review article | Q7318358 |
scholarly article | Q13442814 |
P50 | author | Yukiko Kuroda | Q64683249 |
Koichi Matsuo | Q56810711 | ||
Tsukasa Oikawa | Q49414211 | ||
P2860 | cites work | Purified inositol 1,4,5-trisphosphate receptor mediates calcium flux in reconstituted lipid vesicles | Q59095132 |
WASp deficiency in mice results in failure to form osteoclast sealing zones and defects in bone resorption | Q61053891 | ||
Crucial role for autophagy in degranulation of mast cells | Q63609781 | ||
Phosphorylation of a Wiscott-Aldrich syndrome protein-associated signal complex is critical in osteoclast bone resorption | Q64377259 | ||
Formation of non-resorbing osteoclasts from peripheral blood mononuclear cells of patients with malignant juvenile osteopetrosis | Q73416495 | ||
A new specialized cell-matrix interaction in actively resorbing osteoclasts | Q73634054 | ||
Regulation of collagenolytic protease secretion through c-Src in osteoclasts | Q73937025 | ||
Phosphatidylinositol 3-kinase association with the osteoclast cytoskeleton, and its involvement in osteoclast attachment and spreading | Q74062887 | ||
Osteoclast ruffled border has distinct subdomains for secretion and degraded matrix uptake | Q78859808 | ||
v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation | Q79383955 | ||
PI-3-kinase-dependent membrane recruitment of centaurin-alpha2 is essential for its effect on ARF6-mediated actin cytoskeleton reorganisation. | Q50698333 | ||
Tyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts. | Q52530335 | ||
Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase. | Q52533403 | ||
Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. | Q52533405 | ||
Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification. | Q52537176 | ||
A unique domain in RANK is required for Gab2 and PLCgamma2 binding to establish osteoclastogenic signals. | Q53364532 | ||
Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2. | Q53621799 | ||
Cofilin takes the lead. | Q53628956 | ||
Tension-induced fusion of bilayer membranes and vesicles. | Q53870828 | ||
Class IA phosphatidylinositol 3-kinase regulates osteoclastic bone resorption through protein kinase B-mediated vesicle transport. | Q54496603 | ||
Trafficking of Matrix Collagens Through Bone-Resorbing Osteoclasts | Q56341625 | ||
Regulation of Actin Ring Formation by Rho GTPases in Osteoclasts | Q57372361 | ||
Filamin A Regulates Monocyte Migration Through Rho Small GTPases During Osteoclastogenesis | Q57986696 | ||
Cot kinase promotes Ca2+ oscillation/calcineurin-independent osteoclastogenesis by stabilizing NFATc1 protein | Q42270419 | ||
Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet | Q42442818 | ||
Endocytic pathway from the basal plasma membrane to the ruffled border membrane in bone-resorbing osteoclasts | Q42443064 | ||
Abnormal localisation and hyperclustering of (alpha)(V)(beta)(3) integrins and associated proteins in Src-deficient or tyrphostin A9-treated osteoclasts | Q42497023 | ||
Autoamplification of NFATc1 expression determines its essential role in bone homeostasis | Q42972503 | ||
The role of phosphoinositide 3-kinase in spreading osteoclasts induced by colony-stimulating factor-1. | Q43557963 | ||
PYK2 autophosphorylation, but not kinase activity, is necessary for adhesion-induced association with c-Src, osteoclast spreading, and bone resorption | Q44270131 | ||
Osteoclasts express high levels of p60c-src, preferentially on ruffled border membranes | Q44362843 | ||
Endocytic trafficking in actively resorbing osteoclasts | Q44755306 | ||
Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis | Q44956032 | ||
Vav3 regulates osteoclast function and bone mass | Q45265424 | ||
Recombinant VSV G proteins reveal a novel raft-dependent endocytic pathway in resorbing osteoclasts | Q46665328 | ||
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. | Q46711436 | ||
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis | Q47761859 | ||
Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. | Q48083226 | ||
c-Src control of chloride channel support for osteoclast HCl transport and bone resorption | Q24296702 | ||
Tks5-dependent formation of circumferential podosomes/invadopodia mediates cell-cell fusion | Q24322030 | ||
Amino-terminal basic residues of Src mediate membrane binding through electrostatic interaction with acidic phospholipids | Q24564497 | ||
RANK is essential for osteoclast and lymph node development | Q24598872 | ||
Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages | Q24655851 | ||
Impaired differentiation of osteoclasts in TREM-2-deficient individuals | Q24672735 | ||
A novel member of the leukocyte receptor complex regulates osteoclast differentiation | Q24675157 | ||
Cell biology of Ca2+-triggered exocytosis | Q26269905 | ||
The phosphoinositide 3-kinase pathway | Q27860738 | ||
