scholarly article | Q13442814 |
P50 | author | Gen Sobue | Q67219868 |
Hideyuki Takeuchi | Q87350460 | ||
Koji Yamanaka | Q37377501 | ||
Mariko Noda | Q42177315 | ||
P2093 | author name string | Yan Zhou | |
Hua Li | |||
Jun Sato | |||
Hiroyuki Mizoguchi | |||
Rarami Mori | |||
Akio Suzumura | |||
Jun Kawanokuchi | |||
Shijie Jin | |||
Tetsuya Mizuno | |||
Bijay Parajuli | |||
Yoshifumi Sonobe | |||
Yukiko Doi | |||
Endong Li | |||
Jianfeng Liang | |||
Satoko Yasuoka | |||
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Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease | Q24621854 | ||
Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model | Q24631645 | ||
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo | Q28131779 | ||
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons | Q28298056 | ||
Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine | Q29465775 | ||
Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation | Q29547561 | ||
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms | Q29547835 | ||
Unraveling the mechanisms involved in motor neuron degeneration in ALS | Q29619073 | ||
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Onset and progression in inherited ALS determined by motor neurons and microglia | Q29619515 | ||
Gating and regulation of connexin 43 (Cx43) hemichannels | Q30480722 | ||
Microglia activated with the toll-like receptor 9 ligand CpG attenuate oligomeric amyloid {beta} neurotoxicity in in vitro and in vivo models of Alzheimer's disease | Q30491484 | ||
Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function. | Q31832269 | ||
Newer aspects of glutamine/glutamate metabolism: the role of acute pH changes | Q33749201 | ||
Gap junctions, synchrony and seizures | Q33826762 | ||
Oral vaccination with a viral vector containing Abeta cDNA attenuates age-related Abeta accumulation and memory deficits without causing inflammation in a mouse Alzheimer model | Q48251811 | ||
Accumulation of phosphorylated alpha-synuclein in aging human brain | Q48266774 | ||
Macrophage-induced cytotoxicity of N-methyl-D-aspartate receptor positive neurons involves excitatory amino acids rather than reactive oxygen intermediates and cytokines | Q48440751 | ||
Astrocytic gap junctions remain open during ischemic conditions. | Q48493362 | ||
Effective reduction of infarct volume by gap junction blockade in a rodent model of stroke | Q48577890 | ||
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins | Q48601563 | ||
Amyotrophic lateral sclerosis with numerous axonal spheroids in the corticospinal tract and massive degeneration of the cortex | Q48629386 | ||
Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. | Q53278044 | ||
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Microglia rules: insights into microglial-neuronal signaling | Q80547750 | ||
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Targeting drugs to the brain by redox chemical delivery systems. | Q33996838 | ||
Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse | Q34007194 | ||
Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. | Q34417339 | ||
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Inflammatory processes in amyotrophic lateral sclerosis | Q34936474 | ||
Microglia in diseases of the central nervous system | Q35054979 | ||
Microglia at brain stab wounds express connexin 43 and in vitro form functional gap junctions after treatment with interferon-gamma and tumor necrosis factor-alpha | Q35059879 | ||
Amyotrophic lateral sclerosis: a consensus viewpoint on designing and implementing a clinical trial | Q35809317 | ||
Gap junctional communication in tissue inflammation and repair. | Q36162602 | ||
MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: induction of Ia antigen expression by gamma-interferon | Q36431988 | ||
Roles of glia-derived cytokines on neuronal degeneration and regeneration | Q36693990 | ||
Properties of gap junction blockers and their behavioural, cognitive and electrophysiological effects: animal and human studies | Q37375210 | ||
Pre-symptomatic detection of chronic motor deficits and genotype prediction in congenic B6.SOD1(G93A) ALS mouse model. | Q37440150 | ||
Dual effect of CD4+CD25+ regulatory T cells in neurodegeneration: a dialogue with microglia | Q37569879 | ||
The gap junction proteome and its relationship to disease | Q37640469 | ||
Motor neuron disease: systematic reviews of treatment for ALS and SMA. | Q37656842 | ||
17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration | Q40374915 | ||
Microglial phagocytosis of fibrillar beta-amyloid through a beta1 integrin-dependent mechanism. | Q40496060 | ||
Glia-neuron intercommunications and synaptic plasticity | Q41173085 | ||
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Brain metabolism of branched-chain amino acids | Q41595192 | ||
Rates of utilization of glucose, glutamine and oleate and formation of end-products by mouse peritoneal macrophages in culture | Q41967685 | ||
Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines | Q42148708 | ||
Astrocytic gap junction blockage and neuronal Ca2+ oscillation in neuron-astrocyte cocultures in vitro | Q42459376 | ||
Functional and morphological changes induced by transient in vivo ischemia | Q42492866 | ||
Ischemia-induced brain damage depends on specific gap-junctional coupling | Q43937493 | ||
