Tetanus neurotoxin utilizes two sequential membrane interactions for channel formation.

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Tetanus neurotoxin utilizes two sequential membrane interactions for channel formation. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M114.559302
P932PMC publication ID4139251
P698PubMed publication ID24973217

P50authorJoshua R BurnsQ88088537
P2093author name stringMichael R Baldwin
P2860cites workBotulinum neurotoxin B recognizes its protein receptor with high affinity and specificityQ27643303
Glycosylated SV2 and Gangliosides as Dual Receptors for Botulinum Neurotoxin Serotype FQ27655649
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Unique Ganglioside Recognition Strategies for Clostridial NeurotoxinsQ27671814
Botulinum Neurotoxin Serotype C Associates with Dual Ganglioside Receptors to Facilitate Cell EntryQ27673821
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Botulinum neurotoxin devoid of receptor binding domain translocates active proteaseQ33394567
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Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxinsQ33793263
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Sequence variation within botulinum neurotoxin serotypes impacts antibody binding and neutralizationQ34034156
Receptor binding enables botulinum neurotoxin B to sense low pH for translocation channel assembly.Q35626467
Beltless translocation domain of botulinum neurotoxin A embodies a minimum ion-conductive channelQ35693923
Botulinum neurotoxins B and E translocate at different rates and exhibit divergent responses to GT1b and low pHQ36099792
Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cellsQ36325534
Tetanus toxin fragment forms channels in lipid vesicles at low pHQ36325692
General aspects and recent advances on bacterial protein toxinsQ36554621
Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons.Q36992893
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Entry of a recombinant, full-length, atoxic tetanus neurotoxin into Neuro-2a cellsQ37546383
Channels formed by botulinum, tetanus, and diphtheria toxins in planar lipid bilayers: relevance to translocation of proteins across membranesQ37680475
Double anchorage to the membrane and intact inter-chain disulfide bond are required for the low pH induced entry of tetanus and botulinum neurotoxins into neurons.Q39500669
Type F botulism due to neurotoxigenic Clostridium baratii from an unknown source in an adultQ40214264
SV2 is the protein receptor for botulinum neurotoxin A.Q40303506
Sequence homology and structural analysis of the clostridial neurotoxinsQ41695875
Kinetic intermediate reveals staggered pH-dependent transitions along the membrane insertion pathway of the diphtheria toxin T-domainQ42562431
On the analysis of membrane protein circular dichroism spectraQ43104925
Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptorQ43299518
Arg(362) and Tyr(365) of the botulinum neurotoxin type a light chain are involved in transition state stabilizationQ43876643
Two carbohydrate binding sites in the H(CC)-domain of tetanus neurotoxin are required for toxicityQ44312023
Synaptotagmins I and II act as nerve cell receptors for botulinum neurotoxin G.Q44881077
A novel strain of Clostridium botulinum that produces type B and type H botulinum toxinsQ45345427
Analysis of active site residues of botulinum neurotoxin E by mutational, functional, and structural studies: Glu335Gln is an apoenzymeQ46530120
Molecular basis for tetanus toxin coreceptor interactionsQ46547987
Sequences of the botulinal neurotoxin E derived from Clostridium botulinum type E (strain Beluga) and Clostridium butyricum (strains ATCC 43181 and ATCC 43755)Q48184773
Micellar properties of glycosphingolipids in aqueous mediaQ48604649
Insertion of Anthrax Protective Antigen into Liposomal MembranesQ57213769
Light Chain of Botulinum Neurotoxin Serotype A: Structural Resolution of a Catalytic Intermediate†,‡Q61779321
Membrane interactions of tetanus and botulinum neurotoxins: a photolabelling study with photoactivatable phospholipidsQ68682703
Inhibition of vacuolar adenosine triphosphatase antagonizes the effects of clostridial neurotoxins but not phospholipase A2 neurotoxinsQ72389951
Spectroscopic analysis of low pH and lipid-induced structural changes in type A botulinum neurotoxin relevant to membrane channel formation and translocationQ74769349
Botulinum neurotoxin light chain refolds at endosomal pH for its translocationQ79370818
P433issue32
P407language of work or nameEnglishQ1860
P1104number of pages9
P304page(s)22450-22458
P577publication date2014-06-27
P1433published inJournal of Biological ChemistryQ867727
P1476titleTetanus neurotoxin utilizes two sequential membrane interactions for channel formation
P478volume289