Rho GTPases in cell biology | Q27860969 | ||
TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src | Q28142620 | ||
GIT proteins, A novel family of phosphatidylinositol 3,4, 5-trisphosphate-stimulated GTPase-activating proteins for ARF6 | Q28143263 | ||
Mutations in the a3 subunit of the vacuolar H(+)-ATPase cause infantile malignant osteopetrosis | Q28143618 | ||
Phosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolin | Q28189293 | ||
Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man | Q28201425 | ||
Involvement of the Src-cortactin pathway in podosome formation and turnover during polarization of cultured osteoclasts | Q28274068 | ||
Removal of osteoclast bone resorption products by transcytosis | Q28307077 | ||
DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells | Q28506839 | ||
Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis | Q28509083 | ||
SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts | Q28510858 | ||
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation | Q28511207 | ||
Synaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretion | Q28512093 | ||
Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase | Q28512805 | ||
Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption | Q28576916 | ||
Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans | Q28586887 | ||
Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span | Q28590421 | ||
Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav | Q28646540 | ||
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice | Q29547898 | ||
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells | Q29614565 | ||
ARF proteins: roles in membrane traffic and beyond | Q29618078 | ||
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts | Q29618116 | ||
Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand | Q29619331 | ||
Dynasore, a cell-permeable inhibitor of dynamin | Q29619881 | ||
Transcriptional regulation by calcium, calcineurin, and NFAT | Q29620410 | ||
The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells | Q30160317 | ||
A functional link between dynamin and the actin cytoskeleton at podosomes | Q30442034 | ||
Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation | Q30452661 | ||
Rab3D regulates a novel vesicular trafficking pathway that is required for osteoclastic bone resorption | Q30475918 | ||
Cortactin has an essential and specific role in osteoclast actin assembly | Q30477461 | ||
Osteoblasts induce Ca2+ oscillation-independent NFATc1 activation during osteoclastogenesis | Q30482448 | ||
Analysis of the signaling pathways regulating Src-dependent remodeling of the actin cytoskeleton | Q30497716 | ||
MT1-MMP is required for myeloid cell fusion via regulation of Rac1 signaling | Q33657191 | ||
MFR, a putative receptor mediating the fusion of macrophages | Q33781252 | ||
Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity | Q33877069 | ||
Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization | Q33882828 | ||
A rhombohedral phase of lipid containing a membrane fusion intermediate structure | Q34180636 | ||
Requirement for Arf6 in Cell Adhesion, Migration, and Cancer Cell Invasion | Q34275593 | ||
An invasive podosome-like structure promotes fusion pore formation during myoblast fusion. | Q34368627 | ||
Regulation of phospholipase C gamma isoforms in haematopoietic cells: why one, not the other? | Q34401877 | ||
Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane | Q34455391 | ||
Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function. | Q35107102 | ||
Rac deletion in osteoclasts causes severe osteopetrosis | Q35576455 | ||
Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice | Q35607627 | ||
Autophagy proteins regulate the secretory component of osteoclastic bone resorption | Q35629038 | ||
RGS10-null mutation impairs osteoclast differentiation resulting from the loss of [Ca2+]i oscillation regulation | Q35893658 | ||
Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development | Q36074211 | ||
The actin regulator N-WASp is required for muscle-cell fusion in mice | Q36094269 | ||
Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border | Q36213974 | ||
Polarized secretion of lysosomal enzymes: co-distribution of cation-independent mannose-6-phosphate receptors and lysosomal enzymes along the osteoclast exocytic pathway | Q36219001 | ||
Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength | Q36316394 | ||
The tyrosine kinase activity of c-Src regulates actin dynamics and organization of podosomes in osteoclasts | Q36325944 | ||
Regulation of podosomes by integrin alphavbeta3 and Rho GTPase-facilitated phosphoinositide signaling | Q36388132 | ||
Protein kinase C-delta deficiency perturbs bone homeostasis by selective uncoupling of cathepsin K secretion and ruffled border formation in osteoclasts | Q36399967 | ||
