Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling

scientific article

Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.201412049
P932PMC publication ID4442803
P698PubMed publication ID26008745

P50authorStephan WilmesQ43078742
Changjiang YouQ43078748
Sandra PellegriniQ56543875
Zhi LiQ56557868
Gilles UzéQ63415316
P2093author name stringJacob Piehler
Patrizia Hanhart
Christian P Richter
Véronique Francois-Newton
Cindy Kroll
Dennis Janning
Oliver Beutel
Katharina Hötte
P2860cites workAn allosteric mechanism for activation of the kinase domain of epidermal growth factor receptorQ24293598
Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chainQ24300242
Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15Q24301975
Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 systemQ24310081
The human interferon alpha/beta receptor: characterization and molecular cloningQ24313421
UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activityQ24337310
Dynamic recruitment of phospholipase C gamma at transiently immobilized GPI-anchored receptor clusters induces IP3-Ca2+ signaling: single-molecule tracking study 2Q24683115
The human type I interferon receptor: NMR structure reveals the molecular basis of ligand bindingQ27641616
Structural Linkage between Ligand Discrimination and Receptor Activation by Type I InterferonsQ27671836
Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkinesQ27674753
Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretationQ27687338
The receptor of the type I interferon familyQ28255299
IL-2 and IL-15 receptor alpha-subunits are coexpressed in a supramolecular receptor cluster in lipid rafts of T cellsQ28272922
Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alphaQ28289207
Interferons, interferon-like cytokines, and their receptorsQ28293630
Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1Q28509674
Seeing the light: preassembly and ligand-induced changes of the interferon gamma receptor complex in cellsQ28646255
The Human Type I Interferon ReceptorQ29307820
A Reducing and Oxidizing System Minimizes Photobleaching and Blinking of Fluorescent DyesQ29392208
Quantification of Biological Interactions with Particle Image Cross-Correlation Spectroscopy (PICCS)Q29396175
Fluorescence imaging for monitoring the colocalization of two single molecules in living cellsQ30476487
Lateral ligand-receptor interactions on membranes probed by simultaneous fluorescence-interference detectionQ30499953
Live cell micropatterning reveals the dynamics of signaling complexes at the plasma membraneQ30597262
Behavior of a cloned murine interferon alpha/beta receptor expressed in homospecific or heterospecific background.Q30839933
Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferaseQ33225546
gp130 dimerization in the absence of ligand: preformed cytokine receptor complexesQ33246799
An interferon alpha2 mutant optimized by phage display for IFNAR1 binding confers specifically enhanced antitumor activitiesQ33274608
Respiratory Chain Complexes in Dynamic Mitochondria Display a Patchy Distribution in Life CellsQ33650944
Differential recognition of the type I interferon receptor by interferons tau and alpha is responsible for their disparate cytotoxicitiesQ33663348
Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2.Q33862977
Interferon-alpha and -beta differentially regulate osteoclastogenesis: role of differential induction of chemokine CXCL11 expression.Q33920086
Structure of the interferon-receptor complex determined by distance constraints from double-mutant cycles and flexible dockingQ33949253
USP18-based negative feedback control is induced by type I and type III interferons and specifically inactivates interferon α responseQ33968305
Dynamic organizing principles of the plasma membrane that regulate signal transduction: commemorating the fortieth anniversary of Singer and Nicolson's fluid-mosaic model.Q34294955
Interferon-stimulated genes: a complex web of host defensesQ34405609
Mechanism of activation of protein kinase JAK2 by the growth hormone receptorQ34420222
Determination of the two-dimensional interaction rate constants of a cytokine receptor complexQ34524706
Interferon-alpha/beta-receptor interactions: a complex story unfoldingQ34946055
Multifaceted activities of type I interferon are revealed by a receptor antagonistQ35031568
Stochastic receptor expression determines cell fate upon interferon treatmentQ35139921
ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand bindingQ35534115
Interferons: mechanisms of action and clinical applicationsQ35587300
Epstein-Barr virus IL-10 engages IL-10R1 by a two-step mechanism leading to altered signaling propertiesQ36137341
The yin and yang of type I interferon activity in bacterial infectionQ36234715
Determination of the human type I interferon receptor binding site on human interferon-alpha2 by cross saturation and an NMR-based model of the complexQ36458100
Ligand-induced association of the type I interferon receptor componentsQ36553478
Interaction affinity between cytokine receptor components on the cell surfaceQ36642017
Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: a fluorescence resonance energy transfer studyQ36719639
Interleukin-5 receptor subunit oligomerization and rearrangement revealed by fluorescence resonance energy transfer imagingQ36741561
