Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes

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Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2009PNAS..106.9138W
P356DOI10.1073/PNAS.0904064106
P3181OpenCitations bibliographic resource ID2892387
P932PMC publication ID2695123
P698PubMed publication ID19497877
P5875ResearchGate publication ID26268102

P2093author name stringH Eric Xu
James B Lok
Kelly Suino-Powell
X Edward Zhou
Xin Gao
David J Mangelsdorf
Steven A Kliewer
John M Hawdon
Zhu Wang
Richard J Auchus
Daniel L Motola
Kamalesh K Sharma
Aoife Conneely
Craig Ogata
P2860cites workCrystal structure of the ligand-binding domain of the human nuclear receptor RXR-alphaQ27730245
A specific amyloid-beta protein assembly in the brain impairs memoryQ28854597
Ancylostoma secreted protein 2: cloning and characterization of a second member of a family of nematode secreted proteins from Ancylostoma caninumQ30700909
A cDNA encoding a nuclear hormone receptor of the steroid/thyroid hormone-receptor superfamily from the human parasitic nematode Strongyloides stercoralisQ30838179
Serum-stimulated feeding in vitro by third-stage infective larvae of the canine hookworm Ancylostoma caninumQ34153024
Syndrome of hyperinfection with Strongyloides stercoralisQ34276255
A conserved endocrine mechanism controls the formation of dauer and infective larvae in nematodesQ34602464
Parasitic nematode interactions with mammals and plantsQ35550708
Drug resistance in nematodes of veterinary importance: a status report.Q35885287
New technologies for the control of human hookworm infectionQ36482272
Ivermectin: uses and impact 20 years on.Q36639735
Cloning and characterization of Ancylostoma-secreted protein. A novel protein associated with the transition to parasitism by infective hookworm larvaeQ36799624
Nuclear hormone receptors in C. elegansQ37020688
Strongyloides spp.Q37020771
A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninumQ37157246
A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and agingQ37495431
Identification of C. elegans DAF-12-binding sites, response elements, and target genesQ38335332
Phosphoinositide-3-OH-kinase inhibitor LY294002 prevents activation of Ancylostoma caninum and Ancylostoma ceylanicum third-stage infective larvae.Q38919676
The use of ketoconazole as an inhibitor of steroid productionQ39667196
Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptorQ39886953
Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.Q46985126
Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase.Q47068821
Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewalQ47071774
Hookworm larval infectivity, arrest and amphiparatenesis: the Caenorhabditis elegans daf-c paradigmQ56420958
Stereocontrolled synthesis of dafachronic acid A, the ligand for the DAF-12 nuclear receptor of Caenorhabditis elegansQ80689494
P433issue23
P407language of work or nameEnglishQ1860
P921main subject(25S)-Delta(7)-dafachronic acidQ27139706
P304page(s)9138-43
P577publication date2009-06-09
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleIdentification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes
P478volume106

