| P50 | author | Robert Dallmann | Q58671621 |
| | Frédéric Gachon | Q37619711 |
| P2093 | author name string | Steven A Brown | |
| P2860 | cites work | Gut clock: implication of circadian rhythms in the gastrointestinal tract. | Q37889545 |
| | The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications. | Q38065688 |
| | Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond | Q38074718 |
| | The times they're a-changing: effects of circadian desynchronization on physiology and disease. | Q38094825 |
| | Regulation of alternative splicing by the circadian clock and food related cues | Q38324240 |
| | Cardiac-specific mutation of Clock alters the quantitative measurements of physical activities without changing behavioral circadian rhythms | Q38572679 |
| | Circadian variation of blood-pressure | Q39539239 |
| | Blunted sleep-time relative blood pressure decline increases cardiovascular risk independent of blood pressure level--the "normotensive non-dipper" paradox | Q39541406 |
| | The molecular mechanism regulating 24-hour rhythm of CYP2E1 expression in the mouse liver | Q39974462 |
| | Molecular basis for rhythmic expression of CYP3A4 in serum-shocked HepG2 cells | Q40051622 |
| | Diurnal blood pressure pattern and risk of congestive heart failure | Q40312077 |
| | Human intestinal circadian clock: expression of clock genes in colonocytes lining the crypt. | Q40333920 |
| | Cellular interactions of 5-fluorouracil and the camptothecin analogue CPT-11 (irinotecan) in a human colorectal carcinoma cell line | Q41056508 |
| | Circadian variation in the propagation velocity of the migrating motor complex | Q41472383 |
| | Diurnal rhythms of bile acid production in the rat | Q41475455 |
| | Time to pay attention: attentional performance time-stamped prefrontal cholinergic activation, diurnality, and performance. | Q42324773 |
| | Circadian rhythms of biliary protein and lipid excretion in rats | Q42479702 |
| | The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification | Q42497646 |
| | cAMP-dependent signaling as a core component of the mammalian circadian pacemaker | Q42541521 |
| | Heritability of diurnal type: a nationwide study of 8753 adult twin pairs | Q42622577 |
| | Aryl hydrocarbon receptor-mediated Cyp1a1 expression is modulated in a CLOCK-dependent circadian manner | Q42726203 |
| | Endogenous dopamine regulates the rhythm of expression of the clock protein PER2 in the rat dorsal striatum via daily activation of D2 dopamine receptors. | Q42852553 |
| | Circadian dysregulation disrupts bile acid homeostasis | Q43066229 |
| | Circadian expression profiles of drug-processing genes and transcription factors in mouse liver | Q43125380 |
| | Circadian changes in estimated hepatic blood flow in healthy subjects | Q43205178 |
| | Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6. | Q43214302 |
| | Liver circadian clock, a pharmacologic target of cyclin-dependent kinase inhibitor seliciclib | Q43280937 |
| | Surface detection of circadian rhythm in32P content of cancer of the breast | Q44522962 |
| | Sex moderates circadian chemotherapy effects on survival of patients with metastatic colorectal cancer: a meta-analysis. | Q44527159 |
| | Influence of feeding schedule on 24-h rhythm of hepatotoxicity induced by acetaminophen in mice | Q44942848 |
| | Circadian variation in gastric emptying of meals in humans | Q45283826 |
| | Disruption of peripheral circadian timekeeping in a mouse model of Huntington's disease and its restoration by temporally scheduled feeding | Q45299047 |
| | Circadian clock-controlled intestinal expression of the multidrug-resistance gene mdr1a in mice | Q46387381 |
| | Circadian variation of the response of T cells to antigen. | Q46700396 |
| | Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1. | Q47071799 |
| | A study on diurnal mRNA expression of CYP1A1, AHR, ARNT, and PER2 in rat pituitary and liver | Q47754197 |
| | Evidence that dark-phase hyperphagia induced by neurotoxin 6-hydroxydopamine may be due to decreased leptin and increased neuropeptide Y signaling | Q48001111 |
| | Serotonergic integration of circadian clock and ultradian sleep-wake cycles. | Q48217317 |
| | Control mechanism of the circadian clock for timing of cell division in vivo | Q48219610 |
| | The human circadian system adapts to prior photic history | Q48321910 |
| | Circadian variation in acute ischemic stroke: a hospital-based study | Q48398529 |
| | The corticotropin-releasing factor (CRF)(1) receptor antagonists CP154,526 and DMP695 inhibit light-induced phase advances of hamster circadian activity rhythms | Q48610527 |
| | Diurnal activity and pulsatility of the hypothalamus-pituitary-adrenal system in male depressed patients and healthy controls | Q48822983 |
| | Circadian rhythm of glomerular filtration rate in normal individuals | Q48940606 |
| | The dim light melatonin onset as a marker for circadian phase position | Q48948299 |
| | Effects of controlled-onset extended-release verapamil on nocturnal blood pressure (dippers versus nondippers). COER-Verapamil Study Group. | Q50936762 |
| | Chronokinetics of active biliary ampicillin secretion in rats. | Q51505207 |
| | Assessing the probability of drug-induced QTc-interval prolongation during clinical drug development. | Q51505796 |
