| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1016895952 |
| P356 | DOI | 10.1038/35047014 |
| P3181 | OpenCitations bibliographic resource ID | 4075381 |
| P698 | PubMed publication ID | 11130063 |
| P5875 | ResearchGate publication ID | 12199002 |
| P50 | author | John Sondek | Q39895709 |
| P2093 | author name string | K L Rossman | |
| D K Worthylake | |||
| P2860 | cites work | Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein | Q22004024 |
| The structural basis of the activation of Ras by Sos | Q24320225 | ||
| Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf | Q24554485 | ||
| Improved methods for building protein models in electron density maps and the location of errors in these models | Q26776980 | ||
| Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination | Q26778405 | ||
| MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures | Q26778412 | ||
| Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI | Q27621400 | ||
| An open conformation of switch I revealed by the crystal structure of a Mg2+-free form of RHOA complexed with GDP. Implications for the GDP/GTP exchange mechanism | Q27622083 | ||
| Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain | Q27732194 | ||
| The structure of the Escherichia coli EF-Tu.EF-Ts complex at 2.5 A resolution | Q27732595 | ||
| The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue | Q27734818 | ||
| Structure and mutagenesis of the Dbl homology domain | Q27766337 | ||
| Raster3D Version 2.0. A program for photorealistic molecular graphics | Q27860485 | ||
| The CCP4 suite: programs for protein crystallography | Q27861090 | ||
| Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons | Q27861091 | ||
| GEFs: structural basis for their activation of small GTP-binding proteins | Q28141028 | ||
| The Dbl family of oncogenes | Q28288875 | ||
| Lck regulates Vav activation of members of the Rho family of GTPases | Q28610619 | ||
| Rho GTPases and signaling networks | Q28646215 | ||
| Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav | Q28646540 | ||
| UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans. | Q30176258 | ||
| A role for Rac in Tiam1-induced membrane ruffling and invasion | Q34310851 | ||
| NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio | Q34477302 | ||
| Inhibition of invasion of epithelial cells by Tiam1-Rac signaling | Q41075588 | ||
| Isolation of a new human oncogene from a diffuse B-cell lymphoma. | Q42814928 | ||
| Targeting of Tiam1 to the plasma membrane requires the cooperative function of the N-terminal pleckstrin homology domain and an adjacent protein interaction domain | Q42834604 | ||
| Rho GTPases | Q47724821 | ||
| Pleckstrin homology domains: a common fold with diverse functions | Q47910921 | ||
| Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins | Q48082495 | ||
| Functional diversity of PH domains: an exhaustive modelling study | Q53173230 | ||
| Rho family proteins and Ras transformation: the RHOad less traveled gets congested. | Q53429986 | ||
| Structural Basis for Activation of ARF GTPase | Q56288670 | ||
| Analysis of intrinsic and CDC25-stimulated guanine nucleotide exchange of p21ras-nucleotide complexes by fluorescence measurements | Q70793466 | ||
| High affinity binding of the pleckstrin homology domain of mSos1 to phosphatidylinositol (4,5)-bisphosphate | Q71985042 | ||
| P433 | issue | 6813 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | guanine | Q169313 |
| crystal structure | Q895901 | ||
| P304 | page(s) | 682-8 | |
| P577 | publication date | 2000-12-07 | |
| P1433 | published in | Nature | Q180445 |
| P1476 | title | Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1 | |
| P478 | volume | 408 |
| Q27654526 | 3D structure of a binary ROP-PRONE complex: the final intermediate for a complete set of molecular snapshots of the RopGEF reaction |
| Q27643770 | A Catalytic Coiled Coil: Structural Insights into the Activation of the Rab GTPase Sec4p by Sec2p |
| Q24292431 | A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange |
| Q29040265 | A growing family of guanine nucleotide exchange factors is responsible for activation of ras-family GTPases |
| Q34623781 | A minimal Rac activation domain in the unconventional guanine nucleotide exchange factor Dock180. |
| Q36916713 | A negative-feedback loop regulating ERK1/2 activation and mediated by RasGPR2 phosphorylation. |
| Q30992965 | A new family of RhoGEFs activates the Rop molecular switch in plants |
| Q36917600 | A novel pathway spatiotemporally activates Rac1 and redox signaling in response to fluid shear stress |