Podosome and sealing zone: specificity of the osteoclast model | Q36424995 | ||
Dynamin, a membrane-remodelling GTPase | Q36460251 | ||
Regulation of PTEN function as a PIP3 gatekeeper through membrane interaction | Q36544446 | ||
Protein-driven membrane stresses in fusion and fission | Q36566327 | ||
The p85alpha subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration | Q36994766 | ||
Mechanisms of osteoclastic secretion | Q37033700 | ||
Src-dependent repression of ARF6 is required to maintain podosome-rich sealing zones in bone-digesting osteoclasts | Q37083543 | ||
Actin cytoskeletal organisation in osteoclasts: a model to decipher transmigration and matrix degradation | Q37092466 | ||
Rho GTPases in osteoclasts: orchestrators of podosome arrangement | Q37147506 | ||
PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase | Q37384701 | ||
Ca2+-NFATc1 signaling is an essential axis of osteoclast differentiation | Q37597633 | ||
The osteoclast and its unique cytoskeleton | Q37968677 | ||
Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase | Q38326223 | ||
Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos | Q38342636 | ||
PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2. | Q38744013 | ||
The transient appearance of zipper-like actin superstructures during the fusion of osteoclasts. | Q39393636 | ||
Evidence for a role for the p110-alpha isoform of PI3K in skeletal function | Q39772050 | ||
Cbp recruitment of Csk into lipid rafts is critical to c-Src kinase activity and bone resorption in osteoclasts. | Q39782096 | ||
The Rho GTPase Wrch1 regulates osteoclast precursor adhesion and migration | Q39896864 | ||
High molecular weight tropomyosins regulate osteoclast cytoskeletal morphology | Q39954880 | ||
Stalk model of membrane fusion: solution of energy crisis | Q40201228 | ||
Critical role of cortactin in actin ring formation and osteoclastic bone resorption. | Q40238899 | ||
RANKL-induced expression of tetraspanin CD9 in lipid raft membrane microdomain is essential for cell fusion during osteoclastogenesis | Q40271536 | ||
From lysosomes to the plasma membrane: localization of vacuolar-type H+ -ATPase with the a3 isoform during osteoclast differentiation | Q40658848 | ||
PTEN regulates RANKL- and osteopontin-stimulated signal transduction during osteoclast differentiation and cell motility | Q40686068 | ||
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration | Q40900789 | ||
Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories. | Q41075059 | ||
Molecular roles of Myo1c function in lipid raft exocytosis | Q41573210 | ||
Possible role of IRTKS in Tks5-driven osteoclast fusion | Q41573318 | ||
The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase | Q41758466 | ||
Osteoclasts express high levels of pp60c-src in association with intracellular membranes | Q41774224 | ||
P275 | copyright license | Creative Commons Attribution 2.0 Generic | Q19125117 |
P6216 | copyright status | copyrighted | Q50423863 |
P433 | issue | 18 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | cell | Q7868 |
regulation of gene expression | Q411391 | ||
membrane lipids | Q6815134 | ||
lipid | Q11367 | ||
P304 | page(s) | 3341-53 | |
P577 | publication date | 2013-09-01 | |
P1433 | published in | Cellular and Molecular Life Sciences | Q5058352 |
P1476 | title | Regulation of osteoclasts by membrane-derived lipid mediators | |
P478 | volume | 70 |
Q38252662 | An overview of inborn errors of complex lipid biosynthesis and remodelling |
Q38204173 | Coupling between acto-adhesive machinery and ECM degradation in invadosomes. |
Q49611769 | Effect of L-Caldesmon on Osteoclastogenesis in RANKL-Induced RAW264.7 Cells. |
Q35819965 | FTY720 inhibited proinflammatory cytokine release and osteoclastogenesis induced by Aggregatibacter actinomycetemcomitans |
Q61443977 | L-caldesmon alters cell spreading and adhesion force in RANKL-induced osteoclasts |
Q85841218 | Late stages of the synchronized macrophage fusion in osteoclast formation depend on dynamin |
Q92421981 | Long Non-Coding RNAs Target Pathogenetically Relevant Genes and Pathways in Rheumatoid Arthritis |
Q35686043 | Long-Term Endurance Exercise in Humans Stimulates Cell Fusion of Myoblasts along with Fusogenic Endogenous Retroviral Genes In Vivo |
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Q52887993 | Protocatechuic Acid Attenuates Osteoclastogenesis by Downregulating JNK/c-Fos/NFATc1 Signaling and Prevents Inflammatory Bone Loss in Mice. |
Q37738764 | Rab27A regulates transport of cell surface receptors modulating multinucleation and lysosome-related organelles in osteoclasts. |
Q36029297 | Sphingosine-1-Phosphate Receptor 2 Regulates Proinflammatory Cytokine Production and Osteoclastogenesis. |
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