Drosophila Lung Cancer Models Identify Trametinib plus Statin as Candidate Therapeutic

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Drosophila Lung Cancer Models Identify Trametinib plus Statin as Candidate Therapeutic is …
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scholarly articleQ13442814

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P356DOI10.1016/J.CELREP.2015.12.105
P8608Fatcat IDrelease_4346nopuyrd2thq7aph6bncauu
P3181OpenCitations bibliographic resource ID3748296
P932PMC publication ID4904304
P698PubMed publication ID26832408
P5875ResearchGate publication ID292338039

P2093author name stringRoss L Cagan
Benjamin D Levine
P2860cites workFGF-10 is a chemotactic factor for distal epithelial buds during lung developmentQ24314375
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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates AktQ29547767
Drug combination studies and their synergy quantification using the Chou-Talalay methodQ29617422
Matrix metalloproteinases: regulators of the tumor microenvironmentQ29619858
FGF is an essential mitogen and chemoattractant for the air sacs of the drosophila tracheal systemQ34145948
Increased RhoA prenylation in the loechrig (loe) mutant leads to progressive neurodegenerationQ34412406
Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.Q34443426
HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosisQ34605246
Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention.Q35823933
The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for LongevityQ35898911
Atorvastatin delays progression of pancreatic lesions to carcinoma by regulating PI3/AKT signaling in p48Cre/+ LSL-KrasG12D/+ miceQ36035654
Mechanisms of steroid-triggered programmed cell death in DrosophilaQ36083635
Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targetsQ36856455
Atorvastatin overcomes gefitinib resistance in KRAS mutant human non-small cell lung carcinoma cellsQ37211974
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibitionQ37331610
Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitorsQ37355543
Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition.Q37396608
Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaborationQ37602752
Molecular aspects of respiratory and vascular tube development.Q37733862
A Drosophila asthma model - what the fly tells us about inflammatory diseases of the lungQ37962858
MEK inhibition in non-small cell lung cancerQ38254501
Statin induces inhibition of triple negative breast cancer (TNBC) cells via PI3K pathwayQ39105805
Statins exhibit anticancer effects through modifications of the pAkt signaling pathwayQ39459037
Combination of EGFR and MEK1/2 inhibitor shows synergistic effects by suppressing EGFR/HER3-dependent AKT activation in human gastric cancer cellsQ39799421
In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models.Q39830937
Statins inhibit Akt/PKB signaling via P2X7 receptor in pancreatic cancer cellsQ39835633
Fluvastatin prevents oxidized low-density lipoprotein-induced injury of renal tubular epithelial cells by inhibiting the phosphatidylinositol 3-kinase/Akt-signaling pathwayQ40250359
Ras Isoprenylation and pAkt Inhibition by Zoledronic Acid and Fluvastatin Enhances Paclitaxel Activity in T24 Bladder Cancer CellsQ41815934
Isoprenoids control germ cell migration downstream of HMGCoA reductaseQ44762411
Tracheal branch repopulation precedes induction of the Drosophila dorsal air sac primordiumQ44776302
Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in DrosophilaQ46834686
Specification of differentiated adult progenitors via inhibition of endocycle entry in the Drosophila trachea.Q52783292
A cellular process that includes asymmetric cytokinesis remodels the dorsal tracheal branches in Drosophila larvae.Q52803044
Gas6/Axl-PI3K/Akt pathway plays a central role in the effect of statins on inorganic phosphate-induced calcification of vascular smooth muscle cellsQ79464851
P4510describes a project that usesImageJQ1659584
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectlung cancerQ47912
DrosophilaQ312154
P304page(s)1477-1487
P577publication date2016-01-27
P1433published inCell ReportsQ5058165
P1476titleDrosophila Lung Cancer Models Identify Trametinib plus Statin as Candidate Therapeutic
P478volume14

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