The Mycobacterial Cell Wall--Peptidoglycan and Arabinogalactan

scientific article published on 27 March 2015

The Mycobacterial Cell Wall--Peptidoglycan and Arabinogalactan is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1101/CSHPERSPECT.A021113
P932PMC publication ID4526729
P698PubMed publication ID25818664

P50authorLuke J AlderwickQ56872527
P2093author name stringJames Harrison
Helen L Birch
Georgina S Lloyd
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Identification of a Novel Arabinofuranosyltransferase AftB Involved in a Terminal Step of Cell Wall Arabinan Biosynthesis in Corynebacterianeae, such asCorynebacterium glutamicumandMycobacterium tuberculosisQ58040456
Arabinan-deficient mutants of Corynebacterium glutamicum and the consequent flux in decaprenylmonophosphoryl-d-arabinose metabolismQ58040518
Characterization of the in vitro synthesized arabinan of mycobacterial cell wallsQ58040729
Mycobacterial arabinan biosynthesis: the use of synthetic arabinoside acceptors in the development of an arabinosyl transfer assayQ58040733
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The Galactosamine Residue in Mycobacterial Arabinogalactan Is α-LinkedQ63360963
Predominant structural features of the cell wall arabinogalactan of Mycobacterium tuberculosis as revealed through characterization of oligoglycosyl alditol fragments by gas chromatography/mass spectrometry and by 1H and 13C NMR analysesQ67283043
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Demonstration that the galactosyl and arabinosyl residues in the cell-wall arabinogalactan of Mycobacterium leprae and Mycobacterium tuberculosis are furanoidQ70366212
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Isolation and mass spectrometric identification of the peptide subunits of mycobacterial cell wallsQ71537005
A new interpretation of the structure of the mycolyl-arabinogalactan complex of Mycobacterium tuberculosis as revealed through characterization of oligoglycosylalditol fragments by fast-atom bombardment mass spectrometry and 1H nuclear magnetic resoQ72125562
Recognition of the lipid intermediate for arabinogalactan/arabinomannan biosynthesis and its relation to the mode of action of ethambutol on mycobacteriaQ72181562
Chemical structure of the cell wall of Mycobacterium smegmatis. I — Isolation and partial characterization of the peptidoglycanQ72396813
L'acide N-glycolyl-muramique, constituant des parois de Mycobacterium smegmatis: Identification par spectrometrie de masseQ77921782
Formation of adenosine 5'-tetraphosphate from the acyl phosphate intermediate: a difference between the MurC and MurD synthetases of Escherichia coliQ77993628
A new synthetic compound with antituberculous activity in mice: ethambutol (dextro-2,2'-(ethylenediimino)-di-l-butanol)Q79081359
Discovery of pyrazolopyridones as a novel class of noncovalent DprE1 inhibitor with potent anti-mycobacterial activityQ87855071
Chemical analyses of mycobacterial cell wallsQ93767241
Use of bacteriolytic enzymes in determination of wall structure and their role in cell metabolismQ40871593
Evidence for the incorporation of molecular oxygen, a pathway in biosynthesis of N-glycolylmuramic acid in Mycobacterium phleiQ41043993
A role for the class A penicillin-binding protein PonA2 in the survival of Mycobacterium smegmatis under conditions of nonreplicationQ41787109
Galactosamine in walls of slow-growing mycobacteriaQ41836041
Benzothiazinones mediate killing of Corynebacterineae by blocking decaprenyl phosphate recycling involved in cell wall biosynthesisQ41984312
Formation of the glycan chains in the synthesis of bacterial peptidoglycanQ28185380
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Study of the formation of N-glycolylmuramic acid from Nocardia asteroides (author's transl)Q28341963
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Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesisQ28486345
Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosisQ28486429