| Q46652681 | A switch 3 point mutation in the alpha subunit of transducin yields a unique dominant-negative inhibitor |
| Q24316183 | APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment |
| Q40033262 | Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process |
| Q78761464 | Activation of G-protein Galpha subunits by receptors through Galpha-Gbeta and Galpha-Ggamma interactions |
| Q27657391 | Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor |
| Q27642578 | Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase |
| Q35971384 | Always look on the bright site of Rho: structural implications for a conserved intermolecular interface |
| Q34533184 | Amino acids of the bacterial toxin SopE involved in G nucleotide exchange on Cdc42. |
| Q55385594 | An Efficient Implementation of the Nwat-MMGBSA Method to Rescore Docking Results in Medium-Throughput Virtual Screenings. |
| Q90454153 | An Intellectual Disability-Related Missense Mutation in Rac1 Prevents LTP Induction |
| Q30358425 | Analysis of protein hydration in ultrahigh-resolution structures of the SRP GTPase Ffh |
| Q45829274 | Array CGH demonstrates characteristic aberration signatures in human papillary thyroid carcinomas governed by RET/PTC. |
| Q57945244 | Auto-inhibition of the Dbl Family Protein Tim by an N-terminal Helical Motif |
| Q44524293 | Backbone 1H, 13C, and 15N resonance assignments for the 21 kDa GTPase Rac1 complexed to GDP and Mg2+. |
| Q28069232 | Cancer Stem Cells and Radioresistance: Rho/ROCK Pathway Plea Attention |
| Q33535907 | Caspase-1 activation via Rho GTPases: a common theme in mucosal infections? |
| Q34664567 | Cdc42p GDP/GTP cycling is necessary for efficient cell fusion during yeast mating |
| Q44922057 | Cell migration and signaling specificity is determined by the phosphatidylserine recognition motif of Rac1. |
| Q48327637 | Cells lay their own tracks - optogenetic Cdc42 activation stimulates fibronectin deposition supporting directed migration |
| Q35921528 | Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase |
| Q28299305 | Characterization of the biochemical and transforming properties of the neuroepithelial transforming protein 1 |
| Q44693557 | Comparative functional analysis of the Rac GTPases |
| Q42107904 | Comparing the Affinity of GTPase-binding Proteins using Competition Assays |
| Q89151870 | Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis |
| Q97885449 | Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion |
| Q40710757 | Critical role of the pleckstrin homology and cysteine-rich domains in Vav signaling and transforming activity |
| Q42804184 | Critical role of the pleckstrin homology domain in Dbs signaling and growth regulation. |
| Q38459968 | Crossroads of PI3K and Rac pathways. |
| Q27642843 | Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism |
| Q57945276 | Crystal structure of Rac1 bound to its effector phospholipase C-β2 |
| Q27644726 | Crystal structure of the Sec4p⋅Sec2p complex in the nucleotide exchanging intermediate state |
| Q27643433 | Crystal structure of the rac activator, Asef, reveals its autoinhibitory mechanism |
| Q28209857 | Dbl family guanine nucleotide exchange factors |
| Q42158425 | Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins |
| Q100428131 | Deep phylogeny of cancer drivers and compensatory mutations |
| Q34438720 | Dimerization of DOCK2 is essential for DOCK2-mediated Rac activation and lymphocyte migration. |
| Q27684228 | Direct metal recognition by guanine nucleotide-exchange factor in the initial step of the exchange reaction |
| Q42117338 | Discovery and characterization of small molecule Rac1 inhibitors |
| Q41451621 | Disruption of RhoGDI and RhoA regulation by a Rac1 specificity switch mutant |
| Q50337050 | Dissociation of GDP dissociation inhibitor and membrane translocation are required for efficient activation of Rac by the Dbl homology-pleckstrin homology region of Tiam. |
| Q41262163 | Dissociation of Rac1(GDP).RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3,4,5-trisphosphate, Rac guanine nucleotide exchange factor, and GTP. |
| Q58796473 | Distinct CED-10/Rac1 domains confer context-specific functions in development |
| Q28187402 | Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration |
| Q51843111 | Engineering the phosphoinositide-binding profile of a class I pleckstrin homology domain. |
| Q35001183 | Entamoeba histolytica RacC selectively engages p21-activated kinase effectors |
