaging studiesQ32082435
Do antipsychotic drugs affect brain structure? A systematic and critical review of MRI findingsQ33425487
Neuroimaging predictors of transition to psychosis--a systematic review and meta-analysis.Q33530424
Differential targeting of the CA1 subfield of the hippocampal formation by schizophrenia and related psychotic disordersQ33555684
Hippocampal subdivision and amygdalar volumes in patients in an at-risk mental state for schizophreniaQ33563154
Resting-state perfusion in nonmedicated schizophrenic patients: a continuous arterial spin-labeling 3.0-T MR studyQ33588407
Role of the prefrontal cortex in altered hippocampal-accumbens synaptic plasticity in a developmental animal model of schizophreniaQ33718088
Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia.Q33814201
Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volumeQ33849008
Meta-analysis of regional brain volumes in schizophreniaQ33885349
To model a psychiatric disorder in animals: schizophrenia as a reality testQ33913794
Glutamate in schizophrenia: a focused review and meta-analysis of ¹H-MRS studiesQ33957510
Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophreniaQ33963430
Resting quantitative cerebral blood flow in schizophrenia measured by pulsed arterial spin labeling perfusion MRI.Q33989669
Reduced frontal glutamate + glutamine and N-acetylaspartate levels in patients with chronic schizophrenia but not in those at clinical high risk for psychosis or with first-episode schizophreniaQ34048560
Elevated gamma-aminobutyric acid levels in chronic schizophreniaQ34142882
Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison.Q34174069
Relationship between brain glutamate levels and clinical outcome in individuals at ultra high risk of psychosisQ34270086
Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies.Q34351095
Resting neural activity distinguishes subgroups of schizophrenia patientsQ34356672
The genomics of schizophrenia: update and implications.Q34381708
Glutamate as a marker of cognitive function in schizophrenia: a proton spectroscopic imaging study at 4 Tesla.Q34424470
Hypofrontality in schizophrenia: distributed dysfunctional circuits in neuroleptic-naïve patientsQ34429796
From dopamine to salience to psychosis--linking biology, pharmacology and phenomenology of psychosis.Q34432432
Dopamine-mediated disinhibition in the CA1 region of rat hippocampus via D3 receptor activation.Q34450964
Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individualsQ34492046
Dopamine in schizophrenia: a review and reconceptualizationQ34568816
Calcium and excitotoxic neuronal injury.Q40586805
The medial temporal lobe in schizophreniaQ41581012
Presynaptic striatal dopamine dysfunction in people at ultra-high risk for psychosis: findings in a second cohort.Q42519170
Neuropharmacological and neurobiological relevance of in vivo ¹H-MRS of GABA and glutamate for preclinical drug discovery in mental disordersQ42544819
Subanesthetic doses of ketamine stimulate psychosis in schizophreniaQ42557972
The effects of early rearing environment on the development of GABAA and central benzodiazepine receptor levels and novelty-induced fearfulness in the rat.Q42620039
Altered relationship between hippocampal glutamate levels and striatal dopamine function in subjects at ultra high risk of psychosisQ42967481
Abnormal frontostriatal interactions in people with prodromal signs of psychosis: a multimodal imaging studyQ42984373
Hippocampal pathology in individuals at ultra-high risk for psychosis: a multi-modal magnetic resonance study.Q43095693
Neuroanatomical abnormalities that predate the onset of psychosis: a multicenter studyQ43851337
Striatal glutamate and the conversion to psychosis: a prospective 1H-MRS imaging studyQ43987270
Glutamate and glutamine measured with 4.0 T proton MRS in never-treated patients with schizophrenia and healthy volunteersQ44201512
Structural and metabolic changes in language areas linked to formal thought disorder.Q44251481
Glutamate-receptor-mediated encoding and retrieval of paired-associate learningQ44508738
Whole-brain mapping of direct inputs to midbrain dopamine neuronsQ44901176
Disruption of neurogenesis on gestational day 17 in the rat causes behavioral changes relevant to positive and negative schizophrenia symptoms and alters amphetamine-induced dopamine release in nucleus accumbensQ44938375
