Structural and functional features of enzymes of Mycobacterium tuberculosis peptidoglycan biosynthesis as targets for drug development.

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Structural and functional features of enzymes of Mycobacterium tuberculosis peptidoglycan biosynthesis as targets for drug development. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.TUBE.2015.01.006
P932PMC publication ID4659487
P698PubMed publication ID25701501
P5875ResearchGate publication ID271773396

P50authorCláudio Nahum AlvesQ56788259
Glenn E.M. MaguireQ60640032
Jerônimo LameiraQ89998615
Gyanu LamichhaneQ37830009
Thavendran GovenderQ41437127
Hendrik G. KrugerQ42717752
P2093author name stringPaulo Robson Monteiro de Sousa
Guelber Cardoso Gomes
Gleiciane Leal Moraes
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The femR315 gene from Staphylococcus aureus, the interruption of which results in reduced methicillin resistance, encodes a phosphoglucosamine mutaseQ24678020
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Crystal structure of UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: meso-diaminopimelate ligase from Escherichia coliQ27629001
Crystal structures of Streptococcus pneumoniae N-acetylglucosamine-1-phosphate uridyltransferase, GlmU, in apo form at 2.33 A resolution and in complex with UDP-N-acetylglucosamine and Mg(2+) at 1.96 A resolutionQ27629008
Crystal Structures of Active Fully Assembled Substrate- and Product-Bound Complexes of UDP-N-Acetylmuramic Acid:L-Alanine Ligase (MurC) from Haemophilus influenzaeQ27641592
A new view of the mechanisms of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) and 5-enolpyruvylshikimate-3-phosphate synthase (AroA) derived from X-ray structures of their tetrahedral reaction intermediate statesQ27642065
Crystal structure of uridine-diphospho-N-acetylglucosamine pyrophosphorylase from Candida albicans and catalytic reaction mechanismQ27644263
Structural and functional characterization of enantiomeric glutamic acid derivatives as potential transition state analogue inhibitors of MurD ligaseQ27644808
Structure of a small-molecule inhibitor complexed with GlmU from Haemophilus influenzae reveals an allosteric binding siteQ27649707
PknB-mediated phosphorylation of a novel substrate, N-acetylglucosamine-1-phosphate uridyltransferase, modulates its acetyltransferase activityQ27653322
Structure and function of GlmU fromMycobacterium tuberculosisQ27653924
ATP-dependent MurE ligase in Mycobacterium tuberculosis: biochemical and structural characterisationQ27658363
The Fungal Product Terreic Acid Is a Covalent Inhibitor of the Bacterial Cell Wall Biosynthetic Enzyme UDP- N -Acetylglucosamine 1-Carboxyvinyltransferase (MurA),Q27660525
Essential residues for the enzyme activity of ATP-dependent MurE ligase from Mycobacterium tuberculosisQ27666292
Crystal structure of a bacterial phosphoglucomutase, an enzyme involved in the virulence of multiple human pathogensQ27666625
Crystal Structure of Bacillus anthracis Phosphoglucosamine Mutase, an Enzyme in the Peptidoglycan Biosynthetic PathwayQ27670473
Functional Consequence of Covalent Reaction of Phosphoenolpyruvate with UDP-N-acetylglucosamine 1-Carboxyvinyltransferase (MurA)Q27677546
The structure of the substrate-free form of MurB, an essential enzyme for the synthesis of bacterial cell wallsQ27733360
Substrate binding is required for assembly of the active conformation of the catalytic site in Ntn amidotransferases: evidence from the 1.8 A crystal structure of the glutaminase domain of glucosamine 6-phosphate synthaseQ27733391
Crystal structure of UDP-N-acetylglucosamine enolpyruvyltransferase, the target of the antibiotic fosfomycinQ27733409
Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycinQ27734363
Coupled formation of an amidotransferase interdomain ammonia channel and a phosphoribosyltransferase active siteQ27745868
Involvement of the C terminus in intramolecular nitrogen channeling in glucosamine 6-phosphate synthase: evidence from a 1.6 A crystal structure of the isomerase domainQ27765339
Recent advances in the formation of the bacterial peptidoglycan monomer unitQ28204307
Coordinated regulation of glutamine:fructose-6-phosphate amidotransferase activity by insulin, glucose, and glutamine. Role of hexosamine biosynthesis in enzyme regulationQ28279123
Enzymes of UDP-GlcNAc biosynthesis in yeastQ28291422
On the specificity of the uridine diphospho-N-acetylmuramyl-alanyl-D-glutamic acid: diamino acid ligase of Bifidobacterium globosumQ28333474
Comparison of the UDP-N-acetylmuramate:L-alanine ligase enzymes from Mycobacterium tuberculosis and Mycobacterium lepraeQ28487429
Characterisation of ATP-dependent Mur ligases involved in the biogenesis of cell wall peptidoglycan in Mycobacterium tuberculosisQ28488668
Identification of the Pseudomonas aeruginosa glmM gene, encoding phosphoglucosamine mutaseQ28492574
Peptidoglycan structure and architectureQ29617858
Structural classification of proteins: new superfamiliesQ30425123
Antibiofilm activity of GlmU enzyme inhibitors against catheter-associated uropathogensQ33241226
High-throughput screening identifies novel inhibitors of the acetyltransferase activity of Escherichia coli GlmU.Q33427348
Expression of the Staphylococcus aureus UDP-N-acetylmuramoyl- L-alanyl-D-glutamate:L-lysine ligase in Escherichia coli and effects on peptidoglycan biosynthesis and cell growthQ33635739
Probing the role of cysteine residues in glucosamine-1-phosphate acetyltransferase activity of the bifunctional GlmU protein from Escherichia coli: site-directed mutagenesis and characterization of the mutant enzymesQ33736898
Reaction mechanism of phosphoglucosamine mutase from Escherichia coli.Q33860899