| Q40322541 | Essential role of the NH2-terminal region of Cdc24 guanine nucleotide exchange factor in its initial polarized localization in Saccharomyces cerevisiae |
| Q83348024 | Exchange of a single amino acid switches the substrate properties of RhoA and RhoD toward glucosylating and transglutaminating toxins |
| Q36210720 | Function of the nucleotide exchange activity of vav1 in T cell development and activation |
| Q44195381 | Functional analysis of cdc42 residues required for Guanine nucleotide exchange |
| Q35924172 | Functional analysis of the Caenorhabditis elegans UNC-73B PH domain demonstrates a role in activation of the Rac GTPase in vitro and axon guidance in vivo |
| Q34334653 | G protein signaling in the parasite Entamoeba histolytica |
| Q36061579 | G-protein signaling: back to the future |
| Q27664432 | GDP-bound and Nucleotide-free Intermediates of the Guanine Nucleotide Exchange in the Rab5{middle dot}Vps9 System |
| Q29547630 | GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors |
| Q73734560 | GEFs: master regulators of G-protein activation |
| Q33822971 | Galpha q allosterically activates and relieves autoinhibition of p63RhoGEF. |
| Q24658016 | Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain |
| Q30475942 | Global conformational rearrangements during the activation of the GDP/GTP exchange factor Vav3. |
| Q36568490 | Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis. |
| Q46675868 | Heterotrimeric G-protein alpha-subunit adopts a "preactivated" conformation when associated with betagamma-subunits |
| Q27639966 | High resolution crystal structures of human Rab5a and five mutants with substitutions in the catalytically important phosphate-binding loop |
| Q43848235 | How Vav proteins discriminate the GTPases Rac1 and RhoA from Cdc42. |
| Q53209424 | Identification and evaluation of inhibitors of the EhGEF1 protein from Entamoeba histolytica. |
| Q34388235 | Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4. |
| Q39471091 | Identifying transient protein-protein interactions in EphB2 signaling by blue native PAGE and mass spectrometry |
| Q34587853 | Interactions of UNC-34 Enabled with Rac GTPases and the NIK kinase MIG-15 in Caenorhabditis elegans axon pathfinding and neuronal migration |
| Q27680081 | Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB |
| Q45005871 | Involvement of phosphoinositide 3-kinase gamma, Rac, and PAK signaling in chemokine-induced macrophage migration |
| Q24299546 | Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells |
| Q40957134 | Juvenile myelomonocytic leukemia displays mutations in components of the RAS pathway and the PRC2 network. |
| Q37405222 | Kinetic analysis of the guanine nucleotide exchange activity of TRAPP, a multimeric Ypt1p exchange factor |
| Q28190494 | Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA |
| Q28506616 | Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting |
| Q43823922 | Mechanism of elongation factor (EF)-Ts-catalyzed nucleotide exchange in EF-Tu. Contribution of contacts at the guanine base |
| Q42834452 | Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant |
| Q42733267 | Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG). |
| Q35609309 | Membrane recognition and targeting by lipid-binding domains |
| Q44035580 | Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours. |
| Q38327730 | Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho-GTPase pathway genes in NF1 tumorigenesis |
| Q35681638 | Molecular basis for Rho GTPase signaling specificity |
| Q28592987 | Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation |
| Q33946075 | Mutant G protein alpha subunit activated by Gbeta gamma: a model for receptor activation? |
| Q37358214 | New insights into how the Rho guanine nucleotide dissociation inhibitor regulates the interaction of Cdc42 with membranes |
| Q40649057 | New insights into the dimerization of small GTPase Rac/ROP guanine nucleotide exchange factors in rice |
| Q35742955 | New insights into the molecular mechanism of the Rab GTPase Sec4p activation |
| Q30163879 | Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool-2/alpha-Pix |
| Q24307945 | Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4. |
| Q88757865 | Nup159 Weakens Gle1 Binding to Dbp5 But Does Not Accelerate ADP Release |
| Q24291439 | Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly |
| Q43506391 | Oligomerization regulates the localization of Cdc24, the Cdc42 activator in Saccharomyces cerevisiae |
| Q30439430 | On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF. |
| Q37372485 | Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density |
