Combinatorial enzymatic assay for the screening of a new class of bacterial cell wall inhibitors

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Combinatorial enzymatic assay for the screening of a new class of bacterial cell wall inhibitors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0968-0896(02)00447-9
P8608Fatcat IDrelease_b6ffhz4t7bhorcshnmnzjpynji
P698PubMed publication ID12628682

P50authorNormand VoyerQ83978785
P2093author name stringRoger C Levesque
François Sanschagrin
Ahmed El Zoeiby
Eric Dubuc
Mélanie Beaumont
P2860cites workDesign and synthesis of conformationally-constrained MMP inhibitorsQ27766404
An improved assay for nanomole amounts of inorganic phosphateQ29620585
Identification and characterization of new inhibitors of the Escherichia coli MurA enzymeQ31016009
Cloning and sequencing of Escherichia coli murZ and purification of its product, a UDP-N-acetylglucosamine enolpyruvyl transferaseQ33202551
Intracellular steps of bacterial cell wall peptidoglycan biosynthesis: enzymology, antibiotics, and antibiotic resistanceQ34541598
Biochemical characterization of a phosphinate inhibitor of Escherichia coli MurC.Q38296349
Inhibitors of the bacterial cell wall biosynthesis enzyme MurC.Q43621566
Matrix metalloproteinase inhibitors: a structure-activity studyQ44313673
Conditionally lethal Escherichia coli murein mutants contain point defects that map to regions conserved among murein and folyl poly-gamma-glutamate ligases: identification of a ligase superfamilyQ48049705
Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin.Q54590227
Invariant Amino Acids in the Mur Peptide Synthetases of Bacterial Peptidoglycan Synthesis and Their Modification by Site-Directed Mutagenesis in the UDP-MurNAc:l-Alanine Ligase from Escherichia coliQ57998991
Effect of analogues of diaminopimelic acid on the meso -diaminopimelate-adding enzyme from Escherichia coliQ60481030
Overexpression, purification, and mechanistic study of UDP-N-acetylenolpyruvylglucosamine reductaseQ70597134
Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of UDP-GlcNAc enolpyruvoyl transferase by the antibiotic fosfomycinQ72160246
Phosphonomycin: structure and synthesisQ72531472
Combinatorial chemistry and new drugsQ73200719
4-Thiazolidinones: novel inhibitors of the bacterial enzyme MurBQ73715141
In vitro reconstruction of the biosynthetic pathway of peptidoglycan cytoplasmic precursor in Pseudomonas aeruginosaQ74257167
Phosphinate Inhibitors of the D-Glutamic Acid-Adding Enzyme of Peptidoglycan BiosynthesisQ74822592
Inhibitors of the bacterial cell wall biosynthesis enzyme MurDQ77748921
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectcell wallQ128700
P304page(s)1583-1592
P577publication date2003-04-01
P1433published inBioorganic & Medicinal ChemistryQ2904200
P1476titleCombinatorial enzymatic assay for the screening of a new class of bacterial cell wall inhibitors
P478volume11

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cites work (P2860)
Q343521653,5-dioxopyrazolidines, novel inhibitors of UDP-N- acetylenolpyruvylglucosamine reductase (MurB) with activity against gram-positive bacteria
Q80546533Naphthyl tetronic acids as multi-target inhibitors of bacterial peptidoglycan biosynthesis
Q38240597The biology of Mur ligases as an antibacterial target

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