A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1.

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A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1. is …
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scholarly articleQ13442814

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P819ADS bibcode2015NatCo...6.8297Y
P6179Dimensions Publication ID1044858117
P356DOI10.1038/NCOMMS9297
P8608Fatcat IDrelease_mpfbbgru5fbufjhqctgr63gq6q
P3181OpenCitations bibliographic resource ID3350196
P932PMC publication ID4589873
P698PubMed publication ID26420335
P5875ResearchGate publication ID282326866

P50authorVladimir Yarov-YarovoyQ57027923
Fan YangQ59248985
Jie ZhengQ90427662
P2093author name stringMingqiang Rong
Ren Lai
Shilong Yang
Jing Hong
Lei Luo
KeWei Wang
Bowen Li
Ningning Wei
P2860cites workThe bite and habits of a giant centipede (Scolopendra subspinipes) in the Philippine IslandsQ80715894
The capsaicin receptor: a heat-activated ion channel in the pain pathwayQ24322558
Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain modelsQ24605644
Chemical punch packed in venoms makes centipedes excellent predatorsQ24606345
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From foe to friend: using animal toxins to investigate ion channel functionQ26864410
Structure of the TRPV1 ion channel determined by electron cryo-microscopyQ27680759
TRPV1 structures in distinct conformations reveal activation mechanismsQ27680762
Automated NOESY interpretation with ambiguous distance restraints: the refined NMR solution structure of the pleckstrin homology domain from beta-spectrinQ27739804
Version 1.2 of the Crystallography and NMR systemQ27860583
NMRPipe: a multidimensional spectral processing system based on UNIX pipesQ27860859
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Centipede envenomationQ28204427
Voltage-dependent inhibition of N- and P-type calcium channels by the peptide toxin omega-grammotoxin-SIAQ28257902
Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humansQ28272480
ARIA2: automated NOE assignment and data integration in NMR structure calculationQ28275170
RosettaScripts: a scripting language interface to the Rosetta macromolecular modeling suiteQ28743250
ROSETTA3: an object-oriented software suite for the simulation and design of macromoleculesQ28914720
An introduction to TRP channelsQ29615753
Multipass membrane protein structure prediction using RosettaQ30352314
Molecular determinants of gating at the potassium-channel selectivity filterQ30439755
Conotoxins and the posttranslational modification of secreted gene productsQ33228036
Anti-infection peptidomics of amphibian skinQ33271638
Temperature-dependent activation of neurons by continuous near-infrared laserQ33387264
Thermosensitive TRP channel pore turret is part of the temperature activation pathway.Q33859583
A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domainQ34118030
Natural products and ion channel pharmacologyQ34128527
Voltage-gated ion channels and gating modifier toxins.Q34161355
Thermodynamics of Heat Activation of Single Capsaicin Ion Channels VR1Q34183505
Voltage-sensor activation with a tarantula toxin as cargo.Q34442179
Spider toxins activate the capsaicin receptor to produce inflammatory pain.Q34580428
Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockersQ34698238
Acid potentiation of the capsaicin receptor determined by a key extracellular siteQ35177598
Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channelQ35756403
Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations.Q35860150
Proton block of proton-activated TRPV1 currentQ35894332
Selectivity changes during activation of mutant Shaker potassium channelsQ36445050
Gating at the selectivity filter in cyclic nucleotide-gated channelsQ36491086
A yeast genetic screen reveals a critical role for the pore helix domain in TRP channel gatingQ36710217
Restriction site-independent formation of chimeras from homologous neurotransmitter-transporter cDNAs.Q36725246
Divalent cations activate TRPV1 through promoting conformational change of the extracellular regionQ37417921
Divalent cations potentiate TRPV1 channel by lowering the heat activation thresholdQ37417929
BK channel opening involves side-chain reorientation of multiple deep-pore residuesQ37474795
The toxicogenomic multiverse: convergent recruitment of proteins into animal venomsQ37565656
On the venom system of centipedes (Chilopoda), a neglected group of venomous animalsQ37831459
Molecular mechanism of TRP channelsQ38110511
Structure and function of the thermoTRP channel poreQ38264647
Isolation and characterization of SsmTx-I, a Specific Kv2.1 blocker from the venom of the centipede Scolopendra Subspinipes Mutilans L. KochQ39030509
Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block.Q39080979
Membrane potential-dependent binding of scorpion toxin to the action potential Na+ ionophore. Studies with a toxin derivative prepared by lactoperoxidase-catalyzed iodinationQ39461858
Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domainQ39711589
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channelsQ40526282
Permeation and dynamics of an open-activated TRPV1 channel.Q41606734
Thermosensitive TRPV channel subunits coassemble into heteromeric channels with intermediate conductance and gating propertiesQ41969847
Conformational changes in S6 coupled to the opening of cyclic nucleotide-gated channelsQ42653386
Molecular basis for species-specific sensitivity to "hot" chili peppersQ45712451
Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling.Q46510733
Effects of a centipede venom fraction on insect nervous system, a native Xenopus oocyte receptor and on an expressed Drosophila muscarinic receptorQ48912597
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)8297
P577publication date2015-09-30
P1433published inNature CommunicationsQ573880
P1476titleA pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1.
P478volume6

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cites work (P2860)
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