Cytoplasmic steps of peptidoglycan biosynthesis

scientific article published on 11 February 2008

Cytoplasmic steps of peptidoglycan biosynthesis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/J.1574-6976.2008.00104.X
P698PubMed publication ID18266853
P5875ResearchGate publication ID5585020

P50authorStanislav GobecQ41595019
P2093author name stringAndreja Kovac
Didier Blanot
Hélène Barreteau
Audrey Boniface
Matej Sova
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Structural and functional analysis of two glutamate racemase isozymes from Bacillus anthracis and implications for inhibitor designQ24643595
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Crystal structure of the bifunctional N-acetylglucosamine 1-phosphate uridyltransferase from Escherichia coli: a paradigm for the related pyrophosphorylase superfamilyQ27619240
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Crystal structure of Streptococcus pneumoniae N-acetylglucosamine-1-phosphate uridyltransferase bound to acetyl-coenzyme A reveals a novel active site architectureQ27628944
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(E)-enolbutyryl-UDP-N-acetylglucosamine as a mechanistic probe of UDP-N-acetylenolpyruvylglucosamine reductase (MurB)Q27732705
The structure of the substrate-free form of MurB, an essential enzyme for the synthesis of bacterial cell wallsQ27733360
Substrate binding is required for assembly of the active conformation of the catalytic site in Ntn amidotransferases: evidence from the 1.8 A crystal structure of the glutaminase domain of glucosamine 6-phosphate synthaseQ27733391
Crystal structure of UDP-N-acetylglucosamine enolpyruvyltransferase, the target of the antibiotic fosfomycinQ27733409
Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycinQ27734363
X-ray crystal structures of the S229A mutant and wild-type MurB in the presence of the substrate enolpyruvyl-UDP-N-acetylglucosamine at 1.8-A resolutionQ27734743
D-alanine:D-alanine ligase: phosphonate and phosphinate intermediates with wild type and the Y216F mutantQ27734914
Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin.Q54590227
Regulation of the glutamate racemase of Escherichia coli investigated by site-directed mutagenesis.Q54590633
Study of the overproduced uridine-diphosphate-N-acetylmuramate:L-alanine ligase from Escherichia coli.Q54590638
Structural studies of Escherichia coli UDP-N-acetylmuramate:L-alanine ligase.Q54593807
Biochemical evidence for the formation of a covalent acyl-phosphate linkage between UDP-N-acetylmuramate and ATP in the Escherichia coli UDP-N-acetylmuramate:L-alanine ligase-catalyzed reaction.Q54593810
The mode of action of bacilysin and anticapsin and biochemical properties of bacilysin-resistant mutantsQ54613752
Detection of the covalent intermediate of UDP-N-acetylglucosamine enolpyruvyl transferase by solution-state and time-resolved solid-state NMR spectroscopy.Q54622132
The glutamate racemase activity from Escherichia coli is regulated by peptidoglycan precursor UDP-N-acetylmuramoyl-L-alanine.Q54633620
Over-production, purification and properties of the uridine-diphosphate-N-acetylmuramoyl-L-alanyl-D-glutamate: meso-2,6-diaminopimelate ligase from Escherichia coli.Q54704735
Partial purification and specificity studies of the D-glutamate-adding and D-alanyl-D-alanine-adding enzymes from Escherichia coli K12.Q54762576
Glucosamine synthetase from Escherichia coli: purification, properties, and glutamine-utilizing site location.Q54765865
Specificity of the uridine-diphosphate-N-acetylmuramyl-L-alanyl-D-glutamate: meso-2,6-diaminopimelate synthetase from Escherichia coli.Q54790491
Crystal Structures ofN-Acetylglucosamine-phosphate Mutase, a Member of the α-d-Phosphohexomutase Superfamily, and Its Substrate and Product ComplexesQ56689893
Thermotoga maritima sp. nov. represents a new genus of unique extremely thermophilic eubacteria growing up to 90°CQ56701239
Crystallization and Preliminary X-ray Analysis of the Two Domains of Glucosamine-6-phosphate Synthase from Escherichia coliQ57276497
Formation and Stability of Organic Zwitterions in Aqueous Solution: Enolates of the Amino Acid Glycine and Its DerivativesQ57880470
Lysine 22 in UDP-N-Acetylglucosamine Enolpyruvyl Transferase fromEnterobacter cloacaeIs Crucial for Enzymatic Activity and the Formation of Covalent Adducts with the Substrate Phosphoenolpyruvate and the Antibiotic Fosfomycin†Q57978316
Role of the Ortholog and Paralog Amino Acid Invariants in the Active Site of the UDP-MurNAc-l-alanine:d-glutamate Ligase (MurD)†Q57998973
