Nephronophthisis-associated CEP164 regulates cell cycle progression, apoptosis and epithelial-to-mesenchymal transition

scientific article (publication date: October 2014)

Nephronophthisis-associated CEP164 regulates cell cycle progression, apoptosis and epithelial-to-mesenchymal transition is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PGEN.1004594
P3181OpenCitations bibliographic resource ID404043
P932PMC publication ID4207587
P698PubMed publication ID25340510
P5875ResearchGate publication ID267747563

P50authorTri Q NguyenQ42700458
Indra A. ShaltielQ55458830
Rachel H GilesQ63372740
Marijn F StokmanQ63867777
Friedhelm HildebrandtQ28050923
Glenn van de HoekQ32421636
Marianne C. VerhaarQ40340965
P2093author name stringAmiya K Ghosh
Gisela G Slaats
Iain A Drummond
Roel Goldschmeding
Ive Logister
Lucas L Falke
Timothy D Klasson
Stéphanie Le Corre
P2860cites workExome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signalingQ24294774
Defective planar cell polarity in polycystic kidney diseaseQ46845250
Mesenchymal transition in kidney collecting duct epithelial cells.Q52585581
The intra-S phase checkpoint targets Dna2 to prevent stalled replication forks from reversing.Q53163831
Genome stability, progressive kidney failure and agingQ84630228
Cep164, a novel centriole appendage protein required for primary cilium formationQ24298367
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathwaysQ24302034
Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1Q24657907
The role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologiesQ27026481
Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesisQ28000119
Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determinationQ28188363
Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidneyQ28505069
Snail blocks the cell cycle and confers resistance to cell deathQ28572344
Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosisQ28586772
The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expressionQ28595042
Visualizing spatiotemporal dynamics of multicellular cell-cycle progressionQ29617610
In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitroQ29617927
Distinct phosphatases antagonize the p53 response in different phases of the cell cycleQ30578888
Intrarenal cells, not bone marrow-derived cells, are the major source for regeneration in postischemic kidneyQ33218591
Live-cell assay for detection of apoptosis by dual-laser flow cytometry using Hoechst 33342 and 7-amino-actinomycin D.Q33280770
UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivityQ33406218
tp53 mutant zebrafish develop malignant peripheral nerve sheath tumorsQ33722903
Origin and function of myofibroblasts in kidney fibrosisQ33792700
Murine Joubert syndrome reveals Hedgehog signaling defects as a potential therapeutic target for nephronophthisisQ33919616
Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic interventionQ35615604
Renal fibrosis and the origin of the renal fibroblastQ36556298
Apoptosis and loss of renal tissue in polycystic kidney diseasesQ36707140
Phenotypic transitions and fibrosis in diabetic nephropathyQ36753326
Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategyQ37552382
Snail and Slug, key regulators of TGF-β-induced EMT, are sufficient for the induction of single-cell invasionQ39160417
Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrationsQ39465329
Snail1 is involved in the renal epithelial-mesenchymal transition.Q40095313
Functional aspects of primary cilia in signaling, cell cycle and tumorigenesisQ40963789
Bcl-2 overexpression prevents apoptosis-induced Madin-Darby canine kidney simple epithelial cyst formationQ40979524
NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathiesQ41883398
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectapoptotic processQ14599311
P304page(s)e1004594
P577publication date2014-10-01
P1433published inPLOS GeneticsQ1893441
P1476titleNephronophthisis-associated CEP164 regulates cell cycle progression, apoptosis and epithelial-to-mesenchymal transition
P478volume10

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cites work (P2860)
Q47706146A human patient-derived cellular model of Joubert syndrome reveals ciliary defects which can be rescued with targeted therapies
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Q26769756Cellular Mechanisms of Ciliary Length Control
Q38650721Centrosomes in the DNA damage response--the hub outside the centre
Q54978155Ciliary signalling in cancer.
Q47290076Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation
Q26771488Current topics of functional links between primary cilia and cell cycle
Q50286581EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase.
Q92995595Embryonic and foetal expression patterns of the ciliopathy gene CEP164
Q38397620FUCCI sensors: powerful new tools for analysis of cell proliferation.
Q41918379Germline mutations affecting the histone H4 core cause a developmental syndrome by altering DNA damage response and cell cycle control
Q42180881Inhibition of centrosomal protein 164 sensitizes rhabdomyosarcoma cells to radiotherapy
Q41611551Loss of Glis2/NPHP7 causes kidney epithelial cell senescence and suppresses cyst growth in the Kif3a mouse model of cystic kidney disease.
Q37054775Low expression of centrosomal protein 78 (CEP78) is associated with poor prognosis of colorectal cancer patients
Q47833085Many Genes-One Disease? Genetics of Nephronophthisis (NPHP) and NPHP-Associated Disorders.
Q38964728Mechanisms of ciliogenesis suppression in dividing cells
Q47674642Microtubule stabilization drives 3D centrosome migration to initiate primary ciliogenesis
Q90647026Nek2 kinase displaces distal appendages from the mother centriole prior to mitosis
Q88539141Nephronophthisis: A review of genotype-phenotype correlation
Q38556258Nephronophthisis: should we target cysts or fibrosis?
Q39231616Oral-facial-digital syndrome type I cells exhibit impaired DNA repair; unanticipated consequences of defective OFD1 outside of the cilia network
Q92763167Positioning of the Centrosome and Golgi Complex
Q37269150Rnf25/AO7 positively regulates wnt signaling via disrupting Nkd1-Axin inhibitory complex independent of its ubiquitin ligase activity
Q38821382Screen-based identification and validation of four new ion channels as regulators of renal ciliogenesis
Q35229307The more we know, the more we have to discover: an exciting future for understanding cilia and ciliopathies
Q91447644The role of DNA damage as a therapeutic target in autosomal dominant polycystic kidney disease
Q64096239WDR5, BRCA1, and BARD1 Co-regulate the DNA Damage Response and Modulate the Mesenchymal-to-Epithelial Transition during Early Reprogramming
Q26750633Zebrafish: a vertebrate tool for studying basal body biogenesis, structure, and function

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