| scholarly article | Q13442814 |
| P2093 | author name string | C David Stout | |
| James R Halpert | |||
| Arthur G Roberts | |||
| Qinghai Zhang | |||
| Sean C Gay | |||
| Wen-Xu Hong | |||
| Keiko Maekawa | |||
| Jyothi C Talakad | |||
| P2860 | cites work | Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution | Q24294558 |
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| An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution | Q27642370 | ||
| Structural and Thermodynamic Consequences of 1-(4-Chlorophenyl)imidazole Binding to Cytochrome P450 2B4 † , ‡ | Q27648413 | ||
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| Features and development of Coot | Q27861079 | ||
| Evaluation of site-directed spin labeling for characterizing protein-ligand complexes using simulated restraints | Q28346150 | ||
| Protein structure modeling with MODELLER | Q29617759 | ||
| Detecting and overcoming crystal twinning | Q29620960 | ||
| Engineering of a water-soluble plant cytochrome P450, CYP73A1, and NMR-based orientation of natural and alternate substrates in the active site | Q30882779 | ||
| Ensemble approach for NMR structure refinement against (1)H paramagnetic relaxation enhancement data arising from a flexible paramagnetic group attached to a macromolecule | Q30928243 | ||
| Validation of the 53A6 GROMOS force field | Q30986204 | ||
| Theory, practice, and applications of paramagnetic relaxation enhancement for the characterization of transient low-population states of biological macromolecules and their complexes. | Q33671554 | ||
| NMR spectral quantitation by principal component analysis | Q34285111 | ||
| Analysis of mammalian cytochrome P450 structure and function by site-directed mutagenesis | Q34317426 | ||
| Structural diversity of human xenobiotic-metabolizing cytochrome P450 monooxygenases | Q36255503 | ||
| Structure-function analysis of cytochromes P450 2B. | Q36578635 | ||
| What common structural features and variations of mammalian P450s are known to date? | Q36636833 | ||
| NMR studies of substrate binding to cytochrome P450 BM3: comparisons to cytochrome P450 cam. | Q36688144 | ||
| Thermodynamics of water mediating protein-ligand interactions in cytochrome P450cam: a molecular dynamics study | Q36786061 | ||
| Mechanism-based inactivation of cytochrome P450 enzymes: chemical mechanisms, structure-activity relationships and relationship to clinical drug-drug interactions and idiosyncratic adverse drug reactions | Q36855287 | ||
| Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans | Q37641606 | ||
| A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding | Q38359211 | ||
| Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite | Q39790140 | ||
| Pharmacokinetic and metabolic characteristics of ticlopidine in relation to its inhibitory properties on platelet function | Q40188721 | ||
| New applications of simulated annealing in X-ray crystallography and solution NMR. | Q41398215 | ||
| Ticlopidine decreases the in vivo activity of CYP2C19 as measured by omeprazole metabolism | Q41593466 | ||
| Mechanism of interactions of alpha-naphthoflavone with cytochrome P450 3A4 explored with an engineered enzyme bearing a fluorescent probe. | Q42173777 | ||
| Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding | Q42625456 | ||
| Investigation of bioactivation of ticlopidine using linear ion trap/orbitrap mass spectrometry and an improved mass defect filtering technique | Q43125272 | ||
| Identification of the active metabolite of ticlopidine from rat in vitro metabolites | Q43262474 | ||
| Ticlopidine as a selective mechanism-based inhibitor of human cytochrome P450 2C19. | Q43753143 | ||
| Potent Mechanism-Based Inhibition of Human CYP2B6 by Clopidogrel and Ticlopidine | Q44620932 | ||
| Characterization of novel dihydrothienopyridinium and thienopyridinium metabolites of ticlopidine in vitro: role of peroxidases, cytochromes p450, and monoamine oxidases | Q44717269 | ||
| Effector-mediated alteration of substrate orientation in cytochrome P450 2C9. | Q44902704 | ||
| Selective inhibition of CYP2B6-catalyzed bupropion hydroxylation in human liver microsomes in vitro | Q44904682 | ||
| Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. | Q45951521 | ||
| Metabolism of ticlopidine in rats: identification of the main biliary metabolite as a glutathione conjugate of ticlopidine S-oxide. | Q45960921 | ||
| A statistic for local intensity differences: robustness to anisotropy and pseudo-centering and utility for detecting twinning. | Q46039301 | ||
| Comparison of human cytochrome P450 inhibition by the thienopyridines prasugrel, clopidogrel, and ticlopidine | Q46175757 | ||
| Mechanism-based inhibition of human cytochrome P450 2B6 by ticlopidine, clopidogrel, and the thiolactone metabolite of prasugrel | Q46220322 | ||
| Cooperative binding of midazolam with testosterone and alpha-naphthoflavone within the CYP3A4 active site: a NMR T1 paramagnetic relaxation study | Q46771295 | ||
| Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction. | Q46864550 | ||
| Conformational flexibility of mammalian cytochrome P450 2B4 in binding imidazole inhibitors with different ring chemistry and side chains. Solution thermodynamics and molecular modeling | Q46913522 | ||
| Cooperative binding of acetaminophen and caffeine within the P450 3A4 active site | Q46982603 | ||
| Use of Voigt lineshape for quantification of in vivo 1H spectra. | Q48722469 | ||
| Distance-constrained molecular docking by simulated annealing. | Q51655181 | ||
| An analytical derivation of a popular approximation of the Voigt function for quantification of NMR spectra. | Q52083351 | ||
