Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro

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Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro is …
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scholarly articleQ13442814

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P356DOI10.1016/J.NEUROBIOLAGING.2015.05.002
P932PMC publication ID4465078
P698PubMed publication ID26058840
P5875ResearchGate publication ID276152317

P50authorMaud GratuzeQ59195478
P2093author name stringAlexis Bretteville
Anastasia Noël
Emmanuel Planel
Franck R Petry
François Marcouiller
Françoise Morin
Geoffrey Truchetti
Isabelle Poitras
Kevin Wong
László Virág
Marie-Amélie Papon
Noura El Khoury
Robert A Whittington
P2860cites workTau pathology in Alzheimer disease and other tauopathiesQ22252520
Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filamentsQ24599152
Measurement of protein using bicinchoninic acidQ26778491
The effects of increasing plasma concentrations of dexmedetomidine in humansQ28141747
The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effectsQ28205334
Propofol directly increases tau phosphorylationQ28477036
A novel neurotrophic drug for cognitive enhancement and Alzheimer's diseaseQ28478380
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathologyQ29617284
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's diseaseQ29617286
Consensus statement: First International Workshop on Anesthetics and Alzheimer's diseaseQ30438119
Anesthesia induces phosphorylation of tauQ33691128
A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresisQ33720044
Stress-induced tau phosphorylation: functional neuroplasticity or neuronal vulnerability?Q34003380
Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairmentQ34198357
Pharmacological properties, central nervous system effects, and potential therapeutic applications of atipamezole, a selective alpha2-adrenoceptor antagonist.Q34481160
Alzheimer's disease and anesthesiaQ34554509
Brain and behavior changes in 12-month-old Tg2576 and nontransgenic mice exposed to anestheticsQ34577164
The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathiesQ34587678
Assessment of the role of alpha2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic miceQ35026932
Role of serine/threonine protein phosphatase in Alzheimer's diseaseQ35059545
Recognition of the minimal epitope of monoclonal antibody Tau‐1 depends upon the presence of a phosphate group but not its locationQ72073020
Lack in effects of therapeutic concentrations of dexmedetomidine and clonidine on the neuromuscular blocking action of rocuronium in isolated rat diaphragmsQ80210706
Role of tau protein in both physiological and pathological conditions.Q35715199
Paired helical filament tau in Alzheimer's disease. The kinase connectionQ35833298
The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during developmentQ36335067
β2 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer disease modelsQ36760275
Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivoQ37029878
Anesthesia and tau pathologyQ37089765
Dexmedetomidine may impair cognitive testing during endovascular embolization of cerebral arteriovenous malformations: a retrospective case report seriesQ37159524
Tau aggregates: toxic, inert, or protective species?Q37238290
Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesiaQ37280755
Biochemical isolation of insoluble tau in transgenic mouse models of tauopathiesQ38004969
Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trialQ38383872
Pharmacokinetic implications for the clinical use of propofolQ38722656
c-jun N-terminal kinase hyperphosphorylates R406W tau at the PHF-1 site during mitosisQ39512404
Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A.Q39967325
Memory deficits associated with senescence: A neurophysiological and behavioral study in the ratQ40232008
The effects of dexmedetomidine on neuromuscular blockade in human volunteersQ41612261
Dexmedetomidine is neuroprotective in an in vitro model for traumatic brain injury.Q42142119
Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau proteinQ42827866
Dexmedetomidine in the care of critically ill patients from 2001 to 2007: an observational cohort studyQ42976771
Cognitive improvement during continuous sedation in critically ill, awake and responsive patients: the Acute Neurological ICU Sedation Trial (ANIST).Q43106418
Dexmedetomidine provides cortical neuroprotection: impact on anaesthetic-induced neuroapoptosis in the rat developing brainQ43225217
Abnormal Tau phosphorylation of the Alzheimer-type also occurs during mitosis.Q44210287
Phosphorylated serine 199 of microtubule-associated protein tau is a neuronal epitope abundantly expressed in youth and an early marker of tau pathologyQ44283795
Interaction of the alpha-2 adrenergic- and opioid receptor with the cGMP system in the mouse cerebellumQ44350628
Mitotic-like tau phosphorylation by p25-Cdk5 kinase complexQ44491452
Tau phosphorylation and sevoflurane anesthesia: an association to postoperative cognitive impairment.Q45195626
A hypnotic response to dexmedetomidine, an alpha 2 agonist, is mediated in the locus coeruleus in ratsQ46023890
Effects of intravenous dexmedetomidine in humans. II. Hemodynamic changesQ46041432
Detection of Phosphorylated Ser262 in Fetal Tau, Adult Tau, and Paired Helical Filament TauQ46127208
Differential effects of alpha 2-adrenoceptors in the modulation of the thermoregulatory response in mice induced by meperidineQ46518888
Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms.Q46522758
Dexmedetomidine increases hippocampal phosphorylated extracellular signal-regulated protein kinase 1 and 2 content by an alpha 2-adrenoceptor-independent mechanism: evidence for the involvement of imidazoline I1 receptorsQ46739677
Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia.Q48232865
Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoformsQ48254354
Phosphorylated serine422 on tau proteins is a pathological epitope found in several diseases with neurofibrillary degenerationQ48255703
Evaluation of spatial memory of C57BL/6J and CD1 mice in the Barnes maze, the Multiple T-maze and in the Morris water mazeQ48313979
Microtubule-associated protein tau. A component of Alzheimer paired helical filamentsQ48344680
Plaques, tangles and dementia. A quantitative studyQ48874775
Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.Q53199978
Conformational change as one of the earliest alterations of tau in Alzheimer's disease.Q53238045
Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.Q53246695
Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205.Q54613756
Rapid Tau Protein Dephosphorylation and Differential Rephosphorylation during Cardiac Arrest-Induced Cerebral Ischemia and ReperfusionQ57897037
P4510describes a project that usesImageQuantQ112270642
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
dexmedetomidineQ412133
P304page(s)2414-2428
P577publication date2015-05-09
P1433published inNeurobiology of AgingQ7002141
P1476titleDexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro
P478volume36

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cites work (P2860)
Q90218549Administration of the benzodiazepine midazolam increases tau phosphorylation in the mouse brain
Q47651365Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6.
Q37733003Hydrogen-rich saline attenuates isoflurane-induced caspase-3 activation and cognitive impairment via inhibition of isoflurane-induced oxidative stress, mitochondrial dysfunction, and reduction in ATP levels
Q64107948Lasting effects of general anesthetics on the brain in the young and elderly: "mixed picture" of neurotoxicity, neuroprotection and cognitive impairment
Q38983421Lasting impact of general anaesthesia on the brain: mechanisms and relevance
Q47420946Protein phosphatase 2A and tau: an orchestrated 'Pas de Deux'.
Q61814347The Role of Neuroinflammation in Postoperative Cognitive Dysfunction: Moving From Hypothesis to Treatment

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