Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.

scientific article

Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CELREP.2012.02.003
P3181OpenCitations bibliographic resource ID1604213
P932PMC publication ID3314296
P698PubMed publication ID22832194
P5875ResearchGate publication ID230567682

P50authorPietro RoversiQ28039121
Oscar LlorcaQ39715512
Susan M. LeaQ42425353
Federico FornerisQ55457275
Piet GrosQ88960310
P2093author name stringDoryen Bubeck
Michael K Pangburn
B Paul Morgan
Svetlana Hakobyan
Michael A Hadders
P2860cites workRole of the human C8 subunits in complement-mediated bacterial killing: evidence that C8 gamma is not essentialQ24315542
A common fold mediates vertebrate defense and bacterial attackQ27647495
Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defenseQ27648205
Structure of and influence of a tick complement inhibitor on human complement component 5Q27650767
The structural basis for membrane binding and pore formation by lymphocyte perforinQ27665482
Structure of human C8 protein provides mechanistic insight into membrane pore formation by complementQ27667378
Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC)Q27676846
Structure of a cholesterol-binding, thiol-activated cytolysin and a model of its membrane formQ27738974
XDSQ27860472
Coot: model-building tools for molecular graphicsQ27860505
Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNTQ27860590
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
Phasercrystallographic softwareQ27860930
EMAN2: an extensible image processing suite for electron microscopyQ27861052
The CCP4 suite: programs for protein crystallographyQ27861090
Structure of C3b reveals conformational changes that underlie complement activityQ28269312
Structures of complement component C3 provide insights into the function and evolution of immunityQ28273530
Evidence that C5b recognizes and mediates C8 incorporation into the cytolytic complex of complementQ28301977
Molecular organization of C9 within the membrane attack complex of complement. Induction of circular C9 polymerization by the C5b-8 assemblyQ28610976
Bsoft: image processing and molecular modeling for electron microscopyQ29614289
Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunitQ30157689
Image processing for electron microscopy single-particle analysis using XMIPP.Q33341061
Regulation of the complement membrane attack pathwayQ33697279
Joint X-ray and neutron refinement with phenix.refineQ34257680
Evidence for presence of an internal thiolester bond in third component of human complement.Q36409419
The membrane attack complex of complement: relation of C7 to the metastable membrane binding site of the intermediate complex C5b-7.Q36495504
Complement in human diseases: Lessons from complement deficienciesQ37501005
Proteolytic transformation of SC5b-9 into an amphiphilic macromolecule resembling the C5b-9 membrane attack complex of complementQ39694126
Incorporation of human complement C8 into the membrane attack complex is mediated by a binding site located within the C8beta MACPF domainQ40290270
The membrane attack complex of complement. Assembly, structure and cytotoxic activityQ40741469
Function of the factor I modules (FIMS) of human complement component C6.Q41699451
Evidence of direct insertion of terminal complement proteins into cell membrane bilayers during cytolysis. Labeling by a photosensitive membrane probe reveals a major role for the eighth and ninth componentsQ42259068
The reaction mechanism of human C5 in immune hemolysisQ42835268
Monoclonal antibodies recognizing a neoantigen of poly(C9) detect the human terminal complement complex in tissue and plasmaQ43762567
SC5b-7, SC5b-8 and SC5b-9 complexes of complement: ultrastructure and localization of the S-protein (vitronectin) within the macromoleculesQ50335849
The membrane attack complex of complement: C5b-8 complex as accelerator of C9 polymerization.Q54458101
Complement components C5 and C7: recombinant factor I modules of C7 bind to the C345C domain of C5.Q54499187
The Mechanism of Membrane Insertion for a Cholesterol-Dependent CytolysinQ56917809
Functional Studies of the MACPF Domain of Human Complement Protein C8α Reveal Sites for Simultaneous Binding of C8β, C8γ, and C9†Q57837353
Biochemical characterization of the sixth component (C6) of human complementQ70331443
Ultrastructure of the membrane attack complex of complement. Heterogeneity of the complex caused by different degree of C9 polymerizationQ71394036
SC5b-9 complex of complement: formation of the dimeric membrane attack complex by removal of S-proteinQ72130336
Functional role of the noncatalytic subunit of complement C5 convertaseQ73368160
P433issue3
P921main subjectComplement C5Q426181
Complement C6Q5156406
Complement C9Q21102471
Complement C8 alpha chainQ21102473
Complement C8 beta chainQ21102474
Complement C7Q21102480
P304page(s)200-207
P577publication date2012-02-23
P1433published inCell ReportsQ5058165
P1476titleAssembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.
P478volume1

