An Integrative Analysis Reveals a Central Role of P53 Activation via MDM2 in Zika Virus Infection Induced Cell Death

scientific article published on 20 July 2017

An Integrative Analysis Reveals a Central Role of P53 Activation via MDM2 in Zika Virus Infection Induced Cell Death is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3389/FCIMB.2017.00327
P932PMC publication ID5517408
P698PubMed publication ID28775961

P50authorBaihan LinQ37368416
P2093author name stringDan Feng
Pei Zhang
Dehua Bi
Xiaoping An
Yuan Jin
Yue Teng
Shufeng Liu
Yigang Tong
Zhiqiang Mi
Xiaocan Guo
Shuxia Liu
Tongtong He
P2860cites workZika Virus in the Americas — Yet Another Arbovirus ThreatQ22248116
Biology of Zika Virus Infection in Human Skin CellsQ22330706
Current Zika virus epidemiology and recent epidemicsQ22330739
Zika Virus Associated with MicrocephalyQ22683189
Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their GrowthQ23008981
Teratogenic effects of the Zika virus and the role of the placentaQ23012830
Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control studyQ23012849
Zika virus in the Americas: Early epidemiological and genetic findingsQ23649767
Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem CellsQ23670968
Zika VirusQ23671721
The 3.8 Å resolution cryo-EM structure of Zika virusQ23680595
Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus InfectionQ23748220
Zika Virus and Birth Defects — Reviewing the Evidence for CausalityQ23815222
The Brazilian Zika virus strain causes birth defects in experimental modelsQ24047993
Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in MiceQ24048030
Zika virus NS1 structure reveals diversity of electrostatic surfaces among flavivirusesQ24048197
Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal DemiseQ24050115
Structure of the thermally stable Zika virusQ24082710
Guillain-Barré syndrome associated with Zika virus infectionQ24246781
Zika Virus and MicrocephalyQ24247108
Association between Zika virus and microcephaly in French Polynesia, 2013–15: a retrospective studyQ24255260
First Complete Genome Sequence of Zika Virus (Flaviviridae, Flavivirus) from an Autochthonous Transmission in BrazilQ24261254
Zika VirusQ24261255
From Mosquitos to Humans: Genetic Evolution of Zika VirusQ24261407
A Mouse Model of Zika Virus PathogenesisQ24261408
Zika virus: History, emergence, biology, and prospects for controlQ24261421
Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case studyQ24311332
p53 Activation following Rift Valley fever virus infection contributes to cell death and viral productionQ24319790
Cytoscape: a software environment for integrated models of biomolecular interaction networksQ24515682
Illustrating and homology modeling the proteins of the Zika virusQ27313484
ZIKA virus elicits P53 activation and genotoxic stress in human neural progenitors similar to mutations involved in severe forms of genetic microcephaly and p53Q27610734
Synthesis and evaluation of novel orally active p53-MDM2 interaction inhibitorsQ27684642
Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain OrganoidsQ28578660
CPAP promotes timely cilium disassembly to maintain neural progenitor poolQ28973602
AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibilityQ29547658
Flavivirus-mosquito interactionsQ34580911
Comparative mapping of host-pathogen protein-protein interactionsQ36319585
KEGG as a reference resource for gene and protein annotationQ36434599
PANTHER version 10: expanded protein families and functions, and analysis tools.Q36434795
Pathogenesis of flavivirus infections: using and abusing the host cellQ37452139
Role of host cell factors in flavivirus infection: Implications for pathogenesis and development of antiviral drugsQ37746052
Neuroinvasive flavivirus infectionsQ37956596
West Nile virus capsid protein interaction with importin and HDM2 protein is regulated by protein kinase C-mediated phosphorylationQ39711100
West Nile virus capsid protein induces p53-mediated apoptosis via the sequestration of HDM2 to the nucleolus.Q40094517
P4510describes a project that usesCytoscapeQ3699942
P921main subjectZika virusQ202864
cell deathQ2383867
Zika virus infectionQ27043680
P5008on focus list of Wikimedia projectWikiProject Zika CorpusQ54439832
P304page(s)327
P577publication date2017-07-20
P1433published inFrontiers in Cellular and Infection MicrobiologyQ27724376
P1476titleAn Integrative Analysis Reveals a Central Role of P53 Activation via MDM2 in Zika Virus Infection Induced Cell Death
P478volume7

Reverse relations

cites work (P2860)
Q92503902Basal Level p53 Suppresses Antiviral Immunity against Foot-and-Mouth Disease Virus
Q56339761Correlation between apoptosis and in situ immune response in fatal cases of microcephaly caused by Zika virus
Q99200987Host cell p53 associates with the feline calicivirus major viral capsid protein VP1, the protease-polymerase NS6/7, and the double-stranded RNA playing a role in virus replication
Q110771053Non-Structural Protein 5 of Zika Virus Interacts with p53 in Human Neural Progenitor Cells and Induces p53-Mediated Apoptosis
Q91710672Pathophysiology and Mechanisms of Zika Virus Infection in the Nervous System
Q110764548Research progress of the causal link between Zika virus and microcephaly
Q90020206The journey of Zika to the developing brain
Q104753232Viral strategies for circumventing p53: the case of severe acute respiratory syndrome coronavirus
Q92076770Zika virus: Molecular responses and tissue tropism in the mammalian host
Q47249024Zika virus: The transboundary pathogen from mosquito and updates

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