Dafachronic acid promotes larval development in Haemonchus contortus by modulating dauer signalling and lipid metabolism

scientific article published on 23 July 2019

Dafachronic acid promotes larval development in Haemonchus contortus by modulating dauer signalling and lipid metabolism is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1007960
P932PMC publication ID6677322
P698PubMed publication ID31335899

P50authorPasi K. KorhonenQ30518625
Neil D. YoungQ30518653
Shuai NieQ61819618
Guangxu MaQ64620908
Ching-Seng AngQ39061637
Gavin E. ReidQ39440335
Nicholas A. WilliamsonQ40376378
Tao WangQ41560597
Robin B. GasserQ42326677
P2860cites workThe genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discoveryQ21183984
A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegansQ24644224
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Signalling through the lipid products of phosphoinositide-3-OH kinaseQ28241516
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HcSTK, a Caenorhabditis elegans PAR-1 homologue from the parasitic nematode, Haemonchus contortusQ31077111
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The genome and developmental transcriptome of the strongylid nematode Haemonchus contortusQ33741666
Co-option of the hormone-signalling module dafachronic acid-DAF-12 in nematode evolutionQ34123533
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Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress responseQ59794156
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Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.Q46985126
A genome resequencing-based genetic map reveals the recombination landscape of an outbred parasitic nematode in the presence of polyploidy and polyandry.Q47266449
Methylprednisolone acetate induces, and Δ7-dafachronic acid suppresses, Strongyloides stercoralis hyperinfection in NSG miceQ47569441
Lipid and Carbohydrate Metabolism in Caenorhabditis elegansQ47696246
Nuclear option prevents hyperinfection in the Strongyloides worm war.Q49838050
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Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.Q51848345
Molecular alterations during larval development of Haemonchus contortus in vitro are under tight post-transcriptional controlQ56984524
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RNAseq analysis of the parasitic nematode Strongyloides stercoralis reveals divergent regulation of canonical dauer pathways.Q34474570
A conserved endocrine mechanism controls the formation of dauer and infective larvae in nematodesQ34602464
The nuclear receptor DAF-12 regulates nutrient metabolism and reproductive growth in nematodesQ35182450
A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signalingQ35677835
The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradationQ35814123
Regulation of Life Cycle Checkpoints and Developmental Activation of Infective Larvae in Strongyloides stercoralis by Dafachronic AcidQ35884031
Expanding the view on the evolution of the nematode dauer signalling pathways: refinement through gene gain and pathway co-optionQ36062844
Indicted: worms caught using steroidsQ36431288
Diapause is associated with a change in the polarity of secretion of insulin-like peptidesQ36548911
Impact of gastrointestinal parasitic nematodes of sheep, and the role of advanced molecular tools for exploring epidemiology and drug resistance - an Australian perspectiveQ36922132
DauerQ36995488
RNA-seq analysis is easy as 1-2-3 with limma, Glimma and edgeR.Q37077625
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Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor, regulating C. elegans development and lifespanQ37584863
The dauer hypothesis and the evolution of parasitism: 20 years on and still going strongQ37625960
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Making sense of genomes of parasitic worms: Tackling bioinformatic challengesQ38766142
The Pathophysiology, Ecology and Epidemiology of Haemonchus contortus Infection in Small RuminantsQ38847628
Immunity to Haemonchus contortus and Vaccine Development.Q38847640
Anthelmintic Resistance in Haemonchus contortus: History, Mechanisms and DiagnosisQ38847644
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Low cost whole-organism screening of compounds for anthelmintic activity.Q39368368
Hypobiosis in parasitic nematodes--an updateQ39747269
Nuclear hormone receptor regulation of microRNAs controls developmental progression.Q39864735
Arrested development of nematodes and some related phenomenaQ39889003
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P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that useslimmaQ112236343
edgeRQ113334690
P433issue7
P921main subjectHaemonchus contortusQ1754336
P304page(s)e1007960
P577publication date2019-07-23
P1433published inPLOS PathogensQ283209
P1476titleDafachronic acid promotes larval development in Haemonchus contortus by modulating dauer signalling and lipid metabolism
P478volume15