| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1027734578 |
| P356 | DOI | 10.1038/NSMB.3159 |
| P8608 | Fatcat ID | release_axpn6mgcy5e43nxprraawdugfy |
| P3181 | OpenCitations bibliographic resource ID | 1666126 |
| P932 | PMC publication ID | 4876856 |
| P698 | PubMed publication ID | 26779611 |
| P5875 | ResearchGate publication ID | 290992866 |
| P50 | author | Gabriel C. Lander | Q50129859 |
| Mark Herzik | Q42855197 | ||
| P2093 | author name string | Seok-Yong Lee | |
| Lejla Zubcevic | |||
| Zhirui Liu | |||
| Ben C Chung | |||
| P2860 | cites work | A capsaicin-receptor homologue with a high threshold for noxious heat | Q22009379 |
| The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity | Q24312830 | ||
| The capsaicin receptor: a heat-activated ion channel in the pain pathway | Q24322558 | ||
| Evolutionary origin of a secondary structure: π-helices as cryptic but widespread insertional variations of α-helices that enhance protein functionality | Q24605540 | ||
| PHENIX: a comprehensive Python-based system for macromolecular structure solution | Q24654617 | ||
| Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment | Q27649044 | ||
| Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM. | Q27677990 | ||
| Structural basis for Ca2+ selectivity of a voltage-gated calcium channel | Q27680676 | ||
| Structure of the TRPV1 ion channel determined by electron cryo-microscopy | Q27680759 | ||
| TRPV1 structures in distinct conformations reveal activation mechanisms | Q27680762 | ||
| Initiation of Translation by Cricket Paralysis Virus IRES Requires Its Translocation in the Ribosome | Q27683626 | ||
| Coot: model-building tools for molecular graphics | Q27860505 | ||
| EMAN: semiautomated software for high-resolution single-particle reconstructions | Q27860772 | ||
| Accurate determination of local defocus and specimen tilt in electron microscopy | Q27861008 | ||
| Osmosensation in TRPV2 dominant negative expressing skeletal muscle fibres. | Q50442022 | ||
| PI3-kinase promotes TRPV2 activity independently of channel translocation to the plasma membrane. | Q51809442 | ||
| Structure of the N-terminal Ankyrin Repeat Domain of the TRPV2 Ion Channel | Q57339156 | ||
| A TRP channel that senses cold stimuli and menthol | Q28511363 | ||
| TRPV2 enhances axon outgrowth through its activation by membrane stretch in developing sensory and motor neurons | Q28585747 | ||
| RELION: implementation of a Bayesian approach to cryo-EM structure determination | Q29547673 | ||
| Appion: an integrated, database-driven pipeline to facilitate EM image processing | Q29614288 | ||
| Bsoft: image processing and molecular modeling for electron microscopy | Q29614289 | ||
| Automated molecular microscopy: the new Leginon system | Q29614290 | ||
| An introduction to TRP channels | Q29615753 | ||
| HOLE: a program for the analysis of the pore dimensions of ion channel structural models | Q29619250 | ||
| Topology representing network enables highly accurate classification of protein images taken by cryo electron-microscope without masking. | Q31015634 | ||
| TRPV2 is critical for the maintenance of cardiac structure and function in mice | Q33729367 | ||
| Principles of selective ion transport in channels and pumps | Q33991793 | ||
| 3(10) helices in channels and other membrane proteins | Q34152313 | ||
| Ca2+-dependent desensitization of TRPV2 channels is mediated by hydrolysis of phosphatidylinositol 4,5-bisphosphate | Q34401757 | ||
| A hot-sensing cold receptor: C-terminal domain determines thermosensation in transient receptor potential channels. | Q34521627 | ||
| Dissection of the components for PIP2 activation and thermosensation in TRP channels | Q34634374 | ||
| Localization of the PIP2 sensor of TRPV1 ion channels | Q34684697 | ||
| TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons | Q34786310 | ||
| Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels | Q35090957 | ||
| Acid potentiation of the capsaicin receptor determined by a key extracellular site | Q35177598 | ||
| Mechanism for phosphoinositide selectivity and activation of TRPV1 ion channels | Q35543110 | ||
| Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel | Q35756403 | ||
| Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations. | Q35860150 | ||
| TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids | Q36640761 | ||
| From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs | Q36913317 | ||
| What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel? | Q37198480 | ||
| Carboxyl-terminal domain of transient receptor potential vanilloid 1 contains distinct segments differentially involved in capsaicin- and heat-induced desensitization. | Q37388775 | ||
| DoG Picker and TiltPicker: software tools to facilitate particle selection in single particle electron microscopy | Q37401395 | ||
| TRPV2 has a pivotal role in macrophage particle binding and phagocytosis | Q39665507 | ||
| Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain | Q39711589 | ||
