Lock and key binding of the HOX YPWM peptide to the PBX homeodomain

scientific article

Lock and key binding of the HOX YPWM peptide to the PBX homeodomain is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M207504200
P698PubMed publication ID12409300

P50authorTara SprulesQ115913356
Kalle GehringQ28037054
Mark FeatherstoneQ56809366
P2093author name stringNancy Green
P2860cites workStructure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formationQ22008845
Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complexQ24317529
The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativityQ24533177
Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animalsQ24545590
PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteinsQ24554397
Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activityQ24554470
Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solutionQ24649924
Transverse relaxation optimized triple-resonance NMR experiments for nucleic acidsQ73825283
Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complexQ27617465
Conformational changes in the PBX homeodomain and C-terminal extension upon binding DNA and HOX-derived YPWM peptidesQ27626368
Automated NOESY interpretation with ambiguous distance restraints: the refined NMR solution structure of the pleckstrin homology domain from beta-spectrinQ27739804
The program XEASY for computer-supported NMR spectral analysis of biological macromoleculesQ27860993
A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALLQ28254962
A conserved C-terminal domain in PBX increases DNA binding by the PBX homeodomain and is not a primary site of contact for the YPWM motif of HOXA1Q28270511
Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteinsQ28300459
Distinct HOX N-terminal arm residues are responsible for specificity of DNA recognition by HOX monomers and HOX.PBX heterodimersQ28306533
The HoxB1 hexapeptide is a prefolded domain: implications for the Pbx1/Hox interactionQ28365679
Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteinsQ28588001
The PBX-regulating protein PREP1 is present in different PBX-complexed forms in mouseQ28592785
Cross-regulation in the mouse HoxB complex: the expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1Q28593607
Hox genes in vertebrate developmentQ29618109
An Abd-B class HOX.PBX recognition sequence is required for expression from the mouse Ren-1c geneQ30176402
The Abd-B-like Hox homeodomain proteins can be subdivided by the ability to form complexes with Pbx1a on a novel DNA targetQ32874802
Gifa V. 4: A complete package for NMR data set processing.Q33699055
The hexapeptide LFPWMR in Hoxb-8 is required for cooperative DNA binding with Pbx1 and Pbx2 proteinsQ33889933
Homeodomain proteinsQ34326855
Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factorQ34997317
Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.Q36552793
Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motifQ36553133
Pbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the Hox locusQ36558712
Measurement of HN-H alpha J couplings in calcium-free calmodulin using new 2D and 3D water-flip-back methodsQ36711324
A structural model for a homeotic protein-extradenticle-DNA complex accounts for the choice of HOX protein in the heterodimerQ37580602
An enhancer element in the EphA2 (Eck) gene sufficient for rhombomere-specific expression is activated by HOXA1 and HOXB1 homeobox proteins.Q38333527
The pentapeptide motif of Hox proteins is required for cooperative DNA binding with Pbx1, physically contacts Pbx1, and enhances DNA binding by Pbx1.Q40017430
Homeodomain-DNA recognitionQ40680227
Extra specificity from extradenticle: the partnership between HOX and PBX/EXD homeodomain proteinsQ41078307
[(13)C,(13)C]- and [(13)C,(1)H]-TROSY in a triple resonance experiment for ribose-base and intrabase correlations in nucleic acidsQ43677094
A robust method for determining the magnitude of the fully asymmetric alignment tensor of oriented macromolecules in the absence of structural informationQ47879770
NMR studies of the pbx1 TALE homeodomain protein free in solution and bound to DNA: proposal for a mechanism of HoxB1-Pbx1-DNA complex assembly.Q52175061
Direct structure refinement against residual dipolar couplings in the presence of rhombicity of unknown magnitude.Q52243648
Transverse Relaxation-Optimized Spectroscopy (TROSY) for NMR Studies of Aromatic Spin Systems in13C-Labeled ProteinsQ57825799
Residues flanking the HOX YPWM motif contribute to cooperative interactions with PBXQ73520977
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)1053-8
P577publication date2003-01-10
P1433published inJournal of Biological ChemistryQ867727
P1476titleLock and key binding of the HOX YPWM peptide to the PBX homeodomain
P478volume278

Reverse relations

cites work (P2860)
Q39792261Alternative splicing modulates Ubx protein function in Drosophila melanogaster
Q55364585Atomistic molecular dynamics simulations of bioactive engrailed 1 interference peptides (EN1-iPeps).
Q82505140Concerted Dynamics Link Allosteric Sites in the PBX Homeodomain
Q47590612Cross-talk between the paired domain and the homeodomain of Pax3: DNA binding by each domain causes a structural change in the other domain, supporting interdependence for DNA Binding
Q44483496Efficient expression of isotopically labeled peptides for high resolution NMR studies: application to the Cdc42/Rac binding domains of virulent kinases in Candida albicans
Q85633629Engineering complementary hydrophobic interactions to control β-hairpin peptide self-assembly, network branching, and hydrogel properties
Q34439668Hox genes and their candidate downstream targets in the developing central nervous system
Q58697129Intrinsic DNA Shape Accounts for Affinity Differences between Hox-Cofactor Binding Sites
Q37589675New Insights into Cooperative Binding of Homeodomain Transcription Factors PREP1 and PBX1 to DNA.
Q33659409Relaxation dispersion NMR spectroscopy for the study of protein allostery
Q58416264SLiMSearch: A Webserver for Finding Novel Occurrences of Short Linear Motifs in Proteins, Incorporating Sequence Context
Q42005151Targeted chemical wedges reveal the role of allosteric DNA modulation in protein-DNA assembly
Q33935824Temperature-sensitive protein-DNA dimerizers
Q34194365The broken ring: reduced aromaticity in Lys-Trp cations and high pH tautomer correlates with lower quantum yield and shorter lifetimes

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