Stereospecific Formation of a Ternary Complex of (S)-α,β-Fluoromethylene-dATP with DNA Pol β

scientific article

Stereospecific Formation of a Ternary Complex of (S)-α,β-Fluoromethylene-dATP with DNA Pol β is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/CBIC.201100738
P932PMC publication ID3788113
P698PubMed publication ID22315190

P50authorSamuel H. WilsonQ62027988
P2093author name stringBoris A Kashemirov
Charles E McKenna
David D Shock
Myron F Goodman
Vinod K Batra
William A Beard
Anastasia P Kadina
Brian T Chamberlain
P2860cites work( R )-β,γ-Fluoromethylene-dGTP-DNA Ternary Complex with DNA Polymerase βQ27649120
α,β-Difluoromethylene Deoxynucleoside 5′-Triphosphates: A Convenient Synthesis of Useful Probes for DNA Polymerase β Structure and FunctionQ27654568
Halogenated β,γ-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase β: Structural Evidence for Stereospecific Binding of the Fluoromethylene AnaloguesQ27661593
Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acidQ27664095
AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreadingQ27860652
Is there a link between DNA polymerase beta and cancer?Q28274556
Organic Fluorine Hardly Ever Accepts Hydrogen BondsQ30052358
Fluorine–Protein Interactions and 19F NMR Isotropic Chemical Shifts: An Empirical Correlation with Implications for Drug DesignQ30396809
Hydrogen bonding interactions of covalently bonded fluorine atoms: from crystallographic data to a new angular function in the GRID force fieldQ30966913
Regulation of DNA repair fidelity by molecular checkpoints: "gates" in DNA polymerase beta's substrate selectionQ31086167
Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT.Q33966716
Magnesium-induced assembly of a complete DNA polymerase catalytic complex.Q35792408
Structure and mechanism of DNA polymerase Beta.Q36389634
Requirement of mammalian DNA polymerase-beta in base-excision repair.Q41239890
α-Azido bisphosphonates: synthesis and nucleotide analoguesQ42095650
DNA polymerase beta fidelity: halomethylene-modified leaving groups in pre-steady-state kinetic analysis reveal differences at the chemical transition stateQ46529165
Molecular Pair Analysis: CH⋅⋅⋅F Interactions in the Crystal Structure of Fluorobenzene? And Related MattersQ64028612
P433issue4
P304page(s)528-530
P577publication date2012-02-07
P1433published inChemBioChemQ634395
P1476titleStereospecific formation of a ternary complex of (S)-α,β-fluoromethylene-dATP with DNA pol β
P478volume13

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cites work (P2860)
Q36545114Effect of β,γ-CHF- and β,γ-CHCl-dGTP halogen atom stereochemistry on the transition state of DNA polymerase β.
Q40189472Remarkably Stereospecific Utilization of ATP α,β-Halomethylene Analogues by Protein Kinases.
Q33926415Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization
Q34467599Structural basis for the inefficient nucleotide incorporation opposite cisplatin-DNA lesion by human DNA polymerase β.
Q89624280Structural insights into the promutagenic bypass of the major cisplatin-induced DNA lesion
Q27672742Structures of dNTP Intermediate States during DNA Polymerase Active Site Assembly
Q37701454Transition state in DNA polymerase β catalysis: rate-limiting chemistry altered by base-pair configuration.
Q36355109Two Scaffolds from Two Flips: (α,β)/(β,γ) CH2/NH "Met-Im" Analogues of dTTP
Q86002086Unexpected loss of stereoselectivity in ring-opening reaction of 2-alkoxy-2-thio-1,3,2-oxathiaphospholanes with a pyrophosphate anion