| Q30368988 | Overview of protein structural and functional folds. |
| Q24294423 | P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac |
| Q24299119 | PH domain of ELMO functions in trans to regulate Rac activation via Dock180 |
| Q47361639 | Peptide modulators of Rac1/Tiam1 protein-protein interaction: An alternative approach for cardiovascular diseases. |
| Q40037121 | Phosphatidylinositol 3-kinase-dependent membrane recruitment of Rac-1 and p47phox is critical for alpha-platelet-derived growth factor receptor-induced production of reactive oxygen species |
| Q27320795 | Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins |
| Q34801401 | Pivotal role of extended linker 2 in the activation of Gα by G protein-coupled receptor |
| Q38021241 | Pleckstrin homology (PH) like domains - versatile modules in protein-protein interaction platforms |
| Q34287222 | Pleckstrin homology domain-mediated activation of the rho-specific guanine nucleotide exchange factor Dbs by Rac1. |
| Q34120310 | Pleckstrin homology domains and the cytoskeleton |
| Q54246335 | Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins |
| Q34120933 | Rac GTPases control axon growth, guidance and branching |
| Q60955103 | Rac GTPases in Hematological Malignancies |
| Q38839225 | Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms |
| Q38334837 | Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation |
| Q43610785 | Rapid activation of transducin by mutations distant from the nucleotide-binding site: evidence for a mechanistic model of receptor-catalyzed nucleotide exchange by G proteins |
| Q38012148 | Ras and Rho small G proteins: insights from the Schizophyllum commune genome sequence and comparisons to other fungi |
| Q27690752 | Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? |
| Q42805222 | Rational design and applications of a Rac GTPase-specific small molecule inhibitor |
| Q29616494 | Rational design and characterization of a Rac GTPase-specific small molecule inhibitor |
| Q24597996 | Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases |
| Q41835883 | Real-time NMR study of guanine nucleotide exchange and activation of RhoA by PDZ-RhoGEF. |
| Q33742737 | Redox modifier genes and pathways in amyotrophic lateral sclerosis |
| Q34367882 | Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits |
| Q26825750 | Regulation of small GTPases by GEFs, GAPs, and GDIs |
| Q27647382 | Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression |
| Q41889941 | Remedial strategies in structural proteomics: expression, purification, and crystallization of the Vav1/Rac1 complex |
| Q34285899 | RhoGEF specificity mutants implicate RhoA as a target for Dbs transforming activity |
| Q30157666 | Role of the C-terminal SH3 domain and N-terminal tyrosine phosphorylation in regulation of Tim and related Dbl-family proteins |
| Q24307703 | SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model |
| Q34575915 | Signaling to the Rho GTPases: networking with the DH domain |
| Q34752099 | SmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC. |
| Q33335734 | SopE and SopE2 from Salmonella typhimurium activate different sets of RhoGTPases of the host cell |
| Q34721239 | Specific recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 guanine nucleotide exchange factors |
| Q40068834 | Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. |
| Q27651005 | Structural Basis of Guanine Nucleotide Exchange Mediated by the T-Cell Essential Vav1 |
| Q90080035 | Structural Insights into the Regulation Mechanism of Small GTPases by GEFs |
| Q24309253 | Structural analysis of autoinhibition in the Ras activator Son of sevenless |
| Q36880840 | Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3. |
| Q27675000 | Structural and Functional Characterization of the Kindlin-1 Pleckstrin Homology Domain |
| Q47093610 | Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase |
| Q24291203 | Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1) |
| Q24300730 | Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE. |
| Q47614473 | Structural characterisation and functional significance of transient protein-protein interactions |
| Q28279079 | Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor |
| Q27656575 | Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics |
| Q40251135 | Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates. |
| Q43790564 | Structural mimicry of DH domains by Arfaptin suggests a model for the recognition of Rac-GDP by its guanine nucleotide exchange factors |
