UDP-N-acetylglucosamine enolpyruvyl transferase as a potential target for antibacterial chemotherapy: recent developments

scientific article published on 07 August 2011

UDP-N-acetylglucosamine enolpyruvyl transferase as a potential target for antibacterial chemotherapy: recent developments is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/S00253-011-3512-Z
P698PubMed publication ID21822642

P50authorRupinder TewariQ40274249
P2093author name stringAnkur Gautam
Praveen Rishi
P2860cites workMurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coliQ24671787
Role of the loop containing residue 115 in the induced-fit mechanism of the bacterial cell wall biosynthetic enzyme MurAQ27621570
Structural basis for the interaction of the fluorescence probe 8-anilino-1-naphthalene sulfonate (ANS) with the antibiotic target MurAQ27622627
Comparative X-ray analysis of the un-liganded fosfomycin-target murAQ27622761
???Q27748883
A new view of the mechanisms of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) and 5-enolpyruvylshikimate-3-phosphate synthase (AroA) derived from X-ray structures of their tetrahedral reaction intermediate statesQ27642065
Crystal structure of UDP-N-acetylglucosamine enolpyruvyl transferase from Haemophilus influenzae in complex with UDP-N-acetylglucosamine and fosfomycinQ27649770
Evidence of kinetic control of ligand binding and staged product release in MurA (enolpyruvyl UDP-GlcNAc synthase)-catalyzed reactionsQ27658111
The Fungal Product Terreic Acid Is a Covalent Inhibitor of the Bacterial Cell Wall Biosynthetic Enzyme UDP- N -Acetylglucosamine 1-Carboxyvinyltransferase (MurA),Q27660525
Crystal structure of UDP-N-acetylglucosamine enolpyruvyltransferase, the target of the antibiotic fosfomycinQ27733409
Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycinQ27734363
Peptidoglycan structure and architectureQ29617858
An improved assay for nanomole amounts of inorganic phosphateQ29620585
Determination of the pKa value of C115 in MurA (UDP-N-acetylglucosamine enolpyruvyltransferase) from Enterobacter cloacaeQ30940018
Identification and characterization of new inhibitors of the Escherichia coli MurA enzymeQ31016009
Cloning and sequencing of Escherichia coli murZ and purification of its product, a UDP-N-acetylglucosamine enolpyruvyl transferaseQ33202551
A peptide inhibitor of MurA UDP-N-acetylglucosamine enolpyruvyl transferase: the first committed step in peptidoglycan biosynthesisQ33259874
Identification of a novel UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from Vibrio fischeri that confers high fosfomycin resistance in Escherichia coliQ33416937
Two active forms of UDP-N-acetylglucosamine enolpyruvyl transferase in gram-positive bacteriaQ33601835
Structure-based discovery of antibacterial drugsQ33605661
Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ).Q33699586
In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistanceQ34514901
Molecular mechanisms of antibacterial multidrug resistanceQ34611916
Comparison of the essential cellular functions of the two murA genes of Bacillus anthracisQ36702923
Cytoplasmic steps of peptidoglycan biosynthesisQ37081699
Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product releaseQ37866109
Development of a whole-cell assay for peptidoglycan biosynthesis inhibitorsQ39651496
The UDP-N-acetylglucosamine 1-carboxyvinyl-transferase of Enterobacter cloacae. Molecular cloning, sequencing of the gene and overexpression of the enzymeQ42610701
A novel inhibitor that suspends the induced fit mechanism of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA).Q42647502
Studies on the conformational changes in the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine enolpyruvyltransferase (MurA).Q42680309
Structure-activity relationships of tulipalines, tuliposides, and related compounds as inhibitors of MurA.Q42930172
Molecular mechanisms of fosfomycin resistance in clinical isolates of Escherichia coliQ43195414
The antibacterial properties of 6-tuliposide B. Synthesis of 6-tuliposide B analogues and structure-activity relationship.Q43235543
Asparagine 23 and aspartate 305 are essential residues in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase from Enterobacter cloacaeQ43591572
The nature of Staphylococcus aureus MurA and MurZ and approaches for detection of peptidoglycan biosynthesis inhibitorsQ46082809
The unusual binding mode of cnicin to the antibacterial target enzyme MurA revealed by X-ray crystallographyQ46450774
Alteration of a single amino acid residue reverses fosfomycin resistance of recombinant MurA from Mycobacterium tuberculosisQ47904411
2-Aminotetralones: novel inhibitors of MurA and MurZ.Q52852098
Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA.Q54456599
Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin.Q54590227
Lysine 22 in UDP-N-Acetylglucosamine Enolpyruvyl Transferase fromEnterobacter cloacaeIs Crucial for Enzymatic Activity and the Formation of Covalent Adducts with the Substrate Phosphoenolpyruvate and the Antibiotic Fosfomycin†Q57978316
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectebselenQ5332073
chemotherapyQ974135
P304page(s)211-225
P577publication date2011-08-07
P1433published inApplied Microbiology and BiotechnologyQ13553694
P1476titleUDP-N-acetylglucosamine enolpyruvyl transferase as a potential target for antibacterial chemotherapy: recent developments
P478volume92

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cites work (P2860)
Q28539823Cloning, expression and characterization of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from Wolbachia endosymbiont of human lymphatic filarial parasite Brugia malayi
Q38807273Coprinuslactone protects the edible mushroom Coprinus comatus against biofilm infections by blocking both quorum-sensing and MurA.
Q36742824Global characterization of in vivo enzyme catalytic rates and their correspondence to in vitro kcat measurements
Q30152646Inhibition of the MurA enzyme in Fusobacterium nucleatum by potential inhibitors identified through computational and in vitro approaches
Q35235563Overexpression of the Lactobacillus plantarum peptidoglycan biosynthesis murA2 gene increases the tolerance of Escherichia coli to alcohols and enhances ethanol production
Q39755688Rapid Inhibition Profiling in Bacillus subtilis to Identify the Mechanism of Action of New Antimicrobials
Q26859841Resistance to antibiotics targeted to the bacterial cell wall
Q30400998Study of intra-inter species protein-protein interactions for potential drug targets identification and subsequent drug design for Escherichia coli O104:H4 C277-11.
Q26824482The structural biology of enzymes involved in natural product glycosylation
Q38070780Viable screening targets related to the bacterial cell wall.

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