Molecular determinants of context-dependent progesterone receptor action in breast cancer

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Molecular determinants of context-dependent progesterone receptor action in breast cancer is …
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scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1051720039
P356DOI10.1186/1741-7015-12-32
P8608Fatcat IDrelease_bquoi2yx3zb43ofvppzfvouavi
P3181OpenCitations bibliographic resource ID1433050
P932PMC publication ID3929904
P698PubMed publication ID24552158
P5875ResearchGate publication ID260268650

P50authorCarol A LangeQ101563783
P2093author name stringChristy R Hagan
P2860cites workA functional polymorphism in the promoter of the progesterone receptor gene associated with endometrial cancer riskQ24535819
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Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and BQ24556548
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Estrogen receptor alpha mediates progestin-induced mammary tumor growth by interacting with progesterone receptors at the cyclin D1/MYC promotersQ28116725
Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1- and estrogen receptor-containing transcription complexesQ28306753
MAP kinase phosphatase 3 (MKP3) interacts with and is phosphorylated by protein kinase CK2alphaQ28593793
Two domains of the progesterone receptor interact with the estrogen receptor and are required for progesterone activation of the c-Src/Erk pathway in mammalian cellsQ28771752
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One-thousand-and-one substrates of protein kinase CK2?Q29615345
The role of extranuclear signaling actions of progesterone receptor in mediating progesterone regulation of gene expression and the cell cycleQ30159541
Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinasesQ30167936
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Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cellsQ33295020
Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factorsQ33315228
Progesterone receptors act as sensors for mitogenic protein kinases in breast cancer modelsQ33428469
Protein kinases mediate ligand-independent derepression of sumoylated progesterone receptors in breast cancer cellsQ33496645
Cyclin-dependent kinase activity is required for progesterone receptor function: novel role for cyclin A/Cdk2 as a progesterone receptor coactivatorQ33552193
The progesterone receptor hinge region regulates the kinetics of transcriptional responses through acetylation, phosphorylation, and nuclear retentionQ33699615
Loss of co-ordinate expression of progesterone receptors A and B is an early event in breast carcinogenesisQ38456582
Glucocorticoid receptor activity discriminates between progesterone and medroxyprogesterone acetate effects in breast cells.Q39588977
Androgen receptor inhibits estrogen receptor-alpha activity and is prognostic in breast cancerQ39819693
Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonistQ40202330
Phosphorylation and progesterone receptor function.Q40455187
Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase 2.Q40486142
Biphasic regulation of breast cancer cell growth by progesterone: role of the cyclin-dependent kinase inhibitors, p21 and p27(Kip1).Q41084288
Differential hormone-dependent phosphorylation of progesterone receptor A and B forms revealed by a phosphoserine site-specific monoclonal antibodyQ41713285
Estrogen sensitivity of normal human breast tissue in vivo and implanted into athymic nude mice: analysis of the relationship between estrogen-induced proliferation and progesterone receptor expressionQ42445773
Progesterone regulates transcription of the p21(WAF1) cyclin- dependent kinase inhibitor gene through Sp1 and CBP/p300.Q42454022
Progesterone induces adult mammary stem cell expansionQ42471079
Steroid hormone receptor status of mouse mammary stem cellsQ42498451
Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast.Q42506249
Cloning of the rat progesterone receptor gene 5'-region and identification of two functionally distinct promotersQ42804329
Mitogen-activated protein kinase regulates nuclear association of human progesterone receptors.Q44294752
Progestin drives breast cancer growth by inducing p21(CIP1) expression through the assembly of a transcriptional complex among Stat3, progesterone receptor and ErbB-2.Q44847818
Cross-talk between growth factor and progesterone receptor signaling pathways: implications for breast cancer cell growthQ45248777
Randomized phase II study of lonaprisan as second-line therapy for progesterone receptor-positive breast cancerQ46120245
Breast cancer risk in postmenopausal women using estradiol-progestogen therapyQ46185602
Progesterone/RANKL is a major regulatory axis in the human breast.Q51042996
Breast cancer and hormone-replacement therapy: the Million Women StudyQ56863703
Association of the Progesterone Receptor Gene with Breast Cancer Risk: A Single-Nucleotide Polymorphism Tagging ApproachQ57306187