| Role of cationic channel TRPV2 in promoting prostate cancer migration and progression to androgen resistance | Q39747572 | ||
| Uncoupling proton activation of vanilloid receptor TRPV1. | Q40046254 | ||
| The Integrity of the TRP Domain Is Pivotal for Correct TRPV1 Channel Gating | Q40658200 | ||
| Structural insight into the assembly of TRPV channels. | Q41299652 | ||
| Tools for macromolecular model building and refinement into electron cryo-microscopy reconstructions | Q41606440 | ||
| Beam-induced motion correction for sub-megadalton cryo-EM particles. | Q41607730 | ||
| Crystal structure of the human TRPV2 channel ankyrin repeat domain | Q42129712 | ||
| Molecular basis for species-specific sensitivity to "hot" chili peppers | Q45712451 | ||
| TRP channels and pain | Q46357812 | ||
| FindEM--a fast, efficient program for automatic selection of particles from electron micrographs | Q47815374 | ||
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | structural biology | Q908902 |
| cryogenic electron microscopy | Q5190506 | ||
| P304 | page(s) | 180-186 | |
| P577 | publication date | 2016-02-01 | |
| P1433 | published in | Nature Structural & Molecular Biology | Q1071739 |
| P1476 | title | Cryo-electron microscopy structure of the TRPV2 ion channel | |
| P478 | volume | 23 |
| Q42240980 | A Gate Hinge Controls the Epithelial Calcium Channel TRPV5. |
| Q47664284 | A binding-block ion selective mechanism revealed by a Na/K selective channel. |
| Q37369327 | A competing hydrophobic tug on L596 to the membrane core unlatches S4-S5 linker elbow from TRP helix and allows TRPV4 channel to open |
| Q58610880 | A hypothetical molecular mechanism for TRPV1 activation that invokes rotation of an S6 asparagine |
| Q57952967 | An Overview of the Top Ten Detergents Used for Membrane Protein Crystallization |
| Q92192925 | Applications for Mass Spectrometry in the Study of Ion Channel Structure and Function |
| Q59131871 | Conformational ensemble of the human TRPV3 ion channel |
| Q88574267 | Conformational plasticity in the selectivity filter of the TRPV2 ion channel |
| Q60908059 | Conserved allosteric pathways for activation of TRPV3 revealed through engineering vanilloid-sensitivity |
| Q52684303 | Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms. |
| Q57178721 | Cryo-EM in drug discovery: achievements, limitations and prospects |
| Q52641805 | Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1. |
| Q36413839 | Cryo-EM: beyond the microscope. |
| Q46706138 | Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3. |
| Q41600789 | Cryo-microscopy, an alternative to the X-ray crystallography? |
| Q28568023 | Crystal structure of the epithelial calcium channel TRPV6 |
| Q92701986 | Cytoplasmic Inter-Subunit Interface Controls Use-Dependence of Thermal Activation of TRPV3 Channel |
| Q47552061 | Dawning of a new era in TRP channel structural biology by cryo-electron microscopy. |
| Q47213653 | Decrypting the Heat Activation Mechanism of TRPV1 Channel by Molecular Dynamics Simulation |
| Q50098012 | Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2. |
| Q39012432 | Electron Cryo-microscopy as a Tool for Structure-Based Drug Development |
| Q55192271 | Electron cryo-microscopy structure of the canonical TRPC4 ion channel. |
| Q41597377 | Electron cryo-microscopy structure of the mechanotransduction channel NOMPC. |
| Q64245553 | Emerging Diversity in Lipid-Protein Interactions |
| Q41165261 | Energetics of Ion Permeation in an Open-Activated TRPV1 Channel |
| Q28830324 | Engineering vanilloid-sensitivity into the rat TRPV2 channel |
| Q51557226 | Exploring applications of crowdsourcing to cryo-EM. |
| Q40969055 | Expression, purification, and contaminant detection for structural studies of Ralstonia metallidurance ClC protein rm1. |
| Q29147455 | Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutant |
| Q96641319 | Gating of human TRPV3 in a lipid bilayer |
| Q98506400 | Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms |
| Q91727084 | Heat activation mechanism of TRPV1: New insights from molecular dynamics simulation |
| Q47037337 | Human TRPML1 channel structures in open and closed conformations |
| Q55162200 | Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels. |
| Q90351294 | Involvement of calcium channels in the regulation of adipogenesis |
| Q102075592 | Ion channels as lipid sensors: from structures to mechanisms |
| Q38610407 | IonchanPred 2.0: A Tool to Predict Ion Channels and Their Types |
| Q57881808 | Kryo-Elektronenmikroskopie als Methode für die strukturbasierte Wirkstoffentwicklung |
| Q91731845 | Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2 |
| Q47277824 | Lipid environment of membrane proteins in cryo-EM based structural analysis |
| Q56919661 | Molecular basis for the sensitivity of TRP channels to polyunsaturated fatty acids |
| Q83227870 | Molecular mechanism of TRPV2 channel modulation by cannabidiol |
| Q48152291 | Never at rest: insights into the conformational dynamics of ion channels from cryo-electron microscopy |
| Q52744137 | Opening of the human epithelial calcium channel TRPV6. |
