Design and Optimization of Potent and Orally Bioavailable Tetrahydronaphthalene Raf Inhibitors

scientific article published on February 22, 2011

Design and Optimization of Potent and Orally Bioavailable Tetrahydronaphthalene Raf Inhibitors is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1021/JM101479Y
P953full work available at URLhttps://pubs.acs.org/doi/pdf/10.1021/jm101479y
P698PubMed publication ID21341678

P50authorOle Petter VeibyQ95948918
P2093author name stringQin Zhang
Jason Yano
Kathleen Aertgeerts
Saurabh Menon
Yuan Tian
Mi-Sook Kim
Hongbo Zeng
Christopher Blackburn
Sharmila Adhikari
Tianlin Xu
Jouhara Chouitar
Ruth Adams
Ribo Guo
Shih-Chung Huang
Dong Mei Zhang
Mansoureh Rezaei
Michael D. Smith
Li-Ting Ma
Khristofer Garcia
Hirotake Mizutani
Jeffery Gaulin
Roushan Afroze
Bheemashankar Kulkarni
Juliet Williams
Alexandra E. Gould
Stepan Vyskocil
Ryan Chau
Cheryl Farrer
Dave Janowick
Erin Paske
Ming Tregay
Nancy Forsyth
Natalia Iartchouk
Stephen G. Stroud
Steven P. Langston
R. Scott Rowland
Johnny J. Yang
Paul D. Greenspan
Jane X. Liu
Michael D. Sintchak
Christelle C. Renou
Dylan B. England
Emily F. Calderwood
Katherine M. Galvin
Matthew O. Duffey
Sean J. Harrison
Tricia J. Vos
P2860cites workThe RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective mannerQ21629049
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanomaQ24597152
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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAFQ28251989
Efficient Asymmetric Synthesis of the Four Diastereomers of Diphenacoum and BrodifacoumQ29037036
BRAF mutation predicts sensitivity to MEK inhibitionQ29614281
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesisQ29617585
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancerQ29618155
Mitogen-activated protein kinase pathwaysQ29618431
Melanoma biology and new targeted therapyQ36742015
BRAF as therapeutic target in melanomaQ37720832
RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma modelsQ39692674
AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclQ40093939
Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculatureQ40270911
Synthesis of novel melanocortin 4 receptor agonists and antagonists containing a succinamide coreQ44708040
Comparison between polyethylenglycol and imidazolium ionic liquids as solvents for developing a homogeneous and reusable palladium catalytic system for the Suzuki and Sonogashira couplingQ63887569
Correlation of growth capacity of human tumor cells in hard agarose with their in vivo proliferative capacity at specific metastatic sitesQ69725710
Clinicopathologic significance of BRAF V600E mutation in papillary carcinomas of the thyroid: a meta-analysisQ80372711
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1836-46
P577publication date2011-02-22
2011-03-24
P1433published inJournal of Medicinal ChemistryQ900316
P1476titleDesign and optimization of potent and orally bioavailable tetrahydronaphthalene Raf inhibitors
Design and Optimization of Potent and Orally Bioavailable Tetrahydronaphthalene Raf Inhibitors
P478volume54