| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.M403349200 |
| P698 | PubMed publication ID | 15100217 |
| P2093 | author name string | C David Stout | |
| Eric F Johnson | |||
| James R Halpert | |||
| You Ai He | |||
| Emily E Scott | |||
| Mark A White | |||
| P2860 | cites work | Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination | Q26778405 |
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| Crystal structure of cytochrome P450 14 -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors | Q27630604 | ||
| Pivotal role of water in the mechanism of P450BM-3 | Q27635979 | ||
| Crystal structure of OxyB, a cytochrome P450 implicated in an oxidative phenol coupling reaction during vancomycin biosynthesis | Q27639576 | ||
| Thermophilic cytochrome P450 (CYP119) from Sulfolobus solfataricus: high resolution structure and functional properties | Q27639663 | ||
| The 1.92-A structure of Streptomyces coelicolor A3(2) CYP154C1. A new monooxygenase that functionalizes macrolide ring systems | Q27640294 | ||
| Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 A resolution: evidence for multiple substrate binding modes | Q27641321 | ||
| Crystal structure of human cytochrome P450 2C9 with bound warfarin | Q27641685 | ||
| Structure of mammalian cytochrome P450 2C5 complexed with diclofenac at 2.1 A resolution: evidence for an induced fit model of substrate binding | Q27641778 | ||
| An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution | Q27642370 | ||
| Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site | Q27642793 | ||
| High-resolution crystal structure of cytochrome P450cam | Q27728724 | ||
| The structure of the cytochrome p450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid | Q27734817 | ||
| Maximum-likelihood density modification | Q27860478 | ||
| SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling | Q27860614 | ||
| XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density | Q27861034 | ||
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| Automated MAD and MIR structure solution | Q27861114 | ||
| Error estimates of protein structure coordinates and deviations from standard geometry by full-matrix refinement of gammaB- and betaB2-crystallin. | Q30431619 | ||
| Analysis of mammalian cytochrome P450 structure and function by site-directed mutagenesis | Q34317426 | ||
| Substrate routes to the buried active site may vary among cytochromes P450: mutagenesis of the F-G region in P450 2B1. | Q38360907 | ||
| The role of cytochrome 2B1 substrate recognition site residues 115, 294, 297, 298, and 362 in the oxidation of steroids and 7-alkoxycoumarins | Q43743917 | ||
| Threonine-205 in the F Helix of P450 2B1 Contributes to Androgen 16β-Hydroxylation Activity and Mechanism-Based Inactivation | Q44422944 | ||
| Phe393 mutants of cytochrome P450 BM3 with modified heme redox potentials have altered heme vinyl and propionate conformations | Q44766413 | ||
| Identification of the binding site on cytochrome P450 2B4 for cytochrome b5 and cytochrome P450 reductase. | Q45996870 | ||
| New perspectives on the conformational equilibrium regulating multi-phasic reduction of cytochrome P450 2B4 by cytochrome P450 reductase | Q47603280 | ||
| PRODRG, a program for generating molecular topologies and unique molecular descriptors from coordinates of small molecules. | Q48785859 | ||
| Identification of key residues in rabbit liver microsomal cytochrome P450 2B4: importance in interactions with NADPH-cytochrome P450 reductase. | Q52538505 | ||
| Mutagenesis study of Asp-290 in cytochrome P450 2B11 using a fusion protein with rat NADPH-cytochrome P450 reductase. | Q54594850 | ||
| Site-Directed Mutagenesis as a Tool for Molecular Modeling of Cytochrome P450 2B1 | Q54600140 | ||
| P433 | issue | 26 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 27294-27301 | |
| P577 | publication date | 2004-04-20 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding | |
| P478 | volume | 279 |
| Q57975741 | A Minimal Functional Complex of Cytochrome P450 and FBD of Cytochrome P450 Reductase in Nanodiscs |
| Q27677947 | A Structural Snapshot of CYP2B4 in Complex with Paroxetine Provides Insights into Ligand Binding and Clusters of Conformational States |
| Q37308259 | A comparison of substrate dynamics in human CYP2E1 and CYP2A6 |
| Q30633058 | A model of the membrane-bound cytochrome b5-cytochrome P450 complex from NMR and mutagenesis data. |
| Q42157445 | A single-site mutation (F429H) converts the enzyme CYP 2B4 into a heme oxygenase: a QM/MM study |
| Q24297785 | Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2 |