| Q51199539 | Probing Conformational Changes during the Gating Cycle of a Potassium Channel in Lipid Bilayers. |
| Q92381168 | Production of TRPV2-targeting functional antibody ameliorating dilated cardiomyopathy and muscular dystrophy in animal models |
| Q37065232 | Rational design and validation of a vanilloid-sensitive TRPV2 ion channel |
| Q92376791 | Recent Progress in TRPM8 Modulation: An Update |
| Q46353469 | Regulation of TRPP3 Channel Function by N-terminal Domain Palmitoylation and Phosphorylation. |
| Q64289622 | Regulatory switch at the cytoplasmic interface controls TRPV channel gating |
| Q47294438 | Shared CaM- and S100A1-binding epitopes in the distal TRPM4 N terminus |
| Q39032562 | Side chain flexibility and coupling between the S4-S5 linker and the TRP domain in thermo-sensitive TRP channels: Insights from protein modeling |
| Q57752466 | Structural Basis of TRPV4 N Terminus Interaction with Syndapin/PACSIN1-3 and PIP |
| Q92925405 | Structural Heterogeneity of CNGA1 Channels Revealed by Electrophysiology and Single-Molecule Force Spectroscopy |
| Q88210357 | Structural Insights into IP3R Function |
| Q90659183 | Structural Variability in the RLR-MAVS Pathway and Sensitive Detection of Viral RNAs |
| Q55302878 | Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB. |
| Q48262495 | Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM. |
| Q41620398 | Structural determinants of 5',6'-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel. |
| Q93039386 | Structural insight into TRPV5 channel function and modulation |
| Q89469272 | Structural insights into the gating mechanisms of TRPV channels |
| Q89774395 | Structure and function of the calcium-selective TRP channel TRPV6 |
| Q64963763 | Structure and gating mechanism of the transient receptor potential channel TRPV3. |
| Q38670656 | Structure of IP3R channel: high-resolution insights from cryo-EM. |
| Q48156868 | Structure of the cold- and menthol-sensing ion channel TRPM8. |
| Q27321594 | Structure of the full-length TRPV2 channel by cryo-EM. |
| Q41988618 | Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2). |
| Q88488611 | Structure of the receptor-activated human TRPC6 and TRPC3 ion channels |
| Q92353914 | Structure-Function Relationship and Physiological Roles of Transient Receptor Potential Canonical (TRPC) 4 and 5 Channels |
| Q90833337 | Structures of TRPV2 in distinct conformations provide insight into role of the pore turret |
| Q41635630 | Swapping of transmembrane domains in the epithelial calcium channel TRPV6. |
| Q83232802 | Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes |
| Q28066420 | TRP Channels in Skin Biology and Pathophysiology |
| Q92652817 | TRP ion channels: Proteins with conformational flexibility |
| Q46663560 | TRPC Channel Structure and Properties |
| Q48142884 | TRPM5 in the battle against diabetes and obesity |
| Q33674257 | TRPV1 temperature activation is specifically sensitive to strong decreases in amino acid hydrophobicity |
| Q26738621 | TRPV1: A Target for Rational Drug Design |
| Q92383138 | TRPV6 as A Target for Cancer Therapy |
| Q48326480 | Targeting nociceptive transient receptor potential channels to treat chronic pain: current state of the field. |
| Q30836888 | The First Extracellular Linker Is Important for Several Aspects of the Gating Mechanism of Human TRPA1 Channel. |
| Q33638669 | The S1 helix critically regulates the finely tuned gating of Kv11.1 channels |
| Q41600333 | The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs |
| Q64055901 | The Transient Receptor Potential Vanilloid Type-2(TRPV2) Ion Channels in Neurogenesis andGliomagenesis: Cross-Talk between TranscriptionFactors and Signaling Molecules |
| Q26740761 | The Use of Multiscale Molecular Simulations in Understanding a Relationship between the Structure and Function of Biological Systems of the Brain: The Application to Monoamine Oxidase Enzymes |
| Q83226302 | The ion selectivity filter is not an activation gate in TRPV1-3 channels |
| Q96641329 | The structure of lipid nanodisc-reconstituted TRPV3 reveals the gating mechanism |
| Q38807269 | Toward elucidating the heat activation mechanism of the TRPV1 channel gating by molecular dynamics simulation |
| Q49721375 | Transient Receptor Potential (TRP) Channels. |
| Q92677820 | Transient Receptor Potential Channels and Endothelial Cell Calcium Signaling |
| Q52765711 | Transient receptor potential vanilloid 4 (TRPV4) channel as a target of crotamiton and its bimodal effects. |
| Q41045858 | Tyrosine Residues from the S4-S5 Linker of Kv11.1 Channels Are Critical for Slow Deactivation |
| Q37666900 | Understand spiciness: mechanism of TRPV1 channel activation by capsaicin |
| Q64114313 | Visualizing conformation transitions of the Lipid II flippase MurJ |
| Q92735070 | Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel |
| Q91727088 | What is new about mild temperature sensing? A review of recent findings |
| Q52626095 | X-ray crystallography of TRP channels. |
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