review article | Q7318358 |
scholarly article | Q13442814 |
P356 | DOI | 10.1517/14728222.6.1.1 |
P698 | PubMed publication ID | 11901475 |
P2093 | author name string | David W Green | |
P2860 | cites work | Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen | Q22122393 |
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs | Q24545170 | ||
MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coli | Q24671787 | ||
Determination of the MurD mechanism through crystallographic analysis of enzyme complexes | Q27618457 | ||
X-ray structure of the Asn276Asp variant of the Escherichia coli TEM-1 beta-lactamase: direct observation of electrostatic modulation in resistance to inactivation by clavulanic acid | Q27619141 | ||
Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,) | Q27622586 | ||
Structural basis for the interaction of the fluorescence probe 8-anilino-1-naphthalene sulfonate (ANS) with the antibiotic target MurA | Q27622627 | ||
"Open" structures of MurD: domain movements and structural similarities with folylpolyglutamate synthetase | Q27626831 | ||
Structural proteomics of an archaeon | Q27627315 | ||
Crystal structure of Escherichia coli UDPMurNAc-tripeptide d-alanyl-d-alanine-adding enzyme (MurF) at 2.3 A resolution | Q27628634 | ||
Crystal structure of Streptococcus pneumoniae N-acetylglucosamine-1-phosphate uridyltransferase bound to acetyl-coenzyme A reveals a novel active site architecture | Q27628944 | ||
Crystal structure of UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: meso-diaminopimelate ligase from Escherichia coli | Q27629001 | ||
Crystal structure of cis-prenyl chain elongating enzyme, undecaprenyl diphosphate synthase | Q27631031 | ||
A structural variation for MurB: X-ray crystal structure of Staphylococcus aureus UDP-N-acetylenolpyruvylglucosamine reductase (MurB) | Q27631486 | ||
Structure of the Escherichia coli GlmU pyrophosphorylase and acetyltransferase active sites | Q27631533 | ||
Structure-based design and in-parallel synthesis of inhibitors of AmpC beta-lactamase | Q27632621 | ||
Crystal structure of PBP2x from a highly penicillin-resistant Streptococcus pneumoniae clinical isolate: a mosaic framework containing 83 mutations | Q27634800 | ||
Crystal structure of UDP-N-acetylglucosamine enolpyruvyltransferase, the target of the antibiotic fosfomycin | Q27733409 | ||
Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycin | Q27734363 | ||
Whole genome sequencing of meticillin-resistant Staphylococcus aureus | Q28202807 | ||
Discovery of novel disaccharide antibacterial agents using a combinatorial library approach | Q30760466 | ||
Drug target validation: lethal infection blocked by inducible peptide | Q30833343 | ||
Selective cleavage of D-Ala-D-Lac by small molecules: re-sensitizing resistant bacteria to vancomycin | Q31004680 | ||
Identification and characterization of new inhibitors of the Escherichia coli MurA enzyme | Q31016009 | ||
Synthesis of the nucleoside moiety of liposidomycins: elucidation of the pharmacophore of this family of MraY inhibitors | Q33181002 | ||
Two active forms of UDP-N-acetylglucosamine enolpyruvyl transferase in gram-positive bacteria | Q33601835 | ||
VanX, a bacterial D-alanyl-D-alanine dipeptidase: resistance, immunity, or survival function? | Q33740144 | ||
Crystal structure of UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase from Escherichia coli | Q33886827 | ||
Identification of critical staphylococcal genes using conditional phenotypes generated by antisense RNA. | Q33954835 | ||
Bacterial diaminopimelate metabolism as a target for antibiotic design. | Q33959033 | ||
Mining bacterial genomes for antimicrobial targets | Q34094923 | ||
The mechanism of action of fosfomycin (phosphonomycin) | Q34214482 | ||
Resistance to antibiotics mediated by target alterations | Q34339223 | ||
Beta-lactamase-inhibitor combinations in the 21st century: current agents and new developments | Q34476139 | ||
Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA. | Q34968575 | ||
Separation of abnormal cell wall composition from penicillin resistance through genetic transformation of Streptococcus pneumoniae | Q35604290 | ||
Inhibition of the expression of penicillin resistance in Streptococcus pneumoniae by inactivation of cell wall muropeptide branching genes. | Q35700261 | ||
Replacement of diaminopimelic acid by cystathionine or lanthionine in the peptidoglycan of Escherichia coli | Q36109102 | ||
Identification of the glmU gene encoding N-acetylglucosamine-1-phosphate uridyltransferase in Escherichia coli. | Q36122633 | ||