| Q41333940 | Advances in the Understanding of Protein-Protein Interactions in Drug Metabolizing Enzymes through the Use of Biophysical Techniques |
| Q42173769 | Allosteric mechanisms in cytochrome P450 3A4 studied by high-pressure spectroscopy: pivotal role of substrate-induced changes in the accessibility and degree of hydration of the heme pocket. |
| Q33373477 | Allosteric transitions in cytochrome P450eryF explored with pressure-perturbation spectroscopy, lifetime FRET, and a novel fluorescent substrate, Fluorol-7GA. |
| Q42172367 | Analysis of Cytochrome P450 Conserved Sequence Motifs between Helices E and H: Prediction of Critical Motifs and Residues in Enzyme Functions. |
| Q35450924 | Analysis of cytochrome P450 CYP119 ligand-dependent conformational dynamics by two-dimensional NMR and X-ray crystallography |
| Q52577282 | Anesthetic Drug Discovery and Development: A Case Study of Novel Etomidate Analogs. |
| Q34710067 | Anesthetic drug development: Novel drugs and new approaches |
| Q38342059 | Arabidopsis CYP72C1 is an atypical cytochrome P450 that inactivates brassinosteroids |
| Q46703807 | Association of cytochrome P450 enzymes is a determining factor in their catalytic activity |
| Q34257489 | CYP2C8 exists as a dimer in natural membranes |
| Q36551130 | CYP4B1: an enigmatic P450 at the interface between xenobiotic and endobiotic metabolism |
| Q33697203 | Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function |
| Q37333027 | Carboetomidate: an analog of etomidate that interacts weakly with 11β-hydroxylase |
| Q24648582 | Characterization of CYP2A13*2, a variant cytochrome P450 allele previously found to be associated with decreased incidences of lung adenocarcinoma in smokers |
| Q35587095 | Characterization of protein cross-links via mass spectrometry and an open-modification search strategy. |
| Q43096189 | Characterization of the microsomal cytochrome P450 2B4 O2 activation intermediates by cryoreduction and electron paramagnetic resonance |
| Q46140587 | Comparative docking studies of CYP1b1 and its PCG-associated mutant forms |
| Q34702595 | Comparison of in vitro metabolism of ticlopidine by human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 |
| Q48262569 | Computational modelling of the binding of arachidonic acid to the human monooxygenase CYP2J2. |
| Q27671627 | Conformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine Molecules |
| Q27667024 | Conformational Changes of NADPH-Cytochrome P450 Oxidoreductase Are Essential for Catalysis and Cofactor Binding |
| Q92255704 | Conformational States of Exchange Protein Directly Activated by cAMP (EPAC1) Revealed by Ensemble Modeling and Integrative Structural Biology |
| Q38099062 | Conformational diversity and ligand tunnels of mammalian cytochrome P450s |
| Q34592594 | Conformational dynamics in the F/G segment of CYP51 from Mycobacterium tuberculosis monitored by FRET. |
| Q46913522 | Conformational flexibility of mammalian cytochrome P450 2B4 in binding imidazole inhibitors with different ring chemistry and side chains. Solution thermodynamics and molecular modeling |
| Q37743467 | Conformational plasticity and structure/function relationships in cytochromes P450. |
| Q37366156 | Cooperative properties of cytochromes P450. |
| Q64253030 | Coumarins and P450s, Studies Reported to-Date |
| Q33890883 | Covalent modification of Thr302 in cytochrome P450 2B1 by the mechanism-based inactivator 4-tert-butylphenylacetylene |
| Q33663887 | Cross-linking of human cytochrome P450 2B6 to NADPH-cytochrome P450 reductase: Identification of a potential site of interaction |
| Q27670625 | Crystal Structure of H2O2-dependent Cytochrome P450SP with Its Bound Fatty Acid Substrate: INSIGHT INTO THE REGIOSELECTIVE HYDROXYLATION OF FATTY ACIDS AT THE POSITION |
| Q27653132 | Crystal Structures of Cytochrome P450 105P1 from Streptomyces avermitilis: Conformational Flexibility and Histidine Ligation State |
| Q27655307 | Crystal Structures of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-methyl-1 H -imidazole: Ligand-Induced Structural Response through α-Helical Repositioning , |
| Q24294558 | Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution |
| Q24312811 | Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain |
| Q36543108 | Current views on the fundamental mechanisms of cytochrome P450 allosterism |
| Q39775781 | Cytochrome P450 structure-function: insights from molecular dynamics simulations |
| Q42324882 | Cytochrome b5 Activates the 17,20-Lyase Activity of Human Cytochrome P450 17A1 by Increasing the Coupling of NADPH Consumption to Androgen Production |
