Regulation of osteoclasts by membrane-derived lipid mediators

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Regulation of osteoclasts by membrane-derived lipid mediators is …
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review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1031613282
P356DOI10.1007/S00018-012-1238-4
P3181OpenCitations bibliographic resource ID1289648
P932PMC publication ID3753467
P698PubMed publication ID23296124
P5875ResearchGate publication ID234084270

P50authorYukiko KurodaQ64683249
Koichi MatsuoQ56810711
Tsukasa OikawaQ49414211
P2860cites workPurified inositol 1,4,5-trisphosphate receptor mediates calcium flux in reconstituted lipid vesiclesQ59095132
WASp deficiency in mice results in failure to form osteoclast sealing zones and defects in bone resorptionQ61053891
Crucial role for autophagy in degranulation of mast cellsQ63609781
Phosphorylation of a Wiscott-Aldrich syndrome protein-associated signal complex is critical in osteoclast bone resorptionQ64377259
Formation of non-resorbing osteoclasts from peripheral blood mononuclear cells of patients with malignant juvenile osteopetrosisQ73416495
A new specialized cell-matrix interaction in actively resorbing osteoclastsQ73634054
Regulation of collagenolytic protease secretion through c-Src in osteoclastsQ73937025
Phosphatidylinositol 3-kinase association with the osteoclast cytoskeleton, and its involvement in osteoclast attachment and spreadingQ74062887
Osteoclast ruffled border has distinct subdomains for secretion and degraded matrix uptakeQ78859808
v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formationQ79383955
PI-3-kinase-dependent membrane recruitment of centaurin-alpha2 is essential for its effect on ARF6-mediated actin cytoskeleton reorganisation.Q50698333
Tyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts.Q52530335
Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.Q52533403
Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.Q52533405
Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification.Q52537176
A unique domain in RANK is required for Gab2 and PLCgamma2 binding to establish osteoclastogenic signals.Q53364532
Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2.Q53621799
Cofilin takes the lead.Q53628956
Tension-induced fusion of bilayer membranes and vesicles.Q53870828
Class IA phosphatidylinositol 3-kinase regulates osteoclastic bone resorption through protein kinase B-mediated vesicle transport.Q54496603
Trafficking of Matrix Collagens Through Bone-Resorbing OsteoclastsQ56341625
Regulation of Actin Ring Formation by Rho GTPases in OsteoclastsQ57372361
Filamin A Regulates Monocyte Migration Through Rho Small GTPases During OsteoclastogenesisQ57986696
Cot kinase promotes Ca2+ oscillation/calcineurin-independent osteoclastogenesis by stabilizing NFATc1 proteinQ42270419
Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat dietQ42442818
Endocytic pathway from the basal plasma membrane to the ruffled border membrane in bone-resorbing osteoclastsQ42443064
Abnormal localisation and hyperclustering of (alpha)(V)(beta)(3) integrins and associated proteins in Src-deficient or tyrphostin A9-treated osteoclastsQ42497023
Autoamplification of NFATc1 expression determines its essential role in bone homeostasisQ42972503
The role of phosphoinositide 3-kinase in spreading osteoclasts induced by colony-stimulating factor-1.Q43557963
PYK2 autophosphorylation, but not kinase activity, is necessary for adhesion-induced association with c-Src, osteoclast spreading, and bone resorptionQ44270131
Osteoclasts express high levels of p60c-src, preferentially on ruffled border membranesQ44362843
Endocytic trafficking in actively resorbing osteoclastsQ44755306
Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesisQ44956032
Vav3 regulates osteoclast function and bone massQ45265424
Recombinant VSV G proteins reveal a novel raft-dependent endocytic pathway in resorbing osteoclastsQ46665328
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.Q46711436
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasisQ47761859
Regulation of osteoclast differentiation and function by the CaMK-CREB pathway.Q48083226
c-Src control of chloride channel support for osteoclast HCl transport and bone resorptionQ24296702
Tks5-dependent formation of circumferential podosomes/invadopodia mediates cell-cell fusionQ24322030
Amino-terminal basic residues of Src mediate membrane binding through electrostatic interaction with acidic phospholipidsQ24564497
RANK is essential for osteoclast and lymph node developmentQ24598872
Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophagesQ24655851
Impaired differentiation of osteoclasts in TREM-2-deficient individualsQ24672735
A novel member of the leukocyte receptor complex regulates osteoclast differentiationQ24675157
Cell biology of Ca2+-triggered exocytosisQ26269905
The phosphoinositide 3-kinase pathwayQ27860738
Rho GTPases in cell biologyQ27860969
TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-SrcQ28142620
GIT proteins, A novel family of phosphatidylinositol 3,4, 5-trisphosphate-stimulated GTPase-activating proteins for ARF6Q28143263
Mutations in the a3 subunit of the vacuolar H(+)-ATPase cause infantile malignant osteopetrosisQ28143618
Phosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolinQ28189293
Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and manQ28201425
Involvement of the Src-cortactin pathway in podosome formation and turnover during polarization of cultured osteoclastsQ28274068
Removal of osteoclast bone resorption products by transcytosisQ28307077
DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cellsQ28506839
Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesisQ28509083
SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclastsQ28510858
Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiationQ28511207
Synaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretionQ28512093
Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinaseQ28512805
Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorptionQ28576916
Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humansQ28586887
Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life spanQ28590421
Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by VavQ28646540