Preserved working memory and altered brain activation in persons at risk for psychosis.Q45329878
Regional gray matter volume abnormalities in the at risk mental stateQ34572449
Predicting psychosis: meta-analysis of transition outcomes in individuals at high clinical riskQ34636460
Connectivity-based segregation of the human striatum predicts personality characteristicsQ34887650
Higher levels of glutamate in the associative-striatum of subjects with prodromal symptoms of schizophrenia and patients with first-episode psychosisQ35158156
Hippocampal dysregulation of dopamine system function and the pathophysiology of schizophreniaQ35175354
Divergent activation of ventromedial and ventrolateral dopamine systems in animal models of amphetamine sensitization and schizophreniaQ35230683
A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP.Q35244029
The primate basal ganglia: parallel and integrative networksQ35631862
Selective remediation of reversal learning deficits in the neurodevelopmental MAM model of schizophrenia by a novel mGlu5 positive allosteric modulatorQ35760205
The principal features and mechanisms of dopamine modulation in the prefrontal cortexQ35894171
The hippocampal-VTA loop: controlling the entry of information into long-term memoryQ36144286
NMDA receptor hypofunction, parvalbumin-positive neurons, and cortical gamma oscillations in schizophreniaQ36245009
Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosisQ36442025
Progressive increase in striatal dopamine synthesis capacity as patients develop psychosis: a PET study.Q36871782
Dopamine synthesis capacity before onset of psychosis: a prospective [18F]-DOPA PET imaging studyQ36928703
Mechanisms underlying psychosis and antipsychotic treatment response in schizophrenia: insights from PET and SPECT imaging.Q36941951
Disruption of prefrontal cortical-hippocampal balance in a developmental model of schizophrenia: reversal by sulpirideQ36942898
Cortisol levels and risk for psychosis: initial findings from the North American prodrome longitudinal studyQ37001281
The nature of dopamine dysfunction in schizophrenia and what this means for treatmentQ37062793
Peripubertal diazepam administration prevents the emergence of dopamine system hyperresponsivity in the MAM developmental disruption model of schizophreniaQ37103318
Glutamate levels in the associative striatum before and after 4 weeks of antipsychotic treatment in first-episode psychosis: a longitudinal proton magnetic resonance spectroscopy studyQ37215695
Neural and behavioral correlates of aberrant salience in individuals at risk for psychosisQ37228333
A loss of parvalbumin-containing interneurons is associated with diminished oscillatory activity in an animal model of schizophreniaQ37369353
Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driverQ37665156
Glutamate and GABA imbalance promotes neuronal apoptosis in hippocampus after stressQ37685583
The Hippocampal Formation in SchizophreniaQ37784600
MR spectroscopy in schizophreniaQ37958837
Epidemiological, neurobiological, and genetic clues to the mechanisms linking cannabis use to risk for nonaffective psychosisQ38182624
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectpsychosisQ170082
P304page(s)129-138
P577publication date2014-12-30
P1433published inTrends in NeurosciencesQ3538443
P1476titleTranslating the MAM model of psychosis to humans
P478volume38

Reverse relations

cites work (P2860)
Q47569419A mouse model of the schizophrenia-associated 1q21.1 microdeletion syndrome exhibits altered mesolimbic dopamine transmission
Q99402872A single dose of cannabidiol modulates medial temporal and striatal function during fear processing in people at clinical high risk for psychosis
Q38846609Adolescence as a period of vulnerability and intervention in schizophrenia: Insights from the MAM model
Q67496222Adolescent Social Isolation Affects Schizophrenia-Like Behavior in the MAM-E17 Model of Schizophrenia.
Q38832247Adolescent Stress as a Driving Factor for Schizophrenia Development-A Basic Science Perspective
Q67496287Adolescent social isolation affects parvalbumin expression in the medial prefrontal cortex in the MAM-E17 model of schizophrenia.