| | The selective tachykinin neurokinin 1 (NK1) receptor antagonist, GR 205,171, stereospecifically inhibits light-induced phase advances of hamster circadian activity rhythms. | Q51812136 |
| | Prediction of overall survival through circadian rest-activity monitoring during chemotherapy for metastatic colorectal cancer. | Q52624073 |
| | Glucocorticoid signaling synchronizes the liver circadian transcriptome | Q59209926 |
| | Daily variations in platelet aggregation and adhesion in healthy subjects | Q68080998 |
| | Temporal variations in paracetamol absorption and metabolism in man | Q69100324 |
| | Daytime fluctuations in blood of tissue-type plasminogen activator (t-PA) and its fast-acting inhibitor (PAI-1) | Q70394289 |
| | Time-dependent absorption of theophylline in man | Q70714695 |
| | Nocturnal dosing of a novel delivery system of verapamil for systemic hypertension. Verapamil Study Group | Q71969309 |
| | Circadian rhythm of glomerular filtration rate in patients after kidney transplantation | Q72396672 |
| | Dosing-time-dependent variation in biliary excretion of flomoxef in rats | Q73685097 |
| | The hepatic cytochrome P450 reductase null mouse as a tool to identify a successful candidate entity | Q81605885 |
| | Increased risk of antipsychotic-related QT prolongation during nighttime: a 24-hour holter electrocardiogram recording study | Q83133084 |
| | Circadian rhythms. A new histone code for clocks? | Q85019609 |
| | Diurnal variation in the biliary excretion of flomoxef in patients with percutaneous transhepatic biliary drainage | Q95721553 |
| | REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis | Q21145813 |
| | Krüppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes | Q24338596 |
| | Circadian clock control of the cellular response to DNA damage | Q24602881 |
| | Circadian clocks in human red blood cells | Q24620753 |
| | Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists | Q24629345 |
| | Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes | Q24633002 |
| | Hippocampal-dependent learning requires a functional circadian system | Q24656538 |
| | The period length of fibroblast circadian gene expression varies widely among human individuals | Q24816019 |
| | Circadian control of the immune system | Q27023060 |
| | Circadian desynchrony promotes metabolic disruption in a mouse model of shiftwork | Q27302869 |
| | The circadian clock coordinates ribosome biogenesis | Q27318396 |
| | Genome-wide RNA polymerase II profiles and RNA accumulation reveal kinetics of transcription and associated epigenetic changes during diurnal cycles | Q27318516 |
| | Coordinated transcription of key pathways in the mouse by the circadian clock | Q28217978 |
| | Epidemiology of the human circadian clock | Q28253246 |
| | The circadian clock component BMAL1 is a critical regulator of p21WAF1/CIP1 expression and hepatocyte proliferation | Q28261349 |
| | Haematopoietic stem cell release is regulated by circadian oscillations | Q28267721 |
| | NADPH P450 oxidoreductase: structure, function, and pathology of diseases | Q28284265 |
| | Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes | Q28290094 |
| | Molecular physiology of renal organic anion transporters | Q28290781 |
| | Drug-induced torsade de pointes | Q28336547 |
| | Human blood metabolite timetable indicates internal body time | Q28388632 |
| | Regulation of bile acid synthesis in man. Presence of a diurnal rhythm | Q28390285 |
| | Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex | Q28507441 |
| | Delay in feedback repression by cryptochrome 1 is required for circadian clock function | Q28512076 |
| | Circadian rhythms govern cardiac repolarization and arrhythmogenesis | Q28513521 |
| | Circadian clock genes directly regulate expression of the Na(+)/H(+) exchanger NHE3 in the kidney | Q28572280 |
| | Regulation of bile acid synthesis by the nuclear receptor Rev-erbalpha | Q28585608 |
| | Distinct roles of DBHS family members in the circadian transcriptional feedback loop | Q28590986 |
| | Kinases and phosphatases in the mammalian circadian clock | Q37849981 |
| | Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism | Q28594055 |
| | Circadian Rhythm Disruption in Cancer Biology | Q28972554 |
| | Extensive and divergent circadian gene expression in liver and heart | Q29615206 |
| | Transcriptional architecture and chromatin landscape of the core circadian clock in mammals | Q29616252 |
| | Resetting central and peripheral circadian oscillators in transgenic rats | Q29616557 |
| | Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells | Q29619080 |
| | Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus | Q29619114 |
| | The mammalian circadian timing system: organization and coordination of central and peripheral clocks | Q29619119 |
| | Aging differentially affects the re-entrainment response of central and peripheral circadian oscillators | Q30419321 |
| | Dysregulation of inflammatory responses by chronic circadian disruption | Q30429758 |
| | Coupling governs entrainment range of circadian clocks | Q30497756 |
| | Circadian genes Period 1 and Period 2 in the nucleus accumbens regulate anxiety-related behavior | Q30541494 |
| | Drug-induced prolongation of the QT interval | Q33151147 |