Ligand-independent interaction of the type I interferon receptor complex is necessary to observe its biological activityQ37164886
Receptor density is key to the alpha2/beta interferon differential activities.Q37302247
Cytokine-receptor interactions as drug targetsQ37771522
Fine tuning type I interferon responsesQ38109729
Multifarious determinants of cytokine receptor signaling specificity.Q38175584
Inquiring into the differential action of interferons (IFNs): an IFN-alpha2 mutant with enhanced affinity to IFNAR1 is functionally similar to IFN-betaQ38315801
Binding and activity of all human alpha interferon subtypesQ39487568
Non-random distribution of interleukin receptors on the cell surfaceQ39840019
Nanometer-scale organization of the alpha subunits of the receptors for IL2 and IL15 in human T lymphoma cellsQ40010988
Direct observation of ligand colocalization on individual receptor moleculesQ40119770
Role of the growth hormone (GH) receptor transmembrane domain in receptor predimerization and GH-induced activationQ40141599
Model for growth hormone receptor activation based on subunit rotation within a receptor dimerQ40382202
Functional cartography of the ectodomain of the type I interferon receptor subunit ifnar1.Q40411681
Identification of residues of the IFNAR1 chain of the type I human interferon receptor critical for ligand binding and biological activityQ40510794
New structural and functional aspects of the type I interferon-receptor interaction revealed by comprehensive mutational analysis of the binding interfaceQ40855474
Differential use of the betaL subunit of the type I interferon (IFN) receptor determines signaling specificity for IFNalpha2 and IFNbetaQ41062121
Formation of a uniquely stable type I interferon receptor complex by interferon beta is dependent upon particular interactions between interferon beta and its receptor and independent of tyrosine phosphorylationQ41610176
Stat-mediated signaling induced by type I and type II interferons (IFNs) is differentially controlled through lipid microdomain association and clathrin-dependent endocytosis of IFN receptorsQ41668344
The EM structure of a type I interferon-receptor complex reveals a novel mechanism for cytokine signalingQ41765858
High-fidelity protein targeting into membrane lipid microdomains in living cellsQ42248176
Differential receptor subunit affinities of type I interferons govern differential signal activation.Q42606715
DySCo: quantitating associations of membrane proteins using two-color single-molecule tracking.Q43070642
Functional immobilization and patterning of proteins by an enzymatic transfer reactionQ43187271
RGD-grafted poly-L-lysine-graft-(polyethylene glycol) copolymers block non-specific protein adsorption while promoting cell adhesionQ44407458
Diffusion and interaction dynamics of individual membrane protein complexes confined in micropatterned polymer-supported membranes.Q44705016
Interactions among the components of the interleukin-10 receptor complexQ44784151
Mutation of the IFNAR-1 receptor binding site of human IFN-alpha2 generates type I IFN competitive antagonistsQ46307389
Mutational analysis of the IFNAR1 binding site on IFNalpha2 reveals the architecture of a weak ligand-receptor binding-site.Q46710974
Engineering FRET constructs using CFP and YFP.Q48011343
Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranesQ48878018
Ligand-induced assembling of the type I interferon receptor on supported lipid bilayersQ50335879
Preassembly and ligand-induced restructuring of the chains of the IFN-gamma receptor complex: the roles of Jak kinases, Stat1 and the receptor chainsQ50335881
Nanoscale organization of mitochondrial microcompartments revealed by combining tracking and localization microscopy.Q50667240
Rapid transfer of transmembrane proteins for single molecule dimerization assays in polymer-supported membranes.Q51055786
The human interferon alpha-receptor protein confers differential responses to human interferon-beta versus interferon-alpha subtypes in mouse and hamster cell transfectants.Q54200731
Density-Based Clustering in Spatial Databases: The Algorithm GDBSCAN and Its ApplicationsQ56675309
USP18 establishes the transcriptional and anti-proliferative interferon α/β differentialQ58459901
Transient GPI-anchored protein homodimers are units for raft organization and functionQ58498251
Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domainQ64008501
Mutational and structural analysis of the binding interface between type I interferons and their receptor Ifnar2Q73168213
Systematic mutational mapping of sites on human interferon-beta-1a that are important for receptor binding and functional activityQ73514314
Erythropoietin receptor activation by a ligand-induced conformation changeQ78111818
Probing 2-dimensional protein-protein interactions on model membranesQ80286038
Ligand binding induces a conformational change in ifnar1 that is propagated to its membrane-proximal domainQ80758653
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
P1104number of pages15
P304page(s)579-593
P577publication date2015-05-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleReceptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling
P478volume209

