The bacterial cell wall as a source of antibacterial targets

scientific article

The bacterial cell wall as a source of antibacterial targets is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1517/14728222.6.1.1
P698PubMed publication ID11901475

P2093author name stringDavid W Green
P2860cites workComplete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogenQ22122393
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MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coliQ24671787
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X-ray structure of the Asn276Asp variant of the Escherichia coli TEM-1 beta-lactamase: direct observation of electrostatic modulation in resistance to inactivation by clavulanic acidQ27619141
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"Open" structures of MurD: domain movements and structural similarities with folylpolyglutamate synthetaseQ27626831
Structural proteomics of an archaeonQ27627315
Crystal structure of Escherichia coli UDPMurNAc-tripeptide d-alanyl-d-alanine-adding enzyme (MurF) at 2.3 A resolutionQ27628634
Crystal structure of Streptococcus pneumoniae N-acetylglucosamine-1-phosphate uridyltransferase bound to acetyl-coenzyme A reveals a novel active site architectureQ27628944
Crystal structure of UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: meso-diaminopimelate ligase from Escherichia coliQ27629001
Crystal structure of cis-prenyl chain elongating enzyme, undecaprenyl diphosphate synthaseQ27631031
A structural variation for MurB: X-ray crystal structure of Staphylococcus aureus UDP-N-acetylenolpyruvylglucosamine reductase (MurB)Q27631486
Structure of the Escherichia coli GlmU pyrophosphorylase and acetyltransferase active sitesQ27631533
Structure-based design and in-parallel synthesis of inhibitors of AmpC beta-lactamaseQ27632621
Crystal structure of PBP2x from a highly penicillin-resistant Streptococcus pneumoniae clinical isolate: a mosaic framework containing 83 mutationsQ27634800
Crystal structure of UDP-N-acetylglucosamine enolpyruvyltransferase, the target of the antibiotic fosfomycinQ27733409
Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycinQ27734363
Whole genome sequencing of meticillin-resistant Staphylococcus aureusQ28202807
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Drug target validation: lethal infection blocked by inducible peptideQ30833343
Selective cleavage of D-Ala-D-Lac by small molecules: re-sensitizing resistant bacteria to vancomycinQ31004680
Identification and characterization of new inhibitors of the Escherichia coli MurA enzymeQ31016009
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Two active forms of UDP-N-acetylglucosamine enolpyruvyl transferase in gram-positive bacteriaQ33601835
VanX, a bacterial D-alanyl-D-alanine dipeptidase: resistance, immunity, or survival function?Q33740144
Crystal structure of UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase from Escherichia coliQ33886827
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Bacterial diaminopimelate metabolism as a target for antibiotic design.Q33959033
Mining bacterial genomes for antimicrobial targetsQ34094923
The mechanism of action of fosfomycin (phosphonomycin)Q34214482
Resistance to antibiotics mediated by target alterationsQ34339223
Beta-lactamase-inhibitor combinations in the 21st century: current agents and new developmentsQ34476139
Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA.Q34968575
Separation of abnormal cell wall composition from penicillin resistance through genetic transformation of Streptococcus pneumoniaeQ35604290
Inhibition of the expression of penicillin resistance in Streptococcus pneumoniae by inactivation of cell wall muropeptide branching genes.Q35700261
Replacement of diaminopimelic acid by cystathionine or lanthionine in the peptidoglycan of Escherichia coliQ36109102
Identification of the glmU gene encoding N-acetylglucosamine-1-phosphate uridyltransferase in Escherichia coli.Q36122633
???Q27748883
Serine beta-lactamases and penicillin-binding proteinsQ36784607
The structure of an asymmetric dimer relevant to the mode of action of the glycopeptide antibioticsQ38305406
Kinetic characterization of wild-type and S229A mutant MurB: evidence for the role of Ser 229 as a general acidQ38349191
Acetyltransfer precedes uridylyltransfer in the formation of UDP-N-acetylglucosamine in separable active sites of the bifunctional GlmU protein of Escherichia coliQ38362743
A simple screen for murein transglycosylase inhibitorsQ39473696
Novel scintillation proximity assay for measuring membrane-associated steps of peptidoglycan biosynthesis in Escherichia coliQ39476540
Identification and characterization of a monofunctional glycosyltransferase from Staphylococcus aureusQ39526567
Vancomycin resistance: decoding the molecular logicQ40856100
The versatility of phosphoenolpyruvate and its vinyl ether products in biosynthesisQ41112852
Antimicrobial-drug resistanceQ41171288
Phosphinic acid inhibitors of D-alanyl-D-alanine ligaseQ42209062
Dissection of the bifunctional Escherichia coli N-acetylglucosamine-1-phosphate uridyltransferase enzyme into autonomously functional domains and evidence that trimerization is absolutely required for glucosamine-1-phosphate acetyltransferase activiQ43510086
Effect of beta-lactam antibiotics on the in vitro development of resistance in Pseudomonas aeruginosaQ43586040
Asparagine 23 and aspartate 305 are essential residues in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase from Enterobacter cloacaeQ43591572
Inhibitors of the bacterial cell wall biosynthesis enzyme MurC.Q43621566
Using bioinformatics in gene and drug discoveryQ43633753
Genetic basis for activity differences between vancomycin and glycolipid derivatives of vancomycin.Q43718660
Synthesis and evaluation of inhibitors of bacterial D-alanine:D-alanine ligasesQ44437680
FemABX family members are novel nonribosomal peptidyltransferases and important pathogen-specific drug targetsQ47814472
A method for demonstrating gene essentiality in Staphylococcus aureusQ47849267
Cloning and sequencing of Staphylococcus aureus murC, a gene essential for cell wall biosynthesisQ47909491
Plasmid-encoded fosfomycin resistance in bacteria isolated from the urinary tract in a multicentre surveyQ48044137
Kinetic mechanism of the Escherichia coli UDPMurNAc-tripeptide D-alanyl-D-alanine-adding enzyme: use of a glutathione S-transferase fusionQ48056619
Sequence divergence of the murB and rrfB genes from Escherichia coli and Salmonella typhimuriumQ48086447
Better substrates for bacterial transglycosylasesQ49315804
Topological analysis of the MraY protein catalysing the first membrane step of peptidoglycan synthesis.Q54072596
Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase.Q54118077
Amino acid substitutions that reduce the affinity of penicillin-binding protein 3 of Escherichia coli for cephalexin.Q54445869
Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin.Q54590227
Biochemical evidence for the formation of a covalent acyl-phosphate linkage between UDP-N-acetylmuramate and ATP in the Escherichia coli UDP-N-acetylmuramate:L-alanine ligase-catalyzed reaction.Q54593810
High-throughput x-ray crystallography for structure-based drug designQ57830933
Role of the Ortholog and Paralog Amino Acid Invariants in the Active Site of the UDP-MurNAc-l-alanine:d-glutamate Ligase (MurD)†Q57998973
Invariant Amino Acids in the Mur Peptide Synthetases of Bacterial Peptidoglycan Synthesis and Their Modification by Site-Directed Mutagenesis in the UDP-MurNAc:l-Alanine Ligase from Escherichia coliQ57998991
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectcell wallQ128700
P304page(s)1-19
P577publication date2002-02-01
P1433published inExpert Opinion on Therapeutic TargetsQ5421214
P1476titleThe bacterial cell wall as a source of antibacterial targets
P478volume6

Reverse relations

cites work (P2860)
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