Mycobacterial cell wall biosynthesis: a multifaceted antibiotic target

scientific article published on 15 December 2016

Mycobacterial cell wall biosynthesis: a multifaceted antibiotic target is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1017/S0031182016002377
P932PMC publication ID5964476
P698PubMed publication ID27976597

P50authorKatherine A AbrahamsQ52125562
P2093author name stringGurdyal S Besra
P2860cites worktargetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysisQ21202793
The Galactosamine Residue in Mycobacterial Arabinogalactan Is α-LinkedQ63360963
Acylation State of the Phosphatidylinositol Mannosides fromMycobacterium bovisBacillus Calmette Guérin and Ability to Induce Granuloma and Recruit Natural Killer T CellsQ63361575
Galactose-derived phosphonate analogues as potential inhibitors of phosphatidylinositol biosynthesis in mycobacteriaQ63363181
Predominant structural features of the cell wall arabinogalactan of Mycobacterium tuberculosis as revealed through characterization of oligoglycosyl alditol fragments by gas chromatography/mass spectrometry and by 1H and 13C NMR analysesQ67283043
Location of the mycolyl ester substituents in the cell walls of mycobacteriaQ67992902
Evidence for the nature of the link between the arabinogalactan and peptidoglycan of mycobacterial cell wallsQ68556386
Demonstration that the galactosyl and arabinosyl residues in the cell-wall arabinogalactan of Mycobacterium leprae and Mycobacterium tuberculosis are furanoidQ70366212
Amphomycin: effect of the lipopeptide antibiotic on the glycosylation and extraction of dolichyl monophosphate in calf brain membranesQ70754020
A new interpretation of the structure of the mycolyl-arabinogalactan complex of Mycobacterium tuberculosis as revealed through characterization of oligoglycosylalditol fragments by fast-atom bombardment mass spectrometry and 1H nuclear magnetic resoQ72125562
Recognition of the lipid intermediate for arabinogalactan/arabinomannan biosynthesis and its relation to the mode of action of ethambutol on mycobacteriaQ72181562
TREATMENT of pulmonary tuberculosis with isoniazid; an interim report to the Medical Research Council by their Tuberculosis Chemotherapy Trials CommitteeQ73953257
THE STRUCTURE OF A MYOINOSITOL MANNOSIDE FROM MYCOBACTERIUM TUBERCULOSIS GLYCOLIPIDQ76915146
Structural studies on the myo-inositol phospholipids of Mycobacterium tuberculosis (var. bovis, strain BCG)Q79572464
5-Benzylidenethiazolidin-4-ones as Multitarget Inhibitors of Bacterial Mur LigasesQ58216000
Characterization of a putative α-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosisQ58286606
Crystal Structure of a Novel β-Lactam-insensitive Peptidoglycan TranspeptidaseQ58346927
ESI-MS Assay of M. tuberculosis Cell Wall Antigen 85 Enzymes Permits Substrate Profiling and Design of a Mechanism-Based InhibitorQ60914231
The Carboxy Terminus of EmbC fromMycobacterium smegmatisMediates Chain Length Extension of the Arabinan in LipoarabinomannanQ62736137
Biphenyl-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzymeQ34269294
Acetylene-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzymeQ34286689
Biochemistry and comparative genomics of SxxK superfamily acyltransferases offer a clue to the mycobacterial paradox: presence of penicillin-susceptible target proteins versus lack of efficiency of penicillin as therapeutic agentQ34300761
Pharmacodynamics and pharmacokinetics of SQ109, a new diamine-based antitubercular drugQ34383718
Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coliQ34619663
Structure, biochemistry and mechanism of action of glycopeptide antibioticsQ34665729
Mycobacterial lipoarabinomannans: modulators of dendritic cell function and the apoptotic responseQ34727406
Bioinformatics identification of MurJ (MviN) as the peptidoglycan lipid II flippase in Escherichia coliQ34843809
Lipoarabinomannan biosynthesis in Corynebacterineae: the interplay of two α(1→2)-mannopyranosyltransferases MptC and MptD in mannan branchingQ35069666
A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organismsQ35122617
Discovery of a capuramycin analog that kills nonreplicating Mycobacterium tuberculosis and its synergistic effects with translocase I inhibitorsQ35243846
Direct inhibitors of InhA are active against Mycobacterium tuberculosis.Q35247307
Covalent modification of the Mycobacterium tuberculosis FAS-II dehydratase by Isoxyl and ThiacetazoneQ35461578