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cites work (P2860)
Q41923577A panel of synthetic antibodies that selectively recognize and antagonize members of the interferon alpha family
Q36344846Binding of interferon reduces the force of unfolding for interferon receptor 1.
Q66680693Decoding type I and III interferon signalling during viral infection
Q50963822Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling.
Q46447221Dimerization dictates the message.
Q28818276ER residency of the ceramide phosphoethanolamine synthase SMSr relies on homotypic oligomerization mediated by its SAM domain
Q99591319Emerging Roles of USP18: From Biology to Pathophysiology
Q52608910Enhanced labeling density and whole-cell 3D dSTORM imaging by repetitive labeling of target proteins.
Q29147543Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation
Q99603540Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency
Q61135820How nanoscale protein interactions determine the mesoscale dynamic organisation of bacterial outer membrane proteins
Q38486383IFNA2: The prototypic human alpha interferon.
Q27702599Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency
Q83225765Kinetics of cytokine receptor trafficking determine signaling and functional selectivity
Q41077405Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments.
Q57490861Mapping Determinants of Cytokine Signaling via Protein Engineering
Q47561859Molecular identification of goose (Anser cygnoide) suppressor ubiquitin-specific protease 18 (USP18) and the effects of goose IFN and TMUV on its comparative transcripts
Q47133063Monitoring Changes in the Oligomeric State of a Candidate Endoplasmic Reticulum (ER) Ceramide Sensor by Single-molecule Photobleaching
Q38669306Peginterferon α-2a for the treatment of HIV infection
Q58729482Plasticity of Type I Interferon-Mediated Responses in Cancer Therapy: From Anti-tumor Immunity to Resistance
Q30830679Receptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling.
Q92822402Regulatory interplay between deubiquitinating enzymes and cytokines
Q38717767STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling.
Q37492886Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex.
Q91987001Structure of the IFNγ receptor complex guides design of biased agonists
Q46021163Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling.
Q38718364Synthetic Deletion of the Interleukin 23 Receptor (IL-23R) Stalk Region Led to Autonomous IL-23R Homodimerization and Activation
Q92134796The Comparison Between the Mutated HuIFN-β 27-101 and the Wild Type Interferon β: the Comprehensive In Silico Study to Evaluate the Effect of Mutations on IFN-β
Q101053409The Role of Type I Interferons in the Pathogenesis and Treatment of COVID-19
Q38561063The journey of integrins and partners in a complex interactions landscape studied by super-resolution microscopy and single protein tracking.
Q39176574The molecular basis for differential type I interferon signaling
Q46304711Two-Color Single-Molecule Tracking in Live Cells
Q38378144Type I Interferon Signaling Is Decoupled from Specific Receptor Orientation through Lenient Requirements of the Transmembrane Domain
Q59329027USP18 - a multifunctional component in the interferon response

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