Inflammatory and Senescent Phenotype of Pancreatic Stellate Cells Induced by Sqstm1 Downregulation Facilitates Pancreatic Cancer Progression

scientific article published on 21 April 2019

Inflammatory and Senescent Phenotype of Pancreatic Stellate Cells Induced by Sqstm1 Downregulation Facilitates Pancreatic Cancer Progression is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.7150/IJBS.27825
P932PMC publication ID6535784
P698PubMed publication ID31182922

P2093author name stringWei Chen
Jian Shen
Zhiyuan Xu
Xiaoguang Wang
Xiangdong Cheng
Kequn Chai
Chuxiao Shao
Chaoyong Tu
P2860cites workATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasionQ27330342
Membrane-to-Nucleus Signals and Epigenetic Mechanisms for Myofibroblastic Activation and Desmoplastic Stroma: Potential Therapeutic Targets for Liver Metastasis?Q28084572
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesisQ28242612
p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver CancerQ29144909
FOLFIRINOX versus gemcitabine for metastatic pancreatic cancerQ29547638
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesisQ29614405
Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabineQ29616728
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinomaQ33896442
Fibroblast heterogeneity in the cancer woundQ33964324
Stromal response to Hedgehog signaling restrains pancreatic cancer progressionQ34002580
Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapyQ34253198
Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survivalQ34269713
Ectopic overexpression of Sonic Hedgehog (Shh) induces stromal expansion and metaplasia in the adult murine pancreasQ35444326
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer.Q37683769
Physiological significance of selective degradation of p62 by autophagyQ37691820
Stromal biology and therapy in pancreatic cancer: a changing paradigmQ38494338
Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in MiceQ38719300
Senescent Carcinoma-Associated Fibroblasts Upregulate IL8 to Enhance Prometastatic PhenotypesQ38743451
Genomic analyses identify molecular subtypes of pancreatic cancerQ38791499
Role of CCL20 mediated immune cell recruitment in NF-κB mediated TRAIL resistance of pancreatic cancerQ38966213
Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis.Q38977381
p62 in Cancer: Signaling Adaptor Beyond AutophagyQ38987558
Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United StatesQ39190004
Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progressionQ39518102
GM-CSF Mediates Mesenchymal-Epithelial Cross-talk in Pancreatic CancerQ39762588
Sonic hedgehog promotes desmoplasia in pancreatic cancerQ39933626
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion.Q41432721
p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating CellsQ42716243
Vitamin A inhibits pancreatic stellate cell activation: implications for treatment of pancreatic fibrosisQ42844327
Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in PancreasQ46092740
Reprograming Carcinoma Associated Fibroblasts by microRNAsQ48579445
Pancreatic ductal adenocarcinoma: State-of-the-art 2017 and new therapeutic strategiesQ50224945
Paracrine IL-6 signaling mediates the effects of pancreatic stellate cells on epithelial-mesenchymal transition via Stat3/Nrf2 pathway in pancreatic cancer cells.Q51384283
Calycosin suppresses expression of pro-inflammatory cytokines via the activation of p62/Nrf2-linked heme oxygenase 1 in rheumatoid arthritis synovial fibroblasts.Q51455073
P433issue5
P921main subjectpancreatic cancerQ212961
P304page(s)1020-1029
P577publication date2019-04-21
P1433published inInternational Journal of Biological SciencesQ6051326
P1476titleInflammatory and Senescent Phenotype of Pancreatic Stellate Cells Induced by Sqstm1 Downregulation Facilitates Pancreatic Cancer Progression
P478volume15

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