Alzheimer's amyloid beta-peptide enhances ATP/gap junction-mediated calcium-wave propagation in astrocytes | Q44497733 | ||
Neuroscience. Microglia: the enemy within? | Q44681258 | ||
Neuritic beading induced by activated microglia is an early feature of neuronal dysfunction toward neuronal death by inhibition of mitochondrial respiration and axonal transport | Q45216891 | ||
Blockade of glutamate release from microglia attenuates experimental autoimmune encephalomyelitis in mice | Q46124391 | ||
Blockade of microglial glutamate release protects against ischemic brain injury | Q46385482 | ||
Macrophage-induced neurotoxicity is mediated by glutamate and attenuated by glutaminase inhibitors and gap junction inhibitors | Q46614579 | ||
Excitatory amino acid transporter expression by astrocytes is neuroprotective against microglial excitotoxicity | Q46645810 | ||
Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons. | Q46733868 | ||
Interferon-beta is neuroprotective against the toxicity induced by activated microglia | Q46974690 | ||
The effect of microglia on embryonic dopaminergic neuronal survival in vitro: diffusible signals from neurons and glia change microglia from neurotoxic to neuroprotective. | Q48228480 | ||
Neurochemical diversity of dystrophic neurites in the early and late stages of Alzheimer's disease. | Q48245330 | ||
Reduction of methamphetamine-induced sensitization and reward in matrix metalloproteinase-2 and -9-deficient mice | Q48248931 | ||
P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
P6216 | copyright status | copyrighted | Q50423863 |
P433 | issue | 6 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | Alzheimer's disease | Q11081 |
amyotrophic lateral sclerosis | Q206901 | ||
P304 | page(s) | e21108 | |
P577 | publication date | 2011-01-01 | |
P1433 | published in | PLOS One | Q564954 |
P1476 | title | Blockade of gap junction hemichannel suppresses disease progression in mouse models of amyotrophic lateral sclerosis and Alzheimer's disease | |
P478 | volume | 6 |
Q91665749 | A New Tool for In Vivo Study of Astrocyte Connexin 43 in Brain |
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Q47287911 | A potential role for neuronal connexin 36 in the pathogenesis of amyotrophic lateral sclerosis. |
Q39143832 | ATP is required and advances cytokine-induced gap junction formation in microglia in vitro. |
Q31122599 | Ablation of keratan sulfate accelerates early phase pathogenesis of ALS. |
Q26852070 | Astrocytes conspire with neurons during progression of neurological disease |
Q38422519 | Astrocytes in neurodegenerative disease |
Q34579376 | Blockade of gap junction hemichannel protects secondary spinal cord injury from activated microglia-mediated glutamate exitoneurotoxicity |
Q52608889 | Blocking distinct interactions between Glioblastoma cells and their tissue microenvironment: A novel multi-targeted therapeutic approach. |
Q94460602 | CCR2 is localized in microglia and neurons, as well as infiltrating monocytes, in the lumbar spinal cord of ALS mice |
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Q30718703 | Chronic Hyponatremia Causes Neurologic and Psychologic Impairments |
Q44345787 | Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Experimental Autoimmune Encephalomyelitis. |
Q36141133 | Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection |
Q39387318 | Connexin Channels at the Glio-Vascular Interface: Gatekeepers of the Brain |
Q28073033 | Connexins and Pannexins: New Insights into Microglial Functions and Dysfunctions |
Q47770967 | Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications |
Q50016422 | Connexins in the Central Nervous System: Physiological Traits and Neuroprotective Targets. |
Q58023568 | Dark side of astrocytes: Toxic, reactive astrocytes induced by activated microglia |
Q26797404 | Diseases associated with leaky hemichannels |
Q34478062 | Early disruption of glial communication via connexin gap junction in multiple sclerosis, Baló's disease and neuromyelitis optica |
Q96953332 | Efficacy of THN201, a Combination of Donepezil and Mefloquine, to Reverse Neurocognitive Deficits in Alzheimer's Disease |
Q35149204 | Evidence for aberrant astrocyte hemichannel activity in Juvenile Neuronal Ceroid Lipofuscinosis (JNCL). |
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Q42367703 | Influences of yokukansankachimpihange on aggressive behavior of zinc-deficient mice and actions of the ingredients on excessive neural exocytosis in the hippocampus of zinc-deficient rats |
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Q92941476 | Inhibition of Gap Junctions Sensitizes Primary Glioblastoma Cells for Temozolomide |
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Q39496127 | Minocycline selectively inhibits M1 polarization of microglia |
Q55541817 | Modulating membrane fluidity corrects Batten disease phenotypes in vitro and in vivo. |
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Q31031047 | Neuron-Glia Crosstalk in the Autonomic Nervous System and Its Possible Role in the Progression of Metabolic Syndrome: A New Hypothesis |
Q94450925 | Potential of activated microglia as a source of dysregulated extracellular microRNAs contributing to neurodegeneration in amyotrophic lateral sclerosis |
Q53056978 | Protective effect of INI-0602, a gap junction inhibitor, on dopaminergic neurodegeneration of mice with unilateral 6-hydroxydopamine injection. |
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