Invariant Amino Acids in the Mur Peptide Synthetases of Bacterial Peptidoglycan Synthesis and Their Modification by Site-Directed Mutagenesis in the UDP-MurNAc:l-Alanine Ligase from Escherichia coliQ57998991
Reverse-phase high-pressure liquid chromatography of uridine diphosphate N-acetylmuramyl peptide precursors of bacterial cell wall peptidoglycanQ57999080
Phosphinate Inhibitors of UDP-N-Acetylmuramoyl-L-Alanyl-D-Glutamate:L-Lysine Ligase (MurE)Q58216076
A new approach towards peptidosulfonamides: synthesis of potential inhibitors of bacterial peptidoglycan biosynthesis enzymes MurD and MurEQ58216085
Quantitative Structure-Activity Relationships ofStreptococcus pneumoniae MurD Transition State Analogue InhibitorsQ58216123
A Molecular Dynamics Simulation of the Binding Modes ofd-Glutamate andd-Glutamine to Glutamate RacemaseQ58616189
Phosphonopeptides, a new class of synthetic antibacterial agentsQ59070196
Time-dependent inhibition of Bacillus stearothermophilus alanine racemase by (1-aminoethyl)phosphonate isomers by isomerization to noncovalent slowly dissociating enzyme-(1-aminoethyl)phosphonate complexesQ43019265
Characterization of L-glutamine:D-fructose-6-phosphate amidotransferase from an extreme thermophile Thermus thermophilus HB8.Q43024394
D-Ala-D-X ligases: evaluation of D-alanyl phosphate intermediate by MIX, PIX and rapid quench studiesQ43505305
Dissection of the bifunctional Escherichia coli N-acetylglucosamine-1-phosphate uridyltransferase enzyme into autonomously functional domains and evidence that trimerization is absolutely required for glucosamine-1-phosphate acetyltransferase activiQ43510086
Asparagine 23 and aspartate 305 are essential residues in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase from Enterobacter cloacaeQ43591572
Inhibitors of the bacterial cell wall biosynthesis enzyme MurC.Q43621566
An efficient chemoenzymatic strategy for the synthesis of wild-type and vancomycin-resistant bacterial cell-wall precursors: UDP-N-acetylmuramyl-peptidesQ43754436
Phenyl thiazolyl urea and carbamate derivatives as new inhibitors of bacterial cell-wall biosynthesisQ43835367
Characterization and inhibition study of MurA enzyme by capillary electrophoresisQ43871900
Benzylidene rhodanines as novel inhibitors of UDP-N-acetylmuramate/L-alanine ligaseQ43886263
Synthesis and antimicrobial activities of N-substituted imidesQ44023577
4-Substituted D-glutamic acid analogues: the first potent inhibitors of glutamate racemase (MurI) enzyme with antibacterial activityQ44101696
Discovery of the first antibacterial small molecule inhibitors of MurB.Q44345485
N(2)-substituted D,L-cycloserine derivatives: synthesis and evaluation as alanine racemase inhibitorsQ44418072
Synthesis and evaluation of inhibitors of bacterial D-alanine:D-alanine ligasesQ44437680
A structure-based design approach for the identification of novel inhibitors: application to an alanine racemase.Q44490685
2-Phenyl-5,6-dihydro-2H-thieno[3,2-c]pyrazol-3-ol derivatives as new inhibitors of bacterial cell wall biosynthesisQ44508067
Conversion of a PLP-dependent racemase into an aldolase by a single active site mutationQ44554743
Bacterial diaminopimelate metabolism as a target for antibiotic design.Q33959033
Glutamate racemase is an endogenous DNA gyrase inhibitorQ34147905
Differences in effects on DNA gyrase activity between two glutamate racemases of Bacillus subtilis, the poly-gamma-glutamate synthesis-linking Glr enzyme and the YrpC (MurI) isozymeQ34209278
Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2.Q34215657
Mutant analysis shows that alanine racemases from Pseudomonas aeruginosa and Escherichia coli are dimeric.Q34315547
3,5-dioxopyrazolidines, novel inhibitors of UDP-N- acetylenolpyruvylglucosamine reductase (MurB) with activity against gram-positive bacteriaQ34352165
Characterization of the essential gene glmM encoding phosphoglucosamine mutase in Escherichia coliQ34370285
Substrate-induced conformational changes in Bacillus subtilis glutamate racemase and their implications for drug discovery.Q34465494
Properties of glutamate racemase from Bacillus subtilis IFO 3336 producing poly-gamma-glutamateQ34469721
The MurE synthetase from Thermotoga maritima is endowed with an unusual D-lysine adding activityQ34510574
In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistanceQ34514901
Intracellular steps of bacterial cell wall peptidoglycan biosynthesis: enzymology, antibiotics, and antibiotic resistanceQ34541598
Structure, function and dynamics in the mur family of bacterial cell wall ligasesQ34560768
Structure of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC).Q34586308