| Q24301031 | Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor |
| Q33613391 | Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors |
| Q33218525 | Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange |
| Q27660409 | Structure of Shigella IpgB2 in Complex with Human RhoA: IMPLICATIONS FOR THE MECHANISM OF BACTERIAL GUANINE NUCLEOTIDE EXCHANGE FACTOR MIMICRY |
| Q27658791 | Structure of the GTPase and GDI domains of FeoB, the ferrous iron transporter of Legionella pneumophila |
| Q56803043 | Structure of the RGS-like Domain from PDZ-RhoGEF |
| Q27642799 | Structure of the catalytic fragment of translation initiation factor 2B and identification of a critically important catalytic residue |
| Q43595428 | Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange |
| Q33215188 | Substrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2. |
| Q36723211 | Synthetic non-peptide mimetics of alpha-helices |
| Q30531107 | Synthetic spatially graded Rac activation drives cell polarization and movement |
| Q38830217 | TIAM1 variants improve clinical outcome in neuroblastoma |
| Q59791854 | TIPE2 acts as a biomarker for GIST risk category and suppresses the viability and invasiveness of GIST cells |
| Q58782084 | TIPE2 acts as a biomarker for tumor aggressiveness and suppresses cell invasiveness in papillary thyroid cancer (PTC) |
| Q93167001 | Targeting Rac and Cdc42 GEFs in Metastatic Cancer |
| Q36677555 | Targeting and localized signalling by small GTPases |
| Q24606819 | The 'invisible hand': regulation of RHO GTPases by RHOGDIs |
| Q28267097 | The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids |
| Q24675414 | The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activation |
| Q24297620 | The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering |
| Q52722195 | The Interdependent Activation of Son-of-Sevenless and Ras. |
| Q27662864 | The Minimal Autoinhibited Unit of the Guanine Nucleotide Exchange Factor Intersectin |
| Q24314777 | The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module |
| Q35978229 | The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells |
| Q27334152 | The Rac GTP exchange factor TIAM-1 acts with CDC-42 and the guidance receptor UNC-40/DCC in neuronal protrusion and axon guidance |
| Q26864271 | The Rac1 hypervariable region in targeting and signaling: a tail of many stories |
| Q47838338 | The Tiam1 guanine nucleotide exchange factor is auto-inhibited by its pleckstrin homology coiled-coil extension domain. |
| Q24312384 | The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle |
| Q37226965 | The exchange factor Cdc24 is required for cell fusion during yeast mating |
| Q35451156 | The guanine nucleotide exchange factor (GEF) Asef2 promotes dendritic spine formation via Rac activation and spinophilin-dependent targeting |
| Q28575934 | The light chain 1 subunit of the microtubule-associated protein 1B (MAP1B) is responsible for Tiam1 binding and Rac1 activation in neuronal cells |
| Q34460152 | The many faces of Ras: recognition of small GTP-binding proteins |
| Q30433928 | The novel Cdc42 guanine nucleotide exchange factor, zizimin1, dimerizes via the Cdc42-binding CZH2 domain |
| Q30010281 | The role of collybistin in gephyrin clustering at inhibitory synapses: facts and open questions |
| Q38011133 | The role of small GTPases in neuronal morphogenesis and polarity |
| Q28304550 | The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration |
| Q30434688 | The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoA. |
| Q90616382 | Tiam1 is Critical for Glutamatergic Synapse Structure and Function in the Hippocampus |
| Q34140558 | Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism |
| Q28116790 | Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons |
| Q42803379 | Transformation by the Rho-specific guanine nucleotide exchange factor Dbs requires ROCK I-mediated phosphorylation of myosin light chain. |
| Q28191525 | Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors |
| Q38981719 | Type III Secreted Virulence Factors Manipulating Signaling to Actin Dynamics. |
| Q36082708 | Tyrosine Phosphorylation of SGEF Regulates RhoG Activity and Cell Migration. |
| Q24301883 | Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex |
| Q33492741 | Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity |
| Q96302801 | Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factor |
| Q33913738 | XGef mediates early CPEB phosphorylation during Xenopus oocyte meiotic maturation |
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