Rapamycin combined with anti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation

scientific article (publication date: 2011)

Rapamycin combined with anti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...628434G
P356DOI10.1371/JOURNAL.PONE.0028434
P932PMC publication ID3235119
P698PubMed publication ID22174806
P5875ResearchGate publication ID51884764

P50authorMaria Grazia RoncaroloQ56426635
Andrea ValleQ96092257
Nicola GaglianiQ97069653
Tatiana JofraQ116997208
Angela StabiliniQ116997209
Manuela BattagliaQ38642202
Silvia GregoriQ38642221
P2093author name stringMark Atkinson
David M Rothstein
P2860cites workA function for interleukin 2 in Foxp3-expressing regulatory T cellsQ28590646
Anti-CD154 mAb and rapamycin induce T regulatory cell mediated tolerance in rat-to-mouse islet transplantationQ28752432
FOXP3+ regulatory T cells in the human immune systemQ29307487
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitisQ29619339
CTLA-4 up-regulation plays a role in tolerance mediated by CD45.Q31793582
Antigen-specific dependence of Tr1-cell therapy in preclinical models of islet transplantQ33604471
Molecular pathways in the induction of interleukin-27-driven regulatory type 1 cells.Q34242160
IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cellsQ34318928
Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response.Q34966662
Interleukin-10 therapy--review of a new approachQ35139563
Role for granulocyte colony-stimulating factor in the generation of human T regulatory type 1 cellsQ52010476
Prevention and reversal of renal allograft rejection by antibody against CD45RBQ60079374
CD4+ CD45RB low-density cells from untreated mice prevent acute allograft rejectionQ73160715
Prolongation of allograft survival by administration of anti-CD45RB monoclonal antibody is due to alteration of CD45RBhi: CD45RBlo T-cell proportionsQ79858864
Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10Q80785928
Treatment with granulocyte colony-stimulating factor prevents diabetes in NOD mice by recruiting plasmacytoid dendritic cells and functional CD4(+)CD25(+) regulatory T-cellsQ81191262
G-CSF treatment prevents cyclophosphamide acceleration of autoimmune diabetes in the NOD mouseQ81648171
Towards the identification of biomarkers of transplantation toleranceQ83956260
Tregs and transplantation toleranceQ35951541
The pleiotropic effects of mTor inhibitorsQ35981412
Antibody-mediated targeting of CD45 isoforms: A novel immunotherapeutic strategyQ36010833
Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cellsQ36842568
Granulocyte colony-stimulating factor for the induction of T-cell tolerance.Q36882397
Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans.Q36891917
ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanismsQ36936238
Contrasting roles for all-trans retinoic acid in TGF-beta-mediated induction of Foxp3 and Il10 genes in developing regulatory T cellsQ37106740
Regulatory T cells after organ transplantation: where does their action take place?Q37220729
In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppressionQ37273329
Immunologic Basis of Graft Rejection and Tolerance Following Transplantation of Liver or Other Solid OrgansQ37400370
Mycophenolate mofetil and calcineurin-inhibitor reduction: recent progressQ37602218
Potential T regulatory cell therapy in transplantation: how far have we come and how far can we go?Q37765648
An update on regulatory T cells in transplant tolerance and rejection.Q37777645
Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.Q45299244
Induction of tolerance in type 1 diabetes via both CD4+CD25+ T regulatory cells and T regulatory type 1 cellsQ45858705
Rapamycin and interleukin-10 treatment induces T regulatory type 1 cells that mediate antigen-specific transplantation tolerance.Q45889459
Donor treatment with pegylated G-CSF augments the generation of IL-10-producing regulatory T cells and promotes transplantation tolerance.Q47262629
Cutting edge: transplantation tolerance through enhanced CTLA-4 expressionQ47368720
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectsirolimusQ32089
P304page(s)e28434
P577publication date2011-01-01
P1433published inPLOS OneQ564954
P1476titleRapamycin combined with anti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation
P478volume6

Reverse relations

cites work (P2860)
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Q28289781Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
Q35665104Combination of an Antigen-Specific Therapy and an Immunomodulatory Treatment to Simultaneous Block Recurrent Autoimmunity and Alloreactivity in Non-Obese Diabetic Mice
Q38365254Extra-thymically induced T regulatory cell subsets: the optimal target for antigen-specific immunotherapy.
Q40278618Hepatic Infiltrates in Operational Tolerant Patients After Liver Transplantation Show Enrichment of Regulatory T Cells Before Proinflammatory Genes Are Downregulated
Q39076791IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo
Q37077578IL-10 induction from implants delivering pancreatic islets and hyaluronan
Q38574966In vivo induction of regulatory T cells for immune tolerance in hemophilia
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Q41275399Lack of the protein tyrosine phosphatase PTPN22 strengthens transplant tolerance to pancreatic islets in mice.
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Q42208547The regulatory T cell effector molecule fibrinogen-like protein 2 is necessary for the development of rapamycin-induced tolerance to fully MHC-mismatched murine cardiac allografts
Q52717429Tr1 cell immunotherapy promotes transplant tolerance via de novo Tr1 cell induction in mice and is safe and effective during acute viral infection.
Q42782622Transplant tolerance to pancreatic islets is initiated in the graft and sustained in the spleen

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