Synaptic Vesicle Recycling Is Unaffected in the Ts65Dn Mouse Model of Down Syndrome

scientific article (publication date: 2016)

Synaptic Vesicle Recycling Is Unaffected in the Ts65Dn Mouse Model of Down Syndrome is …
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scholarly articleQ13442814

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P819ADS bibcode2016PLoSO..1147974M
P356DOI10.1371/JOURNAL.PONE.0147974
P932PMC publication ID4726538
P698PubMed publication ID26808141
P5875ResearchGate publication ID291946715

P50authorJamie R. K. MarlandQ64499119
Michael A CousinQ59693288
Karen Janet SmillieQ42726692
P2093author name stringJamie R K Marland
P2860cites workRegulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylationQ24339194
The molecular physiology of activity-dependent bulk endocytosis of synaptic vesiclesQ24616029
Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1Q24654657
Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophreniaQ24678573
A genetic cause of Alzheimer disease: mechanistic insights from Down syndromeQ26798983
Mouse models of Down syndrome as a tool to unravel the causes of mental disabilitiesQ26863005
Regulation of synaptic vesicle recycling by complex formation between intersectin 1 and the clathrin adaptor complex AP2Q27659883
Fiji: an open-source platform for biological-image analysisQ27860912
A conserved family of calcineurin regulators.Q27933946
Trisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomesQ28118988
DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathwaysQ28138804
A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signalingQ28139025
Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's diseaseQ28210455
App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndromeQ28511479
Essential role of phosphoinositide metabolism in synaptic vesicle recyclingQ28511682
Adaptor protein complexes 1 and 3 are essential for generation of synaptic vesicles from activity-dependent bulk endosomesQ28581279
Intersectin is a negative regulator of dynamin recruitment to the synaptic endocytic zone in the central synapse.Q30159491
Fetal life in Down syndrome starts with normal neuronal density but impaired dendritic spines and synaptosomal structureQ32054544
Calcineurin is universally involved in vesicle endocytosis at neuronal and nonneuronal secretory cellsQ33804443
Amyloid precursor protein is trafficked and secreted via synaptic vesiclesQ33893776
Activity-dependent bulk endocytosis and clathrin-dependent endocytosis replenish specific synaptic vesicle pools in central nerve terminalsQ33929652
Reducing GABAA α5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome.Q34035851
The role of calcium/calmodulin-activated calcineurin in rapid and slow endocytosis at central synapsesQ34196522
RCAN1 regulates vesicle recycling and quantal release kinetics via effects on calcineurin activityQ85385985
Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome.Q46035669
DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's diseaseQ46819146
The Down syndrome critical region protein RCAN1 regulates long-term potentiation and memory via inhibition of phosphatase signalingQ46876545
Down syndrome: the brain in trisomic modeQ48287894
Dendritic atrophy in children with Down's syndromeQ48296709
The kinetics of synaptic vesicle reacidification at hippocampal nerve terminals.Q48640074
Synaptic development in the human fetus: a morphometric analysis of normal and Down's syndrome neocortexQ48692759
Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome.Q51979066
Altered long-term potentiation in the young and old Ts65Dn mouse, a model for Down Syndrome.Q51995807
Excitatory amino acids and monoamines in parahippocampal gyrus and frontal cortical pole of adults with Down syndrome.Q52005136
A mouse model for Down syndrome exhibits learning and behaviour deficits.Q52013436
Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT).Q52166624
Amino acid neurotransmitter deficits in adult Down's syndrome brain tissueQ61714007
Phosphorylation by Dyrk1A of clathrin coated vesicle-associated proteins: identification of the substrate proteins and the effects of phosphorylationQ34238748
Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory.Q34268889
Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinaseQ34280119
Working memory impairment in calcineurin knock-out mice is associated with alterations in synaptic vesicle cycling and disruption of high-frequency synaptic and network activity in prefrontal cortexQ34355386
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.Q34504363
The phospho-dependent dynamin-syndapin interaction triggers activity-dependent bulk endocytosis of synaptic vesiclesQ34987475
Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1.Q35069723
Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndromeQ35573506
Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutationsQ35745983
Increased cortical synaptic activation of TrkB and downstream signaling markers in a mouse model of Down SyndromeQ36399166
Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn.Q36422268
Synaptic vesicle generation from activity-dependent bulk endosomes requires calcium and calcineurin.Q36660705
Fast neurotransmitter release regulated by the endocytic scaffold intersectinQ36855303
Short-term treatment with the GABAA receptor antagonist pentylenetetrazole produces a sustained pro-cognitive benefit in a mouse model of Down's syndromeQ36965872
Control of synaptic vesicle endocytosis by an extracellular signalling moleculeQ37187025
Synaptic degeneration in Alzheimer's diseaseQ37458270
Ultrafast endocytosis at mouse hippocampal synapses.Q37642826
Presynaptic dysfunction in Huntington's disease.Q37713855
Presynaptic function in health and diseaseQ37877363
Synaptic vesicle endocytosisQ38024048
Synaptic Vesicle Endocytosis and Endosomal Recycling in Central Nerve Terminals: Discrete Trafficking Routes?Q38229899
Synaptic vesicle generation from central nerve terminal endosomesQ38262876
Activity-dependent phosphorylation of dynamin 1 at serine 857.Q39303566
Clathrin-mediated endocytosis is the dominant mechanism of vesicle retrieval at hippocampal synapses.Q39751968
Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome.Q40418155
Activity-dependent control of slow synaptic vesicle endocytosis by cyclin-dependent kinase 5.Q40803584
Bulk synaptic vesicle endocytosis is rapidly triggered during strong stimulationQ41599069
Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndromeQ41811378
CDK5 serves as a major control point in neurotransmitter release.Q41862687
Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.Q42467654
Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndromeQ42483994
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.Q42497675
Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regionsQ42694136
Overexpression of Dyrk1A causes the defects in synaptic vesicle endocytosisQ42785129
Phosphorylation of amphiphysin I by minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase, a kinase implicated in Down syndromeQ42801227
MNB/DYRK1A phosphorylation regulates the interactions of synaptojanin 1 with endocytic accessory proteinsQ43055134
Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic-like memoryQ43815520
Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome.Q46020053
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectDown syndromeQ47715
P304page(s)e0147974
P577publication date2016-01-25
P1433published inPLOS OneQ564954
P1476titleSynaptic Vesicle Recycling Is Unaffected in the Ts65Dn Mouse Model of Down Syndrome
P478volume11

Reverse relations

Q90400921RCAN1 Knockdown Reverts Defects in the Number of Calcium-Induced Exocytotic Events in a Cellular Model of Down Syndromecites workP2860

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