| P2093 | author name string | Jürgen Wienands | |
| | Melanie Spitzner | |
| | Marian Grade | |
| | Reinhard Ebner | |
| | Hendrik Wolff | |
| | B. Ghadimi | |
| P2860 | cites work | Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway | Q24650927 |
| | Genomic and computational approaches to dissect the mechanisms of STAT3's universal and cell type-specific functions | Q38177816 |
| | The IL-6 feed-forward loop: a driver of tumorigenesis | Q38194762 |
| | Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells | Q38360859 |
| | A phase II trial of saracatinib, an inhibitor of src kinases, in previously-treated advanced non-small-cell lung cancer: the princess margaret hospital phase II consortium | Q38394418 |
| | Expression of activated and latent signal transducer and activator of transcription 3 in 303 non-small cell lung carcinomas and 44 malignant mesotheliomas: possible role for chemotherapeutic intervention | Q38430501 |
| | Oxidative stress impairs multiple regulatory events to drive persistent cytokine-stimulated STAT3 phosphorylation. | Q39052620 |
| | Linifanib (ABT-869) enhances radiosensitivity of head and neck squamous cell carcinoma cells | Q39181154 |
| | Inhibition of signal transducer and activator of transcription 3 and cyclooxygenase-2 is involved in radiosensitization of cepharanthine in HeLa cells. | Q39184452 |
| | The radio-sensitizing effect of xanthohumol is mediated by STAT3 and EGFR suppression in doxorubicin-resistant MCF-7 human breast cancer cells | Q39224981 |
| | Reduction of STAT3 expression induces mitochondrial dysfunction and autophagy in cardiac HL-1 cells | Q39252813 |
| | Clinical Cancer Advances 2013: Annual Report on Progress Against Cancer from the American Society of Clinical Oncology | Q39297282 |
| | Targeting signal transducer and activator of transcription 3 pathway by cucurbitacin I diminishes self-renewing and radiochemoresistant abilities in thyroid cancer-derived CD133+ cells. | Q39397476 |
| | The role of DNA methyltransferase 3b in esophageal squamous cell carcinoma | Q39418634 |
| | CK2 inhibitors enhance the radiosensitivity of human non-small cell lung cancer cells through inhibition of stat3 activation | Q39516649 |
| | Inhibition of STAT-3 results in greater cetuximab sensitivity in head and neck squamous cell carcinoma | Q39518165 |
| | A gene expression signature for chemoradiosensitivity of colorectal cancer cells. | Q39640918 |
| | STAT3 modulates the DNA damage response pathway | Q39661738 |
| | Inhibition of STAT3 and ErbB2 suppresses tumor growth, enhances radiosensitivity, and induces mitochondria-dependent apoptosis in glioma cells | Q39683274 |
| | The cdk5 kinase regulates the STAT3 transcription factor to prevent DNA damage upon topoisomerase I inhibition. | Q39697762 |
| | Akt signaling pathway: a target for radiosensitizing human malignant glioma. | Q39712690 |
| | Significance of interleukin-6 signaling in the resistance of pharyngeal cancer to irradiation and the epidermal growth factor receptor inhibitor | Q39731855 |
| | Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. | Q53794992 |
| | Colorectal cancer | Q55924124 |
| | Esophageal Cancer | Q56209683 |
| | Postoperative Concurrent Radiotherapy and Chemotherapy for High-Risk Squamous-Cell Carcinoma of the Head and Neck | Q56532861 |
| | Sorafenib Enhances Radiation-Induced Apoptosis in Hepatocellular Carcinoma by Inhibiting STAT3 | Q58215137 |
| | Elevated phosphorylation of AKT and Stat3 in prostate, breast, and cervical cancer cells | Q73893877 |
| | The important role of operations in the management of anaplastic thyroid carcinoma | Q77764202 |
| | Inhibition of signal transducer and activator of transcription 3 activity results in down-regulation of Survivin following irradiation | Q79377407 |
| | Targeting STAT3 in cancer: how successful are we? | Q82824786 |
| | Constitutive STAT5 activation correlates with better survival in cervical cancer patients treated with radiation therapy | Q83386045 |
| | Phase III, open-label, randomized study comparing concurrent gemcitabine plus cisplatin and radiation followed by adjuvant gemcitabine and cisplatin versus concurrent cisplatin and radiation in patients with stage IIB to IVA carcinoma of the cervix | Q83737796 |
| | Regulation of Stat3 nuclear export | Q39741143 |
| | STAT3 blockade with shRNA enhances radiosensitivity in Hep-2 human laryngeal squamous carcinoma cells | Q39757049 |
| | Cucurbitacin I inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer-derived CD133-positive cells. | Q39794629 |
| | Cucurbitacin I suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous carcinoma--derived CD44(+)ALDH1(+) cells. | Q39818856 |
| | Inhibition of STAT-3 results in radiosensitization of human squamous cell carcinoma | Q39823619 |
| | Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog. | Q39834991 |
| | Augmentation of radiation response by panitumumab in models of upper aerodigestive tract cancer | Q39939644 |
| | Reciprocal regulation of SOCS 1 and SOCS3 enhances resistance to ionizing radiation in glioblastoma multiforme | Q40145078 |
| | Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells | Q40366043 |
| | Compilation of vertebrate-encoded transcription factors | Q40411319 |
| | Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma. | Q40724591 |
| | Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells | Q40761356 |
| | Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins | Q41509409 |
| | Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis | Q42679964 |
| | Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis. | Q42742420 |
| | Identification of novel direct Stat3 target genes for control of growth and differentiation | Q42819623 |
| | Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. | Q42833476 |
| | STAT3 transcriptional factor activated by reactive oxygen species induces IL6 in starvation-induced autophagy of cancer cells | Q42866546 |
| | STAT3 tyrosine phosphorylation influences survival in glioblastoma | Q43068296 |
| | IL-6 gene amplification and expression in human glioblastomas | Q43202792 |
| | Cancer-specific mortality after surgery or radiation for patients with clinically localized prostate cancer managed during the prostate-specific antigen era. | Q43467766 |
| | Inhibition of STAT signalling in bladder cancer by diindolylmethane: relevance to cell adhesion, migration and proliferation | Q46223881 |
| | Extracellular signal-dependent nuclear import of STAT3 is mediated by various importin alphas | Q46421072 |
| | Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation. | Q46581121 |
| | Regulation of Stat3 nuclear import by importin alpha5 and importin alpha7 via two different functional sequence elements | Q46812595 |
| | STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo. | Q47806027 |
| | Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality | Q24685515 |
| | Targeting JAK2 in the therapy of myeloproliferative neoplasms | Q26860796 |
| | Current role of EGF receptor monoclonal antibodies and tyrosine kinase inhibitors in the management of head and neck squamous cell carcinoma | Q26991953 |
| | Management of low (favourable)-risk prostate cancer | Q26996501 |
| | Cancer statistics, 2013 | Q27860762 |
| | A road map for those who don't know JAK-STAT | Q28201970 |
| | Interferon-γ: an overview of signals, mechanisms and functions | Q28207081 |
| | SOCS proteins: negative regulators of cytokine signaling | Q28216055 |
| | Stat3 enhances vimentin gene expression by binding to the antisilencer element and interacting with the repressor protein, ZBP-89 | Q28237778 |
| | New and old functions of STAT3: a pivotal target for individualized treatment of cancer | Q28265930 |
| | Past, present, and future of radiotherapy for the benefit of patients | Q28280008 |
| | Regulation of cytokine signaling pathways by PIAS proteins | Q28297056 |
| | A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ | Q28298440 |
| | Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice | Q28487437 |
| | STATs and gene regulation | Q29547796 |
| | Stat3 as an oncogene | Q29614606 |
| | Malignant gliomas in adults | Q29615708 |
| | STATs in oncogenesis | Q29617571 |
| | Advances and challenges in the treatment of glioblastoma: a clinician's perspective | Q30620774 |
| | Role of STAT3 in cancer metastasis and translational advances | Q31142794 |
| | JAK/STAT-dependent gene regulation by cytokines. | Q33220017 |
| | In vitro identification and characterization of CD133(pos) cancer stem-like cells in anaplastic thyroid carcinoma cell lines | Q33380152 |
| | Honokiol inhibits epithelial-mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E-cadherin axis | Q33563809 |
| | Protein tyrosine phosphatases, TC-PTP, SHP1, and SHP2, cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiation | Q33565458 |
| | Overexpression of STAT3 potentiates growth, survival, and radioresistance of non-small-cell lung cancer (NSCLC) cells | Q33626244 |
| | Time trends and local variation in primary treatment of localized prostate cancer | Q33710948 |
| | MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion | Q33901817 |
| | Dynamics of the STAT3 transcription factor: nuclear import dependent on Ran and importin-β1. | Q33916478 |
| | A chemical biology approach to developing STAT inhibitors: molecular strategies for accelerating clinical translation | Q33934987 |
| | STAT signaling in head and neck cancer | Q33941351 |
| | UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer | Q33955751 |
| | Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors | Q33959754 |
| | Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas. | Q37080992 |
| | Signal transducer and activator of transcription-3: a molecular hub for signaling pathways in gliomas | Q37174303 |
| | The Src inhibitor AZD0530 blocks invasion and may act as a radiosensitizer in lung cancer cells. | Q37277870 |
| | Mitochondrial localized Stat3 promotes breast cancer growth via phosphorylation of serine 727 | Q37312229 |
| | Radiation therapy for early-stage breast cancer after breast-conserving surgery | Q37360898 |
| | Function of mitochondrial Stat3 in cellular respiration | Q37378567 |
| | On the path to seeking novel radiosensitizers | Q37404038 |
| | Cutting edge: inherent and acquired resistance to radiation-induced apoptosis in B cells: a pivotal role for STAT3. | Q37406213 |
| | Management of early and locally advanced cervical cancer | Q37426912 |
| | Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection | Q37574096 |
