Abstract is: Susan Mary Lea FRS FMedSci (born 1969) is a British biologist who serves as chief of the center for structural biology at the National Cancer Institute. Her research investigates host-pathogen interactions and biomolecular pathways. She was elected a Fellow of the Royal Society in 2022.
| human | Q5 |
| P2671 | Google Knowledge Graph ID | /g/11gfmpr1mb |
| P1960 | Google Scholar author ID | 8DKOUO8AAAAJ |
| P213 | ISNI | 0000000124453942 |
| P856 | official website | https://ccr.cancer.gov/staff-directory/susan-m-lea |
| P496 | ORCID iD | 0000-0001-9287-8053 |
| P3368 | Prabook ID | 481924 |
| P3829 | Publons author ID | 2865504 |
| P1053 | ResearcherID | B-7678-2009 |
| P1153 | Scopus author ID | 7006553146 |
| P4012 | Semantic Scholar author ID | 3118791 |
| P4789 | Who's Who UK ID | U290639 |
| P2002 | X username | s_m_lea |
| P166 | award received | Fellow of the Royal Society | Q15631401 |
| Fellow of the Academy of Medical Sciences | Q24081923 | ||
| fellow of Wadham College, Oxford | Q96203560 | ||
| P27 | country of citizenship | United Kingdom | Q145 |
| P69 | educated at | University of Oxford | Q34433 |
| Oxford High School | Q7115353 | ||
| P108 | employer | University of Oxford | Q34433 |
| National Cancer Institute | Q664846 | ||
| Sir William Dunn School of Pathology | Q7529574 | ||
| P734 | family name | Lea | Q6508166 |
| Lea | Q6508166 | ||
| Lea | Q6508166 | ||
| P735 | given name | Susan | Q14936243 |
| Susan | Q14936243 | ||
| P1412 | languages spoken, written or signed | English | Q1860 |
| P463 | member of | European Molecular Biology Organization | Q1376791 |
| P106 | occupation | university teacher | Q1622272 |
| microbiologist | Q3779582 | ||
| cancer researcher | Q30086937 | ||
| P21 | sex or gender | female | Q6581072 |
| Q40681155 | A Comparative Structure/Function Analysis of Two Type IV Pilin DNA Receptors Defines a Novel Mode of DNA Binding |
| Q42915611 | A complex iron-calcium cofactor catalyzing phosphotransfer chemistry |
| Q27651367 | A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition |
| Q42043588 | A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies |
| Q53626531 | A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi. |
| Q119062871 | A novel inhibitor of complement C5 provides structural insights into activation |
| Q37696002 | A signal sequence suppressor mutant that stabilizes an assembled state of the twin arginine translocase. |
| Q27655587 | A structural study of the interaction between the Dr haemagglutinin DraE and derivatives of chloramphenicol |
| Q34092668 | An aptamer that neutralizes R5 strains of human immunodeficiency virus type 1 blocks gp120-CCR5 interaction |
| Q54500945 | An atomic resolution model for assembly, architecture, and function of the Dr adhesins. |
| Q92217539 | An inhibitor of complement C5 provides structural insights into activation |
| Q72409716 | Analysis of antigenic surfaces of proteins |
| Q40039364 | Antigenic heterogeneity of a foot-and-mouth disease virus serotype in the field is mediated by very limited sequence variation at several antigenic sites. |
| Q27675415 | Architecture of the major component of the type III secretion system export apparatus |
| Q27670907 | Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9. |
| Q57843582 | Author Correction: Structure of the core of the type III secretion system export apparatus |
| Q101476516 | Author Correction: Structures of the stator complex that drives rotation of the bacterial flagellum |
| Q33417246 | Autoantibodies to CD59, CD55, CD46 or CD35 are not associated with atypical haemolytic uraemic syndrome (aHUS). |
| Q27677832 | Bifunctional Lipocalin Ameliorates Murine Immune Complex-induced Acute Lung Injury |
| Q43095136 | Biological activity, membrane-targeting modification, and crystallization of soluble human decay accelerating factor expressed in E. coli. |
| Q38202459 | Building a secreting nanomachine: a structural overview of the T3SS. |
| Q40194202 | Characterisation of Shigella Spa33 and Thermotoga FliM/N reveals a new model for C-ring assembly in T3SS. |
| Q44195968 | Characterizing sequence variation in the VP1 capsid proteins of foot and mouth disease virus (serotype 0) with respect to virion structure |
| Q60181903 | Chicken TAP genes are polymorphic and co-evolve with the dominantly-expressed class I gene |
