ZIKA virus elicits P53 activation and genotoxic stress in human neural progenitors similar to mutations involved in severe forms of genetic microcephaly and p53

scientific article (publication date: 27 October 2016)

ZIKA virus elicits P53 activation and genotoxic stress in human neural progenitors similar to mutations involved in severe forms of genetic microcephaly and p53 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/CDDIS.2016.266
P8608Fatcat IDrelease_7sxp6zifxzcy5go5n7cw5mvsfe
P932PMC publication ID5133962
P698PubMed publication ID27787521

P50authorMalgorzata RakQ29460560
Ferdinando Di CuntoQ29460599
Etienne Simon-LoriereQ29460611
Sandrine PassemardQ29460618
Marco VignuzziQ39190581
Laetitia AubryQ58246078
Ivan MolinerisQ60319513
Pierre GressensQ37364990
Federico T BianchiQ37367094
Bryan C MounceQ37367118
Vincent El GhouzziQ37367140
P2093author name stringSophie Lebon
Marta Gai
Chiara Tocco
Francesco Sgrò
Gaia E Berto
Gianmarco Pallavicini
Alessandra MA Chiotto
P2860cites workTopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusionsQ21999527
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Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem CellsQ23670968
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Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3betaQ24306430
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CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombinationQ28589697
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Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signalingQ29615601
The exon junction complex in neural development and neurodevelopmental disease.Q30386814
Prolonged Mitosis of Neural Progenitors Alters Cell Fate in the Developing BrainQ30696843
Tissue-specific control of midbody microtubule stability by Citron kinase through modulation of TUBB3 phosphorylationQ30742850
Growth of the developing cerebral cortex is controlled by microRNA-7 through the p53 pathwayQ33793899
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Dual Role of p53 in Innate Antiviral ImmunityQ38613932
Microcephaly and Zika virus infectionQ39404041
Hepatitis C virus NS4B induces unfolded protein response and endoplasmic reticulum overload response-dependent NF-kappaB activationQ39821567
p53 regulates Toll-like receptor 3 expression and function in human epithelial cell linesQ39941925
Induction of p53-dependent and mitochondria-mediated cell death pathway by dengue virus infection of human and animal cellsQ39964340
p53-mediated control of gene expression via mRNA translation during Endoplasmic Reticulum stressQ39984297
ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signallingQ40047410
West Nile virus capsid protein induces p53-mediated apoptosis via the sequestration of HDM2 to the nucleolus.Q40094517
The effect of interferon-beta on mouse neural progenitor cell survival and differentiationQ40976248
Citron-kinase, a protein essential to cytokinesis in neuronal progenitors, is deleted in the flathead mutant rat.Q41166591
Viruses and the DNA Damage Response: Activation and AntagonismQ41681279
Differentiation from human pluripotent stem cells of cortical neurons of the superficial layers amenable to psychiatric disease modeling and high-throughput drug screeningQ41765005
Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosisQ41926260
A Dynamic Unfolded Protein Response Contributes to the Control of Cortical NeurogenesisQ41926959
Neuronal death resulting from targeted disruption of the Snf2 protein ATRX is mediated by p53.Q41938609
Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the proteinQ42215813
Nuclear localization is essential for the activity of p53 proteinQ57835304
Citron kinase controls abscission through RhoA and anillinQ34208692
Tbr2 is essential for hippocampal lineage progression from neural stem cells to intermediate progenitors and neuronsQ34272444
MicrocephalyQ34341490
Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functionsQ35171563
De novo nonsense mutations in KAT6A, a lysine acetyl-transferase gene, cause a syndrome including microcephaly and global developmental delayQ35221908
Aspm sustains postnatal cerebellar neurogenesis and medulloblastoma growth in mice.Q36462666
What primary microcephaly can tell us about brain growth.Q36531152
Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells.Q36577607
Citron kinase controls a molecular network required for midbody formation in cytokinesisQ36932255
Microcephaly syndromesQ36990888
PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53Q37194715
Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampusQ37352375
Investigating microcephalyQ38118290
Congenital microcephalyQ38210879
Molecular and cellular basis of autosomal recessive primary microcephalyQ38303675
Elongator, a conserved complex required for wobble uridine modifications in eukaryotesQ38326905
What next-generation sequencing (NGS) technology has enabled us to learn about primary autosomal recessive microcephaly (MCPH).Q38518978
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectZika virusQ202864
microcephalyQ431643
genotoxicityQ1009245
P5008on focus list of Wikimedia projectWikiProject Zika CorpusQ54439832
P304page(s)e2440
P577publication date2016-10-27
P1433published inCell Death and DiseaseQ2197222
P1476titleZIKA virus elicits P53 activation and genotoxic stress in human neural progenitors similar to mutations involved in severe forms of genetic microcephaly and p53
P478volume7

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