ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion

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ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion is …
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scholarly articleQ13442814

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P819ADS bibcode2016NatCo...712630C
P6179Dimensions Publication ID1050226141
P356DOI10.1038/NCOMMS12630
P3181OpenCitations bibliographic resource ID3649004
P932PMC publication ID5023948
P698PubMed publication ID27600527

P50authorDariusz LachowskiQ59301305
Ben FabryQ41410957
P2093author name stringAntonios Chronopoulos
Ernesto Cortes
Benjamin Robinson
Saba Ghassemi
Vera Auernheimer
Simon Attwood
Armando Del Río Hernández
Rebeca García
Muge Sarper
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Persistent activation of pancreatic stellate cells creates a microenvironment favorable for the malignant behavior of pancreatic ductal adenocarcinomaQ27012236
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The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins.Q30500836
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Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinomaQ33896442
Stromal response to Hedgehog signaling restrains pancreatic cancer progressionQ34002580
All-trans retinoic acid (ATRA) downregulates MMP-9 by modulating its regulatory moleculesQ34219471
Tension is required but not sufficient for focal adhesion maturation without a stress fiber templateQ34250775
Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapyQ34253198
Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survivalQ34269713
Rho kinase inhibitors block activation of pancreatic stellate cellsQ35045926
Hepatic stellate cells require a stiff environment for myofibroblastic differentiation.Q35087094
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Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasisQ35628173
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All-trans retinoic acid inhibits migration, invasion and proliferation, and promotes apoptosis in glioma cells in vitroQ35759006
Retinoic Acid Ameliorates Pancreatic Fibrosis and Inhibits the Activation of Pancreatic Stellate Cells in Mice with Experimental Chronic Pancreatitis via Suppressing the Wnt/β-Catenin Signaling PathwayQ35837893
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Cancer-associated stromal fibroblasts promote pancreatic tumor progressionQ36844475
Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts.Q37331580
The mechanical integrin cycle.Q37360851
Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RAR beta 2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockoutsQ37578119
Stars and stripes in pancreatic cancer: role of stellate cells and stroma in cancer progressionQ37583130
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The role of stroma in pancreatic cancer: diagnostic and therapeutic implicationsQ38019761
Hepatic stellate cells and extracellular matrix in hepatocellular carcinoma: more complicated than ever.Q38176402
Fibrosis--a lethal component of systemic sclerosisQ38206104
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Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progressionQ39518102
All-trans retinoic acid is capable of inducing folate receptor β expression in KG-1 cellsQ39679996
Mechanism of regulation and suppression of melanoma invasiveness by novel retinoic acid receptor-gamma target gene carbohydrate sulfotransferase 10.Q39846927
Pancreatic stellate cells: partners in crime with pancreatic cancer cellsQ39996299
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Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cellsQ40515728
Traction forces of fibroblasts are regulated by the Rho-dependent kinase but not by the myosin light chain kinaseQ42128424
Vitamin A inhibits pancreatic stellate cell activation: implications for treatment of pancreatic fibrosisQ42844327
Blebbistatin inhibits contraction and accelerates migration in mouse hepatic stellate cellsQ42910952
Retinoic acids reduce matrilysin (matrix metalloproteinase 7) and inhibit tumor cell invasion in human colon cancerQ43635457
Cell prestress. I. Stiffness and prestress are closely associated in adherent contractile cellsQ43879158
Vitamin A upregulates matrix metalloproteinase-9 activity by murine myeloid dendritic cells through a nonclassical transcriptional mechanismQ46530595
Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channelsQ46917020
Stress fluctuations and motion of cytoskeletal-bound markersQ48906001
Effects of cytoskeletal prestress on cell rheological behavior.Q51201724
Fibrogenic signalling in hepatic stellate cells.Q54465640
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P304page(s)12630
P577publication date2016-09-07
P1433published inNature CommunicationsQ573880
P1476titleATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion
P478volume7

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