| Q34753608 | Competition between antagonistic complement factors for a single protein on N. meningitidis rules disease susceptibility |
| Q57836598 | Complement Factor H: Using Atomic Resolution Structure to Illuminate Disease Mechanisms |
| Q33382097 | Complement factor H: using atomic resolution structure to illuminate disease mechanisms |
| Q33395108 | Complement factor I in health and disease |
| Q27643002 | Complement regulation at the molecular level: The structure of decay-accelerating factor |
| Q50417537 | Correction: Design and Evaluation of Meningococcal Vaccines through Structure-Based Modification of Host and Pathogen Molecules |
| Q119057039 | Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target |
| Q119057042 | Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals |
| Q27671051 | Crystal Structure and Functional Characterization of the Complement Regulator Mannose-binding Lectin (MBL)/Ficolin-associated Protein-1 (MAP-1) |
| Q27650631 | Crystal structure of Spa40, the specificity switch for theShigella flexneritype III secretion system |
| Q41898025 | Crystal structure of the Bacillus subtilis phosphodiesterase PhoD reveals an iron and calcium-containing active site |
| Q27679997 | Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly |
| Q45876076 | Crystallization and preliminary X-ray analysis of three serotypes of foot-and-mouth disease virus |
| Q57836658 | Crystallization and preliminary X-ray diffraction analysis of a biologically active fragment of CD55 |
| Q47716590 | Crystallization and preliminary X-ray diffraction analysis of three EGF domains of EMR2, a 7TM immune-system molecule. |
| Q47716609 | Crystallization and preliminary crystallographic analysis of BbCRASP-1, a complement regulator-acquiring surface protein of Borrelia burgdorferi |
| Q57836670 | Crystallographic studies of human complement factor I |
| Q28610934 | Decay-accelerating factor must bind both components of the complement alternative pathway C3 convertase to mediate efficient decay |
| Q45603766 | Deconvolution of fully overlapped reflections from crystals of foot-and-mouth disease virus O1 G67. |
| Q27676318 | Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen |
| Q119057028 | Delivering a toxic metal to the active site of urease |
| Q27675010 | Design and Evaluation of Meningococcal Vaccines through Structure-Based Modification of Host and Pathogen Molecules |
| Q40996836 | Determination of the affinity and kinetic constants for the interaction between the human virus echovirus 11 and its cellular receptor, CD55. |
| Q27639329 | Determination of the structure of a decay accelerating factor-binding clinical isolate of echovirus 11 allows mapping of mutants with altered receptor requirements for infection |
| Q41241216 | Different modes of variation for each BG lineage suggest different functions |
| Q27676814 | Dimerization of complement factor H-related proteins modulates complement activation in vivo |
| Q40015542 | Dissecting the roles of VP0 cleavage and RNA packaging in picornavirus capsid stabilization: the structure of empty capsids of foot-and-mouth disease virus |
| Q34916886 | Distinct binding and immunogenic properties of the gonococcal homologue of meningococcal factor h binding protein |
| Q27678414 | ErpC, a member of the complement regulator-acquiring family of surface proteins fromBorrelia burgdorferi, possesses an architecture previously unseen in this protein family |
| Q57836585 | Erratum: Corrigendum: Three-dimensional reconstruction of the Shigella T3SS transmembrane regions reveals 12-fold symmetry and novel features throughout |
| Q57836603 | Erratum: Structure of and influence of a tick complement inhibitor on human complement component 5 |
| Q40593889 | EspM2 is a RhoA guanine nucleotide exchange factor |
| Q119057031 | Expanding the Huntington’s disease research toolbox; validated subdomain protein constructs for biochemical and structural investigation of huntingtin |
| Q35573295 | Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding |
| Q35846730 | Expression, limited proteolysis and preliminary crystallographic analysis of IpaD, a component of the Shigella flexneri type III secretion system |
| Q43167342 | Expression, purification, cocrystallization and preliminary crystallographic analysis of sucrose octasulfate/human complement regulator factor H SCRs 6-8. |
