Crystal structure of UDP-N-acetylglucosamine enolpyruvyltransferase, the target of the antibiotic fosfomycin (scientific article)

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PROCHECK: a program to check the stereochemical quality of protein structures

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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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Structure and topological symmetry of the glyphosate target 5-enolpyruvylshikimate-3-phosphate synthase: a distinctive protein fold

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The structure of the substrate-free form of MurB, an essential enzyme for the synthesis of bacterial cell walls

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Automated refinement of protein models

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CRYSOL– a Program to Evaluate X-ray Solution Scattering of Biological Macromolecules from Atomic Coordinates

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AMoRe: an automated package for molecular replacement

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Cloning and sequencing of Escherichia coli murZ and purification of its product, a UDP-N-acetylglucosamine enolpyruvyl transferase

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The mechanism of action of fosfomycin (phosphonomycin)

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The herbicide glyphosate is a potent inhibitor of 5-enolpyruvyl-shikimic acid-3-phosphate synthase

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Structural mechanisms for domain movements in proteins

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Intracellular steps of bacterial cell wall peptidoglycan biosynthesis: enzymology, antibiotics, and antibiotic resistance

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The versatility of phosphoenolpyruvate and its vinyl ether products in biosynthesis

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The UDP-N-acetylglucosamine 1-carboxyvinyl-transferase of Enterobacter cloacae. Molecular cloning, sequencing of the gene and overexpression of the enzyme

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Stable enzyme-phosphoenolpyruvate intermediate in the synthesis of uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-0-enolpyruvyl ether

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Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin.

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Time-resolved solid-state NMR spectroscopy of 5-enolpyruvylshikimate-3-phosphate synthase.

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5-Enolpyruvylshikimate-3-phosphate synthase of Klebsiella pneumoniae 2. Inhibition by glyphosate [N-(phosphonomethyl)glycine]

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Crystallization and preliminary X-ray diffraction analysis of UDP-N-acetylglucosamine enolpyruvyltransferase of Enterobacter cloacae

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An enzyme-substrate complex involved in bacterial cell wall biosynthesis

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Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of UDP-GlcNAc enolpyruvoyl transferase by the antibiotic fosfomycin

Q72160246

Evidence that the reaction of the UDP-N-acetylglucosamine 1-carboxyvinyltransferase proceeds through the O-phosphothioketal of pyruvic acid bound to Cys115 of the enzyme

Q72709263

P433

issue

P921

main subject

antibiotic

Q12187

crystal structure

Q895901

P304

page(s)

1065-75

P577

publication date

1996-09-15

P1433

published in

Structure

Q15709970

P1476

title

Crystal structure of UDP-N-acetylglucosamine enolpyruvyltransferase, the target of the antibiotic fosfomycin

P478

volume

Reverse relations

cites work (P2860)

Q27642065	A new view of the mechanisms of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) and 5-enolpyruvylshikimate-3-phosphate synthase (AroA) derived from X-ray structures of their tetrahedral reaction intermediate states
Q42647502	A novel inhibitor that suspends the induced fit mechanism of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA).
Q24633997	Closing down on glyphosate inhibition--with a new structure for drug discovery
Q27622761	Comparative X-ray analysis of the un-liganded fosfomycin-target murA
Q38420842	Comprehensive structural and functional characterization of Mycobacterium tuberculosis UDP-NAG enolpyruvyl transferase (Mtb-MurA) and prediction of its accurate binding affinities with inhibitors
Q51773259	Computed insight into a peptide inhibitor preventing the induced fit mechanism of MurA enzyme from Pseudomonas aeruginosa.
Q27621335	Crystal structure of RNA 3'-terminal phosphate cyclase, a ubiquitous enzyme with unusual topology
Q33886827	Crystal structure of UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase from Escherichia coli
Q37081699	Cytoplasmic steps of peptidoglycan biosynthesis
Q57975583	Effect of the Peptide Moiety of Lipid II on Bacterial Transglycosylase
Q33976610	Emergence of fosfomycin-resistant isolates of Shiga-like toxin-producing Escherichia coli O26
Q37866109	Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product release
Q27677546	Functional Consequence of Covalent Reaction of Phosphoenolpyruvate with UDP-N-acetylglucosamine 1-Carboxyvinyltransferase (MurA)
Q27677278	Heteroresistance to Fosfomycin Is Predominant in Streptococcus pneumoniae and Depends on the murA1 Gene
Q31016009	Identification and characterization of new inhibitors of the Escherichia coli MurA enzyme
Q30152646	Inhibition of the MurA enzyme in Fusobacterium nucleatum by potential inhibitors identified through computational and in vitro approaches
Q24628981	Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail
Q24627654	Molecular basis of glyphosate resistance-different approaches through protein engineering
Q56784778	Molecular modeling and bioinformatical analysis of the antibacterial target enzyme MurA from a drug design perspective
Q44609711	Nonenzymatic Breakdown of the Tetrahedral (α-Carboxyketal Phosphate) Intermediates of MurA and AroA, Two Carboxyvinyl Transferases. Protonation of Different Functional Groups Controls the Rate and Fate of Breakdown
Q37810971	Peptidoglycan biosynthesis machinery: a rich source of drug targets
Q27670812	Structural and Functional Characterization of NikO, an Enolpyruvyl Transferase Essential in Nikkomycin Biosynthesis
Q36319020	Structural and functional features of enzymes of Mycobacterium tuberculosis peptidoglycan biosynthesis as targets for drug development.
Q27622627	Structural basis for the interaction of the fluorescence probe 8-anilino-1-naphthalene sulfonate (ANS) with the antibiotic target MurA
Q27678532	Structure of MurA (UDP-N-acetylglucosamine enolpyruvyl transferase) fromVibrio fischeriin complex with substrate UDP-N-acetylglucosamine and the drug fosfomycin
Q27660525	The Fungal Product Terreic Acid Is a Covalent Inhibitor of the Bacterial Cell Wall Biosynthetic Enzyme UDP- N -Acetylglucosamine 1-Carboxyvinyltransferase (MurA),
Q34568935	The bacterial cell wall as a source of antibacterial targets
Q28660742	The effect of MEP pathway and other inhibitors on the intracellular localization of a plasma membrane-targeted, isoprenylable GFP reporter protein in tobacco BY-2 cells
Q33601835	Two active forms of UDP-N-acetylglucosamine enolpyruvyl transferase in gram-positive bacteria
Q37913126	UDP-N-acetylglucosamine enolpyruvyl transferase as a potential target for antibacterial chemotherapy: recent developments

P356	DOI	10.1016/S0969-2126(96)00113-X
P698	PubMed publication ID	8805592