Survival perspectives from the world's most successful pathogen, Mycobacterium tuberculosis.Q35546031
Lead selection and characterization of antitubercular compounds using the Nested Chemical LibraryQ35584789
Identification of the surface-exposed lipids on the cell envelopes of Mycobacterium tuberculosis and other mycobacterial speciesQ35601166
Combinations of β-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis InfectionQ35860128
Antigen 85C inhibition restricts Mycobacterium tuberculosis growth through disruption of cord factor biosynthesisQ35867371
SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosisQ35867500
Identification of the apparent carrier in mycolic acid synthesisQ36000971
Synthesis and evaluation of new 2-aminothiophenes against Mycobacterium tuberculosisQ36037140
Fluorescence-based assay for polyprenyl phosphate-GlcNAc-1-phosphate transferase (WecA) and identification of novel antimycobacterial WecA inhibitorsQ36105224
The murG gene of Escherichia coli codes for the UDP-N-acetylglucosamine: N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase involved in the membrane steps of peptidoglycan synthesisQ36150070
Inactivation of Mycobacterium tuberculosis l,d-transpeptidase LdtMt₁ by carbapenems and cephalosporinsQ36171768
Meropenem inhibits D,D-carboxypeptidase activity in Mycobacterium tuberculosisQ36310020
MraY Inhibitors as Novel Antibacterial AgentsQ36321142
Molecular docking studies on InhA, MabA and PanK enzymes from Mycobacterium tuberculosis of ellagic acid derivatives from Ludwigia adscendens and Trewia nudiflora.Q36352683
In vitro antimycobacterial activities of capuramycin analoguesQ36424956
Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening.Q36575914
Critical roles for lipomannan and lipoarabinomannan in cell wall integrity of mycobacteria and pathogenesis of tuberculosisQ36613333
The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugatesQ36721545
Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant.Q36737388
Truncated structural variants of lipoarabinomannan in ethambutol drug-resistant strains of Mycobacterium smegmatis. Inhibition of arabinan biosynthesis by ethambutolQ36831508
Mutations in pimE restore lipoarabinomannan synthesis and growth in a Mycobacterium smegmatis lpqW mutantQ28486481
Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis. PimA is essential for growth of mycobacteriaQ28486491
Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosisQ28486505
Identification and active expression of the Mycobacterium tuberculosis gene encoding 5-phospho-{alpha}-d-ribose-1-diphosphate: decaprenyl-phosphate 5-phosphoribosyltransferase, the first enzyme committed to decaprenylphosphoryl-d-arabinose synthesisQ28486563
MabA (FabG1), a Mycobacterium tuberculosis protein involved in the long-chain fatty acid elongation system FAS-IIQ28486575
The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosisQ28486719
Antigen 85C-mediated acyl-transfer between synthetic acyl donors and fragments of the arabinanQ28486729
Identification of an alpha(1-->6) mannopyranosyltransferase (MptA), involved in Corynebacterium glutamicum lipomanann biosynthesis, and identification of its orthologue in Mycobacterium tuberculosisQ28486750
Decaprenylphosphoryl arabinofuranose, the donor of the D-arabinofuranosyl residues of mycobacterial arabinan, is formed via a two-step epimerization of decaprenylphosphoryl riboseQ28486790
Mycobacterium tuberculosis Rv1302 and Mycobacterium smegmatis MSMEG_4947 have WecA function and MSMEG_4947 is required for the growth of M. smegmatisQ28486792
Identification of a novel arabinofuranosyltransferase (AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosisQ28486804
The mmaA2 gene of Mycobacterium tuberculosis encodes the distal cyclopropane synthase of the alpha-mycolic acidQ28486806
Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosisQ28486808
Expression, purification, and characterization of a galactofuranosyltransferase involved in Mycobacterium tuberculosis arabinogalactan biosynthesisQ28486851
Inactivation of the antigen 85C gene profoundly affects the mycolate content and alters the permeability of the Mycobacterium tuberculosis cell envelopeQ28486853
Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosisQ28486928
Mycobacterium tuberculosis phoP mutant: lipoarabinomannan molecular structureQ28487144
Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetaseQ28487197