Identification and active expression of the Mycobacterium tuberculosis gene encoding 5-phospho-{alpha}-d-ribose-1-diphosphate: decaprenyl-phosphate 5-phosphoribosyltransferase, the first enzyme committed to decaprenylphosphoryl-d-arabinose synthesisQ28486563
rmlB and rmlC genes are essential for growth of mycobacteriaQ28486579
Expression, essentiality, and a microtiter plate assay for mycobacterial GlmU, the bifunctional glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferaseQ28486586
The serine/threonine kinase PknB of Mycobacterium tuberculosis phosphorylates PBPA, a penicillin-binding protein required for cell divisionQ28486785
Decaprenylphosphoryl arabinofuranose, the donor of the D-arabinofuranosyl residues of mycobacterial arabinan, is formed via a two-step epimerization of decaprenylphosphoryl riboseQ28486790
Mycobacterium tuberculosis Rv1302 and Mycobacterium smegmatis MSMEG_4947 have WecA function and MSMEG_4947 is required for the growth of M. smegmatisQ28486792
Construction and use of low-copy number T7 expression vectors for purification of problem proteins: purification of mycobacterium tuberculosis RmlD and pseudomonas aeruginosa LasI and RhlI proteins, and functional analysis of purified RhlIQ28486796
Identification of a novel arabinofuranosyltransferase (AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosisQ28486804
Determination of the pathway for rhamnose biosynthesis in mycobacteria: cloning, sequencing and expression of the Mycobacterium tuberculosis gene encoding alpha-D-glucose-1-phosphate thymidylyltransferaseQ28486841
Mycobacterium tuberculosis RmlC epimerase (Rv3465): a promising drug-target structure in the rhamnose pathwayQ28486876
Biosynthetic origin of mycobacterial cell wall galactofuranosyl residuesQ28486923
Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnoseQ28486980
Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetaseQ28487197
Comparison of the UDP-N-acetylmuramate:L-alanine ligase enzymes from Mycobacterium tuberculosis and Mycobacterium lepraeQ28487429
Characterization of CrgA, a new partner of the Mycobacterium tuberculosis peptidoglycan polymerization complexesQ28487435
Galactan biosynthesis in Mycobacterium tuberculosis. Identification of a bifunctional UDP-galactofuranosyltransferaseQ28487466
Inactivation of the mycobacterial rhamnosyltransferase, which is needed for the formation of the arabinogalactan-peptidoglycan linker, leads to irreversible loss of viabilityQ28487566
Conversion of dTDP-4-keto-6-deoxyglucose to free dTDP-4-keto-rhamnose by the rmIC gene products of Escherichia coli and Mycobacterium tuberculosisQ28487619
Transfer of the first arabinofuranose residue to galactan is essential for Mycobacterium smegmatis viabilityQ28501832
Deletion of Cg-emb in corynebacterianeae leads to a novel truncated cell wall arabinogalactan, whereas inactivation of Cg-ubiA results in an arabinan-deficient mutant with a cell wall galactan coreQ33220238
Sequencing of oligoarabinosyl units released from mycobacterial arabinogalactan by endogenous arabinanase: identification of distinctive and novel structural motifsQ33266918
The identification and location of succinyl residues and the characterization of the interior arabinan region allow for a model of the complete primary structure of Mycobacterium tuberculosis mycolyl arabinogalactanQ33321365
Inhibition of Escherichia coli glycosyltransferase MurG and Mycobacterium tuberculosis Gal transferase by uridine-linked transition state mimicsQ33540441
Interaction and modulation of two antagonistic cell wall enzymes of mycobacteria.Q33649862
A truncated lipoglycan from mycobacteria with altered immunological propertiesQ33664341
N Glycolylation of the nucleotide precursors of peptidoglycan biosynthesis of Mycobacterium spp. is altered by drug treatmentQ33716658
The Mycobacterium tuberculosis protein LdtMt2 is a nonclassical transpeptidase required for virulence and resistance to amoxicillin.Q33778121
Cell walls of mycobacteria and related organisms; Chemistry and immunostimulant propertiesQ34013861
Molecular mechanics of the mycobacterial cell wall: from horizontal layers to vertical scaffoldsQ34014265
Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membraneQ34169371
Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2'-oxidase DprE1.Q34242071
Structure-function analysis of MurJ reveals a solvent-exposed cavity containing residues essential for peptidoglycan biogenesis in Escherichia coliQ34363302
Three-dimensional structure of the bacterial cell wall peptidoglycanQ34574689
Topology and mutational analysis of the single Emb arabinofuranosyltransferase of Corynebacterium glutamicum as a model of Emb proteins of Mycobacterium tuberculosisQ34579687
Functional characterization and membrane topology of Escherichia coli WecA, a sugar-phosphate transferase initiating the biosynthesis of enterobacterial common antigen and O-antigen lipopolysaccharideQ34604149
Three monophyletic superfamilies account for the majority of the known glycosyltransferasesQ34648585
The methyl-branched fortifications of Mycobacterium tuberculosisQ34657803
Inhibition of mycobacterial alanine racemase activity and growth by thiadiazolidinonesQ34726267
Bioinformatics identification of MurJ (MviN) as the peptidoglycan lipid II flippase in Escherichia coliQ34843809
The architecture of the murein (peptidoglycan) in gram-negative bacteria: vertical scaffold or horizontal layer(s)?Q35876950
A small multidrug resistance-like transporter involved in the arabinosylation of arabinogalactan and lipoarabinomannan in mycobacteriaQ36407935
Substrate-bound crystal structures reveal features unique to Mycobacterium tuberculosis N-acetyl-glucosamine 1-phosphate uridyltransferase and a catalytic mechanism for acetyl transferQ36407940
Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening.Q36575914
The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugatesQ36721545
Chemical and immunological studies on mycobacterial polysaccharides. 1. Purification and properties of polysaccharides from human tubercle bacilliQ36846963
Cytoplasmic steps of peptidoglycan biosynthesisQ37081699
Highlights of glucosamine-6P synthase catalysisQ37086239
Inhibition of the first step in synthesis of the mycobacterial cell wall core, catalyzed by the GlcNAc-1-phosphate transferase WecA, by the novel caprazamycin derivative CPZEN-45Q37234023
AftD, a novel essential arabinofuranosyltransferase from mycobacteriaQ37376674
Metabolomics Reveal d-Alanine:d-Alanine Ligase As the Target of d-Cycloserine in Mycobacterium tuberculosisQ37519148
Nonclassical transpeptidases of Mycobacterium tuberculosis alter cell size, morphology, the cytosolic matrix, protein localization, virulence, and resistance to β-lactamsQ37713160
A Burkholderia cenocepacia MurJ (MviN) homolog is essential for cell wall peptidoglycan synthesis and bacterial viabilityQ39000262
Cell wall core galactofuran synthesis is essential for growth of mycobacteriaQ39503992
Roles of Mycobacterium smegmatis D-alanine:D-alanine ligase and D-alanine racemase in the mechanisms of action of and resistance to the peptidoglycan inhibitor D-cycloserineQ39730806
Tertiary Structure of Bacterial Murein: the Scaffold ModelQ39753941
Biogenesis of the mycobacterial cell wall and the site of action of ethambutolQ39780773
A single point mutation in the embB gene is responsible for resistance to ethambutol in Mycobacterium smegmatisQ39785399
Biosynthetic origin of mycobacterial cell wall arabinosyl residuesQ39839519
Galactofuranose biosynthesis in Escherichia coli K-12: identification and cloning of UDP-galactopyranose mutaseQ39840295
Effects of ethambutol on accumulation and secretion of trehalose mycolates and free mycolic acid in Mycobacterium smegmatisQ39855786
Nucleotide sequences of the gal E gene and the gal T gene of E. coliQ40418917
The role of the embA and embB gene products in the biosynthesis of the terminal hexaarabinofuranosyl motif of Mycobacterium smegmatis arabinogalactan.Q40679743
P433issue8
P921main subjectcell wallQ128700
P304page(s)a021113
P577publication date2015-03-27
P1433published inCold Spring Harbor Perspectives in MedicineQ21042440
P1476titleThe Mycobacterial Cell Wall--Peptidoglycan and Arabinogalactan
P478volume5

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