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in miceQ29547898
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cellsQ29614565
ARF proteins: roles in membrane traffic and beyondQ29618078
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclastsQ29618116
Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligandQ29619331
Dynasore, a cell-permeable inhibitor of dynaminQ29619881
Transcriptional regulation by calcium, calcineurin, and NFATQ29620410
The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cellsQ30160317
A functional link between dynamin and the actin cytoskeleton at podosomesQ30442034
Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activationQ30452661
Rab3D regulates a novel vesicular trafficking pathway that is required for osteoclastic bone resorptionQ30475918
Cortactin has an essential and specific role in osteoclast actin assemblyQ30477461
Osteoblasts induce Ca2+ oscillation-independent NFATc1 activation during osteoclastogenesisQ30482448
Analysis of the signaling pathways regulating Src-dependent remodeling of the actin cytoskeletonQ30497716
MT1-MMP is required for myeloid cell fusion via regulation of Rac1 signalingQ33657191
MFR, a putative receptor mediating the fusion of macrophagesQ33781252
Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activityQ33877069
Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarizationQ33882828
A rhombohedral phase of lipid containing a membrane fusion intermediate structureQ34180636
Requirement for Arf6 in Cell Adhesion, Migration, and Cancer Cell InvasionQ34275593
An invasive podosome-like structure promotes fusion pore formation during myoblast fusion.Q34368627
Regulation of phospholipase C gamma isoforms in haematopoietic cells: why one, not the other?Q34401877
Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membraneQ34455391
Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function.Q35107102
Rac deletion in osteoclasts causes severe osteopetrosisQ35576455
Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in miceQ35607627
Autophagy proteins regulate the secretory component of osteoclastic bone resorptionQ35629038
RGS10-null mutation impairs osteoclast differentiation resulting from the loss of [Ca2+]i oscillation regulationQ35893658
Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and developmentQ36074211
The actin regulator N-WASp is required for muscle-cell fusion in miceQ36094269
Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled borderQ36213974
Polarized secretion of lysosomal enzymes: co-distribution of cation-independent mannose-6-phosphate receptors and lysosomal enzymes along the osteoclast exocytic pathwayQ36219001
Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strengthQ36316394
The tyrosine kinase activity of c-Src regulates actin dynamics and organization of podosomes in osteoclastsQ36325944
Regulation of podosomes by integrin alphavbeta3 and Rho GTPase-facilitated phosphoinositide signalingQ36388132
Protein kinase C-delta deficiency perturbs bone homeostasis by selective uncoupling of cathepsin K secretion and ruffled border formation in osteoclastsQ36399967
Podosome and sealing zone: specificity of the osteoclast modelQ36424995
Dynamin, a membrane-remodelling GTPaseQ36460251
Regulation of PTEN function as a PIP3 gatekeeper through membrane interactionQ36544446
Protein-driven membrane stresses in fusion and fissionQ36566327
The p85alpha subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migrationQ36994766
Mechanisms of osteoclastic secretionQ37033700
Src-dependent repression of ARF6 is required to maintain podosome-rich sealing zones in bone-digesting osteoclastsQ37083543
Actin cytoskeletal organisation in osteoclasts: a model to decipher transmigration and matrix degradationQ37092466
Rho GTPases in osteoclasts: orchestrators of podosome arrangementQ37147506
PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinaseQ37384701
Ca2+-NFATc1 signaling is an essential axis of osteoclast differentiationQ37597633
The osteoclast and its unique cytoskeletonQ37968677
Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinaseQ38326223
Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-FosQ38342636
PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.Q38744013
The transient appearance of zipper-like actin superstructures during the fusion of osteoclasts.Q39393636
Evidence for a role for the p110-alpha isoform of PI3K in skeletal functionQ39772050
Cbp recruitment of Csk into lipid rafts is critical to c-Src kinase activity and bone resorption in osteoclasts.Q39782096
The Rho GTPase Wrch1 regulates osteoclast precursor adhesion and migrationQ39896864
High molecular weight tropomyosins regulate osteoclast cytoskeletal morphologyQ39954880
Stalk model of membrane fusion: solution of energy crisisQ40201228
Critical role of cortactin in actin ring formation and osteoclastic bone resorption.Q40238899
RANKL-induced expression of tetraspanin CD9 in lipid raft membrane microdomain is essential for cell fusion during osteoclastogenesisQ40271536
From lysosomes to the plasma membrane: localization of vacuolar-type H+ -ATPase with the a3 isoform during osteoclast differentiationQ40658848
PTEN regulates RANKL- and osteopontin-stimulated signal transduction during osteoclast differentiation and cell motilityQ40686068
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migrationQ40900789
Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.Q41075059
Molecular roles of Myo1c function in lipid raft exocytosisQ41573210
Possible role of IRTKS in Tks5-driven osteoclast fusionQ41573318
The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinaseQ41758466
Osteoclasts express high levels of pp60c-src in association with intracellular membranesQ41774224
P275copyright licenseCreative Commons Attribution 2.0 GenericQ19125117
P6216copyright statuscopyrightedQ50423863
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectcellQ7868
regulation of gene expressionQ411391
membrane lipidsQ6815134
lipidQ11367
P304page(s)3341-53
P577publication date2013-09-01
P1433published inCellular and Molecular Life SciencesQ5058352
P1476titleRegulation of osteoclasts by membrane-derived lipid mediators
P478volume70

Reverse relations

cites work (P2860)
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