Purification and biochemical characterization of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthases KasA and KasBQ28487213
A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosisQ28487225
Identification of a polyprenylphosphomannosyl synthase involved in the synthesis of mycobacterial mannosidesQ28487273
Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membraneQ28487303
Biosynthetic origin of the galactosamine substituent of Arabinogalactan in Mycobacterium tuberculosisQ28487338
Comparison of the UDP-N-acetylmuramate:L-alanine ligase enzymes from Mycobacterium tuberculosis and Mycobacterium lepraeQ28487429
Galactan biosynthesis in Mycobacterium tuberculosis. Identification of a bifunctional UDP-galactofuranosyltransferaseQ28487466
Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosisQ28487484
Redundant function of cmaA2 and mmaA2 in Mycobacterium tuberculosis cis cyclopropanation of oxygenated mycolatesQ28487498
Inactivation of the mycobacterial rhamnosyltransferase, which is needed for the formation of the arabinogalactan-peptidoglycan linker, leads to irreversible loss of viabilityQ28487566
Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesisQ28487576
Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteriaQ28487603
Lipoarabinomannan of Mycobacterium: mannose capping by a multifunctional terminal mannosyltransferaseQ28487622
Characterisation of ATP-dependent Mur ligases involved in the biogenesis of cell wall peptidoglycan in Mycobacterium tuberculosisQ28488668
New insights into the early steps of phosphatidylinositol mannoside biosynthesis in mycobacteria: PimB' is an essential enzyme of Mycobacterium smegmatisQ28501847
Platensimycin activity against mycobacterial beta-ketoacyl-ACP synthasesQ21562402
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequenceQ22122411
The Envelope of MycobacteriaQ22241995
Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architectureQ24535935
Reconstitution of functional mycobacterial arabinosyltransferase AftC proteoliposome and assessment of decaprenylphosphorylarabinose analogues as arabinofuranosyl donorsQ24614299
Galactosyl transferases in mycobacterial cell wall synthesisQ24641902
Development of a microtitre plate-based assay for lipid-linked glycosyltransferase products using the mycobacterial cell wall rhamnosyltransferase WbbLQ24642902
Biosynthesis of mycobacterial arabinogalactan: identification of a novel alpha(1-->3) arabinofuranosyltransferaseQ24656511
Identification of a novel galactosyl transferase involved in biosynthesis of the mycobacterial cell wallQ24678269
Lipid Flippases for Bacterial Peptidoglycan BiosynthesisQ26770493
Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteriaQ27644814
Structure and function of GlmU fromMycobacterium tuberculosisQ27653924
Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosisQ27653976
Structure of the Mycobacterium tuberculosis d -Alanine: d -Alanine Ligase, a Target of the Antituberculosis Drug d -CycloserineQ27665159
The C-Terminal Domain of the Arabinosyltransferase Mycobacterium tuberculosis EmbC Is a Lectin-Like Carbohydrate Binding ModuleQ27667217
Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitorsQ27681391
Towards a new combination therapy for tuberculosis with next generation benzothiazinonesQ27681604
Encoded library technology as a source of hits for the discovery and lead optimization of a potent and selective class of bactericidal direct inhibitors of Mycobacterium tuberculosis InhAQ27688958
THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteriaQ27727961
The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases. Gene cloning, protein expression, and catalytic mechanism.Q27936943
Kinetic mechanism and inhibition of Mycobacterium tuberculosis D-alanine:D-alanine ligase by the antibiotic D-cycloserineQ28282522
Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosisQ28302775
The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug developmentQ28305447
Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosisQ28375163
High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitorsQ28471626
Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteriaQ28471837
Ppm1-encoded polyprenyl monophosphomannose synthase activity is essential for lipoglycan synthesis and survival in mycobacteriaQ28484652
Identification of novel imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrBQ28484670
Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3Q28486239
Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase IIQ28486328
The peptidoglycan of stationary-phase Mycobacterium tuberculosis predominantly contains cross-links generated by L,D-transpeptidationQ28486366
Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosisQ28486429
PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of phosphatidylinositol mannoside in mycobacteriaQ28501849
Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of mycobacterium speciesQ28501856
A Mycobacterium smegmatis mutant with a defective inositol monophosphate phosphatase gene homolog has altered cell envelope permeabilityQ28501859
Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosisQ28533721
Mycobacterial dihydrofolate reductase inhibitors identified using chemogenomic methods and in vitro validationQ28544916
Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug targetQ28545065
Identification of KasA as the cellular target of an anti-tubercular scaffoldQ28830072
inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosisQ29617412
Peptidoglycan structure and architectureQ29617858
Discovery and development of SQ109: a new antitubercular drug with a novel mechanism of actionQ30419537
Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32Q30432374
Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activityQ31473388
Structural analysis of mycobacterial lipoglycansQ33205731
Deletion of Cg-emb in corynebacterianeae leads to a novel truncated cell wall arabinogalactan, whereas inactivation of Cg-ubiA results in an arabinan-deficient mutant with a cell wall galactan coreQ33220238
Pharmacoproteomic effects of isoniazid, ethambutol, and N-geranyl-N'-(2-adamantyl)ethane-1,2-diamine (SQ109) on Mycobacterium tuberculosis H37RvQ33221264
Genetic basis for the synthesis of the immunomodulatory mannose caps of lipoarabinomannan in Mycobacterium tuberculosisQ33243649
Identification of new diamine scaffolds with activity against Mycobacterium tuberculosisQ33244525
The identification and location of succinyl residues and the characterization of the interior arabinan region allow for a model of the complete primary structure of Mycobacterium tuberculosis mycolyl arabinogalactanQ33321365
Loss of a mycobacterial gene encoding a reductase leads to an altered cell wall containing beta-oxo-mycolic acid analogs and accumulation of ketonesQ33370732
The mycolyltransferase 85A, a putative drug target of Mycobacterium tuberculosis: development of a novel assay and quantification of glycolipid-status of the mycobacterial cell wallQ33512644
Inhibition of Escherichia coli glycosyltransferase MurG and Mycobacterium tuberculosis Gal transferase by uridine-linked transition state mimicsQ33540441
Specificity of the transport of lipid II by FtsW in Escherichia coliQ33652106
A truncated lipoglycan from mycobacteria with altered immunological propertiesQ33664341
N Glycolylation of the nucleotide precursors of peptidoglycan biosynthesis of Mycobacterium spp. is altered by drug treatmentQ33716658
Mycobacterial lipid II is composed of a complex mixture of modified muramyl and peptide moieties linked to decaprenyl phosphateQ33726863
Novel inhibitors of InhA efficiently kill Mycobacterium tuberculosis under aerobic and anaerobic conditions.Q33917913
MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212Q34056972
Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membraneQ34169371
Bacterial cell wall. MurJ is the flippase of lipid-linked precursors for peptidoglycan biogenesis.Q34175962
Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitorQ37034701
Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesisQ37038925
Cytoplasmic steps of peptidoglycan biosynthesisQ37081699
The penicillin-binding proteins: structure and role in peptidoglycan biosynthesisQ37081708
Lcp1 Is a Phosphotransferase Responsible for Ligating Arabinogalactan to Peptidoglycan in Mycobacterium tuberculosis.Q37168695
Inhibition of the first step in synthesis of the mycobacterial cell wall core, catalyzed by the GlcNAc-1-phosphate transferase WecA, by the novel caprazamycin derivative CPZEN-45Q37234023
Activity of SQ641, a capuramycin analog, in a murine model of tuberculosisQ37247725
AftD, a novel essential arabinofuranosyltransferase from mycobacteriaQ37376674
Metabolomics Reveal d-Alanine:d-Alanine Ligase As the Target of d-Cycloserine in Mycobacterium tuberculosisQ37519148