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cites work (P2860)
Q27319860A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity
Q92593070Advances in the Molecular and Cellular Biology of Strongyloides spp
Q47245256Ancylostoma ceylanicum infective third-stage larvae are activated by co-culture with HT-29-MTX intestinal epithelial cells.
Q34123533Co-option of the hormone-signalling module dafachronic acid-DAF-12 in nematode evolution
Q60909619Comparative bioinformatic analysis suggests that specific dauer-like signalling pathway components regulate Toxocara canis development and migration in the mammalian host
Q37584863Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor, regulating C. elegans development and lifespan
Q38093067Current drug targets for helminthic diseases
Q33981313DAF-12 regulates a connected network of genes to ensure robust developmental decisions.
Q92121715Dafachronic acid promotes larval development in Haemonchus contortus by modulating dauer signalling and lipid metabolism
Q64215099Dauer signalling pathway model for Haemonchus contortus
Q51920996Developmental biology. Strategies to get arrested.
Q42608519Developmental plasticity and the evolution of parasitism in an unusual nematode, Parastrongyloides trichosuri
Q36062844Expanding the view on the evolution of the nematode dauer signalling pathways: refinement through gene gain and pathway co-option
Q34517777Exploring the role of two interacting phosphoinositide 3-kinases of Haemonchus contortus.
Q36161840Expression profile of heat shock response factors during hookworm larval activation and parasitic development.
Q46284217Gain and Loss of Small RNA Classes-Characterization of Small RNAs in the Parasitic Nematode Family Strongyloididae
Q38784780Genetics: modes of reproduction and genetic analysis
Q38211821How to become a parasite without sex chromosomes: a hypothesis for the evolution of Strongyloides spp. and related nematodes
Q97570174Human strongyloidiasis: identifying knowledge gaps, with emphasis on environmental control
Q34845409It's no fluke: the planarian as a model for understanding schistosomes
Q36343899Mating dynamics in a nematode with three sexes and its evolutionary implications
Q33637461Meeting report: nuclear receptors: transcription factors and drug targets connecting basic research with translational medicine
Q47569441Methylprednisolone acetate induces, and Δ7-dafachronic acid suppresses, Strongyloides stercoralis hyperinfection in NSG mice
Q27329700Molecular characterization of the Haemonchus contortus phosphoinositide-dependent protein kinase-1 gene (Hc-pdk-1).
Q36222414Molecular characterization of thyroid hormone receptor beta from Schistosoma japonicum and assessment of its potential as a vaccine candidate antigen against schistosomiasis in BALB/c mice
Q34590386Nuclear hormone receptors in nematodes: evolution and function
Q34283432Nuclear hormone receptors in parasitic helminths
Q49838050Nuclear option prevents hyperinfection in the Strongyloides worm war.
Q30380930Nuclear receptor nhr-48 is required for pathogenicity of the second stage (J2) of the plant parasite Meloidogyne incognita.
Q39122042Nuclear receptors: emerging drug targets for parasitic diseases.
Q35667636Orphan Genes Find a Home: Interspecific Competition and Gene Network Evolution
Q26744518Phenotypic plasticity and developmental innovations in nematodes
Q34140411Profile of David J. Mangelsdorf
Q91474649Profiling microRNAs through development of the parasitic nematode Haemonchus identifies nematode-specific miRNAs that suppress larval development
Q64105019RNAi-mediated knockdown of daf-12 in the model parasitic nematode Strongyloides ratti
Q34474570RNAseq analysis of the parasitic nematode Strongyloides stercoralis reveals divergent regulation of canonical dauer pathways.
Q35884031Regulation of Life Cycle Checkpoints and Developmental Activation of Infective Larvae in Strongyloides stercoralis by Dafachronic Acid
Q26773752Rendering the Intractable More Tractable: Tools from Caenorhabditis elegans Ripe for Import into Parasitic Nematodes
Q40104639Signaling in Parasitic Nematodes: Physicochemical Communication Between Host and Parasite and Endogenous Molecular Transduction Pathways Governing Worm Development and Survival
Q50437764Small-molecule pheromones and hormones controlling nematode development
Q64115554Stage-specific transcriptome of Bursaphelenchus xylophilus reveals temporal regulation of effector genes and roles of the dauer-like stages in the lifecycle
Q43172260Steroid hormones controlling the life cycle of the nematode Caenorhabditis elegans: stereoselective synthesis and biology
Q37569266Sterol regulation of metabolism, homeostasis, and development
Q34305587Strongyloides stercoralis age-1: a potential regulator of infective larval development in a parasitic nematode.
Q55006255Strongyloides stercoralis and relatives: recent advances in general and molecular biology.
Q27676200Structural Conservation of Ligand Binding Reveals a Bile Acid-like Signaling Pathway in Nematodes
Q33786575Structural and functional characterisation of the fork head transcription factor-encoding gene, Hc-daf-16, from the parasitic nematode Haemonchus contortus (Strongylida)
Q39508177The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity.
Q37625960The dauer hypothesis and the evolution of parasitism: 20 years on and still going strong
Q97533544The development of the dog heartworm is highly sensitive to sterols which activate the orthologue of the nuclear receptor DAF-12
Q35182450The nuclear receptor DAF-12 regulates nutrient metabolism and reproductive growth in nematodes
Q33882797cGMP and NHR signaling co-regulate expression of insulin-like peptides and developmental activation of infective larvae in Strongyloides stercoralis

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