review article | Q7318358 |
scholarly article | Q13442814 |
P50 | author | Cláudio Nahum Alves | Q56788259 |
Glenn E.M. Maguire | Q60640032 | ||
Jerônimo Lameira | Q89998615 | ||
Gyanu Lamichhane | Q37830009 | ||
Thavendran Govender | Q41437127 | ||
Hendrik G. Kruger | Q42717752 | ||
P2093 | author name string | Paulo Robson Monteiro de Sousa | |
Guelber Cardoso Gomes | |||
Gleiciane Leal Moraes | |||
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The mode of action of bacilysin and anticapsin and biochemical properties of bacilysin-resistant mutants | Q54613752 | ||
Over-production, purification and properties of the uridine-diphosphate-N-acetylmuramoyl-L-alanyl-D-glutamate: meso-2,6-diaminopimelate ligase from Escherichia coli. | Q54704735 | ||
Thermotoga maritima sp. nov. represents a new genus of unique extremely thermophilic eubacteria growing up to 90°C | Q56701239 | ||
Invariant Amino Acids in the Mur Peptide Synthetases of Bacterial Peptidoglycan Synthesis and Their Modification by Site-Directed Mutagenesis in the UDP-MurNAc:l-Alanine Ligase from Escherichia coli | Q57998991 | ||
Effect of analogues of diaminopimelic acid on the meso -diaminopimelate-adding enzyme from Escherichia coli | Q60481030 | ||
Molecular Modeling of T. rangeli, T. brucei gambiense, and T. evansi Sialidases in Complex with the DANA Inhibitor | Q62631085 | ||
Purification and characterization of the D-alanyl-D-alanine-adding enzyme from Escherichia coli | Q68509453 | ||
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase from Bacillus sphaericus: activation by potassium phosphate | Q69539773 | ||
Overexpression, purification, and mechanistic study of UDP-N-acetylenolpyruvylglucosamine reductase | Q70597134 | ||
An enzyme-substrate complex involved in bacterial cell wall biosynthesis | Q71726994 | ||
Over‐production, Purification and Properties of the Uridine‐diphosphate‐N ‐Acetylmuramate: l‐alanine Ligase from Escherichia coli | Q71845700 | ||
Isolation and mutation site determination of the temperature-sensitive murB mutants of Staphylococcus aureus | Q73417915 | ||
4-Thiazolidinones: novel inhibitors of the bacterial enzyme MurB | Q73715141 | ||
Formation of adenosine 5'-tetraphosphate from the acyl phosphate intermediate: a difference between the MurC and MurD synthetases of Escherichia coli | Q77993628 | ||
Discovering new inhibitors of bacterial glucosamine-6P synthase (GlmS) by docking simulations | Q79754802 | ||
Quaternary structure, conformational variability and global motions of phosphoglucosamine mutase | Q84569338 | ||
Computational analysis of human OGA structure in complex with PUGNAc and NAG-thiazoline derivatives | Q84909232 | ||
Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure | Q24644604 | ||
The mechanism of sugar phosphate isomerization by glucosamine 6-phosphate synthase | Q24672775 | ||
The femR315 gene from Staphylococcus aureus, the interruption of which results in reduced methicillin resistance, encodes a phosphoglucosamine mutase | Q24678020 | ||
The Helicobacter pylori ureC gene codes for a phosphoglucosamine mutase | Q24678582 | ||
Determination of the MurD mechanism through crystallographic analysis of enzyme complexes | Q27618457 | ||
"Open" structures of MurD: domain movements and structural similarities with folylpolyglutamate synthetase | Q27626831 | ||
Crystal structure of Escherichia coli UDPMurNAc-tripeptide d-alanyl-d-alanine-adding enzyme (MurF) at 2.3 A resolution | Q27628634 | ||
Crystal structure of UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: meso-diaminopimelate ligase from Escherichia coli | Q27629001 | ||
Crystal structures of Streptococcus pneumoniae N-acetylglucosamine-1-phosphate uridyltransferase, GlmU, in apo form at 2.33 A resolution and in complex with UDP-N-acetylglucosamine and Mg(2+) at 1.96 A resolution | Q27629008 | ||
Crystal Structures of Active Fully Assembled Substrate- and Product-Bound Complexes of UDP-N-Acetylmuramic Acid:L-Alanine Ligase (MurC) from Haemophilus influenzae | Q27641592 | ||