| Q38385149 | Directed evolution of cytochrome P450 enzymes for biocatalysis: exploiting the catalytic versatility of enzymes with relaxed substrate specificity. |
| Q46387102 | Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide |
| Q34360317 | Do mammalian cytochrome P450s show multiple ligand access pathways and ligand channelling? |
| Q27670900 | Double electron-electron resonance shows cytochrome P450cam undergoes a conformational change in solution upon binding substrate |
| Q35069990 | Dynamics and flexibility of human aromatase probed by FTIR and time resolved fluorescence spectroscopy |
| Q37377648 | Effect of conformational dynamics on substrate recognition and specificity as probed by the introduction of a de novo disulfide bond into cytochrome P450 2B1. |
| Q34242752 | Engineering of LadA for enhanced hexadecane oxidation using random- and site-directed mutagenesis |
| Q37640865 | Examining how enzymes self-organize in a membrane. |
| Q36453123 | Experimental documentation of the structural consequences of hydrogen-bonding interactions to the proximal cysteine of a cytochrome P450. |
| Q51639702 | Exploring coumarin egress channels in human cytochrome P450 2A6 by random acceleration and steered molecular dynamics simulations. |
| Q28548581 | F429 Regulation of Tunnels in Cytochrome P450 2B4: A Top Down Study of Multiple Molecular Dynamics Simulations |
| Q24646983 | Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates |
| Q41058699 | Functional importance of a peripheral pocket in mammalian cytochrome P450 2B enzymes. |
| Q34396417 | Heme enzyme structure and function |
| Q41666716 | Hepatic cytochromes P450: structural degrons and barcodes, posttranslational modifications and cellular adapters in the ERAD-endgame |
| Q41176588 | Identification and analysis of conserved sequence motifs in cytochrome P450 family 2. Functional and structural role of a motif 187RFDYKD192 in CYP2B enzymes. |
| Q33234228 | Identification of 17-alpha-ethynylestradiol-modified active site peptides and glutathione conjugates formed during metabolism and inactivation of P450s 2B1 and 2B6. |
| Q36852513 | Immobilized Cytochrome P450 for Monitoring of P450-P450 Interactions and Metabolism |
| Q36238767 | Inhibition of CYP2B4 by 2-ethynylnaphthalene: evidence for the co-binding of substrate and inhibitor within the active site |
| Q36406310 | Inhibition of bupropion metabolism by selegiline: mechanism-based inactivation of human CYP2B6 and characterization of glutathione and peptide adducts |
| Q36497020 | Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions. |
| Q43149378 | Insights into the role of substrates on the interaction between cytochrome b5 and cytochrome P450 2B4 by NMR. |
| Q24293148 | Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes |
| Q34424291 | Intramolecular heme ligation of the cytochrome P450 2C9 R108H mutant demonstrates pronounced conformational flexibility of the B-C loop region: implications for substrate binding. |
| Q27675363 | Investigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active-site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzyme |
| Q36952243 | Investigation of the mechanisms underlying the differential effects of the K262R mutation of P450 2B6 on catalytic activity |
| Q41984931 | Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme |
| Q24632373 | Kinetic and molecular analysis of 5-epiaristolochene 1,3-dihydroxylase, a cytochrome P450 enzyme catalyzing successive hydroxylations of sesquiterpenes |
| Q42173777 | Mechanism of interactions of alpha-naphthoflavone with cytochrome P450 3A4 explored with an engineered enzyme bearing a fluorescent probe. |
| Q37416467 | Mechanism-based inactivation of CYP2B1 and its F-helix mutant by two tert-butyl acetylenic compounds: covalent modification of prosthetic heme versus apoprotein |
| Q37194304 | Modeling kinetics of subcellular disposition of chemicals. |
| Q42611204 | Modification of serine 360 by a reactive intermediate of 17-alpha-ethynylestradiol results in mechanism-based inactivation of cytochrome P450s 2B1 and 2B6. |
| Q41865082 | Molecular basis for the inability of an oxygen atom donor ligand to replace the natural sulfur donor heme axial ligand in cytochrome P450 catalysis. Spectroscopic characterization of the Cys436Ser CYP2B4 mutant |
| Q28282980 | Molecular characterization of CYP2B6 substrates |
| Q33999471 | Molecular dynamics analysis reveals structural insights into mechanism of nicotine N-demethylation catalyzed by tobacco cytochrome P450 mono-oxygenase |
| Q36812605 | Molecular mechanism of phase I and phase II drug-metabolizing enzymes: implications for detoxification |