| Q35846733 | Expression, purification, crystallization and preliminary crystallographic analysis of BipD, a component of the Burkholderia pseudomallei type III secretion system |
| Q35846725 | Expression, purification, crystallization and preliminary crystallographic analysis of MxiH, a subunit of the Shigella flexneri type III secretion system needle |
| Q48113964 | FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation. |
| Q40161972 | Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activation |
| Q64449256 | Factor I autoantibodies are associated with atypical haemolytic uraemic syndrome |
| Q33399052 | Factor I autoantibodies in patients with atypical hemolytic uremic syndrome: disease-associated or an epiphenomenon? |
| Q27683660 | Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands |
| Q28305087 | Functional analysis of the interdependence between DNA uptake sequence and its cognate ComP receptor during natural transformation in Neisseria species |
| Q27678417 | Further structural insights into the binding of complement factor H by complement regulator-acquiring surface protein 1 (CspA) ofBorrelia burgdorferi |
| Q119057049 | HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1 |
| Q57836628 | Helical Packing of Needles from Functionally Altered Shigella Type III Secretion Systems |
| Q28207810 | Helical structure of the needle of the type III secretion system of Shigella flexneri |
| Q45032496 | High resolution studies of the Afa/Dr adhesin DraE and its interaction with chloramphenicol |
| Q24657819 | High-resolution structures of bacterially expressed soluble human CD59 |
| Q57836619 | His-384 Allotypic Variant of Factor H Associated with Age-related Macular Degeneration Has Different Heparin Binding Properties from the Non-disease-associated Form |
| Q53586185 | Human complement factor I glycosylation: structural and functional characterisation of the N-linked oligosaccharides. |
| Q112285866 | Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1 |
| Q34034118 | Hydrophilic domain II of Escherichia coli Dr fimbriae facilitates cell invasion |
| Q27682559 | Identification and characterization of the ‘missing’ terminal enzyme for siroheme biosynthesis in α-proteobacteria |
| Q57836551 | Identification of Jagged1 as a novel ligand for CD46: An interaction required for normal induction and regulation of human TH1 responses |
| Q36324878 | Identifying factors which enhance capacity to engage in clinical education among podiatry practitioners: an action research project |
| Q56787211 | Interactions of CD55 with non-C ligands |
| Q35003499 | Interactions of CD55 with non-complement ligands |
| Q45671245 | Interactions of decay-accelerating factor (DAF) with haemagglutinating human enteroviruses: utilizing variation in primate DAF to map virus binding sites |
| Q37078991 | Intersubunit allosteric communication mediated by a conserved loop in the MCM helicase |
| Q40682669 | Investigating the structure of the factor B vWF-A domain/CD55 protein-protein complex using DEER spectroscopy: successes and pitfalls |
| Q27640215 | Mapping CD55 function. The structure of two pathogen-binding domains at 1.7 A |
| Q27656024 | Mechanism for the Hydrolysis of a Sulfur-Sulfur Bond Based on the Crystal Structure of the Thiosulfohydrolase SoxB |
| Q112577433 | Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex |
| Q38301097 | Mechanism of thiosulfate oxidation in the SoxA family of cysteine-ligated cytochromes |
| Q45722236 | Model of the equine rhinitis A virus capsid: identification of a major neutralizing immunogenic site |
| Q40813484 | Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex. |
| Q36666270 | Molecular basis for Jagged-1/Serrate ligand recognition by the Notch receptor |
| Q112575020 | Molecular basis for redox control by the human cystine/glutamate antiporter system xc− |
| Q119057045 | Molecular basis for redox control by the human cystine/glutamate antiporter system xc− |
| Q45145763 | Molecular dissection of interactions between components of the alternative pathway of complement and decay accelerating factor (CD55). |
| Q35249393 | Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection |
| Q24670035 | Molecular model of a type III secretion system needle: Implications for host-cell sensing |
| Q112598798 | Molecular structure of the intact bacterial flagellar basal body |