Targeted molecular dynamics simulation studies of binding and conformational changes in E. coli MurD.Q34618181
Inhibition of lysine biosynthesis: an evolving antibiotic strategyQ34639518
Biochemistry and molecular genetics of poly-gamma-glutamate synthesisQ34694668
Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA.Q34968575
Structure and function of the Mur enzymes: development of novel inhibitorsQ35030909
Allosteric inhibition of Staphylococcus aureus D-alanine:D-alanine ligase revealed by crystallographic studiesQ35108119
Identification of the mpl gene encoding UDP-N-acetylmuramate: L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase in Escherichia coli and its role in recycling of cell wall peptidoglycan.Q35612553
Antibacterial activity and mechanism of action of phosphonopeptides based on aminomethylphosphonic acidQ35717981
Bacterial glutamate racemase has high sequence similarity with myoglobins and forms an equimolar inactive complex with heminQ35835152
The murI gene of Escherichia coli is an essential gene that encodes a glutamate racemase activityQ36100042
Replacement of diaminopimelic acid by cystathionine or lanthionine in the peptidoglycan of Escherichia coliQ36109102
Identification of the glmU gene encoding N-acetylglucosamine-1-phosphate uridyltransferase in Escherichia coli.Q36122633
Organization of the murE-murG region of Escherichia coli: identification of the murD gene encoding the D-glutamic-acid-adding enzymeQ36184376
Incorporation of LL-diaminopimelic acid into peptidoglycan of Escherichia coli mutants lacking diaminopimelate epimerase encoded by dapF.Q36202185
Isolation, cloning, and sequencing of the Salmonella typhimurium ddlA gene with purification and characterization of its product, D-alanine:D-alanine ligase (ADP forming).Q36350077
Poly-gamma-glutamate in bacteriaQ36475462
Phosphonopeptides as Antibacterial Agents: Rationale, Chemistry, and Structure-Activity RelationshipsQ36480646
Mechanism of the reaction catalyzed by glutamate racemaseQ36741279
DNA sequence of the murE-murD region of Bacillus subtilis 168.Q36777227
Nonenzymatic Breakdown of the Tetrahedral (α-Carboxyketal Phosphate) Intermediates of MurA and AroA, Two Carboxyvinyl Transferases. Protonation of Different Functional Groups Controls the Rate and Fate of BreakdownQ44609711
A method for the enzymatic synthesis and HPLC purification of the peptidoglycan precursor UDP-N-acetylmuramic acidQ44682573
Expression, purification, crystallization and preliminary characterization of uridine 5'-diphospho-N-acetylmuramoyl L-alanyl-D-glutamate:lysine ligase (MurE) from Streptococcus pneumoniae 110K/70.Q44745412
Multiple substrate binding states and chiral recognition in cofactor-independent glutamate racemase: a molecular dynamics studyQ44993613
The gate controlling cell wall synthesis in Staphylococcus aureusQ45014796
Roles and regulation of the glutamate racemase isogenes, racE and yrpC, in Bacillus subtilis.Q45044325
UDP-N-acetylmuramic acid (UDP-MurNAc) is a potent inhibitor of MurA (enolpyruvyl-UDP-GlcNAc synthase).Q45307734
Crystal structure of an Udp-n-acetylmuramate-alanine ligase MurC (TM0231) from Thermotoga maritima at 2.3 A resolutionQ46128390
Effect of a Y265F mutant on the transamination-based cycloserine inactivation of alanine racemaseQ46419302
Efficient gene inactivation in Bacillus anthracisQ46443271
4-Alkyl and 4,4'-dialkyl 1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione derivatives as new inhibitors of bacterial cell wall biosynthesisQ46465514
Stereochemistry of reactions of the inhibitor/substrates L- and D-beta-chloroalanine with beta-mercaptoethanol catalysed by L-aspartate aminotransferase and D-amino acid aminotransferase respectivelyQ46678065
A de novo designed inhibitor of D-Ala-D-Ala ligase from E. coliQ46699876
Pulvinones as bacterial cell wall biosynthesis inhibitorsQ46745402
Amino acid racemases: functions and mechanismsQ46760292
D-Amino acid dipeptide production utilizing D-alanine-D-alanine ligases with novel substrate specificityQ46760957
ATP-dependent inactivation and slow binding inhibition of Salmonella typhimurium D-alanine:D-alanine ligase (ADP) by (aminoalkyl)phosphinate and aminophosphonate analogues of D-alanineQ46877284
On the ionization state of the substrate in the active site of glutamate racemase. A QM/MM study about the importance of being zwitterionic.Q46888627
Alteration of a single amino acid residue reverses fosfomycin resistance of recombinant MurA from Mycobacterium tuberculosisQ47904411
Large-scale preparation, purification, and crystallization of UDP-N-acetylmuramoyl-L-alanine: D-glutamate ligase from Escherichia coliQ47958869
