The Fungal Product Terreic Acid Is a Covalent Inhibitor of the Bacterial Cell Wall Biosynthetic Enzyme UDP- N -Acetylglucosamine 1-Carboxyvinyltransferase (MurA),

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The Fungal Product Terreic Acid Is a Covalent Inhibitor of the Bacterial Cell Wall Biosynthetic Enzyme UDP- N -Acetylglucosamine 1-Carboxyvinyltransferase (MurA), is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/BI100365B
P8608Fatcat IDrelease_hbgiv73uc5gurjdjmnlchb4imy
P932PMC publication ID2884014
P698PubMed publication ID20392080
P5875ResearchGate publication ID43147079

P50authorStephane BetziQ55117889
Huijong HanQ58869810
P2093author name stringAndreas Becker
Ernst Schönbrunn
Yan Yang
Sanne H Olesen
P2860cites workImproved methods for building protein models in electron density maps and the location of errors in these modelsQ26776980
Crystallography & NMR System: A New Software Suite for Macromolecular Structure DeterminationQ26778405
Role of the loop containing residue 115 in the induced-fit mechanism of the bacterial cell wall biosynthetic enzyme MurAQ27621570
Comparative X-ray analysis of the un-liganded fosfomycin-target murAQ27622761
Crystal structure of UDP-N-acetylglucosamine enolpyruvyl transferase from Haemophilus influenzae in complex with UDP-N-acetylglucosamine and fosfomycinQ27649770
Crystal structure of UDP-N-acetylglucosamine enolpyruvyltransferase, the target of the antibiotic fosfomycinQ27733409
Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycinQ27734363
An improved assay for nanomole amounts of inorganic phosphateQ29620585
The mechanism of action of fosfomycin (phosphonomycin)Q34214482
Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinaseQ37177808
Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product releaseQ37866109
Structural and functional analyses of the fosfomycin resistance transposon Tn2921.Q39970000
Tn292l, a transposon encoding fosfomycin resistanceQ39984364
The UDP-N-acetylglucosamine 1-carboxyvinyl-transferase of Enterobacter cloacae. Molecular cloning, sequencing of the gene and overexpression of the enzymeQ42610701
A novel inhibitor that suspends the induced fit mechanism of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA).Q42647502
The antibacterial properties of 6-tuliposide B. Synthesis of 6-tuliposide B analogues and structure-activity relationship.Q43235543
The unusual binding mode of cnicin to the antibacterial target enzyme MurA revealed by X-ray crystallographyQ46450774
Alteration of a single amino acid residue reverses fosfomycin resistance of recombinant MurA from Mycobacterium tuberculosisQ47904411
Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA.Q54456599
Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin.Q54590227
Studies on terreic acidQ70651070
Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of UDP-GlcNAc enolpyruvoyl transferase by the antibiotic fosfomycinQ72160246
Evidence that the reaction of the UDP-N-acetylglucosamine 1-carboxyvinyltransferase proceeds through the O-phosphothioketal of pyruvic acid bound to Cys115 of the enzymeQ72709263
P433issue19
P407language of work or nameEnglishQ1860
P921main subjectcell wallQ128700
P304page(s)4276-82
P577publication date2010-05-18
P1433published inBiochemistryQ764876
P1476titleThe Fungal Product Terreic Acid Is a Covalent Inhibitor of the Bacterial Cell Wall Biosynthetic Enzyme UDP- N -Acetylglucosamine 1-Carboxyvinyltransferase (MurA),
P478volume49

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cites work (P2860)
Q28548513Biodiversity, Anti-Trypanosomal Activity Screening, and Metabolomic Profiling of Actinomycetes Isolated from Mediterranean Sponges
Q51773259Computed insight into a peptide inhibitor preventing the induced fit mechanism of MurA enzyme from Pseudomonas aeruginosa.
Q36175676Differential antibacterial properties of the MurA inhibitors terreic acid and fosfomycin
Q52889316Escherichia coli N-Acetylglucosamine-1-Phosphate-Uridyltransferase/Glucosamine-1-Phosphate-Acetyltransferase (GlmU) Inhibitory Activity of Terreic Acid Isolated from Aspergillus terreus.
Q27677546Functional Consequence of Covalent Reaction of Phosphoenolpyruvate with UDP-N-acetylglucosamine 1-Carboxyvinyltransferase (MurA)
Q47910117Genome-Wide Expression Profiles Drive Discovery of Novel Compounds that Reduce Binge Drinking in Mice.
Q27677278Heteroresistance to Fosfomycin Is Predominant in Streptococcus pneumoniae and Depends on the murA1 Gene
Q48022320Identification of druggable targets for Acinetobacter baumannii via subtractive genomics and plausible inhibitors for MurA and MurB.
Q45278217MurA as a primary target of tulipalin B and 6-tuliposide B.
Q61810328PTA-271 Counteracts Botryosphaeria Dieback in Grapevine, Triggering Immune Responses and Detoxification of Fungal Phytotoxins
Q38907906Polyketides in Aspergillus terreus: biosynthesis pathway discovery and application
Q33710466Recruitment of genes and enzymes conferring resistance to the nonnatural toxin bromoacetate
Q26859841Resistance to antibiotics targeted to the bacterial cell wall
Q36319020Structural and functional features of enzymes of Mycobacterium tuberculosis peptidoglycan biosynthesis as targets for drug development.
Q27678532Structure of MurA (UDP-N-acetylglucosamine enolpyruvyl transferase) fromVibrio fischeriin complex with substrate UDP-N-acetylglucosamine and the drug fosfomycin
Q37913126UDP-N-acetylglucosamine enolpyruvyl transferase as a potential target for antibacterial chemotherapy: recent developments

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