| Quantitation of resonances in biological 31P NMR spectra via principal component analysis: potential and limitations. | Q52305421 | ||
| High-pressure-induced transitions in microsomal cytochrome P450 2B4 in solution: evidence for conformational inhomogeneity in the oligomers. | Q52335945 | ||
| A simple scheme for the design of solvent-suppression pulses | Q57817878 | ||
| Designing Facial Amphiphiles for the Stabilization of Integral Membrane Proteins | Q57830863 | ||
| 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine as a Substrate of Cytochrome P450 2D6: Allosteric Effects of NADPH−Cytochrome P450 Reductase† | Q58573225 | ||
| Paramagnetic probes of macromolecules | Q69377826 | ||
| Metabolism of ticlopidine in rats: identification and quantitative determination of some its metabolites in plasma, urine and bile | Q70906485 | ||
| Choice of spectroscopic lineshape model affects metabolite peak areas and area ratios | Q73062265 | ||
| Orientation of caffeine within the active site of human cytochrome P450 1A2 based on NMR longitudinal (T1) relaxation measurements | Q73370606 | ||
| Ticlopidine inhibition of phenytoin metabolism mediated by potent inhibition of CYP2C19 | Q73924048 | ||
| Reproducibility of 1H-NMR integrals: a collaborative study | Q74761995 | ||
| The antiplatelet effects of ticlopidine and clopidogrel | Q77292679 | ||
| The (Fo-Fc) Fourier synthesis: a probabilistic study | Q81794023 | ||
| Variable path length and counter-flow continuous variation methods for the study of the formation of high-affinity complexes by absorbance spectroscopy. An application to the studies of substrate binding in cytochrome P450 | Q83347495 | ||
| P433 | issue | 40 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | clopidogrel | Q410237 |
| P304 | page(s) | 8709-20 | |
| P577 | publication date | 2010-10-12 | |
| P1433 | published in | Biochemistry | Q764876 |
| P1476 | title | Structures of Cytochrome P450 2B4 Complexed with the Antiplatelet Drugs Ticlopidine and Clopidogrel, | |
| P478 | volume | 49 |
| Q39671290 | A Comparative Study of Molecular Structure, pKa, Lipophilicity, Solubility, Absorption and Polar Surface Area of Some Antiplatelet Drugs |
| Q27677947 | A Structural Snapshot of CYP2B4 in Complex with Paroxetine Provides Insights into Ligand Binding and Clusters of Conformational States |
| Q41089527 | Bifunctional CYP81AA proteins catalyse identical hydroxylations but alternative regioselective phenol couplings in plant xanthone biosynthesis. |
| Q47736109 | Capturing the photo-signaling state of a photoreceptor in a steady-state fashion by binding a transition metal complex. |
| Q34702595 | Comparison of in vitro metabolism of ticlopidine by human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 |
| Q27671627 | Conformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine Molecules |
| Q38099062 | Conformational diversity and ligand tunnels of mammalian cytochrome P450s |
| Q36893698 | Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations |
| Q42039900 | Effect of detergent binding on cytochrome P450 2B4 structure as analyzed by X-ray crystallography and deuterium-exchange mass spectrometry |
| Q46088734 | Halogen-π Interactions in the Cytochrome P450 Active Site: Structural Insights into Human CYP2B6 Substrate Selectivity. |
| Q43149378 | Insights into the role of substrates on the interaction between cytochrome b5 and cytochrome P450 2B4 by NMR. |
| Q35184715 | NMR-derived models of amidopyrine and its metabolites in complexes with rabbit cytochrome P450 2B4 reveal a structural mechanism of sequential N-dealkylation |
| Q37940726 | New amphiphiles for membrane protein structural biology |
| Q37266116 | Paramagnetic nuclear magnetic resonance relaxation and molecular mechanics studies of the chloroperoxidase-indole complex: insights into the mechanism of chloroperoxidase-catalyzed regioselective oxidation of indole |
| Q37429225 | Plasticity of CYP2B enzymes: structural and solution biophysical methods |
| Q30561291 | Preferred binding orientations of phenacetin in CYP1A1 and CYP1A2 are associated with isoform-selective metabolism |
| Q92738723 | So many roads traveled: A career in science and administration |
| Q27676750 | Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins |
| Q27667508 | Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert -Butylphenylacetylene: Insight into Partial Enzymatic Activity |
| Q35198035 | Structural and biophysical characterization of human cytochromes P450 2B6 and 2A6 bound to volatile hydrocarbons: analysis and comparison. |
| Q27025716 | Structural diversity of eukaryotic membrane cytochrome p450s |
| Q42781425 | Structure and function of cytochromes P450 2B: from mechanism-based inactivators to X-ray crystal structures and back |
| Q27672416 | Structures of Cytochrome P450 2B6 Bound to 4-Benzylpyridine and 4-(4-Nitrobenzyl)pyridine: Insight into Inhibitor Binding and Rearrangement of Active Site Side Chains |
| Q33648450 | The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexes |
| Q37308650 | The structural basis for homotropic and heterotropic cooperativity of midazolam metabolism by human cytochrome P450 3A4. |
| Q26865298 | Trendspotting in the Protein Data Bank |
| Q46246116 | Use of phenoxyaniline analogs to generate biochemical insights into polybrominated diphenyl ether interaction with CYP2B enzymes |
| Q27675799 | X-ray crystal structure of the cytochrome P450 2B4 active site mutant F297A in complex with clopidogrel: Insights into compensatory rearrangements of the binding pocket |
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