Reverse relations

cites work (P2860)
Q59800432A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the Staphylococcus aureus SSL7 Protein
Q35002974A revised mechanism for the activation of complement C3 to C3b: a molecular explanation of a disease-associated polymorphism
Q31154707AAV-mediated expression of human PRELP inhibits complement activation, choroidal neovascularization and deposition of membrane attack complex in mice
Q57751835Advances in cryoEM and its impact on β-pore forming proteins
Q58725179Advances in structure determination by cryo-EM to unravel membrane-spanning pore formation
Q50061912Apicomplexan C-Mannosyltransferases Modify Thrombospondin Type I-Containing Adhesins of the TRAP Family.
Q38234314Bacteria under stress by complement and coagulation.
Q64245049Bacterial killing by complement requires membrane attack complex formation via surface-bound C5 convertases
Q37496310Bioinformatic analysis of the membrane cofactor protein CD46 and microRNA expression in hepatocellular carcinoma
Q98187260C-Mannosylation Enhances the Structural Stability of Human RNase 2
Q51259647Chimeric approach for narrowing a membrane-inserting region within human perforin.
Q55031290Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy.
Q34481071Complement System Part I - Molecular Mechanisms of Activation and Regulation
Q36380682Complement activation, regulation, and molecular basis for complement-related diseases
Q90475736Complement membrane attack complex: new roles, mechanisms of action, and therapeutic targets
Q33828385Complement-Mediated Regulation of Apolipoprotein E in Cultured Human RPE Cells
Q27313232Conformational changes during pore formation by the perforin-related protein pleurotolysin
Q40819035Conserved Patterns of Microbial Immune Escape: Pathogenic Microbes of Diverse Origin Target the Human Terminal Complement Inhibitor Vitronectin via a Single Common Motif
Q60044764CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers
Q42016535CspA from Borrelia burgdorferi inhibits the terminal complement pathway
Q39479462Development of the Cellular Immune System of Drosophila Requires the Membrane Attack Complex/Perforin-Like Protein Torso-Like
Q47976585Distinct localization of the complement C5b-9 complex on Gram-positive bacteria
Q34300045Effects of MACPF/CDC proteins on lipid membranes.
Q49439487Expanding horizons in complement drug discovery: challenges and emerging strategies
Q35199125Functional analysis of a complement polymorphism (rs17611) associated with rheumatoid arthritis
Q38624669How novel structures inform understanding of complement function
Q98465707Immune Evasion Strategies of Relapsing Fever Spirochetes
Q54238314Immunomodulatory Effects of Pneumococcal Extracellular Vesicles on Cellular and Humoral Host Defenses.
Q40223553Incomplete pneumolysin oligomers form membrane pores.
Q38816011Innate Immune System at the Maternal-Fetal Interface: Mechanisms of Disease and Targets of Therapy in Pregnancy Syndromes
Q40672986Invasive meningococcal disease in three siblings with hereditary deficiency of the 8(th) component of complement: evidence for the importance of an early diagnosis
Q28066477Killing of Microbes and Cancer by the Immune System with Three Mammalian Pore-Forming Killer Proteins
Q40654455Novel biomarker and easy to perform ELISA for monitoring complement inhibition in patients with atypical hemolytic uremic syndrome treated with eculizumab.
Q36059050Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins
Q38871927Pathogenic Leptospira Secreted Proteases Target the Membrane Attack Complex: A Potential Role for Thermolysin in Complement Inhibition.
Q37535268Polyphosphate suppresses complement via the terminal pathway
Q36479278Progress and Trends in Complement Therapeutics
Q92807181Protosappanin-A and oleanolic acid protect injured podocytes from apoptosis through inhibition of AKT-mTOR signaling
Q35774133Pseudomonas aeruginosa Uses Dihydrolipoamide Dehydrogenase (Lpd) to Bind to the Human Terminal Pathway Regulators Vitronectin and Clusterin to Inhibit Terminal Pathway Complement Attack
Q26828812Putting the structure into complement
Q36906411Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode.
Q35657115Role of complement and complement regulatory proteins in the complications of diabetes
Q64065747Single-molecule kinetics of pore assembly by the membrane attack complex
Q36300934Staphylococcal protein Ecb impairs complement receptor-1 mediated recognition of opsonized bacteria
Q34552556Streptococcus pneumoniae phosphoglycerate kinase is a novel complement inhibitor affecting the membrane attack complex formation
Q27678091Structural Basis for Recognition of the Pore-Forming Toxin Intermedilysin by Human Complement Receptor CD59
Q27333931Structural basis of complement membrane attack complex formation.
Q38991069Structural insight into proteolytic activation and regulation of the complement system
Q28115911Structure of the poly-C9 component of the complement membrane attack complex
Q38991062Terminal complexes of the complement system: new structural insights and their relevance to function.
Q30152922The Apicomplexan CDC/MACPF-like pore-forming proteins
Q57651515The first transmembrane region of complement component-9 acts as a brake on its self-assembly
Q39384364The mystery behind membrane insertion: a review of the complement membrane attack complex
Q90374972The rational design of affinity-attenuated OmCI for the purification of complement C5
Q36643354The relative merits of therapies being developed to tackle inappropriate ('self'-directed) complement activation
Q39217886The structure and function of thioester-containing proteins in arthropods
Q43742728¹H, ¹³C and ¹⁵N resonance assignments of the complement control protein modules of the complement component C7.

Q107514917C5b6 complement complexdescribed by sourceP1343

Search more.