Crystal structure of UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase from Escherichia coliQ33886827
glmM operon and methicillin-resistant glmM suppressor mutants in Staphylococcus aureusQ33975995
Essential metabolites of Mycobacterium tuberculosis and their mimicsQ34162040
The mechanism of action of fosfomycin (phosphonomycin)Q34214482
3,5-dioxopyrazolidines, novel inhibitors of UDP-N- acetylenolpyruvylglucosamine reductase (MurB) with activity against gram-positive bacteriaQ34352165
Biosynthesis of the arabinogalactan-peptidoglycan complex of Mycobacterium tuberculosisQ34368680
The MurE synthetase from Thermotoga maritima is endowed with an unusual D-lysine adding activityQ34510574
Structure, function and dynamics in the mur family of bacterial cell wall ligasesQ34560768
From Lobry de Bruyn to enzyme-catalyzed ammonia channelling: molecular studies of D-glucosamine-6P synthaseQ34569819
Structure of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC).Q34586308
Glucosamine-6-phosphate synthase--the multi-facets enzyme.Q34666978
Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA.Q34968575
Structure and function of the Mur enzymes: development of novel inhibitorsQ35030909
A role for N-acetylglucosamine as a nutrient sensor and mediator of insulin resistanceQ35100231
Identification of the glmU gene encoding N-acetylglucosamine-1-phosphate uridyltransferase in Escherichia coli.Q36122633
Incorporation of LL-diaminopimelic acid into peptidoglycan of Escherichia coli mutants lacking diaminopimelate epimerase encoded by dapF.Q36202185
The biosynthesis of peptidoglycan lipid-linked intermediatesQ37032866
Cytoplasmic steps of peptidoglycan biosynthesisQ37081699
Highlights of glucosamine-6P synthase catalysisQ37086239
???Q27748883
Dynamics of glucosamine-6-phosphate synthase catalysisQ37779930
Integrated approach to structure-based enzymatic drug design: molecular modeling, spectroscopy, and experimental bioactivityQ38136283
Identification and characterization of amino acid residues essential for the active site of UDP-N-acetylenolpyruvylglucosamine reductase (MurB) from Staphylococcus aureusQ38319722
Comparison of the D-glutamate-adding enzymes from selected gram-positive and gram-negative bacteriaQ39497213
Homology modeling, molecular dynamics and QM/MM study of the regulatory protein PhoP from Corynebacterium pseudotuberculosisQ39736119
Comparative genomic assessment of novel broad-spectrum targets for antibacterial drugsQ39776959
DEG: a database of essential genesQ40403112
The versatility of phosphoenolpyruvate and its vinyl ether products in biosynthesisQ41112852
When fold is not important: a common structural framework for adenine and AMP binding in 12 unrelated protein familiesQ42621329
Kinetic and crystallographic studies of Escherichia coli UDP-N-acetylmuramate:L-alanine ligaseQ42845111
Binding of substrates and modifiers to glucosamine synthetaseQ42922023
Inhibitors of the bacterial cell wall biosynthesis enzyme MurC.Q43621566
Phenyl thiazolyl urea and carbamate derivatives as new inhibitors of bacterial cell-wall biosynthesisQ43835367
Benzylidene rhodanines as novel inhibitors of UDP-N-acetylmuramate/L-alanine ligaseQ43886263
Discovery of the first antibacterial small molecule inhibitors of MurB.Q44345485
Nonenzymatic Breakdown of the Tetrahedral (α-Carboxyketal Phosphate) Intermediates of MurA and AroA, Two Carboxyvinyl Transferases. Protonation of Different Functional Groups Controls the Rate and Fate of BreakdownQ44609711
Identification of amino acids involved in catalytic process of M. tuberculosis GlmU acetyltransferaseQ46115851
Crystal structure of an Udp-n-acetylmuramate-alanine ligase MurC (TM0231) from Thermotoga maritima at 2.3 A resolutionQ46128390
The unusual binding mode of cnicin to the antibacterial target enzyme MurA revealed by X-ray crystallographyQ46450774
4-Alkyl and 4,4'-dialkyl 1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione derivatives as new inhibitors of bacterial cell wall biosynthesisQ46465514
Identification of the Streptococcus gordonii glmM gene encoding phosphoglucosamine mutase and its role in bacterial cell morphology, biofilm formation, and sensitivity to antibioticsQ46608054
Glutamine binding opens the ammonia channel and activates glucosamine-6P synthaseQ46844173
Staphylococcus aureus MurC participates in L-alanine recognition via histidine 343, a conserved motif in the shallow hydrophobic pocketQ46847275
Alteration of a single amino acid residue reverses fosfomycin resistance of recombinant MurA from Mycobacterium tuberculosisQ47904411
Kinetic mechanism of the Escherichia coli UDPMurNAc-tripeptide D-alanyl-D-alanine-adding enzyme: use of a glutathione S-transferase fusionQ48056619
Over-production, purification and properties of the uridine diphosphate N-acetylmuramoyl-L-alanine:D-glutamate ligase from Escherichia coliQ48194967
Letter: New antibacterial agent via photofluorination of a bacterial cell wall constituentQ50234846
Evaluation of the kinetic mechanism of Escherichia coli uridine diphosphate-N-acetylmuramate:L-alanine ligase.Q52262082
Steady-state kinetic mechanism of Escherichia coli UDP-N-acetylenolpyruvylglucosamine reductase.Q52344239
2-Aminotetralones: novel inhibitors of MurA and MurZ.Q52852098
Crystal structure of UDP-N-acetylenolpyruvylglucosamine reductase (MurB) from Thermus caldophilus.Q53584302
P433issue2
P921main subjectMycobacterium tuberculosisQ130971
P304page(s)95-111
P577publication date2015-01-29
P1433published inTuberculosisQ15757844
P1476titleStructural and functional features of enzymes of Mycobacterium tuberculosis peptidoglycan biosynthesis as targets for drug development
P478volume95