Colocalization of Progesterone Receptors A and B by Dual Immunofluorescent Histochemistry in Human Endometrium during the Menstrual Cycle1Q60662131
The antiprogestin RU486 in advanced breast cancer: preliminary clinical trialQ68194017
Phase II study of the progesterone antagonist mifepristone in patients with untreated metastatic breast carcinoma: a National Cancer Institute of Canada Clinical Trials Group studyQ71692742
Characterization of progesterone receptor A and B expression in human breast cancerQ71804872
Hormone replacement therapy with estrogen or estrogen plus medroxyprogesterone acetate is associated with increased epithelial proliferation in the normal postmenopausal breastQ73276429
A hypersensitive estrogen receptor-alpha mutation in premalignant breast lesionsQ74181062
Interactions in the transcriptional regulation exerted by Stat5 and by members of the steroid hormone receptor familyQ78036268
Progesterone receptor isoforms in normal and malignant breastQ81424333
Ulipristal acetate does not impact human normal breast tissueQ84476268
Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland.Q33733718
Onapristone, a progesterone receptor antagonist, as first-line therapy in primary breast cancerQ33871076
Role of phosphorylation in progesterone receptor signaling and specificityQ34029956
Pioneer factors: directing transcriptional regulators within the chromatin environmentQ34212702
Breast cancer and hormone-replacement therapy in the Million Women StudyQ34223870
Protein kinase CK2 signal in neoplasiaQ34238490
Pioneer factors in hormone-dependent cancersQ34272580
Changes in estrogen receptor, progesterone receptor, and pS2 expression in tamoxifen-resistant human breast cancer.Q34300189
Phosphorylated and sumoylation-deficient progesterone receptors drive proliferative gene signatures during breast cancer progressionQ34304234
Identification of phosphorylation sites unique to the B form of human progesterone receptor. In vitro phosphorylation by casein kinase II.Q34327103
Measurement of steroid hormone receptors in breast cancer patients on tamoxifenQ34345668
Breast cancer risk in relation to different types of hormone replacement therapy in the E3N-EPIC cohortQ34552706
Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasomeQ34999960
ck2-dependent phosphorylation of progesterone receptors (PR) on Ser81 regulates PR-B isoform-specific target gene expression in breast cancer cellsQ35096710
MAP kinases couple multiple functions of human progesterone receptors: degradation, transcriptional synergy, and nuclear associationQ35207726
Structural and functional analysis of domains of the progesterone receptorQ35624126
Progesterone receptors upregulate Wnt-1 to induce epidermal growth factor receptor transactivation and c-Src-dependent sustained activation of Erk1/2 mitogen-activated protein kinase in breast cancer cellsQ35642132
Non-overlapping progesterone receptor cistromes contribute to cell-specific transcriptional outcomesQ35910912
Antiprogestins, a new form of endocrine therapy for human breast cancerQ36024326
Research resource: interplay between the genomic and transcriptional networks of androgen receptor and estrogen receptor α in luminal breast cancer cellsQ36367151
Rare steroid receptor-negative basal-like tumorigenic cells in luminal subtype human breast cancer xenografts.Q36558052
Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cycliQ36700634
Disruption of androgen receptor signaling by synthetic progestins may increase risk of developing breast cancerQ36782597
Progestins in hormone replacement therapies reactivate cancer stem cells in women with preexisting breast cancers: a hypothesisQ36938367
A Common Docking Domain in Progesterone Receptor-B links DUSP6 and CK2 signaling to proliferative transcriptional programs in breast cancer cellsQ37236792
Protein kinase CK2 in human diseases.Q37239690
Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cellsQ37249108
The MPA mouse breast cancer model: evidence for a role of progesterone receptors in breast cancer.Q37384523
Estrogen Plus Progestin and Breast Cancer Incidence and Mortality in Postmenopausal WomenQ37480990
A 2009 update on the treatment of patients with hormone receptor-positive breast cancerQ37533811
Progesterone receptor isoform-specific promoter methylation: association of PRA promoter methylation with worse outcome in breast cancer patientsQ37639114
Acquired endocrine resistance in breast cancer: implications for tumour metastasisQ37825181
Progesterone signalling in breast cancer: a neglected hormone coming into the limelightQ38109029
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectprogesteroneQ26963
breast cancerQ128581
breast neoplasmQ23929670
progesterone receptorQ24783718
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)32
P577publication date2014-02-20
P1433published inBMC MedicineQ4835947
P1476titleMolecular determinants of context-dependent progesterone receptor action in breast cancer
P478volume12

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