A new view of the mechanisms of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) and 5-enolpyruvylshikimate-3-phosphate synthase (AroA) derived from X-ray structures of their tetrahedral reaction intermediate states | Q27642065 | ||
Crystal structure of uridine-diphospho-N-acetylglucosamine pyrophosphorylase from Candida albicans and catalytic reaction mechanism | Q27644263 | ||
Structural and functional characterization of enantiomeric glutamic acid derivatives as potential transition state analogue inhibitors of MurD ligase | Q27644808 | ||
Structure of a small-molecule inhibitor complexed with GlmU from Haemophilus influenzae reveals an allosteric binding site | Q27649707 | ||
PknB-mediated phosphorylation of a novel substrate, N-acetylglucosamine-1-phosphate uridyltransferase, modulates its acetyltransferase activity | Q27653322 | ||
Structure and function of GlmU fromMycobacterium tuberculosis | Q27653924 | ||
ATP-dependent MurE ligase in Mycobacterium tuberculosis: biochemical and structural characterisation | Q27658363 | ||
The Fungal Product Terreic Acid Is a Covalent Inhibitor of the Bacterial Cell Wall Biosynthetic Enzyme UDP- N -Acetylglucosamine 1-Carboxyvinyltransferase (MurA), | Q27660525 | ||
Essential residues for the enzyme activity of ATP-dependent MurE ligase from Mycobacterium tuberculosis | Q27666292 | ||
Crystal structure of a bacterial phosphoglucomutase, an enzyme involved in the virulence of multiple human pathogens | Q27666625 | ||
Crystal Structure of Bacillus anthracis Phosphoglucosamine Mutase, an Enzyme in the Peptidoglycan Biosynthetic Pathway | Q27670473 | ||
Functional Consequence of Covalent Reaction of Phosphoenolpyruvate with UDP-N-acetylglucosamine 1-Carboxyvinyltransferase (MurA) | Q27677546 | ||
The structure of the substrate-free form of MurB, an essential enzyme for the synthesis of bacterial cell walls | Q27733360 | ||
Substrate binding is required for assembly of the active conformation of the catalytic site in Ntn amidotransferases: evidence from the 1.8 A crystal structure of the glutaminase domain of glucosamine 6-phosphate synthase | Q27733391 | ||
Crystal structure of UDP-N-acetylglucosamine enolpyruvyltransferase, the target of the antibiotic fosfomycin | Q27733409 | ||
Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycin | Q27734363 | ||
Coupled formation of an amidotransferase interdomain ammonia channel and a phosphoribosyltransferase active site | Q27745868 | ||
Involvement of the C terminus in intramolecular nitrogen channeling in glucosamine 6-phosphate synthase: evidence from a 1.6 A crystal structure of the isomerase domain | Q27765339 | ||
Recent advances in the formation of the bacterial peptidoglycan monomer unit | Q28204307 | ||
Coordinated regulation of glutamine:fructose-6-phosphate amidotransferase activity by insulin, glucose, and glutamine. Role of hexosamine biosynthesis in enzyme regulation | Q28279123 | ||
Enzymes of UDP-GlcNAc biosynthesis in yeast | Q28291422 | ||
On the specificity of the uridine diphospho-N-acetylmuramyl-alanyl-D-glutamic acid: diamino acid ligase of Bifidobacterium globosum | Q28333474 | ||
Comparison of the UDP-N-acetylmuramate:L-alanine ligase enzymes from Mycobacterium tuberculosis and Mycobacterium leprae | Q28487429 | ||
Characterisation of ATP-dependent Mur ligases involved in the biogenesis of cell wall peptidoglycan in Mycobacterium tuberculosis | Q28488668 | ||
Identification of the Pseudomonas aeruginosa glmM gene, encoding phosphoglucosamine mutase | Q28492574 | ||
Peptidoglycan structure and architecture | Q29617858 | ||
Structural classification of proteins: new superfamilies | Q30425123 | ||
Antibiofilm activity of GlmU enzyme inhibitors against catheter-associated uropathogens | Q33241226 | ||
High-throughput screening identifies novel inhibitors of the acetyltransferase activity of Escherichia coli GlmU. | Q33427348 | ||
Expression of the Staphylococcus aureus UDP-N-acetylmuramoyl- L-alanyl-D-glutamate:L-lysine ligase in Escherichia coli and effects on peptidoglycan biosynthesis and cell growth | Q33635739 | ||
