Adaptation to the coupling of glycolysis to toxic methylglyoxal production in tpiA deletion strains of Escherichia coli requires synchronized and counterintuitive genetic changes

scientific article published on 26 May 2018

Adaptation to the coupling of glycolysis to toxic methylglyoxal production in tpiA deletion strains of Escherichia coli requires synchronized and counterintuitive genetic changes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YMBEN.2018.05.012
P698PubMed publication ID29842925

P50authorBernhard PalssonQ4894212
Troy E SandbergQ56994240
Elizabeth BrunkQ57219165
Adam M. FeistQ89604738
Richard SzubinQ114338580
Ying HefnerQ114338583
Douglas McCloskeyQ114563005
P2093author name stringSibei Xu
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Methylglyoxal, an endogenous aldehyde, crosslinks DNA polymerase and the substrate DNA.Q39097246
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The iron-binding CyaY and IscX proteins assist the ISC-catalyzed Fe-S biogenesis in Escherichia coli.Q41645273
The alternative aerobic ribonucleotide reductase of Escherichia coli, NrdEF, is a manganese-dependent enzyme that enables cell replication during periods of iron starvationQ42020372
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Bacterial toxin YafQ is an endoribonuclease that associates with the ribosome and blocks translation elongation through sequence-specific and frame-dependent mRNA cleavageQ46125112
Metabolic flux analysis of Escherichia coli in glucose-limited continuous culture. II. Dynamic response to famine and feast, activation of the methylglyoxal pathway and oscillatory behaviourQ46368004
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P921main subjectmutationQ42918
Escherichia coliQ25419
P304page(s)82-93
P577publication date2018-05-26
P1433published inMetabolic EngineeringQ6822334
P1476titleAdaptation to the coupling of glycolysis to toxic methylglyoxal production in tpiA deletion strains of Escherichia coli requires synchronized and counterintuitive genetic changes
P478volume48

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cites work (P2860)
Q83227435Adaptation to mutational inactivation of an essential gene converges to an accessible suboptimal fitness peak
Q92857437Continuous Adaptive Evolution of a Fast-Growing Corynebacterium glutamicum Strain Independent of Protocatechuate
Q58726514Evolution of gene knockout strains of E. coli reveal regulatory architectures governed by metabolism
Q60938695How adaptive evolution reshapes metabolism to improve fitness: recent advances and future outlook
Q58122460Identification of growth-coupled production strains considering protein costs and kinetic variability
Q98303221Synthetic cross-phyla gene replacement and evolutionary assimilation of major enzymes

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