Botulinum Neurotoxin Serotype C Associates with Dual Ganglioside Receptors to Facilitate Cell Entry

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Botulinum Neurotoxin Serotype C Associates with Dual Ganglioside Receptors to Facilitate Cell Entry is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.404244
P3181OpenCitations bibliographic resource ID5008885
P932PMC publication ID3504792
P698PubMed publication ID23027864

P2093author name stringJung-Ja P Kim
Andrew P-A Karalewitz
Joseph T Barbieri
Michael R Baldwin
Zhuji Fu
P2860cites workMolecular basis for tetanus toxin coreceptor interactionsQ46547987
Binding of Clostridium botulinum type C and D neurotoxins to ganglioside and phospholipid. Novel insights into the receptor for clostridial neurotoxinsQ46663715
Identification of the receptor-binding sites in the carboxyl-terminal half of the heavy chain of botulinum neurotoxin types C and D.Q46777601
Mosaic structures of neurotoxins produced from Clostridium botulinum types C and D organismsQ46880568
Translocation of botulinum neurotoxin light chain protease through the heavy chain channelQ46942366
Protection with recombinant Clostridium botulinum C1 and D binding domain subunit (Hc) vaccines against C and D neurotoxinsQ48080473
Association of botulinum neurotoxin serotypes a and B with synaptic vesicle protein complexes.Q53570184
How do tetanus and botulinum toxins bind to neuronal membranes?Q56226691
A readily retrievable pool of synaptic vesiclesQ57949867
GM1 structure determines SV40-induced membrane invagination and infectionQ58830543
The origin, structure, and pharmacological activity of botulinum toxinQ72518481
Universal template plasmid for introduction of the triple-HA epitope sequence into cloned genesQ73613459
Botulinum neurotoxin B-host receptor recognition: it takes two receptors to tangoQ79487898
Synaptic vesicles interchange their membrane proteins with a large surface reservoir during recyclingQ79921374
Induced domain formation in endocytic invagination, lipid sorting, and scissionQ84772653
Botulinum Toxin as a Biological Weapon: Medical and Public Health ManagementQ23832736
A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactionsQ24597783
Processing of X-ray diffraction data collected in oscillation modeQ26778468
Structural basis of cell surface receptor recognition by botulinum neurotoxin BQ27643302
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificityQ27643303
Crystal Structure of Botulinum Neurotoxin Type A in Complex with the Cell Surface Co-Receptor GT1b—Insight into the Toxin–Neuron InteractionQ27651618
Glycosylated SV2 and Gangliosides as Dual Receptors for Botulinum Neurotoxin Serotype FQ27655649
Gangliosides as High Affinity Receptors for Tetanus NeurotoxinQ27656415
Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent mannerQ27664044
Identification of a Unique Ganglioside Binding Loop within Botulinum Neurotoxins C and D-SA,Q27664131
The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sitesQ27667683
Novel Ganglioside-mediated Entry of Botulinum Neurotoxin Serotype D into NeuronsQ27668123
Structural and mutational analyses of the receptor binding domain of botulinum D/C mosaic neurotoxin: insight into the ganglioside binding mechanismQ27670769
Unique Ganglioside Recognition Strategies for Clostridial NeurotoxinsQ27671814
Coot: model-building tools for molecular graphicsQ27860505
Version 1.2 of the Crystallography and NMR systemQ27860583
Phasercrystallographic softwareQ27860930
SNAREs--engines for membrane fusionQ29547230
Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevinQ29619130
STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosisQ34513459
Shiga toxin induces tubular membrane invaginations for its uptake into cellsQ34719609
Genetic diversity among Botulinum Neurotoxin-producing clostridial strainsQ35634548
Glycosphingolipids-sweets for botulinum neurotoxinQ35932883
Botulinum neurotoxin A blocks synaptic vesicle exocytosis but not endocytosis at the nerve terminalQ36313397
Mechanism of botulinum neurotoxin B and G entry into hippocampal neuronsQ36639118
Identification of a ganglioside recognition domain of tetanus toxin using a novel ganglioside photoaffinity ligand.Q36891826
Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons.Q36992893
Cell entry strategy of clostridial neurotoxinsQ37490213
Molecular circuitry of endocytosis at nerve terminals.Q37540209
Sphingolipids and gangliosides of the nervous system in membrane function and dysfunctionQ37652733
Botulinum neurotoxin: a marvel of protein designQ37710092
Retargeted clostridial neurotoxins as novel agents for treating chronic diseases.Q39449111
SV2 is the protein receptor for botulinum neurotoxin A.Q40303506
Molecular diversity of neurotoxins from Clostridium botulinum type D strainsQ40428135
Substrate recognition of VAMP-2 by botulinum neurotoxin B and tetanus neurotoxinQ40642361
Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptorQ43299518
Synaptotagmins I and II act as nerve cell receptors for botulinum neurotoxin G.Q44881077
P4510describes a project that usesImageJQ1659584
P433issue48
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
P304page(s)40806-16
P577publication date2012-11-23
P1433published inJournal of Biological ChemistryQ867727
P1476titleBotulinum Neurotoxin Serotype C Associates with Dual Ganglioside Receptors to Facilitate Cell Entry
P478volume287

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cites work (P2860)
Q35745530A Heterologous Reporter Defines the Role of the Tetanus Toxin Interchain Disulfide in Light-Chain Translocation
Q52803571A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency.
Q58615344Botulinum and Tetanus Neurotoxins
Q38224215Botulinum neurotoxins: genetic, structural and mechanistic insights.
Q35692529CRISPR/Cas9-Mediated Genomic Deletion of the Beta-1, 4 N-acetylgalactosaminyltransferase 1 Gene in Murine P19 Embryonal Carcinoma Cells Results in Low Sensitivity to Botulinum Neurotoxin Type C.
Q90390390Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy
Q27679493Crystal Structures of Botulinum Neurotoxin DC in Complex with Its Protein Receptors Synaptotagmin I and II
Q26778129Current status and future directions of botulinum neurotoxins for targeting pain processing
Q38847565Detection, differentiation, and identification of botulinum neurotoxin serotypes C, CD, D, and DC by highly specific immunoassays and mass spectrometry.
Q38587703Dissecting the Role of Anti-ganglioside Antibodies in Guillain-Barré Syndrome: an Animal Model Approach.
Q35563112Diverse binding modes, same goal: The receptor recognition mechanism of botulinum neurotoxin.
Q37654972Engineering Botulinum Neurotoxin C1 as a Molecular Vehicle for Intra-Neuronal Drug Delivery.
Q57177243Engineering Botulinum Toxins to Improve and Expand Targeting and SNARE Cleavage Activity
Q37546383Entry of a recombinant, full-length, atoxic tetanus neurotoxin into Neuro-2a cells
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Q98176846Intracellular G-actin targeting of peripheral sensory neurons by the multifunctional engineered protein C2C confers relief from inflammatory pain
Q39648919Retargeting the Clostridium botulinum C2 toxin to the neuronal cytosol
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Q87698566Synaptotagmin II and gangliosides bind independently with botulinum neurotoxin B but each restrains the other
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Q45316693Toxicity of botulinum toxin type C (botC)
Q48026258Two Feet on the Membrane: Uptake of Clostridial Neurotoxins
Q57808978Variations in the Botulinum Neurotoxin Binding Domain and the Potential for Novel Therapeutics
Q50289594botC HC:LC binds GT1b on the target cell surface

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