Probing the role of cysteine residues in glucosamine-1-phosphate acetyltransferase activity of the bifunctional GlmU protein from Escherichia coli: site-directed mutagenesis and characterization of the mutant enzymes | Q33736898 | ||
Reaction mechanism of phosphoglucosamine mutase from Escherichia coli. | Q33860899 | ||
Crystal structure of UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase from Escherichia coli | Q33886827 | ||
glmM operon and methicillin-resistant glmM suppressor mutants in Staphylococcus aureus | Q33975995 | ||
Essential metabolites of Mycobacterium tuberculosis and their mimics | Q34162040 | ||
The mechanism of action of fosfomycin (phosphonomycin) | Q34214482 | ||
3,5-dioxopyrazolidines, novel inhibitors of UDP-N- acetylenolpyruvylglucosamine reductase (MurB) with activity against gram-positive bacteria | Q34352165 | ||
Biosynthesis of the arabinogalactan-peptidoglycan complex of Mycobacterium tuberculosis | Q34368680 | ||
The MurE synthetase from Thermotoga maritima is endowed with an unusual D-lysine adding activity | Q34510574 | ||
Structure, function and dynamics in the mur family of bacterial cell wall ligases | Q34560768 | ||
From Lobry de Bruyn to enzyme-catalyzed ammonia channelling: molecular studies of D-glucosamine-6P synthase | Q34569819 | ||
Structure of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC). | Q34586308 | ||
Glucosamine-6-phosphate synthase--the multi-facets enzyme. | Q34666978 | ||
Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA. | Q34968575 | ||
Structure and function of the Mur enzymes: development of novel inhibitors | Q35030909 | ||
A role for N-acetylglucosamine as a nutrient sensor and mediator of insulin resistance | Q35100231 | ||
Identification of the glmU gene encoding N-acetylglucosamine-1-phosphate uridyltransferase in Escherichia coli. | Q36122633 | ||
Incorporation of LL-diaminopimelic acid into peptidoglycan of Escherichia coli mutants lacking diaminopimelate epimerase encoded by dapF. | Q36202185 | ||
The biosynthesis of peptidoglycan lipid-linked intermediates | Q37032866 | ||
Cytoplasmic steps of peptidoglycan biosynthesis | Q37081699 | ||
Highlights of glucosamine-6P synthase catalysis | Q37086239 | ||
??? | Q27748883 | ||
Dynamics of glucosamine-6-phosphate synthase catalysis | Q37779930 | ||
Integrated approach to structure-based enzymatic drug design: molecular modeling, spectroscopy, and experimental bioactivity | Q38136283 | ||
Identification and characterization of amino acid residues essential for the active site of UDP-N-acetylenolpyruvylglucosamine reductase (MurB) from Staphylococcus aureus | Q38319722 | ||
Comparison of the D-glutamate-adding enzymes from selected gram-positive and gram-negative bacteria | Q39497213 | ||
Homology modeling, molecular dynamics and QM/MM study of the regulatory protein PhoP from Corynebacterium pseudotuberculosis | Q39736119 | ||
Comparative genomic assessment of novel broad-spectrum targets for antibacterial drugs | Q39776959 | ||
DEG: a database of essential genes | Q40403112 | ||
The versatility of phosphoenolpyruvate and its vinyl ether products in biosynthesis | Q41112852 | ||
When fold is not important: a common structural framework for adenine and AMP binding in 12 unrelated protein families | Q42621329 | ||
Kinetic and crystallographic studies of Escherichia coli UDP-N-acetylmuramate:L-alanine ligase | Q42845111 | ||
Binding of substrates and modifiers to glucosamine synthetase | Q42922023 | ||
Inhibitors of the bacterial cell wall biosynthesis enzyme MurC. | Q43621566 | ||
Phenyl thiazolyl urea and carbamate derivatives as new inhibitors of bacterial cell-wall biosynthesis | Q43835367 | ||
Benzylidene rhodanines as novel inhibitors of UDP-N-acetylmuramate/L-alanine ligase | Q43886263 | ||
Discovery of the first antibacterial small molecule inhibitors of MurB. | Q44345485 | ||
