Development of a whole-cell assay for peptidoglycan biosynthesis inhibitors

scientific article published on April 2002

Development of a whole-cell assay for peptidoglycan biosynthesis inhibitors is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/AAC.46.4.943-946.2002
P932PMC publication ID127110
P698PubMed publication ID11897573

P2093author name stringJie Fang
Maria D F S Barbosa
David L Pompliano
Michael G Kurilla
Gaoyun Yang
P2860cites workMultiple antibiotic resistance in a bacterium with suppressed autolytic system.Q54677814
Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of UDP-GlcNAc enolpyruvoyl transferase by the antibiotic fosfomycinQ72160246
Assay for identification of inhibitors for bacterial MraY translocase or MurG transferaseQ73734917
A protein antibiotic in the phage Qbeta virion: diversity in lysis targetsQ74087194
Mining bacterial cell wall biosynthesis with new tools: multitarget screensQ74348921
The lysis protein E of phi X174 is a specific inhibitor of the MraY-catalyzed step in peptidoglycan synthesis.Q31567652
Substrate and inhibitor-induced conformational changes in the structurally related enzymes UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) and 5-enolpyruvylshikimate 3-phosphate synthase (EPSPS).Q33178680
Cloning and sequencing of Escherichia coli murZ and purification of its product, a UDP-N-acetylglucosamine enolpyruvyl transferaseQ33202551
Surface proteins of gram-positive bacteria and mechanisms of their targeting to the cell wall envelopeQ33538951
Inhibition of transglycosylation involved in bacterial peptidoglycan synthesisQ33927707
Pyruvate-uridine diphospho-N-acetylglucosamine transferase. Purification to homogeneity and feedback inhibitionQ33936474
The discovery of cell wall active antibacterial antibioticsQ36335002
Novel scintillation proximity assay for measuring membrane-associated steps of peptidoglycan biosynthesis in Escherichia coliQ39476540
Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genesQ39476891
Escherichia coli mutants lacking all possible combinations of eight penicillin binding proteins: viability, characteristics, and implications for peptidoglycan synthesis.Q39496341
mraY is an essential gene for cell growth in Escherichia coli.Q39568895
Signal transduction by a death signal peptide: uncovering the mechanism of bacterial killing by penicillinQ47878599
Vancomycin derivatives that inhibit peptidoglycan biosynthesis without binding D-Ala-D-Ala.Q54099400
Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin.Q54590227
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)943-946
P577publication date2002-04-01
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleDevelopment of a whole-cell assay for peptidoglycan biosynthesis inhibitors
P478volume46

Reverse relations

cites work (P2860)
Q38635832A population genomics approach to exploiting the accessory 'resistome' of Escherichia coli
Q88906095Adaptation to the coupling of glycolysis to toxic methylglyoxal production in tpiA deletion strains of Escherichia coli requires synchronized and counterintuitive genetic changes
Q42173257An integrated approach for identification and target validation of antifungal compounds active against Erg11p
Q36475457Cell wall assembly in Bacillus subtilis: how spirals and spaces challenge paradigms.
Q33793074Challenges of antibacterial discovery
Q37081699Cytoplasmic steps of peptidoglycan biosynthesis
Q40410564High-throughput screen for inhibitors of transglycosylase and/or transpeptidase activities of Escherichia coli penicillin binding protein 1b.
Q52673281Identification of a Direct Biosynthetic Pathway for UDP-N-Acetylgalactosamine from Glucosamine-6-Phosphate in Thermophilic Crenarchaeon Sulfolobus tokodaii.
Q48022320Identification of druggable targets for Acinetobacter baumannii via subtractive genomics and plausible inhibitors for MurA and MurB.
Q45398702In silico analysis of different generation β lactams antibiotics with penicillin binding protein-2 of Neisseria meningitidis for curing meningococcal disease
Q34722061Mannopeptimycins, new cyclic glycopeptide antibiotics produced by Streptomyces hygroscopicus LL-AC98: antibacterial and mechanistic activities.
Q36103402Modeling bacterial UDP-HexNAc: polyprenol-P HexNAc-1-P transferases
Q37810971Peptidoglycan biosynthesis machinery: a rich source of drug targets
Q37913126UDP-N-acetylglucosamine enolpyruvyl transferase as a potential target for antibacterial chemotherapy: recent developments
Q41991873Utility of muropeptide ligase for identification of inhibitors of the cell wall biosynthesis enzyme MurF.
Q38070780Viable screening targets related to the bacterial cell wall.

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