| | Disruption of STAT3 by niclosamide reverses radioresistance of human lung cancer. | Q37661503 |
| | Molecular pathways: molecular basis for sensitivity and resistance to JAK kinase inhibitors. | Q37708936 |
| | Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer. | Q37714611 |
| | Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: implications for future therapeutic approaches | Q37752807 |
| | Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs | Q37798220 |
| | Strategies to improve radiotherapy with targeted drugs | Q37856721 |
| | Rectal cancer: state of the art in 2012. | Q37997242 |
| | JAK2 inhibition for the treatment of hematologic and solid malignancies | Q38001733 |
| | Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein. | Q38014908 |
| | Interleukin-6 signaling pathway in targeted therapy for cancer | Q38014987 |
| | A systematic review of neoadjuvant and adjuvant chemotherapy for muscle-invasive bladder cancer | Q38017042 |
| | STAT3 inhibition, a novel approach to enhancing targeted therapy in human cancers (review). | Q38030424 |
| | Bladder preservation in the treatment of muscle-invasive bladder cancer (MIBC): a review of the literature and a practical approach to therapy | Q38077272 |
| | Molecular pathways: Jak/STAT pathway: mutations, inhibitors, and resistance | Q38081267 |
| | Management of non-small-cell lung cancer: recent developments | Q38131165 |
| | Managing malignant melanoma | Q38132324 |
| | Dancing rhinos in stilettos: The amazing saga of the genomic and nongenomic actions of STAT3 in the heart | Q38143956 |
| | Progress and controversies: radiation therapy for invasive breast cancer | Q38172886 |
| | Role of Jak kinases and STATs in cytokine signal transduction | Q34246712 |
| | STAT proteins: novel molecular targets for cancer drug discovery | Q34293579 |
| | JAKs and STATs in immunity, immunodeficiency, and cancer | Q34321767 |
| | Aberrant expression and constitutive activation of STAT3 in cervical carcinogenesis: implications in high-risk human papillomavirus infection | Q34321805 |
| | Oesophageal carcinoma | Q34325751 |
| | Negative regulation of cytokine signaling. | Q34350006 |
| | STAT-Related Profiles Are Associated with Patient Response to Targeted Treatments in Locally Advanced SCCHN. | Q34518357 |
| | Preoperative versus postoperative chemoradiotherapy for rectal cancer | Q34552041 |
| | Stat3 inhibitor Stattic exhibits potent antitumor activity and induces chemo- and radio-sensitivity in nasopharyngeal carcinoma | Q34575479 |
| | STAT3 silencing inhibits glioma single cell infiltration and tumor growth | Q34619737 |
| | Stat proteins and oncogenesis | Q34627064 |
| | What does Stat3 do? | Q34627068 |
| | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial | Q34638544 |
| | Transcription factors as targets for cancer therapy | Q34932264 |
| | Inhibition of JAK2 signaling by TG101209 enhances radiotherapy in lung cancer models | Q35013694 |
| | Toward a new STATe: the role of STATs in mitochondrial function | Q35064219 |
| | Enhancement of 5-fluorouracil-induced in vitro and in vivo radiosensitization with MEK inhibition | Q35146186 |
| | Of JAKs, STATs, blind watchmakers, jeeps and trains | Q35163904 |
| | Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival | Q35218738 |
| | Review of breast conservation therapy: then and now | Q35433289 |
| | Targeting the interleukin-6/Jak/stat pathway in human malignancies | Q35925127 |
| | Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts | Q36080795 |
| | Chemoradiation after surgery for high-risk head and neck cancer patients: how strong is the evidence? | Q36081350 |
| | Silencing STAT3 with short hairpin RNA enhances radiosensitivity of human laryngeal squamous cell carcinoma xenografts in vivo | Q36246709 |
| | Signal transducer and activator of transcription-3 (STAT3) is constitutively activated in normal, self-renewing B-1 cells but only inducibly expressed in conventional B lymphocytes | Q36377021 |
| | STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain | Q36567934 |
| | Constitutive activation of STAT3 and STAT5 is present in the majority of nasopharyngeal carcinoma and correlates with better prognosis | Q36670981 |
| | The concurrent chemoradiation paradigm--general principles | Q36720868 |
| | Impact of Stat3 activation upon skin biology: a dichotomy of its role between homeostasis and diseases | Q36865332 |
| | Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis | Q36869961 |
| | IL-6 expression predicts treatment response and outcome in squamous cell carcinoma of the esophagus | Q36885478 |
| | Signal transducer and activator of transcription 3 activation is associated with bladder cancer cell growth and survival | Q36960662 |
| | The role of IL-6 in the radiation response of prostate cancer | Q37028843 |
| | Targeting STAT3 inhibits growth and enhances radiosensitivity in head and neck squamous cell carcinoma | Q37072818 |
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | chemoradiotherapy | Q5090613 |
| P304 | page(s) | 1986-2011 | |
| P577 | publication date | 2014-09-29 | |
| P1433 | published in | Cancers | Q27722963 |
| P1476 | title | STAT3: A Novel Molecular Mediator of Resistance to Chemoradiotherapy | |
| P478 | volume | 6 | |