A Novel Telomerase Activator Suppresses Lung Damage in a Murine Model of Idiopathic Pulmonary Fibrosis

scientific article published on March 14, 2013

A Novel Telomerase Activator Suppresses Lung Damage in a Murine Model of Idiopathic Pulmonary Fibrosis is …
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scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...858423L
P356DOI10.1371/JOURNAL.PONE.0058423
P8608Fatcat IDrelease_v6jtdnw4cjbwpaynhk2racekzi
P953full work available at URLhttp://dx.plos.org/10.1371/journal.pone.0058423
https://europepmc.org/articles/PMC3597721
https://europepmc.org/articles/PMC3597721?pdf=render
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0058423&type=printable
P3181OpenCitations bibliographic resource ID3686760
P932PMC publication ID3597721
P698PubMed publication ID23516479
P5875ResearchGate publication ID236068581

P2093author name stringClaude Jourdan Le Saux
Christopher Brampton
Pooja Shivshankar
Hieu Nguyen
Philip Davy
Richard Allsopp
Calvin B. Harley
Mahesh Ramaseshan
Robert Tressler
Steven Fauce
Zhu Pirot
Seema S. Ahuja
P2860cites workA telomerase component is defective in the human disease dyskeratosis congenitaQ22010917
Telomerase modulates Wnt signalling by association with target gene chromatinQ24310084
Extension of life-span by introduction of telomerase into normal human cellsQ24336088
Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytesQ24644212
Specific Association of Human Telomerase Activity with Immortal Cells and CancerQ27860801
Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapyQ28200083
A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosisQ29417118
Telomerase mutations in families with idiopathic pulmonary fibrosisQ29615671
Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer.Q30374030
Fibrocyte CXCR4 regulation as a therapeutic target in pulmonary fibrosisQ30435304
Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutationsQ33587591
Caveolin-1, cellular senescence and pulmonary emphysemaQ33627898
Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemiaQ34409487
Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumoniaQ35214180
Adult familial cryptogenic fibrosing alveolitis in the United KingdomQ35533607
Adult-onset pulmonary fibrosis caused by mutations in telomeraseQ35759839
Telomerase activity is required for bleomycin-induced pulmonary fibrosis in mice.Q36138013
Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cellsQ36369240
The prognosis of cryptogenic fibrosing alveolitisQ36442446
Proteome alteration induced by hTERT transfection of human fibroblast cellsQ36661483
Telomere loss: mitotic clock or genetic time bomb?Q36706939
Short telomeres are a risk factor for idiopathic pulmonary fibrosisQ36861819
The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis?Q36970923
Idiopathic pulmonary fibrosis: multiple causes and multiple mechanisms?Q36989280
Lung alveolar integrity is compromised by telomere shortening in telomerase-null miceQ37086294
Telomerase regulation of myofibroblast differentiation.Q37101140
Outcome of patients with idiopathic pulmonary fibrosis (IPF) ventilated in intensive care unitQ37219208
Apoptosis in lung injury and fibrosis.Q37337820
Telomerase regulation during entry into the cell cycle in normal human T cellsQ37382464
Determinants of initiation and progression of idiopathic pulmonary fibrosisQ37594222
Imetelstat (GRN163L)--telomerase-based cancer therapyQ37674245
The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo.Q39120582
Oxidative stress induces premature senescence by stimulating caveolin-1 gene transcription through p38 mitogen-activated protein kinase/Sp1-mediated activation of two GC-rich promoter elementsQ40208065
Expression of the chemokine RANTES by a human bronchial epithelial cell line. Modulation by cytokines and glucocorticoids.Q41332821
Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrowQ42528725
Characterization of a new human diploid cell strain, IMR-90.Q42802708
Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivoQ43221614
Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis.Q46515337
Alterations in lung mechanics in decorin-deficient miceQ47921792
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome StabilityQ56508014
Neutralization of the CXC chemokine, macrophage inflammatory protein-2, attenuates bleomycin-induced pulmonary fibrosisQ61942161
Regulation of telomerase activity in rat lung fibroblastsQ77995639
Idiopathic pulmonary fibrosis--new insightsQ80057782
Telomerase activity in bleomycin-induced epithelial cell apoptosis and lung fibrosisQ80340958
Mutations in dyskeratosis congenita: their impact on telomere length and the diversity of clinical presentationQ81583972
Idiopathic pulmonary fibrosis: a disorder of lung regeneration?Q81974285
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectpulmonary fibrosisQ32446
idiopathyQ594841
idiopathic pulmonary fibrosisQ2290446
murine modelQ122890741
P304page(s)e58423
P577publication date2013-01-01
2013-03-14
P1433published inPLOS OneQ564954
P1476titleA novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis
A Novel Telomerase Activator Suppresses Lung Damage in a Murine Model of Idiopathic Pulmonary Fibrosis
P478volume8

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cites work (P2860)
Q37526382A Natural Product Telomerase Activator Lengthens Telomeres in Humans: A Randomized, Double Blind, and Placebo Controlled Study
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Q89578161Cycloastragenol as an Exogenous Enhancer of Chondrogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells. A Morphological Study
Q64993548Cycloastragenol: An exciting novel candidate for age-associated diseases.
Q47988448Differing Expression of Cytokines and Tumor Markers in Combined Pulmonary Fibrosis and Emphysema Compared to Emphysema and Pulmonary Fibrosis
Q58579018Effect of therapies-mediated modulation of telomere and/or telomerase on cancer cells radiosensitivity
Q34990749Medical school hotline: The Institute for Biogenesis Research: a flower in the Pacific
Q38659532Novel strategies for anti-aging drug discovery
Q35624348Overexpression of Telomerase Protects Human and Murine Lung Epithelial Cells from Fas- and Bleomycin-Induced Apoptosis via FLIP Upregulation
Q34677829Pharmacokinetics, metabolism, and excretion of cycloastragenol, a potent telomerase activator in rats
Q36885316Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs
Q46113966TGF-β1 Signaling and Tissue Fibrosis
Q92701873Telomere Abnormalities in the Pathobiology of Idiopathic Pulmonary Fibrosis
Q93082066The Role of Telomerase and Telomeres in Interstitial Lung Diseases: From Molecules to Clinical Implications
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Q93086370Transient induction of telomerase expression mediates senescence and reduces tumorigenesis in primary fibroblasts
Q37514002Up-regulating telomerase and tumor suppressors: focusing on anti-aging interventions at the population level

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