Crystal structure of Bacteroides thetaiotaomicron TetX2: A tetracycline degrading monooxygenase at 2.8 Å resolution

scientific article published on May 16, 2011

Crystal structure of Bacteroides thetaiotaomicron TetX2: A tetracycline degrading monooxygenase at 2.8 Å resolution is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/PROT.23052
P953full work available online athttps://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fprot.23052
https://doi.org/10.1002/prot.23052
https://europepmc.org/articles/PMC3115393
https://europepmc.org/articles/PMC3115393?pdf=render
https://onlinelibrary.wiley.com/doi/pdf/10.1002/prot.23052
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/prot.23052
P932PMC publication ID3115393
P698PubMed publication ID21590745
P5875ResearchGate publication ID51144897

P50authorKatarzyna WalkiewiczQ87264874
P2093author name stringGang Wu
Milya Davlieva
Yousif Shamoo
P2860cites work[29] Preparation of selenomethionyl proteins for phase determinationQ95802115
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceQ24286950
Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistanceQ24548472
PHENIX: a comprehensive Python-based system for macromolecular structure solutionQ24654617
Processing of X-ray diffraction data collected in oscillation modeQ26778468
Crystal structure of the pyocyanin biosynthetic protein PhzSQ27650331
Coot: model-building tools for molecular graphicsQ27860505
BALBES: a molecular-replacement pipelineQ27860570
Toward the structural genomics of complexes: Crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosisQ27860789
Preparation of selenomethionyl proteins for phase determinationQ27860869
Rubredoxin reductase of Pseudomonas oleovorans. Structural relationship to other flavoprotein oxidoreductases based on one NAD and two FAD fingerprintsQ28280271
The CCP4 molecular-graphics projectQ29614462
Prediction of the occurrence of the ADP-binding beta alpha beta-fold in proteins, using an amino acid sequence fingerprintQ29614862
Characterization of the 13-kilobase ermF region of the Bacteroides conjugative transposon CTnDOT.Q33990026
Flavoprotein monooxygenases, a diverse class of oxidative biocatalystsQ34528388
Bacterial resistance to tetracycline: mechanisms, transfer, and clinical significanceQ35474783
Evidence that a novel tetracycline resistance gene found on two Bacteroides transposons encodes an NADP-requiring oxidoreductaseQ36128308
Identification of a novel conserved sequence motif in flavoprotein hydroxylases with a putative dual function in FAD/NAD(P)H bindingQ42845628
Role of protein flexibility in the catalytic cycle of p-hydroxybenzoate hydroxylase elucidated by the Pro293Ser mutantQ44039527
TetX is a flavin-dependent monooxygenase conferring resistance to tetracycline antibioticsQ45081437
Tigecycline is modified by the flavin-dependent monooxygenase TetX.Q46674821
GeoDis: a program for the cladistic nested analysis of the geographical distribution of genetic haplotypesQ56878373
P433issue7
P407language of work or nameEnglishQ1860
P921main subjecttetracyclineQ193045
Bacteroides thetaiotaomicronQ798597
crystal structureQ895901
P304page(s)2335-40
P577publication date2011-05-16
2011-07-01
P1433published inProteinsQ7251514
P1476titleCrystal structure of Bacteroides thetaiotaomicron TetX2: A tetracycline degrading monooxygenase at 2.8 Å resolution
P478volume79

Reverse relations

cites work (P2860)
Q99557290Epidemiological and phylogenetic analysis reveals Flavobacteriaceae as potential ancestral source of tigecycline resistance gene tet(X)
Q27684940Retraction: Crystal structure of a Baeyer-Villiger flavin-containing monooxygenase from Staphylococcus aureus MRSA strain MU50, William C. Hwang, Qingping Xu, Bainan Wu, Adam Godzik
Q36504175Small changes in enzyme function can lead to surprisingly large fitness effects during adaptive evolution of antibiotic resistance

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