Q45839278Altered activation and connectivity in a hippocampal-basal ganglia-midbrain circuit during salience processing in subjects at ultra high risk for psychosis
Q88502234Altered brain cannabinoid 1 receptor mRNA expression across postnatal development in the MAM model of schizophrenia
Q38759421Altering the course of schizophrenia: progress and perspectives
Q88616942An Overview of Animal Models Related to Schizophrenia
Q38621565Can neuroimaging be used to predict the onset of psychosis?
Q92796981Cannabidiol attenuates insular dysfunction during motivational salience processing in subjects at clinical high risk for psychosis
Q38435208Comparative analysis of MBD-seq and MeDIP-seq and estimation of gene expression changes in a rodent model of schizophrenia
Q47600351Cortical GABA In Subjects At Ultra-High Risk Of Psychosis: Relationship To Negative Prodromal Symptoms.
Q47895125Developmental timing and critical windows for the treatment of psychiatric disorders.
Q38852249Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression
Q57403237Effect of Cannabidiol on Medial Temporal, Midbrain, and Striatal Dysfunction in People at Clinical High Risk of Psychosis
Q64267299Emerging Temporal Lobe Dysfunction in People at Clinical High Risk for Psychosis
Q89422888Fear extinction disruption in a developmental rodent model of schizophrenia correlates with an impairment in basolateral amygdala-medial prefrontal cortex plasticity
Q26767711Hippocampal-Prefrontal Interactions in Cognition, Behavior and Psychiatric Disease
Q47959577Impaired contextual fear-conditioning in MAM rodent model of schizophrenia
Q37015339Is neuroimaging clinically useful in subjects at high risk for psychosis?
Q37563725Longitudinal alterations in motivational salience processing in ultra-high-risk subjects for psychosis.
Q39277083MAM (E17) rodent developmental model of neuropsychiatric disease: disruptions in learning and dysregulation of nucleus accumbens dopamine release, but spared executive function
Q38821460NMDA Receptor Internalization by Autoantibodies: A Reversible Mechanism Underlying Psychosis?
Q90750994Neural Circuitry of Novelty Salience Processing in Psychosis Risk: Association With Clinical Outcome
Q38901529Neuroinflammation and Oxidative Stress in Psychosis and Psychosis Risk
Q33854995Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia
Q60625022Oxytocin modulates hippocampal perfusion in people at clinical high risk for psychosis
Q39029199Phosphodiesterase 10 inhibitors in clinical development for CNS disorders
Q39076734Prefrontal Cortex Dysfunction Increases Susceptibility to Schizophrenia-Like Changes Induced by Adolescent Stress Exposure
Q50025633Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis
Q48099270Prefrontal and Striatal Glutamate Differently Relate to Striatal Dopamine: Potential Regulatory Mechanisms of Striatal Presynaptic Dopamine Function?
Q88407120Resting state connectivity dynamics in individuals at risk for psychosis
Q91861211State-dependent effects of the D2 partial agonist aripiprazole on dopamine neuron activity in the MAM neurodevelopmental model of schizophrenia
Q38805970Striatal dopamine, reward, and decision making in schizophrenia
Q89115583TSPO expression and brain structure in the psychosis spectrum
Q49551829The Circuitry of Dopamine System Regulation and its Disruption in Schizophrenia: Insights Into Treatment and Prevention.
Q37198435The Nucleus Reuniens of the Midline Thalamus Gates Prefrontal-Hippocampal Modulation of Ventral Tegmental Area Dopamine Neuron Activity
Q38646326The blood-brain barrier in psychosis
Q97556098The mGluR2/3 agonist pomaglumetad methionil normalizes aberrant dopamine neuron activity via action in the ventral hippocampus
Q48126673The methylazoxymethanol acetate rat model: molecular and epigenetic effect in the developing prefrontal cortex: An Editorial Highlight for 'Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in t
Q93133919The pathophysiological impact of stress on the dopamine system is dependent on the state of the critical period of vulnerability
Q91130303The relationship between grey matter volume and striatal dopamine function in psychosis: a multimodal 18F-DOPA PET and voxel-based morphometry study
Q52562792α7 Nicotinic receptor-modulating agents reverse the hyperdopaminergic tone in the MAM model of schizophrenia.