Structural and Functional Characterization of NikO, an Enolpyruvyl Transferase Essential in Nikkomycin Biosynthesis

scientific article

Structural and Functional Characterization of NikO, an Enolpyruvyl Transferase Essential in Nikkomycin Biosynthesis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M112.352096
P932PMC publication ID3438971
P698PubMed publication ID22810238

P50authorPeter MacherouxQ28359792
Karl GruberQ42315659
P2093author name stringCristian Ginj
Gustav Oberdorfer
Alexandra Binter
P2860cites workThe HHpred interactive server for protein homology detection and structure predictionQ24530456
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A new view of the mechanisms of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) and 5-enolpyruvylshikimate-3-phosphate synthase (AroA) derived from X-ray structures of their tetrahedral reaction intermediate statesQ27642065
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A putative enolpyruvyl transferase gene involved in nikkomycin biosynthesisQ73922860
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Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycinQ27734363
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Molecular characterization of co-transcribed genes from Streptomyces tendae Tü901 involved in the biosynthesis of the peptidyl moiety and assembly of the peptidyl nucleoside antibiotic nikkomycinQ32048119
Cloning and sequencing of Escherichia coli murZ and purification of its product, a UDP-N-acetylglucosamine enolpyruvyl transferaseQ33202551
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A novel inhibitor that suspends the induced fit mechanism of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA).Q42647502
Studies on the conformational changes in the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine enolpyruvyltransferase (MurA).Q42680309
Formation of beta-hydroxy histidine in the biosynthesis of nikkomycin antibioticsQ43884208
Inhibitory effect of nikkomycin Z on chitin synthases in Candida albicansQ43900300
3'-Enolpyruvyl-UMP, a novel and unexpected metabolite in nikkomycin biosynthesisQ46737127
The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambinQ47682341
Molecular characterization of co-transcribed genes from Streptomyces tendae Tü901 involved in the biosynthesis of the peptidyl moiety of the peptidyl nucleoside antibiotic nikkomycinQ47924911
Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin.Q54590227
Lysine 22 in UDP-N-Acetylglucosamine Enolpyruvyl Transferase fromEnterobacter cloacaeIs Crucial for Enzymatic Activity and the Formation of Covalent Adducts with the Substrate Phosphoenolpyruvate and the Antibiotic Fosfomycin†Q57978316
An automated microseed matrix-screening method for protein crystallizationQ62045318
P433issue37
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
P304page(s)31427-31436
P577publication date2012-07-18
P1433published inJournal of Biological ChemistryQ867727
P1476titleStructural and functional characterization of NikO, an enolpyruvyl transferase essential in nikkomycin biosynthesis
P478volume287

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cites work (P2860)
Q40102505Biosynthesis and combinatorial biosynthesis of antifungal nucleoside antibiotics.
Q37348205Carbon extension in peptidylnucleoside biosynthesis by radical SAM enzymes
Q39375330Drugs currently under investigation for the treatment of invasive candidiasis
Q40045666Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi
Q90567824Pyruvate Substitutions on Glycoconjugates
Q36809121The biosynthesis of nitrogen-, sulfur-, and high-carbon chain-containing sugars

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