| Q35184715 | NMR-derived models of amidopyrine and its metabolites in complexes with rabbit cytochrome P450 2B4 reveal a structural mechanism of sequential N-dealkylation |
| Q37641371 | New cytochrome P450 mechanisms: implications for understanding molecular basis for drug toxicity at the level of the cytochrome |
| Q34994964 | New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme |
| Q36477001 | Oxidation of methyl and ethyl nitrosamines by cytochrome P450 2E1 and 2B1 |
| Q28534547 | Perturbation centrality and turbine: a novel centrality measure obtained using a versatile network dynamics tool |
| Q37611698 | Physical Studies of P450-P450 Interactions: Predicting Quaternary Structures of P450 Complexes in Membranes from Their X-ray Crystal Structures |
| Q37429225 | Plasticity of CYP2B enzymes: structural and solution biophysical methods |
| Q27664781 | Plasticity of Cytochrome P450 2B4 as Investigated by Hydrogen-Deuterium Exchange Mass Spectrometry and X-ray Crystallography |
| Q27675674 | Potent Mechanism-Based Inactivation of Cytochrome P450 2B4 by 9-Ethynylphenanthrene: Implications for Allosteric Modulation of Cytochrome P450 Catalysis |
| Q43281575 | Probing possible egress channels for multiple ligands in human CYP3A4: a molecular modeling study. |
| Q41917512 | Probing the transmembrane structure and topology of microsomal cytochrome-p450 by solid-state NMR on temperature-resistant bicelles |
| Q51726659 | Quantitative structure-activity relationships (QSARs) for inhibitors and substrates of CYP2B enzymes: importance of compound lipophilicity in explanation of potency differences. |
| Q31035806 | Quantum mechanically derived AMBER-compatible heme parameters for various states of the cytochrome P450 catalytic cycle |
| Q35651931 | Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide |
| Q42094327 | Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W. |
| Q92738723 | So many roads traveled: A career in science and administration |
| Q41122137 | Stabilization and spectroscopic characterization of the dioxygen complex of wild-type cytochrome P4502B4 (CYP2B4) and its distal side E301Q, T302A and proximal side F429H mutants at subzero temperatures |
| Q27675290 | Structural Analyses of a Constitutively Active Mutant of Exchange Protein Directly Activated by cAMP |
| Q27667508 | Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert -Butylphenylacetylene: Insight into Partial Enzymatic Activity |
| Q27684706 | Structural and Functional Characterization of a Cytochrome P450 2B4 F429H Mutant with an Axial Thiolate–Histidine Hydrogen Bond |
| Q90147409 | Structural and Functional Studies of the Membrane-Binding Domain of NADPH-Cytochrome P450 Oxidoreductase |
| Q27648413 | Structural and Thermodynamic Consequences of 1-(4-Chlorophenyl)imidazole Binding to Cytochrome P450 2B4 † , ‡ |
| Q35198035 | Structural and biophysical characterization of human cytochromes P450 2B6 and 2A6 bound to volatile hydrocarbons: analysis and comparison. |
| Q35025071 | Structural basis for ligand promiscuity in cytochrome P450 3A4. |
| Q27025716 | Structural diversity of eukaryotic membrane cytochrome p450s |
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| Q27645089 | Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants |
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| Q34546874 | Structural motif-based homology modeling of CYP27A1 and site-directed mutational analyses affecting vitamin D hydroxylation |
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| Q46864550 | Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction. |
| Q35015993 | Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2. |
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| Q27664259 | Structures of Cytochrome P450 2B4 Complexed with the Antiplatelet Drugs Ticlopidine and Clopidogrel, |
| Q27672416 | Structures of Cytochrome P450 2B6 Bound to 4-Benzylpyridine and 4-(4-Nitrobenzyl)pyridine: Insight into Inhibitor Binding and Rearrangement of Active Site Side Chains |
| Q33615471 | The Mycobacterium tuberculosis cytochrome P450 system |
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| Q33978913 | The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution |
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| Q35579527 | Thr302 is the site for the covalent modification of human cytochrome P450 2B6 leading to mechanism-based inactivation by tert-butylphenylacetylene |
| Q30498059 | Three clusters of conformational states in p450cam reveal a multistep pathway for closing of the substrate access channel. |
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