Conditionally lethal Escherichia coli murein mutants contain point defects that map to regions conserved among murein and folyl poly-gamma-glutamate ligases: identification of a ligase superfamilyQ48049705
Nucleotide sequence of the Bacillus licheniformis ATCC 10716 dat gene and comparison of the predicted amino acid sequence with those of other bacterial speciesQ48055143
Kinetic mechanism of the Escherichia coli UDPMurNAc-tripeptide D-alanyl-D-alanine-adding enzyme: use of a glutathione S-transferase fusionQ48056619
Over-production, purification and properties of the uridine diphosphate N-acetylmuramoyl-L-alanine:D-glutamate ligase from Escherichia coliQ48194967
Gene cloning and characterization of alanine racemases from Shigella dysenteriae, Shigella boydii, Shigella flexneri, and Shigella sonneiQ48336633
The cell wall and cell division gene cluster in the Mra operon of Pseudomonas aeruginosa: cloning, production, and purification of active enzymesQ48372742
Catabolic alanine racemase from Salmonella typhimurium: DNA sequence, enzyme purification, and characterizationQ48386764
Mechanism of inactivation of alanine racemase by beta, beta, beta-trifluoroalanineQ50196140
Glucosamine synthetase from Escherichia coli: kinetic mechanism and inhibition by N3-fumaroyl-L-2,3-diaminopropionic derivativesQ50198102
Biosynthetic alanine racemase of Salmonella typhimurium: purification and characterization of the enzyme encoded by the alr geneQ50203224
Letter: New antibacterial agent via photofluorination of a bacterial cell wall constituentQ50234846
Rotational resonance determination of the structure of an enzyme-inhibitor complex: phosphorylation of an (aminoalkyl)phosphinate inhibitor of D-alanyl-D-alanine ligase by ATP.Q50464743
Substrate specificity of thermostable D-alanine-D-alanine ligase from Thermotoga maritima ATCC 43589.Q51107577
Expression of alr gene from Corynebacterium glutamicum ATCC 13032 in Escherichia coli and molecular characterization of the recombinant alanine racemase.Q51199505
Evaluation of the kinetic mechanism of Escherichia coli uridine diphosphate-N-acetylmuramate:L-alanine ligase.Q52262082
Steady-state kinetic mechanism of Escherichia coli UDP-N-acetylenolpyruvylglucosamine reductase.Q52344239
1-Aminocyclopropanephosphonate: time-dependent inactivation of 1-aminocyclopropanecarboxylate deaminase and Bacillus stearothermophilus alanine racemase by slow dissociation behavior.Q52594259
Macrocyclic inhibitors of the bacterial cell wall biosynthesis enzyme MurD.Q52860325
Crystal structure of UDP-N-acetylenolpyruvylglucosamine reductase (MurB) from Thermus caldophilus.Q53584302
Crystal structure of the apo form of D-alanine: D-alanine ligase (Ddl) from Thermus caldophilus: a basis for the substrate-induced conformational changes.Q53594959
Structure-based optimization of MurF inhibitors.Q53603346
Structure-activity relationships of novel potent MurF inhibitors.Q53645851
Molecular cloning and DNA sequencing of the Staphylococcus aureus UDP-N-acetylmuramyl tripeptide synthetase (murE) gene, essential for the optimal expression of methicillin resistance.Q54132723
Diazenedicarboxamides as inhibitors of D-alanine-D-alanine ligase (Ddl).Q54447540
Fluorescent reagents for in vitro studies of lipid-linked steps of bacterial peptidoglycan biosynthesis: derivatives of UDPMurNAc-pentapeptide containing d-cysteine at position 4 or 5.Q54448724
Alanine racemase from Helicobacter pylori NCTC 11637: purification, characterization and gene cloning.Q54449278
Purification of an alanine racemase from Streptococcus faecalis and analysis of its inactivation by (1-aminoethyl)phosphonic acid enantiomers.Q54453131
Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA.Q54456599
Design, synthesis and structure-activity relationships of new phosphinate inhibitors of MurD.Q54475713
Localizing the NADP+ binding site on the MurB enzyme by NMR.Q54576368
Multi gram synthesis of UDP-N-acetylmuramic acidQ33179722
Cloning and sequencing of Escherichia coli murZ and purification of its product, a UDP-N-acetylglucosamine enolpyruvyl transferaseQ33202551
Selection of peptide inhibitors against the Pseudomonas aeruginosa MurD cell wall enzymeQ33235482
Antibiofilm activity of GlmU enzyme inhibitors against catheter-associated uropathogensQ33241226
An ultraefficient affinity-based high-throughout screening process: application to bacterial cell wall biosynthesis enzyme MurF.Q33257634
A peptide inhibitor of MurA UDP-N-acetylglucosamine enolpyruvyl transferase: the first committed step in peptidoglycan biosynthesisQ33259874
