Inactivated Enterovirus 71 Vaccine Produced by 200-L Scale Serum-Free Microcarrier Bioreactor System Provides Cross-Protective Efficacy in Human SCARB2 Transgenic Mouse

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Inactivated Enterovirus 71 Vaccine Produced by 200-L Scale Serum-Free Microcarrier Bioreactor System Provides Cross-Protective Efficacy in Human SCARB2 Transgenic Mouse is …
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scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1036420W
P356DOI10.1371/JOURNAL.PONE.0136420
P3181OpenCitations bibliographic resource ID4485713
P932PMC publication ID4543551
P698PubMed publication ID26287531
P5875ResearchGate publication ID281172816

P50authorPei-Wen HsiaoQ40066871
P2093author name stringChi-Hsien Chan
Chia-Ho Kuo
Chia-Ying Wu
Chien-Hung Pan
Ching-Chuan Chang
Chung-Cheng Liu
Hsiu-Fen Tai
Juine-Ruey Chen
Wan-Hsin Liu
Yen-Hung Chow
Yi-Wen Lin
Yung-Tsung Chen
P2860cites workNew low-viscosity overlay medium for viral plaque assaysQ21245137
Genetic characteristics of human enterovirus 71 and coxsackievirus A16 circulating from 1999 to 2004 in Shenzhen, People's Republic of ChinaQ24535192
Production of EV71 vaccine candidatesQ26866091
Immunological and biochemical characterization of coxsackie virus A16 viral particlesQ28485432
Pilot scale production of highly efficacious and stable enterovirus 71 vaccine candidatesQ31056961
Hand, foot, and mouth disease in China, 2008-12: an epidemiological studyQ33668897
Evolutionary genetics of human enterovirus 71: origin, population dynamics, natural selection, and seasonal periodicity of the VP1 geneQ33725572
Immunogenicity studies of bivalent inactivated virions of EV71/CVA16 formulated with submicron emulsion systems.Q33809953
An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group.Q33875086
Neurologic complications in children with enterovirus 71 infectionQ33875092
Purification and characterization of enterovirus 71 viral particles produced from vero cells grown in a serum-free microcarrier bioreactor system.Q33908518
An emerging recombinant human enterovirus 71 responsible for the 2008 outbreak of hand foot and mouth disease in Fuyang city of ChinaQ33911890
Long-term immunogenicity studies of formalin-inactivated enterovirus 71 whole-virion vaccine in macaquesQ34149853
High immunogenic enterovirus 71 strain and its production using serum-free microcarrier Vero cell culture.Q51143326
Epidemic characteristics of hand, foot, and mouth disease in Shanghai from 2009 to 2010: Enterovirus 71 subgenotype C4 as the primary causative agent and a high incidence of mixed infections with coxsackievirus A16Q57096427
Application of a serum-free medium for the growth of Vero cells and the production of reovirusQ73066445
Selection and characterization of vaccine strain for Enterovirus 71 vaccine developmentQ82811412
Active immunization with a Coxsackievirus A16 experimental inactivated vaccine induces neutralizing antibodies and protects mice against lethal infectionQ86408467
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Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trialQ34347924
Human SCARB2 transgenic mice as an infectious animal model for enterovirus 71.Q34603659
An overview of the evolution of enterovirus 71 and its clinical and public health significanceQ34635602
The cross-neutralizing activity of enterovirus 71 subgenotype c4 vaccines in healthy chinese infants and childrenQ35048558
Formalin-inactivated EV71 vaccine candidate induced cross-neutralizing antibody against subgenotypes B1, B4, B5 and C4A in adult volunteersQ35053266
A mouse-adapted enterovirus 71 strain causes neurological disease in mice after oral infectionQ35702513
A non-mouse-adapted enterovirus 71 (EV71) strain exhibits neurotropism, causing neurological manifestations in a novel mouse model of EV71 infectionQ35826494
Human enterovirus 71 epidemics: what's next?Q37168703
Progress on the research and development of inactivated EV71 whole-virus vaccinesQ37530094
Development of enterovirus 71 vaccines.Q37682898
EV71: an emerging infectious disease vaccine target in the Far East?Q37715371
Neural pathogenesis of enterovirus 71 infectionQ37720283
Virology, epidemiology, pathogenesis, and control of enterovirus 71.Q37801742
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Prospect and challenges for the development of multivalent vaccines against hand, foot and mouth diseasesQ38248866
Review of enterovirus 71 vaccinesQ38263484
An inactivated enterovirus 71 vaccine in healthy childrenQ40216677
Complete genome analysis of the C4 subgenotype strains of enterovirus 71: predominant recombination C4 viruses persistently circulating in China for 14 yearsQ41859348
A combination vaccine comprising of inactivated enterovirus 71 and coxsackievirus A16 elicits balanced protective immunity against both virusesQ42222745
Efficacy, safety, and immunogenicity of an enterovirus 71 vaccine in ChinaQ42226974
Enterovirus 71 related severe hand, foot and mouth disease outbreaks in South-East Asia: current situation and ongoing challengesQ42588563
Proinflammatory cytokine reactions in enterovirus 71 infections of the central nervous systemQ44285689
Optimization of microcarrier cell culture process for the inactivated enterovirus type 71 vaccine developmentQ45056729
Protection against lethal enterovirus 71 infection in newborn mice by passive immunization with subunit VP1 vaccines and inactivated virusQ45734536
Dynamic change of mother-source neutralizing antibodies against enterovirus 71 and coxsackievirus A16 in infants.Q45963384
Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edemaQ48235723
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectbioreactorQ864699
virologyQ7215
P304page(s)e0136420
P577publication date2015-01-01
P1433published inPLOS OneQ564954
P1476titleInactivated Enterovirus 71 Vaccine Produced by 200-L Scale Serum-Free Microcarrier Bioreactor System Provides Cross-Protective Efficacy in Human SCARB2 Transgenic Mouse
P478volume10

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Q40062129DNA vaccines against leptospirosis: A literature review.
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Q28076658EV-A71 vaccine licensure: a first step for multivalent enterovirus vaccine to control HFMD and other severe diseases
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