| Q57836592 | Mutational analyses of the BbCRASP-1 protein of Borrelia burgdorferi identify residues relevant for the architecture and binding of host complement regulators FHL-1 and factor H |
| Q27653843 | Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates |
| Q39903567 | Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies |
| Q119057048 | Nonameric structures of the cytoplasmic domain of FlhA and SctV in the context of the full-length protein |
| Q38328071 | Nonfunctional variant 3 factor H binding proteins as meningococcal vaccine candidates |
| Q27023341 | Notch receptor-ligand binding and activation: insights from molecular studies |
| Q39421277 | On the state of crystallography at the dawn of the electron microscopy revolution |
| Q27681812 | Polymorphisms in the Human Inhibitory Signal-regulatory Protein Do Not Affect Binding to Its Ligand CD47 |
| Q26828812 | Putting the structure into complement |
| Q27860590 | Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT |
| Q28185970 | Rev binds specifically to a purine loop in the SL1 region of the HIV-1 leader RNA |
| Q53218420 | SAS-6 oligomerization: the key to the centriole? |
| Q100457750 | SIMPLE 3.0. Stream single-particle cryo-EM analysis in real time |
| Q104136807 | SIMPLE 3.0. Stream single-particle cryo-EM analysis in real time |
| Q35846739 | Self-chaperoning of the type III secretion system needle tip proteins IpaD and BipD. |
| Q27972850 | Semaphorin-7A is an erythrocyte receptor for P. falciparum merozoite-specific TRAP homolog, MTRAP |
| Q42375349 | SepL resembles an aberrant effector in binding to a class 1 type III secretion chaperone and carrying an N-terminal secretion signal |
| Q27665874 | Shigella flexneri Spa15 Crystal Structure Verified in Solution by Double Electron Electron Resonance |
| Q24616615 | Specific DNA recognition mediated by a type IV pilin |
| Q57836556 | Specificity and mechanism of assembly of C4b binding protein |
| Q27680610 | Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands |
| Q42224464 | Structural Basis for Mitotic Centrosome Assembly in Flies |
| Q27678091 | Structural Basis for Recognition of the Pore-Forming Toxin Intermedilysin by Human Complement Receptor CD59 |
| Q57889655 | Structural Insights into Notch Receptor-Ligand Interactions |
| Q37281583 | Structural analysis of substrate binding by the TatBC component of the twin-arginine protein transport system |
| Q28555062 | Structural and Functional Characterization of the Bacterial Type III Secretion Export Apparatus |
| Q27670706 | Structural and Functional Studies on the N-terminal Domain of the Shigella Type III Secretion Protein MxiG |
| Q57836573 | Structural and functional characteristics of MBL/Ficolin-associated Protein-1 (MAP-1) |
| Q27644542 | Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55 |
| Q38749981 | Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands |
| Q40354189 | Structural and functional insights into the interaction of echoviruses and decay-accelerating factor |
| Q24676448 | Structural basis for complement factor H linked age-related macular degeneration |
| Q24622871 | Structural basis for complement factor I control and its disease-associated sequence polymorphisms |
| Q36435139 | Structural basis for specificity and promiscuity in a carrier protein/enzyme system from the sulfur cycle |
| Q27704314 | Structural basis for therapeutic inhibition of complement C5 |
| Q119057046 | Structural basis of antifolate recognition and transport by PCFT |
| Q47098372 | Structural basis of cholesterol binding by a novel clade of dendritic cell modulators from ticks. |
| Q38202760 | Structural biology of Tat protein transport |
| Q34366417 | Structural characterization of an anti-gp120 RNA aptamer that neutralizes R5 strains of HIV-1. |
| Q45771643 | Structural comparison of two strains of foot-and-mouth disease virus subtype O1 and a laboratory antigenic variant, G67. |
| Q57836560 | Structural findings in complement factor H-related proteins unravel the pathogenesis of C3 glomerulopathy |
| Q112573134 | Structure and function of a family of tick-derived complement inhibitors targeting properdin |
| Q112608608 | Structure and mechanism of the proton-driven motor that powers type 9 secretion and gliding motility |
| Q38324873 | Structure of Foot-and-mouth disease virus serotype A10 61 alone and complexed with oligosaccharide receptor: receptor conservation in the face of antigenic variation |