Indoleamides are active against drug-resistant Mycobacterium tuberculosisQ37541307
Recent progress in the identification and development of InhA direct inhibitors of Mycobacterium tuberculosisQ37735233
Targeting InhA, the FASII enoyl-ACP reductase: SAR studies on novel inhibitor scaffolds.Q37979307
Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F.Q38206339
Binding of the terminal mannosyl units of lipoarabinomannan from a virulent strain of Mycobacterium tuberculosis to human macrophages.Q38309145
UDP-GlcNAc pathway: Potential target for inhibitor discovery against M. tuberculosisQ38675255
Assessing the essentiality of the decaprenyl-phospho-d-arabinofuranose pathway in Mycobacterium tuberculosis using conditional mutantsQ39024963
Synthetic UDP-furanoses as potent inhibitors of mycobacterial galactan biogenesis.Q39804087
Molecular mechanisms of isoniazid resistance in Mycobacterium tuberculosis and Mycobacterium bovis.Q39821736
GtrA Protein Rv3789 Is Required for Arabinosylation of Arabinogalactan in Mycobacterium tuberculosisQ40540582
Molecular genetics of drug resistance in Mycobacterium tuberculosisQ40575592
Deciphering the molecular bases of Mycobacterium tuberculosis binding to the lectin DC-SIGN reveals an underestimated complexityQ40679059
The role of the embA and embB gene products in the biosynthesis of the terminal hexaarabinofuranosyl motif of Mycobacterium smegmatis arabinogalactan.Q40679743
Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in miceQ40875190
Design, synthesis, and evaluation of new thiadiazole-based direct inhibitors of enoyl acyl carrier protein reductase (InhA) for the treatment of tuberculosisQ41594961
Galactosamine in walls of slow-growing mycobacteriaQ41836041
Investigation of ABC transporter from mycobacterial arabinogalactan biosynthetic clusterQ41969973
The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosisQ42111035
Mannose metabolism is required for mycobacterial growthQ42113994
MmpL genes are associated with mycolic acid metabolism in mycobacteria and corynebacteriaQ42189366
Novel prenyl-linked benzophenone substrate analogues of mycobacterial mannosyltransferases.Q42253910
Design and synthesis of novel cell wall inhibitors of Mycobacterium tuberculosis GlmM and GlmU.Q42731628
Characterization of a putative alpha-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosisQ43001474
Epimeric and amino disaccharide analogs as probes of an alpha-(1-->6)-mannosyltransferase involved in mycobacterial lipoarabinomannan biosynthesisQ43213868
Antimycobacterial activity of cerulenin and its effects on lipid biosynthesisQ43544331
Synthetic mannosides act as acceptors for mycobacterial alpha1-6 mannosyltransferaseQ43608969
Separation and characterization of individual mycolic acids in representative mycobacteriaQ43655749
Synthesis of disaccharides related to the mycobacterial arabinogalactanQ43707816
Location of functional groups in mycobacterial meromycolate chains; the recognition of new structural principles in mycolic acidsQ44021566
Synthesis and evaluation of galactofuranosyl N,N-dialkyl sulfenamides and sulfonamides as antimycobacterial agents.Q44196146
Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosisQ44198145
The cell surface receptor DC-SIGN discriminates between Mycobacterium species through selective recognition of the mannose caps on lipoarabinomannanQ44258976
Identification of hotspot regions of MurB oxidoreductase enzyme using homology modeling, molecular dynamics and molecular docking techniquesQ44324006
Mycolic acid structure determines the fluidity of the mycobacterial cell wallQ44732618
Phosphonate inhibitors of antigen 85C, a crucial enzyme involved in the biosynthesis of the Mycobacterium tuberculosis cell wallQ44921136
Triclosan as a substrate and inhibitor of 3'-phosphoadenosine 5'-phosphosulfate-sulfotransferase and UDP-glucuronosyl transferase in human liver fractionsQ44989650
Identification of the 5-methylthiopentosyl substituent in Mycobacterium tuberculosis lipoarabinomannanQ44993198
Activity of capuramycin analogues against Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium intracellulare in vitro and in vivoQ45044140
Synthesis of methyl 5-S-alkyl-5-thio-D-arabinofuranosides and evaluation of their antimycobacterial activityQ45059460
Identification of the namH gene, encoding the hydroxylase responsible for the N-glycolylation of the mycobacterial peptidoglycanQ45136861
Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitorsQ46256266
Simultaneous estimation of pharmacokinetic properties in mice of three anti-tubercular ethambutol analogs obtained from combinatorial lead optimization.Q46410603
A novel peptidoglycan cross-linking enzyme for a beta-lactam-resistant transpeptidation pathwayQ46689287
Identification of amino acids and domains required for catalytic activity of DPPR synthase, a cell wall biosynthetic enzyme of Mycobacterium tuberculosisQ46726125
Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-β-d-ribose OxidaseQ49049841
The effect of MSMEG_6402 gene disruption on the cell wall structure of Mycobacterium smegmatis.Q52611102
Effects of moenomycin on Escherichia coli.Q54411026
Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin.Q54590227
Inhibition studies on Mycobacterium tuberculosis N-acetylglucosamine-1-phosphate uridyltransferase (GlmU).Q54698121
Identification of a Novel Arabinofuranosyltransferase AftB Involved in a Terminal Step of Cell Wall Arabinan Biosynthesis in Corynebacterianeae, such asCorynebacterium glutamicumandMycobacterium tuberculosisQ58040456
Biosynthesis of Mycobacterial LipoarabinomannanQ58040726
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P921main subjectcell wallQ128700
cellQ7868
bacteriaQ10876
antibioticQ12187
drug delivery systemQ64829245
P304page(s)116-133
P577publication date2016-12-15
2018-02-01
P1433published inParasitologyQ15753259
P1476titleMycobacterial cell wall biosynthesis: a multifaceted antibiotic target
P478volume145

Reverse relations

cites work (P2860)
Q64062891: Environmental Bacterium Turned Clinical Nightmare
Q93088191Action of Dicumarol on Glucosamine-1-Phosphate Acetyltransferase of GlmU and Mycobacterium tuberculosis
Q63361560AftD functions as an α1 → 5 arabinofuranosyltransferase involved in the biosynthesis of the mycobacterial cell wall core
Q91962456Anti-Idiotype Vaccine Provides Protective Immunity Against Vibrio Harveyi in Grouper (Epinephelus Coioides)
Q38700240Biochemical Investigation of Rv3404c from Mycobacterium tuberculosis
Q97418212Cryo-EM structure of arabinosyltransferase EmbB from Mycobacterium smegmatis
Q55193068Crystallization and structure analysis of the core motif of the Pks13 acyltransferase domain from Mycobacterium tuberculosis.
Q90252636Delving into the Characteristic Features of "Menace" Mycobacterium tuberculosis Homologs: A Structural Dynamics and Proteomics Perspectives
Q89494842Digging Deeper to Save the Old Anti-tuberculosis Target: D-Alanine-D-Alanine Ligase With a Novel Inhibitor, IMB-0283
Q42373964Dissecting the mycobacterial cell envelope and defining the composition of the native mycomembrane
Q47215889Microbial protein targets: towards understanding and intervention
Q89967237Mycobacterium tuberculosis PE31 (Rv3477) Attenuates Host Cell Apoptosis and Promotes Recombinant M. smegmatis Intracellular Survival via Up-regulating GTPase Guanylate Binding Protein-1
Q91720786Mycobacterium tuberculosis Rv2700 Contributes to Cell Envelope Integrity and Virulence
Q91807571New tuberculosis drug targets, their inhibitors, and potential therapeutic impact
Q55251731Phospholipid homeostasis, membrane tenacity and survival of Mtb in lipid rich conditions is determined by MmpL11 function.
Q64249427Revisiting Anti-tuberculosis Therapeutic Strategies That Target the Peptidoglycan Structure and Synthesis
Q96020333Simplified Novel Muraymycin Analogues; using a Serine Template Strategy for Linking Key Pharmacophores
Q55501913Structural and functional determination of homologs of the Mycobacterium tuberculosis N-acetylglucosamine-6-phosphate deacetylase (NagA).
Q92278122Targeting extracellular glycans: tuning multimeric boronic acids for pathogen-selective killing of Mycobacterium tuberculosis
Q52312613The Mechanism of Acetyl Transfer Catalyzed by Mycobacterium tuberculosis GlmU.
Q47596375The structure of glucose-1-phosphate thymidylyltransferase from Mycobacterium tuberculosis reveals the location of an essential magnesium ion in the RmlA-type enzymes
Q49446442Ultrastructural Analysis of Cell Envelope and Accumulation of Lipid Inclusions in Clinical Mycobacterium tuberculosis Isolates from Sputum, Oxidative Stress, and Iron Deficiency
Q47873412α-pyrones and their hydroxylated analogs as promising scaffolds against Mycobacterium tuberculosis

Search more.