Two active forms of UDP-N-acetylglucosamine enolpyruvyl transferase in gram-positive bacteriaQ33601835
Structure/function studies on enzymes in the diaminopimelate pathway of bacterial cell wall biosynthesisQ33744998
Reaction mechanism of phosphoglucosamine mutase from Escherichia coli.Q33860899
Crystal structure of UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase from Escherichia coliQ33886827
Vancomycin resistance in enterococci: reprogramming of the D-ala-D-Ala ligases in bacterial peptidoglycan biosynthesisQ33912915
Active site residues of glutamate racemaseQ33947970
Development of novel inhibitors targeting intracellular steps of peptidoglycan biosynthesisQ36907456
Synthesis of Substrates and Biochemical Probes for Study of the Peptidoglycan Biosynthetic Pathway.Q37004199
The biosynthesis of peptidoglycan lipid-linked intermediatesQ37032866
Functional and biochemical analysis of Chlamydia trachomatis MurC, an enzyme displaying UDP-N-acetylmuramate:amino acid ligase activityQ37051672
The penicillin-binding proteins: structure and role in peptidoglycan biosynthesisQ37081708
Characterization of Chlamydia MurC-Ddl, a fusion protein exhibiting D-alanyl-D-alanine ligase activity involved in peptidoglycan synthesis and D-cycloserine sensitivityQ37864633
Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product releaseQ37866109
Antibiotics, peptidoglycan synthesis and genomics: the chlamydial anomaly revisitedQ37879887
Evidence of a functional requirement for a carbamoylated lysine residue in MurD, MurE and MurF synthetases as established by chemical rescue experimentsQ38294460
Biochemical characterization of a phosphinate inhibitor of Escherichia coli MurC.Q38296349
Identification and characterization of amino acid residues essential for the active site of UDP-N-acetylenolpyruvylglucosamine reductase (MurB) from Staphylococcus aureusQ38319722
Kinetic characterization of wild-type and S229A mutant MurB: evidence for the role of Ser 229 as a general acidQ38349191
Acetyltransfer precedes uridylyltransfer in the formation of UDP-N-acetylglucosamine in separable active sites of the bifunctional GlmU protein of Escherichia coliQ38362743
Development of a whole-cell assay for peptidoglycan biosynthesis inhibitorsQ39651496
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.Q39743843
A combined quantum mechanical and molecular mechanical study of the reaction mechanism and alpha-amino acidity in alanine racemaseQ39778449
Antibacterial activities of fluorovinyl- and chlorovinylglycine and several derived dipeptidesQ39817777
Staphylococcus haemolyticus contains two D-glutamic acid biosynthetic activities, a glutamate racemase and a D-amino acid transaminaseQ39835252
Overexpression, purification, and characterization of UDP-N-acetylmuramyl:L-alanine ligase from Escherichia coliQ39840207
Identification and characterization of cell wall-cell division gene clusters in pathogenic gram-positive cocciQ39847107
Identification of tms-26 as an allele of the gcaD gene, which encodes N-acetylglucosamine 1-phosphate uridyltransferase in Bacillus subtilisQ39939478
Inhibition of cell wall biosynthesis by analogues and alanineQ40322615
Phosphonopeptides as Antibacterial Agents: Mechanism of Action of AlaphosphinQ40620468
Kinetic characterization of human glutamine-fructose-6-phosphate amidotransferase I: potent feedback inhibition by glucosamine 6-phosphateQ40751230
Suicide substrates for the alanine racemase of Escherichia coli BQ40897122
The versatility of phosphoenolpyruvate and its vinyl ether products in biosynthesisQ41112852
The DAP pathway to lysine as a target for antimicrobial agentsQ41213702
UDP-N-acetylmuramyl-L-alanine functions as an activator in the regulation of the Escherichia coli glutamate racemase activityQ41367752
D-alanine: D-alanine ligase of Escherichia coli. Expression, purification and inhibitory studies on the cloned enzymeQ41918276
Functional comparison of the two Bacillus anthracis glutamate racemasesQ41973066
Utility of muropeptide ligase for identification of inhibitors of the cell wall biosynthesis enzyme MurF.Q41991873
Functional and structural characterization of thermostable D-amino acid aminotransferases from Geobacillus spp.Q42122309
(1-Aminoethyl)boronic acid: a novel inhibitor for Bacillus stearothermophilus alanine racemase and Salmonella typhimurium D-alanine:D-alanine ligase (ADP-forming).Q42195961
(1-Amino-2-propenyl) phosphonic acid, an inhibitor of alanine racemase and D-alanine:D-alanine ligaseQ42201557
Inactivation of glucosamine-6-phosphate synthetase from Salmonella typhimurium LT2 by fumaroyl diaminopropanoic acid derivatives, a novel group of glutamine analogsQ42207279