| Q27732027 | Structure of a major immunogenic site on foot-and-mouth disease virus |
| Q27650767 | Structure of and influence of a tick complement inhibitor on human complement component 5 |
| Q34491114 | Structure of human complement C8, a precursor to membrane attack |
| Q27675340 | Structure of the TatC core of the twin-arginine protein transport system |
| Q57843586 | Structure of the core of the type III secretion system export apparatus |
| Q55403226 | Structure-based design of chimeric antigens for multivalent protein vaccines. |
| Q53602216 | Structure-function mapping of BbCRASP-1, the key complement factor H and FHL-1 binding protein of Borrelia burgdorferi. |
| Q27677459 | Structures of CD200/CD200 Receptor Family and Implications for Topology, Regulation, and Evolution |
| Q35943010 | Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction |
| Q89881502 | Structures of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR fold |
| Q27649946 | Structures of the Shigella flexneri Type 3 Secretion System Protein MxiC Reveal Conformational Variability Amongst Homologues |
| Q119057034 | Structures of the Type IX Secretion/Gliding Motility Motor from across the Phylum |
| Q119057035 | Structures of the Type IX Secretion/gliding motility motor from across the phylum Bacteroidetes |
| Q27671061 | Structures of the rat complement regulator CrrY |
| Q99418490 | Structures of the stator complex that drives rotation of the bacterial flagellum |
| Q91874790 | Symmetry mismatch in the MS-ring of the bacterial flagellar rotor explains the structural coordination of secretion and rotation |
| Q41895626 | TatBC, TatB, and TatC form structurally autonomous units within the twin arginine protein transport system of Escherichia coli |
| Q38002809 | Tetartohedral twinning could happen to you too |
| Q24301407 | The CD46-Jagged1 interaction is critical for human TH1 immunity |
| Q27653378 | The Escherichia coli Cell Division Protein and Model Tat Substrate SufI (FtsP) Localizes to the Septal Ring and Has a Multicopper Oxidase-Like Structure |
| Q92381316 | The S. Typhi effector StoD is an E3/E4 ubiquitin ligase which binds K48- and K63-linked diubiquitin |
| Q36127196 | The Salmonella type III secretion system inner rod protein PrgJ is partially folded. |
| Q27644514 | The Structure of OMCI, a Novel Lipocalin Inhibitor of the Complement System |
| Q93023860 | The Structure of an Injectisome Export Gate Demonstrates Conservation of Architecture in the Core Export Gate between Flagellar and Virulence Type III Secretion Systems |
| Q35127642 | The centrosome-specific phosphorylation of Cnn by Polo/Plk1 drives Cnn scaffold assembly and centrosome maturation. |
| Q54472496 | The characterization of weak protein-protein interactions: evidence from DEER for the trimerization of a von Willebrand Factor A domain in solution. |
| Q42425294 | The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies |
| Q27730909 | The structure and antigenicity of a type C foot-and-mouth disease virus |
| Q38328829 | The structure and function of a foot-and-mouth disease virus-oligosaccharide receptor complex. |
| Q40672613 | The structure of an immunodominant loop on foot and mouth disease virus, serotype O1, determined under reducing conditions |
| Q27642610 | The structure of echovirus type 12 bound to a two-domain fragment of its cellular attachment protein decay-accelerating factor (CD 55) |
| Q90207511 | The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion |
| Q36303183 | The type III needle and the damage done |
| Q24644829 | Three-dimensional reconstruction of the Shigella T3SS transmembrane regions reveals 12-fold symmetry and novel features throughout |
| Q37665331 | Timing is everything: the regulation of type III secretion |
| Q57939180 | Towards a structural basis for complement factor H linked age-related macular degeneration |
| Q57836539 | Two cross-reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but have different functional properties |
| Q58599951 | Type 9 secretion system structures reveal a new protein transport mechanism |
| Q36638746 | What's the point of the type III secretion system needle? |
| Q39968674 | With phases: how two wrongs can sometimes make a right |
| Susan Lea (scientist) | wikipedia |
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