Crystal Structures of Botulinum Neurotoxin DC in Complex with Its Protein Receptors Synaptotagmin I and II

scientific article

Crystal Structures of Botulinum Neurotoxin DC in Complex with Its Protein Receptors Synaptotagmin I and II is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.STR.2013.06.026
P3181OpenCitations bibliographic resource ID1584563
P932PMC publication ID3803103
P698PubMed publication ID23932591
P5875ResearchGate publication ID255733761

P50authorLisheng PengQ97538409
Pål StenmarkQ28324836
Ronnie BerntssonQ42717835
P2093author name stringMin Dong
Linda Marie Svensson
P2860cites workSolubilization and characterization of the acceptor for Clostridium botulinum type B neurotoxin from rat brain synaptic membranesQ72634438
SV2 mediates entry of tetanus neurotoxin into central neuronsQ21090499
Botulinum Toxin as a Biological Weapon: Medical and Public Health ManagementQ23832736
Bacterial toxins: a table of lethal amountsQ24634272
Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin BQ27626220
The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxinQ27632675
Structural basis of cell surface receptor recognition by botulinum neurotoxin BQ27643302
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificityQ27643303
Crystal Structure of Botulinum Neurotoxin Type A in Complex with the Cell Surface Co-Receptor GT1b—Insight into the Toxin–Neuron InteractionQ27651618
Glycosylated SV2 and Gangliosides as Dual Receptors for Botulinum Neurotoxin Serotype FQ27655649
Crystal Structure of the Botulinum Neurotoxin Type G Binding Domain: Insight into Cell Surface BindingQ27660172
Structural Analysis of Botulinum Neurotoxin Type G Receptor Binding,Q27662005
Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent mannerQ27664044
Identification of a Unique Ganglioside Binding Loop within Botulinum Neurotoxins C and D-SA,Q27664131
Structural analysis of the receptor binding domain of botulinum neurotoxin serotype DQ27664616
Crystal structure of the receptor binding domain of the botulinum C–D mosaic neurotoxin reveals potential roles of lysines 1118 and 1136 in membrane interactionsQ27666174
The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sitesQ27667683
Novel Ganglioside-mediated Entry of Botulinum Neurotoxin Serotype D into NeuronsQ27668123
Structural and mutational analyses of the receptor binding domain of botulinum D/C mosaic neurotoxin: insight into the ganglioside binding mechanismQ27670769
Unique Ganglioside Recognition Strategies for Clostridial NeurotoxinsQ27671814
Botulinum Neurotoxin Serotype C Associates with Dual Ganglioside Receptors to Facilitate Cell EntryQ27673821
XDSQ27860472
Use of TLS parameters to model anisotropic displacements in macromolecular refinementQ27860499
Coot: model-building tools for molecular graphicsQ27860505
Refinement of macromolecular structures by the maximum-likelihood methodQ27861011
The CCP4 suite: programs for protein crystallographyQ27861090
Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: increased therapeutic dosage and immunogenicityQ28572057
The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nervesQ28578304
A manual collection of Syt, Esyt, Rph3a, Rph3al, Doc2, and Dblc2 genes from 46 metazoan genomes--an open access resource for neuroscience and evolutionary biologyQ30484362
The HCC-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interactionQ31036598
Clostridial toxins as therapeutic agents: benefits of nature's most toxic proteinsQ33765977
Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxinsQ33793263
Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptorsQ33869062
Neurotoxins affecting neuroexocytosisQ33881286
Sequence variation within botulinum neurotoxin serotypes impacts antibody binding and neutralizationQ34034156
Unique ganglioside binding by botulinum neurotoxins C and D-SAQ35207347
Genetic diversity among Botulinum Neurotoxin-producing clostridial strainsQ35634548
The receptor binding domain of botulinum neurotoxin serotype C binds phosphoinositidesQ35751422
Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cellsQ36325534
Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons.Q36992893
Neuro-exocytosis: botulinum toxins as inhibitory probes and versatile therapeuticsQ37460054
Botulinum neurotoxin: a marvel of protein designQ37710092
Molecular structures and functional relationships in clostridial neurotoxinsQ37876965
Analysis of neurotoxin cluster genes in Clostridium botulinum strains producing botulinum neurotoxin serotype A subtypesQ38607324
SV2 is the protein receptor for botulinum neurotoxin A.Q40303506
Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptorQ43299518
Synaptotagmins I and II act as nerve cell receptors for botulinum neurotoxin G.Q44881077
Binding of Clostridium botulinum type C and D neurotoxins to ganglioside and phospholipid. Novel insights into the receptor for clostridial neurotoxinsQ46663715
Mosaic structures of neurotoxins produced from Clostridium botulinum types C and D organismsQ46880568
Identification of protein receptor for Clostridium botulinum type B neurotoxin in rat brain synaptosomes.Q48141244
The N-terminal half of the receptor domain of botulinum neurotoxin A binds to microdomains of the plasma membraneQ61662145
Binding of botulinum type B neurotoxin to Chinese hamster ovary cells transfected with rat synaptotagmin II cDNAQ71660117
P433issue9
P921main subjectcrystal structureQ895901
structural biologyQ908902
P304page(s)1602-11
P577publication date2013-09-03
P1433published inStructureQ15709970
P1476titleCrystal Structures of Botulinum Neurotoxin DC in Complex with Its Protein Receptors Synaptotagmin I and II
P478volume21