Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling.

scientific article published in March 2017

Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CELL.2017.02.011
P932PMC publication ID5526607
P698PubMed publication ID28283060

P50authorIrving WeissmanQ884581
Nicolas GaudenzioQ56586666
Aaron RingQ57547896
Peter J SchnorrQ59305221
Ignacio MoragaQ85544346
Judith A ShizuruQ87929475
Stephan WilmesQ43078742
Philipp StarklQ43100919
P2093author name stringK Christopher Garcia
Hye-Sook Kwon
Jacob Piehler
Stephen J Galli
Riccardo Sibilano
Akanksha Chhabra
Tom S Wehrman
Chia Chi M Ho
Jonathan T Sockolosky
Matthew R Tiffany
Milica Gakovic
P2860cites workStructural basis for activation of the receptor tyrosine kinase KIT by stem cell factorQ24323270
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Ancestim (recombinant human stem cell factor, SCF) in association with filgrastim does not enhance chemotherapy and/or growth factor-induced peripheral blood progenitor cell (PBPC) mobilization in patients with a prior insufficient PBPC collectionQ28278101
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Stem cell factor enhances the survival of murine intestinal stem cells after photon irradiation.Q46165275
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Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranesQ48878018
The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15.Q50335906
Dynamic submicroscopic signaling zones revealed by pair correlation tracking and localization microscopy.Q50610236
Paradoxical signaling by a secreted molecule leads to homeostasis of cell levels.Q51046492
Rapid transfer of transmembrane proteins for single molecule dimerization assays in polymer-supported membranes.Q51055786
Recombinant rat stem cell factor synergizes with recombinant human granulocyte colony-stimulating factor in vivo in mice to mobilize peripheral blood progenitor cells that have enhanced repopulating potentialQ52222892
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Stem-cell factor, the kit ligand, induces direct degranulation of rat peritoneal mast cells in vitro and in vivo: dependence of the in vitro effect on period of culture and comparisons of stem-cell factor with other mast cell-activating agentsQ70869794
Stem cell factor enhances immunoglobulin E-dependent mediator release from cultured rat bone marrow-derived mast cells: activation of previously unresponsive cells demonstrated by a novel ELISPOT assayQ71235539
Stem cell factor enhances the survival but not the self-renewal of murine hematopoietic long-term repopulating cellsQ71632296
Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3'-kinase, and protein kinase CQ71661337
The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transductionQ71666764
In vivo administration of recombinant methionyl human stem cell factor expands the number of human marrow hematopoietic stem cellsQ72088959
Differential release of mast cell interleukin-6 via c-kitQ73235468
Recombinant methionyl human stem cell factor and filgrastim for peripheral blood progenitor cell mobilization and transplantation in non-Hodgkin's lymphoma patients--results of a phase I/II trialQ73292467
Stem cell factor improves the repopulating ability of primitive hematopoietic stem cells after sublethal irradiation (and, to a lesser extent) after bone marrow transplantation in miceQ74467819
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Different epidermal growth factor (EGF) receptor ligands show distinct kinetics and biased or partial agonism for homodimer and heterodimer formationQ34249179
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Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in miceQ35370039
Selection of multiple agonist antibodies from intracellular combinatorial libraries reveals that cellular receptors are functionally pleiotropicQ35549168
Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl miceQ35631334
Endothelial and perivascular cells maintain haematopoietic stem cellsQ35724815
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Regulation of haematopoiesis by growth factors - emerging insights and therapiesQ35790849
Reversible expansion of primate mast cell populations in vivo by stem cell factorQ35823913
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Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.Q36028807
Recombinant human stem cell factor (kit ligand) promotes human mast cell and melanocyte hyperplasia and functional activation in vivoQ36366794
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Yeast surface display for screening combinatorial polypeptide librariesQ36865126
Radioprotection of mice by recombinant rat stem cell factorQ37240187
Amplification mechanisms for the enhancement of antigen-mediated mast cell activationQ37259631
Structural biology of shared cytokine receptorsQ37279324
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Multifarious determinants of cytokine receptor signaling specificity.Q38175584
G-CSF: From granulopoietic stimulant to bone marrow stem cell mobilizing agentQ38240727
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The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancerQ38600953
Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligandsQ38625843
Cytokine pleiotropy and redundancy: a view from the receptorQ40494038
Ligand-based receptor tyrosine kinase partial agonists: New paradigm for cancer drug discovery?Q42050622
Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticksQ42173380
The majority of stem cell factor exists as monomer under physiological conditions. Implications for dimerization mediating biological activityQ43807113
P4510describes a project that usesImageJQ1659584
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectpleiotropyQ1134884
P304page(s)1041-1052.e18
P577publication date2017-03-01
P1433published inCellQ655814
P1476titleDecoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling.
P478volume168

Reverse relations

cites work (P2860)
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Q91987001Structure of the IFNγ receptor complex guides design of biased agonists
Q93158307The Immunobiology of the Interleukin-12 Family: Room for Discovery

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