Chloroalanyl antibiotic peptides: antagonism of their antimicrobial effects by L-alanine and L-alanyl peptides in gram-negative bacteriaQ42207679
Phosphinic acid inhibitors of D-alanyl-D-alanine ligaseQ42209062
Inhibition of alanine racemase by alanine phosphonate: detection of an imine linkage to pyridoxal 5'-phosphate in the enzyme-inhibitor complex by solid-state 15N nuclear magnetic resonanceQ42209759
Inactivation of the dadB Salmonella typhimurium alanine racemase by D and L isomers of beta-substituted alanines: kinetics, stoichiometry, active site peptide sequencing, and reaction mechanismQ42249414
The UDP-N-acetylglucosamine 1-carboxyvinyl-transferase of Enterobacter cloacae. Molecular cloning, sequencing of the gene and overexpression of the enzymeQ42610701
Purification, cloning, and cofactor independence of glutamate racemase from LactobacillusQ42616162
Biochemical characterization and physiological properties of Escherichia coli UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligaseQ42619319
The dnaB-pheA (256 degrees-240 degrees) region of the Bacillus subtilis chromosome containing genes responsible for stress responses, the utilization of plant cell walls and primary metabolism.Q42646571
A novel inhibitor that suspends the induced fit mechanism of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA).Q42647502
Studies on the conformational changes in the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine enolpyruvyltransferase (MurA).Q42680309
Kinetic and crystallographic studies of Escherichia coli UDP-N-acetylmuramate:L-alanine ligaseQ42845111
Binding of substrates and modifiers to glucosamine synthetaseQ42922023
Thermostable alanine racemase from Bacillus stearothermophilus: molecular cloning of the gene, enzyme purification, and characterizationQ43018683
Determination of the structure of alanine racemase from Bacillus stearothermophilus at 1.9-A resolutionQ27734979
Crystallographic study of steps along the reaction pathway of D-amino acid aminotransferaseQ27749055
Reaction of alanine racemase with 1-aminoethylphosphonic acid forms a stable external aldimineQ27764847
Involvement of the C terminus in intramolecular nitrogen channeling in glucosamine 6-phosphate synthase: evidence from a 1.6 A crystal structure of the isomerase domainQ27765339
Crystal structures of L201A mutant of D-amino acid aminotransferase at 2.0 A resolution: implication of the structural role of Leu201 in transaminationQ27765358
Effects of the E177K mutation in D-amino acid transaminase. Studies on an essential coenzyme anchoring group that contributes to stereochemical fidelityQ27766864
Characterization of the essential yeast gene encoding N-acetylglucosamine-phosphate mutase.Q27932464
Saccharomyces cerevisiae GNA1, an essential gene encoding a novel acetyltransferase involved in UDP-N-acetylglucosamine synthesisQ27935714
The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases. Gene cloning, protein expression, and catalytic mechanism.Q27936943
Structure-based design approaches to cell wall biosynthesis inhibitorsQ28188973
Recent advances in the formation of the bacterial peptidoglycan monomer unitQ28204307
Understanding nature's strategies for enzyme-catalyzed racemization and epimerizationQ28214770
Molecular characterization of cyanophycin synthetase, the enzyme catalyzing the biosynthesis of the cyanobacterial reserve material multi-L-arginyl-poly-L-aspartate (cyanophycin)Q28275610
Enzymes of UDP-GlcNAc biosynthesis in yeastQ28291422
On the specificity of the uridine diphospho-N-acetylmuramyl-alanyl-D-glutamic acid: diamino acid ligase of Bifidobacterium globosumQ28333474
(3-Amino-2-oxoalkyl)phosphonic acids and their analogues as novel inhibitors of D-alanine:D-alanine ligaseQ28340967
Characterization of the alanine racemases from two mycobacteriaQ28486479
Comparison of the UDP-N-acetylmuramate:L-alanine ligase enzymes from Mycobacterium tuberculosis and Mycobacterium lepraeQ28487429
The 1.9 A crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active siteQ28487493
Selection of an antibiotic-hypersusceptible mutant of Pseudomonas aeruginosa: identification of the GlmR transcriptional regulatorQ28492559
Identification of the Pseudomonas aeruginosa glmM gene, encoding phosphoglucosamine mutaseQ28492574
Characterization of the alanine racemases from Pseudomonas aeruginosa PAO1Q28493169
Purification and characterization of glutamine:fructose 6-phosphate amidotransferase from rat liverQ28565721
Peptidoglycan structure and architectureQ29617858