??? | Q27748883 | ||
Serine beta-lactamases and penicillin-binding proteins | Q36784607 | ||
The structure of an asymmetric dimer relevant to the mode of action of the glycopeptide antibiotics | Q38305406 | ||
Kinetic characterization of wild-type and S229A mutant MurB: evidence for the role of Ser 229 as a general acid | Q38349191 | ||
Acetyltransfer precedes uridylyltransfer in the formation of UDP-N-acetylglucosamine in separable active sites of the bifunctional GlmU protein of Escherichia coli | Q38362743 | ||
A simple screen for murein transglycosylase inhibitors | Q39473696 | ||
Novel scintillation proximity assay for measuring membrane-associated steps of peptidoglycan biosynthesis in Escherichia coli | Q39476540 | ||
Identification and characterization of a monofunctional glycosyltransferase from Staphylococcus aureus | Q39526567 | ||
Vancomycin resistance: decoding the molecular logic | Q40856100 | ||
The versatility of phosphoenolpyruvate and its vinyl ether products in biosynthesis | Q41112852 | ||
Antimicrobial-drug resistance | Q41171288 | ||
Phosphinic acid inhibitors of D-alanyl-D-alanine ligase | Q42209062 | ||
Dissection of the bifunctional Escherichia coli N-acetylglucosamine-1-phosphate uridyltransferase enzyme into autonomously functional domains and evidence that trimerization is absolutely required for glucosamine-1-phosphate acetyltransferase activi | Q43510086 | ||
Effect of beta-lactam antibiotics on the in vitro development of resistance in Pseudomonas aeruginosa | Q43586040 | ||
Asparagine 23 and aspartate 305 are essential residues in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase from Enterobacter cloacae | Q43591572 | ||
Inhibitors of the bacterial cell wall biosynthesis enzyme MurC. | Q43621566 | ||
Using bioinformatics in gene and drug discovery | Q43633753 | ||
Genetic basis for activity differences between vancomycin and glycolipid derivatives of vancomycin. | Q43718660 | ||
Synthesis and evaluation of inhibitors of bacterial D-alanine:D-alanine ligases | Q44437680 | ||
FemABX family members are novel nonribosomal peptidyltransferases and important pathogen-specific drug targets | Q47814472 | ||
A method for demonstrating gene essentiality in Staphylococcus aureus | Q47849267 | ||
Cloning and sequencing of Staphylococcus aureus murC, a gene essential for cell wall biosynthesis | Q47909491 | ||
Plasmid-encoded fosfomycin resistance in bacteria isolated from the urinary tract in a multicentre survey | Q48044137 | ||
Kinetic mechanism of the Escherichia coli UDPMurNAc-tripeptide D-alanyl-D-alanine-adding enzyme: use of a glutathione S-transferase fusion | Q48056619 | ||
Sequence divergence of the murB and rrfB genes from Escherichia coli and Salmonella typhimurium | Q48086447 | ||
Better substrates for bacterial transglycosylases | Q49315804 | ||
Topological analysis of the MraY protein catalysing the first membrane step of peptidoglycan synthesis. | Q54072596 | ||
Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase. | Q54118077 | ||
Amino acid substitutions that reduce the affinity of penicillin-binding protein 3 of Escherichia coli for cephalexin. | Q54445869 | ||
Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin. | Q54590227 | ||
Biochemical evidence for the formation of a covalent acyl-phosphate linkage between UDP-N-acetylmuramate and ATP in the Escherichia coli UDP-N-acetylmuramate:L-alanine ligase-catalyzed reaction. | Q54593810 | ||
High-throughput x-ray crystallography for structure-based drug design | Q57830933 | ||
Role of the Ortholog and Paralog Amino Acid Invariants in the Active Site of the UDP-MurNAc-l-alanine:d-glutamate Ligase (MurD)† | Q57998973 | ||
Invariant Amino Acids in the Mur Peptide Synthetases of Bacterial Peptidoglycan Synthesis and Their Modification by Site-Directed Mutagenesis in the UDP-MurNAc:l-Alanine Ligase from Escherichia coli | Q57998991 | ||
P433 | issue | 1 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | cell wall | Q128700 |
P304 | page(s) | 1-19 | |
P577 | publication date | 2002-02-01 | |
P1433 | published in | Expert Opinion on Therapeutic Targets | Q5421214 |
P1476 | title | The bacterial cell wall as a source of antibacterial targets | |
P478 | volume | 6 |
Q44508067 | 2-Phenyl-5,6-dihydro-2H-thieno[3,2-c]pyrazol-3-ol derivatives as new inhibitors of bacterial cell wall biosynthesis |
Q33301093 | A MurF inhibitor that disrupts cell wall biosynthesis in Escherichia coli |