| | Circadian orchestration of the hepatic proteome | Q33245770 |
| | System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock | Q33273610 |
| | Harmonics of circadian gene transcription in mammals | Q33426339 |
| | Circadian rhythm of gastric acid secretion in man. | Q33478263 |
| | Discoveries of rhythms in human biological functions: a historical review | Q33500212 |
| | The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist. | Q33613397 |
| | Rhythmic changes in colonic motility are regulated by period genes | Q33655639 |
| | Direct regulation of myocardial triglyceride metabolism by the cardiomyocyte circadian clock. | Q33661472 |
| | Mammalian TIMELESS is required for ATM-dependent CHK2 activation and G2/M checkpoint control | Q33661490 |
| | Circadian rhythms and metabolic syndrome: from experimental genetics to human disease. | Q33722806 |
| | The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts | Q33735789 |
| | Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex | Q33783874 |
| | Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver | Q33834076 |
| | Circadian clock regulates response to pesticides in Drosophila via conserved Pdp1 pathway | Q33856369 |
| | Noninvasive method for assessing the human circadian clock using hair follicle cells | Q34100412 |
| | The cholinergic system, circadian rhythmicity, and time memory | Q34152261 |
| | Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor | Q34178695 |
| | A K(ATP) channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila | Q34234924 |
| | Identification of small molecule activators of cryptochrome | Q34288305 |
| | NONO couples the circadian clock to the cell cycle | Q34319589 |
| | Blood-borne circadian signal stimulates daily oscillations in actin dynamics and SRF activity | Q34325741 |
| | Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study | Q34471434 |
| | Role of Caco-2 cell monolayers in prediction of intestinal drug absorption. | Q34490871 |
| | Circadian regulation of glutathione levels and biosynthesis in Drosophila melanogaster | Q34505418 |
| | The loss of circadian PAR bZip transcription factors results in epilepsy | Q34510790 |
| | Adenosine and sleep | Q35046823 |
| | Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening | Q35657707 |
| | The human circadian metabolome. | Q35786923 |
| | Sleep and circadian rhythm disruption in schizophrenia | Q35864323 |
| | Coordination of the transcriptome and metabolome by the circadian clock | Q35887331 |
| | Molecular regulation of hepatobiliary transport systems: clinical implications for understanding and treating cholestasis | Q36066753 |
| | Induction of phase I, II and III drug metabolism/transport by xenobiotics | Q36099291 |
| | Melatonin: an underappreciated player in retinal physiology and pathophysiology | Q36291423 |
| | Nascent-Seq reveals novel features of mouse circadian transcriptional regulation | Q36382560 |
| | Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factor | Q36411162 |
| | CircaDB: a database of mammalian circadian gene expression profiles | Q36491476 |
| | SCN outputs and the hypothalamic balance of life | Q36654635 |
| | Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction | Q36662865 |
| | Age and gender dependent heart rate circadian model development and performance verification on the proarrhythmic drug case study | Q36688587 |
| | Regulation of human dihydropyrimidine dehydrogenase: implications in the pharmacogenetics of 5-FU-based chemotherapy | Q36745681 |
| | Heme as a magnificent molecule with multiple missions: heme determines its own fate and governs cellular homeostasis | Q36929292 |
| | A cyanobacterial circadian clockwork | Q36979252 |
| | Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease | Q37097780 |
| | Measurement of internal body time by blood metabolomics. | Q37209677 |
| | Disruption of period gene expression alters the inductive effects of dioxin on the AhR signaling pathway in the mouse liver. | Q37263928 |
| | Orexin neurons are necessary for the circadian control of REM sleep. | Q37332460 |
| | Molecular clock is involved in predictive circadian adjustment of renal function | Q37364174 |
| | Molecular-timetable methods for detection of body time and rhythm disorders from single-time-point genome-wide expression profiles | Q37388348 |
| | A circadian clock in macrophages controls inflammatory immune responses. | Q37482242 |
| | Review article: chronobiology: influence of circadian rhythms on the therapy of severe pain | Q37525762 |
| | The role of cell-specific circadian clocks in metabolism and disease | Q37619696 |
| | Melatonin and circadian biology in human cardiovascular disease | Q37764020 |
| | Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease | Q37772758 |
| | Melatonin--a pleiotropic, orchestrating regulator molecule | Q37824733 |
| | Crosstalk between components of circadian and metabolic cycles in mammals | Q37834110 |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 339-361 | |
| P577 | publication date | 2014-01-01 | |
| P1433 | published in | Annual Review of Pharmacology and Toxicology | Q567365 |
| P1476 | title | Chronopharmacology: new insights and therapeutic implications | |
| P478 | volume | 54 | |