Structural and functional similarities in the ADP-forming amide bond ligase superfamily: implications for a substrate-induced conformational change in folylpolyglutamate synthetase.Q30610962
Isolation of peptide ligands that inhibit glutamate racemase activity from a random phage display libraryQ30734306
Purification and characterization of the bacterial MraY translocase catalyzing the first membrane step of peptidoglycan biosynthesisQ30831090
An array of target-specific screening strains for antibacterial discoveryQ30834642
Identification of novel inhibitors of Pseudomonas aeruginosa MurC enzyme derived from phage-displayed peptide librariesQ30890784
Existence of two D-alanine:D-alanine ligases in Escherichia coli: cloning and sequencing of the ddlA gene and purification and characterization of the DdlA and DdlB enzymesQ30909765
Determination of the pKa value of C115 in MurA (UDP-N-acetylglucosamine enolpyruvyltransferase) from Enterobacter cloacaeQ30940018
Identification and characterization of new inhibitors of the Escherichia coli MurA enzymeQ31016009
Biochemical characterization of an inhibitor of Escherichia coli UDP-N-acetylmuramyl-l-alanine ligaseQ31059732
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P433issue2
P304page(s)168-207
P577publication date2008-02-11
P1433published inFEMS Microbiology ReviewsQ15762226
P1476titleCytoplasmic steps of peptidoglycan biosynthesis
P478volume32

Reverse relations

cites work (P2860)
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Q28551115Crystallographic Study of Peptidoglycan Biosynthesis Enzyme MurD: Domain Movement Revisited
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Q41502815D-amino carboxamide-based recruitment of dinitrophenol antibodies to bacterial surfaces via peptidoglycan remodeling
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Q82603395Homology modeling and docking analyses of M. leprae Mur ligases reveals the common binding residues for structure based drug designing to eradicate leprosy
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Q41883174Identification of ypqP as a New Bacillus subtilis biofilm determinant that mediates the protection of Staphylococcus aureus against antimicrobial agents in mixed-species communities.
Q38366006Illumination of growth, division and secretion by metabolic labeling of the bacterial cell surface
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Q36257218Lactobacillus acidophilus-Rutin Interplay Investigated by Proteomics.
Q26770493Lipid Flippases for Bacterial Peptidoglycan Biosynthesis
Q38667595Lytic transglycosylases: concinnity in concision of the bacterial cell wall
Q58751722Mechanical Genomic Studies Reveal the Role of d-Alanine Metabolism in Pseudomonas aeruginosa Cell Stiffness
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Q64992611Minimal exposure of lipid II cycle intermediates triggers cell wall antibiotic resistance.
Q47803193Model-driven design of a minimal medium for Akkermansia muciniphila confirms mucus adaptation
Q33478419Modulation of gene expression in Actinobacillus pleuropneumoniae exposed to bronchoalveolar fluid
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Q38782638Mycobacterial cell wall biosynthesis: a multifaceted antibiotic target
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Q99590699Organoarsenicals inhibit bacterial peptidoglycan biosynthesis by targeting the essential enzyme MurA
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Q92867218Peptidoglycan
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Q92926869Phosphorylation-Dependent Effects on the Structural Flexibility of Phosphoglucosamine Mutase from Bacillus anthracis
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Q41381064Purification and biochemical characterisation of GlmU from Yersinia pestis
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Q92860342Screening of natural compounds that targets glutamate racemase of Mycobacterium tuberculosis reveals the anti-tubercular potential of flavonoids
Q38610086Sequence-structure relationships, expression profiles, and disease-associated mutations in the paralogs of phosphoglucomutase 1
Q34165420Serine/threonine protein phosphatase-mediated control of the peptidoglycan cross-linking L,D-transpeptidase pathway in Enterococcus faecium
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Q37378671Specific labeling of peptidoglycan precursors as a tool for bacterial cell wall studies
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Q36319020Structural and functional features of enzymes of Mycobacterium tuberculosis peptidoglycan biosynthesis as targets for drug development.
