Identification and characterization of new inhibitors of the Escherichia coli MurA enzyme

scientific article

Identification and characterization of new inhibitors of the Escherichia coli MurA enzyme is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.45.11.3182-3188.2001
P932PMC publication ID90801
P698PubMed publication ID11600375

P2093author name stringBush K
Foleno BD
Baum EZ
Webb GC
Montenegro DA
Licata L
Turchi I
P2860cites workCharacterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin.Q54590227
Comparative study of fosfomycin activity in Mueller-Hinton media and in tissuesQ71829315
Detection and characterization of a phospholactoyl-enzyme adduct in the reaction catalyzed by UDP-N-acetylglucosamine enolpyruvoyl transferase, MurZQ72160243
Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of UDP-GlcNAc enolpyruvoyl transferase by the antibiotic fosfomycinQ72160246
Critical evaluation of the research docking program for the CASP2 challengeQ74252623
MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coliQ24671787
Role of the loop containing residue 115 in the induced-fit mechanism of the bacterial cell wall biosynthetic enzyme MurAQ27621570
Crystal structure of UDP-N-acetylglucosamine enolpyruvyltransferase, the target of the antibiotic fosfomycinQ27733409
Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycinQ27734363
Cloning and sequencing of Escherichia coli murZ and purification of its product, a UDP-N-acetylglucosamine enolpyruvyl transferaseQ33202551
Two active forms of UDP-N-acetylglucosamine enolpyruvyl transferase in gram-positive bacteriaQ33601835
In vitro susceptibility testing procedures for fosfomycin tromethamineQ33744499
Emergence of fosfomycin-resistant isolates of Shiga-like toxin-producing Escherichia coli O26Q33976610
Multiple mechanisms of action for inhibitors of histidine protein kinases from bacterial two-component systemsQ33977169
The mechanism of action of fosfomycin (phosphonomycin)Q34214482
Intracellular steps of bacterial cell wall peptidoglycan biosynthesis: enzymology, antibiotics, and antibiotic resistanceQ34541598
Fosfomycin resistance protein (FosA) is a manganese metalloglutathione transferase related to glyoxalase I and the extradiol dioxygenasesQ36855782
Studies on the conformational changes in the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine enolpyruvyltransferase (MurA).Q42680309
Plasmid-encoded fosfomycin resistance in bacteria isolated from the urinary tract in a multicentre surveyQ48044137
A fast flexible docking method using an incremental construction algorithm.Q52298930
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectEscherichia coliQ25419
P304page(s)3182-3188
P577publication date2001-11-01
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleIdentification and characterization of new inhibitors of the Escherichia coli MurA enzyme
P478volume45

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cites work (P2860)
Q245643061,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH)
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Q30895039Combinatorial enzymatic assay for the screening of a new class of bacterial cell wall inhibitors
Q38420842Comprehensive structural and functional characterization of Mycobacterium tuberculosis UDP-NAG enolpyruvyl transferase (Mtb-MurA) and prediction of its accurate binding affinities with inhibitors
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Q38807273Coprinuslactone protects the edible mushroom Coprinus comatus against biofilm infections by blocking both quorum-sensing and MurA.
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Q36175676Differential antibacterial properties of the MurA inhibitors terreic acid and fosfomycin
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Q48022320Identification of druggable targets for Acinetobacter baumannii via subtractive genomics and plausible inhibitors for MurA and MurB.
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Q45278217MurA as a primary target of tulipalin B and 6-tuliposide B.
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Q34568935The bacterial cell wall as a source of antibacterial targets
Q42079513Toxin ζ reversible induces dormancy and reduces the UDP-N-acetylglucosamine pool as one of the protective responses to cope with stress
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Q37913126UDP-N-acetylglucosamine enolpyruvyl transferase as a potential target for antibacterial chemotherapy: recent developments
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