Nonenzymatic Breakdown of the Tetrahedral (α-Carboxyketal Phosphate) Intermediates of MurA and AroA, Two Carboxyvinyl Transferases. Protonation of Different Functional Groups Controls the Rate and Fate of Breakdown | Q44609711 | ||
Identification of amino acids involved in catalytic process of M. tuberculosis GlmU acetyltransferase | Q46115851 | ||
Crystal structure of an Udp-n-acetylmuramate-alanine ligase MurC (TM0231) from Thermotoga maritima at 2.3 A resolution | Q46128390 | ||
The unusual binding mode of cnicin to the antibacterial target enzyme MurA revealed by X-ray crystallography | Q46450774 | ||
4-Alkyl and 4,4'-dialkyl 1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione derivatives as new inhibitors of bacterial cell wall biosynthesis | Q46465514 | ||
Identification of the Streptococcus gordonii glmM gene encoding phosphoglucosamine mutase and its role in bacterial cell morphology, biofilm formation, and sensitivity to antibiotics | Q46608054 | ||
Glutamine binding opens the ammonia channel and activates glucosamine-6P synthase | Q46844173 | ||
Staphylococcus aureus MurC participates in L-alanine recognition via histidine 343, a conserved motif in the shallow hydrophobic pocket | Q46847275 | ||
Alteration of a single amino acid residue reverses fosfomycin resistance of recombinant MurA from Mycobacterium tuberculosis | Q47904411 | ||
Kinetic mechanism of the Escherichia coli UDPMurNAc-tripeptide D-alanyl-D-alanine-adding enzyme: use of a glutathione S-transferase fusion | Q48056619 | ||
Over-production, purification and properties of the uridine diphosphate N-acetylmuramoyl-L-alanine:D-glutamate ligase from Escherichia coli | Q48194967 | ||
Letter: New antibacterial agent via photofluorination of a bacterial cell wall constituent | Q50234846 | ||
Evaluation of the kinetic mechanism of Escherichia coli uridine diphosphate-N-acetylmuramate:L-alanine ligase. | Q52262082 | ||
Steady-state kinetic mechanism of Escherichia coli UDP-N-acetylenolpyruvylglucosamine reductase. | Q52344239 | ||
2-Aminotetralones: novel inhibitors of MurA and MurZ. | Q52852098 | ||
Crystal structure of UDP-N-acetylenolpyruvylglucosamine reductase (MurB) from Thermus caldophilus. | Q53584302 | ||
P433 | issue | 2 | |
P921 | main subject | Mycobacterium tuberculosis | Q130971 |
P304 | page(s) | 95-111 | |
P577 | publication date | 2015-01-29 | |
P1433 | published in | Tuberculosis | Q15757844 |
P1476 | title | Structural and functional features of enzymes of Mycobacterium tuberculosis peptidoglycan biosynthesis as targets for drug development | |
P478 | volume | 95 |
Q40892778 | A comparative modeling and molecular docking study on Mycobacterium tuberculosis targets involved in peptidoglycan biosynthesis. |
Q90681398 | Bioinformatic Exploration of Metal-Binding Proteome of Zoonotic Pathogen Orientia tsutsugamushi |
Q51773259 | Computed insight into a peptide inhibitor preventing the induced fit mechanism of MurA enzyme from Pseudomonas aeruginosa. |
Q35816288 | Depletion of M. tuberculosis GlmU from Infected Murine Lungs Effects the Clearance of the Pathogen |
Q57046258 | Impact of Genomics on Clarifying the Evolutionary Relationships amongst Mycobacteria: Identification of Molecular Signatures Specific for the Tuberculosis-Complex of Bacteria with Potential Applications for Novel Diagnostics and Therapeutics |
Q33600161 | New Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in Mycobacteria |
Q91807571 | New tuberculosis drug targets, their inhibitors, and potential therapeutic impact |
Q57470806 | Reaching toward underexplored targets in antibacterial drug design |
Q64249427 | Revisiting Anti-tuberculosis Therapeutic Strategies That Target the Peptidoglycan Structure and Synthesis |
Q40759526 | Simulating the inhibition reaction of Mycobacterium tuberculosis L,D-transpeptidase 2 by carbapenems. |
Q55501913 | Structural and functional determination of homologs of the Mycobacterium tuberculosis N-acetylglucosamine-6-phosphate deacetylase (NagA). |
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