Q58699706Structural basis of cell wall peptidoglycan amidation by the GatD/MurT complex of Staphylococcus aureus
Q27680320Structure and Function of a Novel LD-Carboxypeptidase A Involved in Peptidoglycan Recycling
Q27667344Structure and Function of the First Full-Length Murein Peptide Ligase (Mpl) Cell Wall Recycling Protein
Q34664425Structure based virtual screening to identify inhibitors against MurE Enzyme of Mycobacterium tuberculosis using AutoDock Vina
Q57170139Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae
Q27655339Structure ofN-acetylglucosamine-1-phosphate uridyltransferase (GlmU) fromMycobacterium tuberculosisin a cubic space group
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Q27678828Substrate Channel Flexibility in Pseudomonas aeruginosa MurB Accommodates Two Distinct Substrates
Q44780083Substrate promiscuity of N-acetylhexosamine 1-kinases
Q34194875Subtractive genomics approach to identify putative drug targets and identification of drug-like molecules for beta subunit of DNA polymerase III in Streptococcus species
Q39257480Suppressor Mutations Linking gpsB with the First Committed Step of Peptidoglycan Biosynthesis in Listeria monocytogenes
Q54419171Synthesis and biological evaluation of N-acylhydrazones as inhibitors of MurC and MurD ligases.
Q27674732Targeting the Cell Wall of Mycobacterium tuberculosis: Structure and Mechanism of L,D-Transpeptidase 2
Q28551826The Absence of a Mature Cell Wall Sacculus in Stable Listeria monocytogenes L-Form Cells Is Independent of Peptidoglycan Synthesis
Q28854136The MurC ligase essential for peptidoglycan biosynthesis is regulated by the serine/threonine protein kinase PknA in Corynebacterium glutamicum
Q64091007The MurG glycosyltransferase provides an oligomeric scaffold for the cytoplasmic steps of peptidoglycan biosynthesis in the human pathogen Bordetella pertussis
Q38394431The Mycobacterial Cell Wall--Peptidoglycan and Arabinogalactan
Q36106787The O-Antigen Flippase Wzk Can Substitute for MurJ in Peptidoglycan Synthesis in Helicobacter pylori and Escherichia coli
Q93350317The bacterial lipid II flippase MurJ functions by an alternating-access mechanism
Q28484507The binding mode of second-generation sulfonamide inhibitors of MurD: clues for rational design of potent MurD inhibitors
Q37032866The biosynthesis of peptidoglycan lipid-linked intermediates
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Q28249287The elucidation of the structure of Thermotoga maritima peptidoglycan reveals two novel types of cross-link
Q50894623The functional vanGCd cluster of Clostridium difficile does not confer vancomycin resistance.
Q55440532The ng_ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis.
Q38065215The physiology of bacterial cell division
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Q27025555The role of peptidoglycan in chlamydial cell division: towards resolving the chlamydial anomaly
Q40235146Toxin-antitoxin systems and their role in disseminating and maintaining antimicrobial resistance
Q89791040Transcriptome analysis of polysaccharide-based microbial flocculant MBFA9 biosynthesis regulated by nitrogen source
Q28484093Transcriptome analysis of responses to rhodomyrtone in methicillin-resistant Staphylococcus aureus
Q37913126UDP-N-acetylglucosamine enolpyruvyl transferase as a potential target for antibacterial chemotherapy: recent developments
Q92888631Uncovering the activities, biological roles, and regulation of bacterial cell wall hydrolases and tailoring enzymes
Q38070780Viable screening targets related to the bacterial cell wall.
Q58215959Virtual screening for potential inhibitors of bacterial MurC and MurD ligases
Q33897752Virtual screening for potential inhibitors of homology modeled Leptospira interrogans MurD ligase
Q39015536c-di-AMP modulates Listeria monocytogenes central metabolism to regulate growth, antibiotic resistance and osmoregulation
Q28741217tRNA as an active chemical scaffold for diverse chemical transformations
Q34206489ε/ζ systems: their role in resistance, virulence, and their potential for antibiotic development

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