Q46714002 | A close-up view of the VraSR two-component system. A mediator of Staphylococcus aureus response to cell wall damage |
Q42647502 | A novel inhibitor that suspends the induced fit mechanism of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA). |
Q38114581 | An in silico structure-based approach to anti-infective drug discovery |
Q92063117 | Antimicrobial Evaluation of Latex and TLC Fractions from the Leaves of Aloe adigratana Reynolds |
Q100235131 | Antimicrobial action and antimicrobial resistance in Mtb |
Q27679476 | Cell-Wall Remodeling by the Zinc-Protease AmpDh3 from Pseudomonas aeruginosa |
Q36880669 | CesRK, a Two-Component Signal Transduction System in Listeria monocytogenes , Responds to the Presence of Cell Wall-Acting Antibiotics and Affects β-Lactam Resistance |
Q27649118 | Characterization of substrate binding and catalysis in the potential antibacterial targetN-acetylglucosamine-1-phosphate uridyltransferase (GlmU) |
Q53632428 | Combination of site directed mutagenesis and secondary structure analysis predicts the amino acids essential for stability of M. leprae MurE. |
Q42736090 | Common beta-lactamases inhibit bacterial biofilm formation |
Q47952651 | Conformational stability of OXA-51 β-lactamase explains its role in carbapenem resistance of Acinetobacter baumannii |
Q36422330 | Determinants for the subcellular localization and function of a nonessential SEDS protein. |
Q33630542 | Dual Inhibitor of MurD and MurE Ligases from Escherichia coli and Staphylococcus aureus. |
Q37866109 | Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product release |
Q51025181 | Expeditious synthesis of enantiopure, orthogonally protected bis-α-amino acids (OPBAAs) and their use in a study of Nod1 stimulation. |
Q41853373 | Expression, purification and preliminary X-ray crystallographic analysis of UDP-galactopyranose mutase from Deinococcus radiodurans |
Q53811451 | Gene Network Analysis of Metallo Beta Lactamase Family Proteins Indicates the Role of Gene Partners in Antibiotic Resistance and Reveals Important Drug Targets. |
Q54352039 | Identification of Novel Inhibitors of UDP-Galactopyranose Mutase by Structure-Based Virtual Screening. |
Q35223524 | Identification of bromophenol thiohydantoin as an inhibitor of DisA, a c-di-AMP synthase, from a 1000 compound library, using the coralyne assay |
Q44324006 | Identification of hotspot regions of MurB oxidoreductase enzyme using homology modeling, molecular dynamics and molecular docking techniques |
Q42281247 | Interaction with lipid II induces conformational changes in bovicin HC5 structure |
Q36314747 | Lipid intermediates in the biosynthesis of bacterial peptidoglycan |
Q59792334 | Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR |
Q41823306 | MurF inhibitors with antibacterial activity: effect on muropeptide levels |
Q33716658 | N Glycolylation of the nucleotide precursors of peptidoglycan biosynthesis of Mycobacterium spp. is altered by drug treatment |
Q33436605 | New high-throughput fluorimetric assay for discovering inhibitors of UDP-N-acetylmuramyl-L-alanine: D-glutamate (MurD) ligase |
Q35056042 | Novel agents for the treatment of resistant Gram-positive infections |
Q36381840 | OXA-type carbapenemases |
Q37192621 | Quorum sensing and virulence regulation in Xanthomonas campestris |
Q44873863 | Rapid analysis of nucleotide-activated sugars by high-performance liquid chromatography coupled with diode-array detection, electrospray ionization mass spectrometry and nuclear magnetic resonance |
Q34454606 | Screen for agents that induce autolysis in Bacillus subtilis |
Q29619896 | Seven-transmembrane receptors |
Q35217401 | Small-molecule inhibitors of signal transduction pathways in leukemia therapeutics: how to assess selectivity for malignant signals |
Q39430096 | Synthesis and study of antibacterial activities of antibacterial glycopeptide antibiotics conjugated with benzoxaboroles |
Q36561313 | Targeting the formation of the cell wall core of M. tuberculosis |
Q38240597 | The biology of Mur ligases as an antibacterial target |
Q34988239 | The future challenges facing the development of new antimicrobial drugs. |
Q47919073 | The situation on antimicrobial agents and chemotherapy in 2002: highlights of the 42nd ICAAC. |
Q35143886 | Vancomycin resistance: occurrence, mechanisms and strategies to combat it. |
Q48632952 | Virulence-targeted Antibacterials: Concept, Promise, and Susceptibility to Resistance Mechanisms |
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