Reverse relations

cites work (P2860)
Q40892778A comparative modeling and molecular docking study on Mycobacterium tuberculosis targets involved in peptidoglycan biosynthesis.
Q90681398Bioinformatic Exploration of Metal-Binding Proteome of Zoonotic Pathogen Orientia tsutsugamushi
Q51773259Computed insight into a peptide inhibitor preventing the induced fit mechanism of MurA enzyme from Pseudomonas aeruginosa.
Q35816288Depletion of M. tuberculosis GlmU from Infected Murine Lungs Effects the Clearance of the Pathogen
Q57046258Impact of Genomics on Clarifying the Evolutionary Relationships amongst Mycobacteria: Identification of Molecular Signatures Specific for the Tuberculosis-Complex of Bacteria with Potential Applications for Novel Diagnostics and Therapeutics
Q33600161New Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in Mycobacteria
Q91807571New tuberculosis drug targets, their inhibitors, and potential therapeutic impact
Q57470806Reaching toward underexplored targets in antibacterial drug design
Q64249427Revisiting Anti-tuberculosis Therapeutic Strategies That Target the Peptidoglycan Structure and Synthesis
Q40759526Simulating the inhibition reaction of Mycobacterium tuberculosis L,D-transpeptidase 2 by carbapenems.
Q55501913Structural and functional determination of homologs of the Mycobacterium tuberculosis N-acetylglucosamine-6-phosphate deacetylase (NagA).

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